Ahmad Faried - Academia.edu (original) (raw)

Papers by Ahmad Faried

Tarumanagara Medical Journal

Anaplastic meningioma is an uncommon neoplasm in childhood and adolescence. In contrast to the ca... more Anaplastic meningioma is an uncommon neoplasm in childhood and adolescence. In contrast to the case in adults, pediatrics have a predominance of males over females. We report a case of a 17 years old with progressive scalp swelling on the right side. Patient underwent subtotal tumor resection at previous hospital three months ago. The operation was stopped due to extensive bleeding. Radiological investigations revealed a dura-based tumor with a cystic component. Following preoperative embolization, a craniotomy was done, and the tumor was almost completely removed. The tumor's histopathological analysis revealed characteristics of an anaplastic meningioma. The aggressive behavior of this tumor necessitates meticulous monitoring of therapeutic measures in such patients.

Molecular and Cellular Biomedical Sciences

Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhan... more Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This benefit occurs via a mechanism that promotes viral clearance by phagocytes and macrophages. This action occurs through the innate (increase in IL-10 production and decrease in TNF-α and IL-12 production) and the adaptive immune system (decrease in IL-17 production, promote regulatory T cell proliferation and inhibit effectors T cell proliferation). MSCs are expected to act as an anti-inflammatory in the hyper-inflammatory state of COVID-19. MSCs enhance immune cell replacement that have been overwhelmed or have been lost due to cytokine storm. Although vaccines are the answer to this pandemic, MSCs can improve COVID-19 patients, especially in patients with chronic illnesses. The focus on keeping death-rates low is a great opportunity for MSCs-based therapy for severe or critically ill patients. MSCs and conditioned medium have the potentia...

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Background Over the last decade, since clinical trials examining targeted therapeutics for glioma... more Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, the emphasis has recently been switched toward innovative techniques for modulating the immune response against tumors and their microenvironments (TME). Cancerous cells have eleven hallmarks which make it distinct from normal ones, among which is immune evasion. Immune evasion in glioblastoma helps it evade various treatment modalities. Summary Glioblastoma’s TME is composed of various array of cellular actors, ranging from peripherally derived immune cells to a variety of organ-resident specialized cell types. For example, the blood–brain barrier (BBB) serves as a selective barrier between the systemic circulation and the brain, which effectively separates it from other tissues. It is capable of blocking around 98% of molecules that transport different medications to the target tumor. Objectives The purpose of this paper i...

The Internet journal of gynecology and obstetrics, 2019

Background: Follicular fluid plays important roles in oocyte quality, which can increase the succ... more Background: Follicular fluid plays important roles in oocyte quality, which can increase the success rate of assisted reproductive technology (ART) program. Oocyte maturity is influenced by the follicular fluid’s chemical component, including insulin-like growth factor (IGF)-I, which increases follicle-stimulating hormone (FSH) receptor; thereby increasing levels of intracellular cyclic adenosine monophosphate (cAMP) as primary mediator of FSH stimulation in aromatase expression. Materials and Methods: This was analytical correlational study with a cross-sectional approach in ART patients program at Dr. Hasan Sadikin Hospital Bandung. The p <0.05 considered as significance. Results: Mature and immature oocytes showed significant differences in FSH expression (p=0.03). The relationship of IGF-I and oocyte maturity showed no statistical significance (p=0.192). The median ratio of mature oocytes to total oocytes was 0.71; those with a median prevalence ratio > 0.71 showed strong ...

