Agnieszka Czylkowska - Academia.edu (original) (raw)

Papers by Agnieszka Czylkowska

Research paper thumbnail of New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

Research paper thumbnail of Influence of Complexation of Thiosemicarbazone Derivatives with Cu (II) Ions on Their Antitumor Activity against Melanoma Cells

International Journal of Molecular Sciences, Mar 18, 2021

Research paper thumbnail of Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer

Research paper thumbnail of Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation

Bioorganic & Medicinal Chemistry Letters, 2004

In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of ... more In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2′-benzyloxy-5′-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiation specific assays. Several candidates of the 5-benzylidene-thiazolidine-2,4-diones (3c, 3d, and 3f) and -thiones (2b, 2e, and 2j), inhibit cell growth with low μM GI50 mediated by inhibition of translation initiation, which involves

Research paper thumbnail of Design, Synthesis and Characterization of Novel Biodegradable Poly(urethane-urea) for Biomedical Applications

Asian Journal of Chemistry, 2013

Research paper thumbnail of Synthesis, Characterization and Thermal Decomposition of Yttrium and Light Lanthanides with 4,4'-Bipyridine and Dichloroacetates

Polish Journal of Chemistry, 2007

A novel mixed-ligand complexes with empirical formulae: Ln(4-bpy)(CCl2HCOO) 3 ·H 2 O (where: Ln =... more A novel mixed-ligand complexes with empirical formulae: Ln(4-bpy)(CCl2HCOO) 3 ·H 2 O (where: Ln = Y, Ce, Nd, Pr and Eu, 4-bpy = 4,4'-bipyridine) were prepared and characterized by chemical and elemental analysis, IR spectroscopy and conductivity measurements (in methanol, dimethylformamide and dimethylsulfoxide). Analysis of the powder diffraction patterns showed that the obtained complexes are crystalline and isostructural compounds. The thermal properties of complexes in the solid state were studied under non-isothermal conditions in air atmosphere. During heating the complexes decompose via intermediate products to the oxides: Ln 2 O 3 (Y, Nd, Eu), Pr 6 O 1 and CeO 2 . A coupled TG-MS system was used to analyse principal volatile thermal decomposition (or fragmentation) products evolved during pyrolysis of Pr(III) and Nd(III) complexes. In air major profiles for ion currents are observed with m/z = 12, 18, 29, 30, 35, 36, 44, 47 amongst others.

Research paper thumbnail of Synthesis, characterization and thermal decomposition of yttrium and light lanthanides with 4,4'-bipyridine and dichloroacetates

Polish Journal of Chemistry, 2007

Research paper thumbnail of Synthesis, Characterization and Molecular structure of bis(2,2′-Bipyridine- N , N ′)Bis(Monochloroacetato-O) Manganese(II) Dihydrate

J Coord Chem, 2004

[Mn(2-bpy)2(mcac-O)2]·2H2O (2-bpy = 2,2′-bipyridine, mcac = ClCH2COO) has been synthesized and ch... more [Mn(2-bpy)2(mcac-O)2]·2H2O (2-bpy = 2,2′-bipyridine, mcac = ClCH2COO) has been synthesized and characterized by elemental and thermal analysis, IR, magnetic and conductivity studies. It crystallizes in space group P21/n. The manganese atom adopts a significantly distorted square bipyramidal coordination. Mn–O bonds are distinctly stronger than Mn–N bonds. Molecules of the title compound are linked by strong hydrogen bonds O–H…O(acetate) to form an infinite hydrogen-bonded chain.

Research paper thumbnail of Thermal and Other Properties of New 4,4'-bipyridine-trichloroacetato Complexes of Mn(II), Ni(II) and Zn(II)

Journal of Thermal Analysis and Calorimetry, 2002

New mixed-ligand complexes of general formulae Mn(4-bpy)(CCl3COO)2⋅H2O, Ni(4-bpy)2(CCl3COO)2⋅2H2O... more New mixed-ligand complexes of general formulae Mn(4-bpy)(CCl3COO)2⋅H2O, Ni(4-bpy)2(CCl3COO)2⋅2H2O and Zn(4-bpy)2(CCl3COO)2⋅2H2O (where 4-bpy=4,4’-bipyridine) were obtained and characterized. The IR spectra, conductivity measurements and other physical properties of these compounds were discussed. The central atoms M(II) form coordinate bonds with title ligands. The thermal behaviour of the synthesized complexes was studied in air. During heating the complexes decompose via different intermediate products

Research paper thumbnail of New complexes of Mn(II), Co(II), Ni(II) AND Cu(II) with 2,2’- OR 2,4’-bipyridine and formates (Synthesis, thermal and other properties)

