Afzal Hussain - Academia.edu (original) (raw)
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Papers by Afzal Hussain
Current Opinion in Biotechnology, 1995
Advances in liposomal drug-delivery systems Chonn and Cullis 69 Table 1. Liposomal drugs currentl... more Advances in liposomal drug-delivery systems Chonn and Cullis 69 Table 1. Liposomal drugs currently under development or on the market. Product name (if any) Drug Conventional drugs ABLC (Abelcet) Amphotericin B AmBisome Amphotericin B Amphocil Amphotericin B Doxil (DOX-SL) Doxorubicin Phase I Medical Research Council, UK
Drug delivery, Jan 24, 2015
To prepare and optimize the topical elastic liposome (EL)-loaded carbopol-980 gel of 5-Fluorourac... more To prepare and optimize the topical elastic liposome (EL)-loaded carbopol-980 gel of 5-Fluorouracil (5-FU) containing permeation enhancers (azone, propylene glycol (PG) and lauryl alcohol (LA)) and further evaluation for permeation flux of 5-FU, the activation energy and irritation in the rat skin. EL formulations were prepared using phosphatidylcholine and varied surfactants (Span 60, Span 80 and Tween-80) by rotator evaporation method and optimized by experimental design. In vitro characterizations dictated the EL containing Span 80 (lipid:surfactant = 7:3) (EL3-S80) for further optimization of gel. Different gel formulations (5% w/w) with varying concentration (1-3%) of permeation enhancers were prepared and evaluated for viscosity, spreadability, the 5-FU permeation and deposition. The activation energy using the Franz diffusion cell and the plausible irritation using the Draize test were assessed on the albino rat and rabbit, respectively. EL3-S80 was selected as an optimized E...
University Journal of Zoology, Rajshahi …, 2009
Zooplankton constitute important food item of many omnivorous and carnivorous fishes. The study w... more Zooplankton constitute important food item of many omnivorous and carnivorous fishes. The study was conducted with an aim to study the zooplankton production including physico-chemical parameters with an emphasis to the existing management practices taken by the operators. The study was carried out in a culture and a non-culture pond of Rajshahi University campus was carried out from September, 2004 to February, 2005. Monthly fluctuations of some physico-chemical parameters were noted. The ponds showed alkaline in nature with moderate bicarbonate alkalinity. Diurnal change of water temperature, free CO 2 and dissolved Oxygen were also studied. Four groups of zooplankton were identified, of which copepods (1260 units/l and 973.33 units/l in pond-1 and pond-2 respectively) were most dominant. A total of 9 genera of zooplankton were identified of which Cyclops (68.25% and 60.28% of total copepods) was most abundant in both ponds. Total zooplankton showed positive correlation with pH, carbonate alkalinity (CO 3) and bicarbonate alkalinity (HCO 3) in both ponds and DO, carbon dioxide (CO 2) in pond-1. Present findings indicated that the culture pond showed better result than that of the non-culture pond regarding zooplankton production.
Current Opinion in Biotechnology, 1995
Advances in liposomal drug-delivery systems Chonn and Cullis 69 Table 1. Liposomal drugs currentl... more Advances in liposomal drug-delivery systems Chonn and Cullis 69 Table 1. Liposomal drugs currently under development or on the market. Product name (if any) Drug Conventional drugs ABLC (Abelcet) Amphotericin B AmBisome Amphotericin B Amphocil Amphotericin B Doxil (DOX-SL) Doxorubicin Phase I Medical Research Council, UK
Drug delivery, Jan 24, 2015
To prepare and optimize the topical elastic liposome (EL)-loaded carbopol-980 gel of 5-Fluorourac... more To prepare and optimize the topical elastic liposome (EL)-loaded carbopol-980 gel of 5-Fluorouracil (5-FU) containing permeation enhancers (azone, propylene glycol (PG) and lauryl alcohol (LA)) and further evaluation for permeation flux of 5-FU, the activation energy and irritation in the rat skin. EL formulations were prepared using phosphatidylcholine and varied surfactants (Span 60, Span 80 and Tween-80) by rotator evaporation method and optimized by experimental design. In vitro characterizations dictated the EL containing Span 80 (lipid:surfactant = 7:3) (EL3-S80) for further optimization of gel. Different gel formulations (5% w/w) with varying concentration (1-3%) of permeation enhancers were prepared and evaluated for viscosity, spreadability, the 5-FU permeation and deposition. The activation energy using the Franz diffusion cell and the plausible irritation using the Draize test were assessed on the albino rat and rabbit, respectively. EL3-S80 was selected as an optimized E...
University Journal of Zoology, Rajshahi …, 2009
Zooplankton constitute important food item of many omnivorous and carnivorous fishes. The study w... more Zooplankton constitute important food item of many omnivorous and carnivorous fishes. The study was conducted with an aim to study the zooplankton production including physico-chemical parameters with an emphasis to the existing management practices taken by the operators. The study was carried out in a culture and a non-culture pond of Rajshahi University campus was carried out from September, 2004 to February, 2005. Monthly fluctuations of some physico-chemical parameters were noted. The ponds showed alkaline in nature with moderate bicarbonate alkalinity. Diurnal change of water temperature, free CO 2 and dissolved Oxygen were also studied. Four groups of zooplankton were identified, of which copepods (1260 units/l and 973.33 units/l in pond-1 and pond-2 respectively) were most dominant. A total of 9 genera of zooplankton were identified of which Cyclops (68.25% and 60.28% of total copepods) was most abundant in both ponds. Total zooplankton showed positive correlation with pH, carbonate alkalinity (CO 3) and bicarbonate alkalinity (HCO 3) in both ponds and DO, carbon dioxide (CO 2) in pond-1. Present findings indicated that the culture pond showed better result than that of the non-culture pond regarding zooplankton production.