International Journal of Integrated Health Sciences, 2017

Objective: To analyze the correlation between the degree of angulation and neurological deficits ... more Objective: To analyze the correlation between the degree of angulation and neurological deficits as well as pain in spondylitis tuberculosis (TB) patients. Methods: This observational-analytic study included bivariate analysis on data collected from the medical records of patients with presented with spondylitis TB to Dr. Hasan Sadikin General Hospital, Bandung outpatient clinic from January 2014 to December 2015. The variables were the degree of gibbus angulation, neurological deficits, and pain. Results: The study showed significant positive correlation between gibbus angulation and sensory neurological deficits (r=0.375; p=0.009) and there was significant positive correlation between gibbus angulation and pain (r=0.638, p=0.000). The study showed an insignificant correlation between gibbus angulation and motoric neurological deficits (r=0.125; p=0.525). Conclusions: There is a significant correlation between the degree of gibbus angulation and pain as well as sensory neurological...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Traumatic brain injury (TBI) stills the leading cause of public health problem and di... more BACKGROUND: Traumatic brain injury (TBI) stills the leading cause of public health problem and disabilities in many countries, especially in lower-middle-income countries. Motor vehicle crashes, especially motorized two-wheeler riders, are the major cause of TBI, followed by fall and assault. During 2013–2014, a total of 2108 TBI cases (65.4% of them being caused by motor vehicle crashes) were documented in the Emergency Unit of Dr. Hasan Sadikin Hospital (RSHS) Bandung. Among these, 30.7% of cases were categorized as moderate and severe TBI, with a mortality rate of 29.2%. Half of the cases arrived at RSHS within 6 h and 14.0% of these cases were alcohol-intoxicated. Individuals with low activity of alcohol-metabolizing enzymes have low tolerance to alcohol and are therefore rapidly intoxicated, making them more susceptible to more serious injuries from motor vehicle crashes. METHODS: A prospective study was designed by consecutive sampling from January to August 2017 to review 30 ...

BMC Research Notes, 2020

Objective To explore the possibility of a new diagnostic approach of endometriosis based on immun... more Objective To explore the possibility of a new diagnostic approach of endometriosis based on immunocytochemistry scoring of Aromatase P450 expressions in endometrial cells collected from menstrual sloughing. This is a case control study. Immuncytochemistry scores vs. histopathological examination in one tertiary- and secondary-level hospital in Bandung; two secondary level hospital in Garut and Sumedang, West Java, Indonesia. Thirty-five patients with and without endometriosis were enrolled. All subjects had diagnostic procedures for endometriosis suspicion, with addition menstrual blood samples for cytopathological examination. The specimens were sent for immunocytochemistry assessment of P450 Aromatase expressions (ICAPEC). The previous procedure resulted in cut-off point of histo score (H-score), sensitivity, specificity, (+) and (−) ICAPEC predictive value. Results The P450 Aromatase expression in endometrial cells of women with endometriosis was significantly stronger than witho...

Breast Cancer, 2018

Background Nipple areola complex (NAC) infiltration in operable breast carcinoma (OBC) is associa... more Background Nipple areola complex (NAC) infiltration in operable breast carcinoma (OBC) is associated with local recurrence. NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC. This study aims to analyze the expression and interactions of these proteins as risk factors for NAC infiltration in OBC. Materials and methods This is an analytic observational cross-sectional study coupled with a categorical comparative study in each 40 subjects of OBC with and without NAC infiltration. The immunohistochemistry performed with a cutoff point based on the result of a receiver operating characteristics (ROC).

Indonesian Journal of Neurosurgery, 2018

Introduction: The worldwide prevalence of intracranial aneurysms is estimated to be 5-10%; approx... more Introduction: The worldwide prevalence of intracranial aneurysms is estimated to be 5-10%; approximately 10-12 million people are affected by intracranial aneurysms in the United States (US), and they are considered a major problem in public health.The manual interpretation of intracranial aneurysms based on visual examinations and direct observation of medical imaging techniques such as computed tomography (CT) scans, magnetic resonance imaging (MRI), or any of the digital subtraction angiography (DSA), are still presented in monochrome form, and it takes time to interpret the medical images.Methods: Alternative methods are in development that would allow for detection of intracranial aneurysms using open source MATLAB software. This method is a way to observe the aneurysm using the 2 dimensional (2D) DSA data based on the calculations of time to peak (TTP) and time duration (TD) of the contrast agent flow in the blood vessel in order to capture the aneurysm and visualize it using ...