Journal of Thermal Analysis and Calorimetry, 2006

New mixed-ligand complexes with empirical formulae: Mn(2-bpy)1.5L22H2O, M(2-bpy)2L23H2O (M(II)=Co... more New mixed-ligand complexes with empirical formulae: Mn(2-bpy)1.5L22H2O, M(2-bpy)2L23H2O (M(II)=Co, Cu), Ni(2-bpy)3L24H2O and M(2,4’-bpy)2L22H2O (where 2-bpy=2,2’-bipyridine, 2,4’-bpy=2,4’-bipyridine; L=HCOO– ) have been obtained in pure solid-state. The complexes were characterized by chemical and elemental analysis, IR and VIS spectroscopy, conductivity (in methanol and dimethylsulfoxide). The way of metal-ligand coordination discussed. The formate and 2,4’-bpy act as monodentate ligands and 2-bpy as chelate

Research paper thumbnail of Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

International Journal of Molecular Sciences

A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and it... more A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal–ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25–800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging.

Research paper thumbnail of Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

International Journal of Molecular Sciences

Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, whic... more Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lun...

Research paper thumbnail of New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

Molecules

New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active lig... more New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N′-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques: elemental analysis (EA), thermogravimetric analysis (TG–DTG), infrared spectroscopy (FTIR), and flame-atomic absorption spectrometry (F-AAS). The biological activity of the obtained compounds was then comprehensively investigated. Rational use of these compounds as potential drugs was proven by ADME analysis. All obtained compounds were screened in vitro for antibacterial, antifungal, and anticancer activities. Some of the studied complexes exhibited significantly higher activity than the ligand alone.

Research paper thumbnail of CCDC 2090557: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2090558: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2058477: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2045148: Experimental Crystal Structure Determination

Research paper thumbnail of Correction to: Steam reforming of ethanol for hydrogen production: influence of catalyst composition (Ni/Al2O3, Ni/Al2O3–CeO2, Ni/Al2O3–ZnO) and process conditions

Reaction Kinetics, Mechanisms and Catalysis, 2021

Research paper thumbnail of Effect of the AACVD based synthesis atmosphere on the structural properties of multi-walled carbon nanotubes

Arabian Journal of Chemistry, 2017

Research paper thumbnail of Anticancer and antimicrobial activity of new copper (II) complexes

Journal of Inorganic Biochemistry

Research paper thumbnail of New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

Research paper thumbnail of Influence of Complexation of Thiosemicarbazone Derivatives with Cu (II) Ions on Their Antitumor Activity against Melanoma Cells

International Journal of Molecular Sciences, Mar 18, 2021

Research paper thumbnail of Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer

Research paper thumbnail of Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation

Bioorganic & Medicinal Chemistry Letters, 2004

In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of ... more In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2′-benzyloxy-5′-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiation specific assays. Several candidates of the 5-benzylidene-thiazolidine-2,4-diones (3c, 3d, and 3f) and -thiones (2b, 2e, and 2j), inhibit cell growth with low μM GI50 mediated by inhibition of translation initiation, which involves

Research paper thumbnail of Design, Synthesis and Characterization of Novel Biodegradable Poly(urethane-urea) for Biomedical Applications

Asian Journal of Chemistry, 2013

Research paper thumbnail of Synthesis, Characterization and Thermal Decomposition of Yttrium and Light Lanthanides with 4,4'-Bipyridine and Dichloroacetates

Polish Journal of Chemistry, 2007

A novel mixed-ligand complexes with empirical formulae: Ln(4-bpy)(CCl2HCOO) 3 ·H 2 O (where: Ln =... more A novel mixed-ligand complexes with empirical formulae: Ln(4-bpy)(CCl2HCOO) 3 ·H 2 O (where: Ln = Y, Ce, Nd, Pr and Eu, 4-bpy = 4,4'-bipyridine) were prepared and characterized by chemical and elemental analysis, IR spectroscopy and conductivity measurements (in methanol, dimethylformamide and dimethylsulfoxide). Analysis of the powder diffraction patterns showed that the obtained complexes are crystalline and isostructural compounds. The thermal properties of complexes in the solid state were studied under non-isothermal conditions in air atmosphere. During heating the complexes decompose via intermediate products to the oxides: Ln 2 O 3 (Y, Nd, Eu), Pr 6 O 1 and CeO 2 . A coupled TG-MS system was used to analyse principal volatile thermal decomposition (or fragmentation) products evolved during pyrolysis of Pr(III) and Nd(III) complexes. In air major profiles for ion currents are observed with m/z = 12, 18, 29, 30, 35, 36, 44, 47 amongst others.