International Journal of Integrated Health Sciences, 2016

Objective: To determine the level of Selenium (Se) in peripheral and intracranial serum in pediat... more Objective: To determine the level of Selenium (Se) in peripheral and intracranial serum in pediatric patients with intracranial tumor. Selenium has chemopreventive potentials and acts as neuromodulator. Methods: This study was conducted on 13 pediatric patients with intracranial tumors who were treated in Dr. Hasan Sadikin Hospital, Bandung in the period of February 2014 to February 2015. Samples were taken from peripheral and intracranial serum. The results were analyzed with independent t-test and Pearson correlation test. Significance is defined as p≤0.05 with 95% confidence interval. Results: The results showed that the average Se concentration in peripheral serum was significantly higher than the Se concentration in intracranial serum (95.92±20.95 μg/L and 66.62±22.37 μg/L, respectively). After classifying the subjects into groups based on sex, age, tumor location, and grades, the difference between Se concentrations were still statistically significant (p≤0.05), with the exception of the supratentorial group (p=0.0053). Pearson correlation test showed very-low to medium strength correlations between peripheral and intracranial serum Se concentration in all groups (r=0.16-0.59, p>0.05). Conclusions: A significant difference is seen between the peripheral and intracranial serum Se concentration means in pediatric patients with intracranial tumors, with higher concentrations observed in the peripheral serum. Further studies are required to investigate the roles of Se in the management of pediatric patients with intracranial tumors.

SSRN Electronic Journal, 2019

Interdisciplinary Neurosurgery, 2016

Acute traumatic subdural hematomas (SDHs) are very common. These hematomas are usually neurosurgi... more Acute traumatic subdural hematomas (SDHs) are very common. These hematomas are usually neurosurgical emergencies, although conservative therapy is indicated in certain cases. SDH can increase intracranial pressure (ICP) and compress or stretch the brainstem. Lately, it has been recognized that increased ICP can lead to hemodynamic instability and bradycardia. Bradycardia can be an early warning sign in many neurosurgical conditions. We observed bradycardia in serial cases of the patient without hypertension and bradypnea, classically known as Cushing's triad, in an acute traumatic SDH patients who were receiving conservative treatment and the bradycardia were proved as an early sign of an increasing ICP. The onset of bradycardia can indicate the need for further evaluation from a conservative management strategy to perform definitive surgery treatment.

Surgical Neurology International

Background: With changes in European and the US academia and education systems, research has beco... more Background: With changes in European and the US academia and education systems, research has become a measurement to define academic productivity, as it is a crucial component in the process of becoming a well-trained neurosurgeon. In this recent study, we aimed to reveal the current status and challenges facing neurosurgical research in Indonesia. Methods: An open-access PubMed MEDLINE database search was performed to reveal all articles published by Indonesian Neurosurgeons from 1980 to July 2021. The detail was extracted to the following parameters: academia center or city of the study, year of publication, study type, topic, journal, institution and Q status, first author, article citation, international collaboration, and the working field. These data were processed and examined. Results: During 1980 and July 2021, a total of 242 PubMed-indexed papers were published from Indonesia. The number of publications started increasing significantly from 2010 to 2021, with an average of...

Organoid Technology for Disease Modelling and Personalized Treatment, 2022

International Journal of Integrated Health Sciences, 2016

Objective: The presentation of cystic meningioma in the inter-hemispheric near the falx cerebri i... more Objective: The presentation of cystic meningioma in the inter-hemispheric near the falx cerebri is uncommon. It is difficult to differentiate it from intra-axial tumors, such as gliomas. Therefore, it is likely that it is misdiagnosed as other types of brain tumors. Methods: In this study, we reported a cystic meningioma case in the inter-hemispheric location, showing an intramural nodule on magnetic resonance imaging scans. Results: Patient underwent surgical treatment and pathological section confirmation revealing meningioma. The patient was a middle-age woman and had been misdiagnosed as suffering from glioma followed by slight hemipharesis on the right extremities. Conclusions: Although this is a rare case, it will be good if we always consider cystic meningioma in inter-hemispheric space when diagnosing this type of cystic lesion if the magnetic resonance imaging (MRI) shows a cystic lesion mimicking glioma image presentation. Keywords: Cystic meningioma, interhemispheric spac...

Processes, 2021

Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type... more Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type (large) amino acid transporter 1 (LAT1) on the cancer cell membrane facilitates such a demand, which is limited in normal organs. Therefore, LAT1 overexpression is ideal as a molecular cancer therapeutic target. JPH203, a LAT1-selective non-transportable blocker, had demonstrated LAT1 inhibition in <10 µM IC50 values and effectively suppressed cancer cell growth in studies involving several types of cancer cell lines and tumor xenograft models. A limited phase I clinical trial was performed on five different solid tumors and showed that JPH203 is well-tolerated and has a promising activity for the treatment of bile duct cancer. This review details the development and prospect of JPH203 as a LAT1-targeting cancer therapy.

Majalah Kedokteran Bandung, 2019

Cerebral contusion is found in 17-34% of traumatic brain injury (TBI) cases. The inertial and con... more Cerebral contusion is found in 17-34% of traumatic brain injury (TBI) cases. The inertial and contact effects responsible for this injury makes the presence and location of contusion almost impossible to detect without appropriate imaging techniques. This study aimed to identify the geometric association between site of impact and cerebral contusion in patients with TBI. Data were collected retrospectively from Dr. Hasan Sadikin Hospital Bandung, Indonesia from January 2016-December 2017. TBI patients were scanned for diagnosis of cerebral contusion on the initial CT scan and the presence of soft tissue swelling as the site of impact. The locations were then geometrically classified into four groups; frontal, right temporoparietal, left temporoparietal, and occipital. Analysis was then performed using the multinomial logistic regression method with α=0.05 and 95% confidence interval (CI). Right temporoparietal contusion was associated with contrecoup impact compared to frontal

Majalah Kedokteran Bandung, 2019

The use of non-human primate (NHP) animal models, which anatomical and physiological similarities... more The use of non-human primate (NHP) animal models, which anatomical and physiological similarities to human, is important for the sake of learning the anatomical properties. This study aimed to characterize the cranial, maxillofacial, and skull base structures of non-human primates as a potential model suitable for a cranial craniotomy model. Adult Macaca fascicularis (MF) skulls classified asspecificpathogen-free for TB, SIV, SV40, Polio, Foamy virus and Herpes B virus from PT Bio Farma (Persero) Animal Lab. Library were used to represent the anatomical model.The open access database from Mammalian Crania Photographic Archive 2 nd Edition (MCPA2) was used for cranial characterization analysis. This study was performed at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital and the Animal Laboratory of PT. Biofarma (Persero) from November 2018 to January 2019. The skull base structures were assessed for its analogies with its human counterpart. Comparison by t-student analysis between male and female skulls shows the mean male cranial length (CL) is greater than in female (116.68 vs 102.50 mm), with p=0.000; the mean male bizygomatic width (BZB) is greater than in female (79.30 vs 69.70 mm) with p=0.001; the mean male posterior cranial breadth (CBN) is greater than in female (63.40 vs 58.79 mm) with p=0.019; and the mean male cranial base length (CBL) is greater than in female (63.32 vs 57.55 mm), with p=0.001. The skull of MF is suitable for Neurosurgery and Neuroscience study since the MF cranial characterization and structure are similar to that of human. Its structure is ideal for performing craniotomy since it has several characteristics such as cranial vault, maxillofacial structure with huge temporal muscle, and skull base structure.

Majalah Kedokteran Bandung, 2019

Amniotic membrane (AM), a hospital waste product, is a potential source for tissue donor. There a... more Amniotic membrane (AM), a hospital waste product, is a potential source for tissue donor. There are several types of AM, namely dried and fresh-AM. AM being challange to be grafted in the clinical application of duramater replacement in neurosurgery cases. This study aimed to characterize the histological properties of dry-lyophilized amniotic membrane, fresh amniotic membrane (AM), and duramater membrane in search for a biologicallyderived material suitable for meninges surface reconstruction. This descriptive study was conducted at the Unit

Interdisciplinary Neurosurgery, 2019

Although an open depressed skull fractures at the anterior cranial fossa is relatively common, co... more Although an open depressed skull fractures at the anterior cranial fossa is relatively common, comorbidity with a progressive vision loss at initial presentation, with acute communicating hydrocephalus is rare. Here we report a rare case of a progressive vision loss presented with communicating hydrocephalus following open depressed skull fractures at a mid-frontobasal. Fragments of skull were extracted and the dural tear was repaired. Within the first post-operative day, the patient already gained full consciousness and his headache was completely resolved. Unfortunately, the ophthalmologic examinations revealed his vision remains impaired. We discussed the pathological mechanisms of a progressive vision loss and acute communicating hydrocephalus in a patient who was diagnosed with traumatic open depressed skull fracture at a mid-frontobasal, with focus on surgical management of this intriguing case. This case makes a strong argument for an early neurosurgical intervention in frontobasal fractures.