Research paper thumbnail of Synthesis, characterization and thermal decomposition of yttrium and light lanthanides with 4,4'-bipyridine and dichloroacetates

Polish Journal of Chemistry, 2007

Research paper thumbnail of Synthesis, Characterization and Molecular structure of bis(2,2′-Bipyridine- N , N ′)Bis(Monochloroacetato-O) Manganese(II) Dihydrate

J Coord Chem, 2004

[Mn(2-bpy)2(mcac-O)2]·2H2O (2-bpy = 2,2′-bipyridine, mcac = ClCH2COO) has been synthesized and ch... more [Mn(2-bpy)2(mcac-O)2]·2H2O (2-bpy = 2,2′-bipyridine, mcac = ClCH2COO) has been synthesized and characterized by elemental and thermal analysis, IR, magnetic and conductivity studies. It crystallizes in space group P21/n. The manganese atom adopts a significantly distorted square bipyramidal coordination. Mn–O bonds are distinctly stronger than Mn–N bonds. Molecules of the title compound are linked by strong hydrogen bonds O–H…O(acetate) to form an infinite hydrogen-bonded chain.

Research paper thumbnail of Thermal and Other Properties of New 4,4'-bipyridine-trichloroacetato Complexes of Mn(II), Ni(II) and Zn(II)

Journal of Thermal Analysis and Calorimetry, 2002

New mixed-ligand complexes of general formulae Mn(4-bpy)(CCl3COO)2⋅H2O, Ni(4-bpy)2(CCl3COO)2⋅2H2O... more New mixed-ligand complexes of general formulae Mn(4-bpy)(CCl3COO)2⋅H2O, Ni(4-bpy)2(CCl3COO)2⋅2H2O and Zn(4-bpy)2(CCl3COO)2⋅2H2O (where 4-bpy=4,4’-bipyridine) were obtained and characterized. The IR spectra, conductivity measurements and other physical properties of these compounds were discussed. The central atoms M(II) form coordinate bonds with title ligands. The thermal behaviour of the synthesized complexes was studied in air. During heating the complexes decompose via different intermediate products

Research paper thumbnail of New complexes of Mn(II), Co(II), Ni(II) AND Cu(II) with 2,2’- OR 2,4’-bipyridine and formates (Synthesis, thermal and other properties)

Journal of Thermal Analysis and Calorimetry, 2006

New mixed-ligand complexes with empirical formulae: Mn(2-bpy)1.5L22H2O, M(2-bpy)2L23H2O (M(II)=Co... more New mixed-ligand complexes with empirical formulae: Mn(2-bpy)1.5L22H2O, M(2-bpy)2L23H2O (M(II)=Co, Cu), Ni(2-bpy)3L24H2O and M(2,4’-bpy)2L22H2O (where 2-bpy=2,2’-bipyridine, 2,4’-bpy=2,4’-bipyridine; L=HCOO– ) have been obtained in pure solid-state. The complexes were characterized by chemical and elemental analysis, IR and VIS spectroscopy, conductivity (in methanol and dimethylsulfoxide). The way of metal-ligand coordination discussed. The formate and 2,4’-bpy act as monodentate ligands and 2-bpy as chelate

Research paper thumbnail of Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

International Journal of Molecular Sciences

A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and it... more A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal–ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25–800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging.

Research paper thumbnail of Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

International Journal of Molecular Sciences

Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, whic... more Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lun...

Research paper thumbnail of New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

Molecules

New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active lig... more New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N′-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques: elemental analysis (EA), thermogravimetric analysis (TG–DTG), infrared spectroscopy (FTIR), and flame-atomic absorption spectrometry (F-AAS). The biological activity of the obtained compounds was then comprehensively investigated. Rational use of these compounds as potential drugs was proven by ADME analysis. All obtained compounds were screened in vitro for antibacterial, antifungal, and anticancer activities. Some of the studied complexes exhibited significantly higher activity than the ligand alone.

Research paper thumbnail of CCDC 2090557: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2090558: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2058477: Experimental Crystal Structure Determination

Research paper thumbnail of CCDC 2045148: Experimental Crystal Structure Determination

Research paper thumbnail of Correction to: Steam reforming of ethanol for hydrogen production: influence of catalyst composition (Ni/Al2O3, Ni/Al2O3–CeO2, Ni/Al2O3–ZnO) and process conditions

Reaction Kinetics, Mechanisms and Catalysis, 2021

Research paper thumbnail of Effect of the AACVD based synthesis atmosphere on the structural properties of multi-walled carbon nanotubes

Arabian Journal of Chemistry, 2017

Research paper thumbnail of Anticancer and antimicrobial activity of new copper (II) complexes

Journal of Inorganic Biochemistry