Tarumanagara Medical Journal

Anaplastic meningioma is an uncommon neoplasm in childhood and adolescence. In contrast to the ca... more Anaplastic meningioma is an uncommon neoplasm in childhood and adolescence. In contrast to the case in adults, pediatrics have a predominance of males over females. We report a case of a 17 years old with progressive scalp swelling on the right side. Patient underwent subtotal tumor resection at previous hospital three months ago. The operation was stopped due to extensive bleeding. Radiological investigations revealed a dura-based tumor with a cystic component. Following preoperative embolization, a craniotomy was done, and the tumor was almost completely removed. The tumor's histopathological analysis revealed characteristics of an anaplastic meningioma. The aggressive behavior of this tumor necessitates meticulous monitoring of therapeutic measures in such patients.

Molecular and Cellular Biomedical Sciences

Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhan... more Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This benefit occurs via a mechanism that promotes viral clearance by phagocytes and macrophages. This action occurs through the innate (increase in IL-10 production and decrease in TNF-α and IL-12 production) and the adaptive immune system (decrease in IL-17 production, promote regulatory T cell proliferation and inhibit effectors T cell proliferation). MSCs are expected to act as an anti-inflammatory in the hyper-inflammatory state of COVID-19. MSCs enhance immune cell replacement that have been overwhelmed or have been lost due to cytokine storm. Although vaccines are the answer to this pandemic, MSCs can improve COVID-19 patients, especially in patients with chronic illnesses. The focus on keeping death-rates low is a great opportunity for MSCs-based therapy for severe or critically ill patients. MSCs and conditioned medium have the potentia...

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Background Over the last decade, since clinical trials examining targeted therapeutics for glioma... more Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, the emphasis has recently been switched toward innovative techniques for modulating the immune response against tumors and their microenvironments (TME). Cancerous cells have eleven hallmarks which make it distinct from normal ones, among which is immune evasion. Immune evasion in glioblastoma helps it evade various treatment modalities. Summary Glioblastoma’s TME is composed of various array of cellular actors, ranging from peripherally derived immune cells to a variety of organ-resident specialized cell types. For example, the blood–brain barrier (BBB) serves as a selective barrier between the systemic circulation and the brain, which effectively separates it from other tissues. It is capable of blocking around 98% of molecules that transport different medications to the target tumor. Objectives The purpose of this paper i...

The Internet journal of gynecology and obstetrics, 2019

Background: Follicular fluid plays important roles in oocyte quality, which can increase the succ... more Background: Follicular fluid plays important roles in oocyte quality, which can increase the success rate of assisted reproductive technology (ART) program. Oocyte maturity is influenced by the follicular fluid’s chemical component, including insulin-like growth factor (IGF)-I, which increases follicle-stimulating hormone (FSH) receptor; thereby increasing levels of intracellular cyclic adenosine monophosphate (cAMP) as primary mediator of FSH stimulation in aromatase expression. Materials and Methods: This was analytical correlational study with a cross-sectional approach in ART patients program at Dr. Hasan Sadikin Hospital Bandung. The p <0.05 considered as significance. Results: Mature and immature oocytes showed significant differences in FSH expression (p=0.03). The relationship of IGF-I and oocyte maturity showed no statistical significance (p=0.192). The median ratio of mature oocytes to total oocytes was 0.71; those with a median prevalence ratio > 0.71 showed strong ...

International Journal of Integrated Health Sciences, 2017

Objective: To analyze the correlation between the degree of angulation and neurological deficits ... more Objective: To analyze the correlation between the degree of angulation and neurological deficits as well as pain in spondylitis tuberculosis (TB) patients. Methods: This observational-analytic study included bivariate analysis on data collected from the medical records of patients with presented with spondylitis TB to Dr. Hasan Sadikin General Hospital, Bandung outpatient clinic from January 2014 to December 2015. The variables were the degree of gibbus angulation, neurological deficits, and pain. Results: The study showed significant positive correlation between gibbus angulation and sensory neurological deficits (r=0.375; p=0.009) and there was significant positive correlation between gibbus angulation and pain (r=0.638, p=0.000). The study showed an insignificant correlation between gibbus angulation and motoric neurological deficits (r=0.125; p=0.525). Conclusions: There is a significant correlation between the degree of gibbus angulation and pain as well as sensory neurological...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Traumatic brain injury (TBI) stills the leading cause of public health problem and di... more BACKGROUND: Traumatic brain injury (TBI) stills the leading cause of public health problem and disabilities in many countries, especially in lower-middle-income countries. Motor vehicle crashes, especially motorized two-wheeler riders, are the major cause of TBI, followed by fall and assault. During 2013–2014, a total of 2108 TBI cases (65.4% of them being caused by motor vehicle crashes) were documented in the Emergency Unit of Dr. Hasan Sadikin Hospital (RSHS) Bandung. Among these, 30.7% of cases were categorized as moderate and severe TBI, with a mortality rate of 29.2%. Half of the cases arrived at RSHS within 6 h and 14.0% of these cases were alcohol-intoxicated. Individuals with low activity of alcohol-metabolizing enzymes have low tolerance to alcohol and are therefore rapidly intoxicated, making them more susceptible to more serious injuries from motor vehicle crashes. METHODS: A prospective study was designed by consecutive sampling from January to August 2017 to review 30 ...

BMC Research Notes, 2020

Objective To explore the possibility of a new diagnostic approach of endometriosis based on immun... more Objective To explore the possibility of a new diagnostic approach of endometriosis based on immunocytochemistry scoring of Aromatase P450 expressions in endometrial cells collected from menstrual sloughing. This is a case control study. Immuncytochemistry scores vs. histopathological examination in one tertiary- and secondary-level hospital in Bandung; two secondary level hospital in Garut and Sumedang, West Java, Indonesia. Thirty-five patients with and without endometriosis were enrolled. All subjects had diagnostic procedures for endometriosis suspicion, with addition menstrual blood samples for cytopathological examination. The specimens were sent for immunocytochemistry assessment of P450 Aromatase expressions (ICAPEC). The previous procedure resulted in cut-off point of histo score (H-score), sensitivity, specificity, (+) and (−) ICAPEC predictive value. Results The P450 Aromatase expression in endometrial cells of women with endometriosis was significantly stronger than witho...

Breast Cancer, 2018

Background Nipple areola complex (NAC) infiltration in operable breast carcinoma (OBC) is associa... more Background Nipple areola complex (NAC) infiltration in operable breast carcinoma (OBC) is associated with local recurrence. NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC. This study aims to analyze the expression and interactions of these proteins as risk factors for NAC infiltration in OBC. Materials and methods This is an analytic observational cross-sectional study coupled with a categorical comparative study in each 40 subjects of OBC with and without NAC infiltration. The immunohistochemistry performed with a cutoff point based on the result of a receiver operating characteristics (ROC).

Indonesian Journal of Neurosurgery, 2018

Introduction: The worldwide prevalence of intracranial aneurysms is estimated to be 5-10%; approx... more Introduction: The worldwide prevalence of intracranial aneurysms is estimated to be 5-10%; approximately 10-12 million people are affected by intracranial aneurysms in the United States (US), and they are considered a major problem in public health.The manual interpretation of intracranial aneurysms based on visual examinations and direct observation of medical imaging techniques such as computed tomography (CT) scans, magnetic resonance imaging (MRI), or any of the digital subtraction angiography (DSA), are still presented in monochrome form, and it takes time to interpret the medical images.Methods: Alternative methods are in development that would allow for detection of intracranial aneurysms using open source MATLAB software. This method is a way to observe the aneurysm using the 2 dimensional (2D) DSA data based on the calculations of time to peak (TTP) and time duration (TD) of the contrast agent flow in the blood vessel in order to capture the aneurysm and visualize it using ...

International Journal of Integrated Health Sciences, 2016

Objective: To determine the level of Selenium (Se) in peripheral and intracranial serum in pediat... more Objective: To determine the level of Selenium (Se) in peripheral and intracranial serum in pediatric patients with intracranial tumor. Selenium has chemopreventive potentials and acts as neuromodulator. Methods: This study was conducted on 13 pediatric patients with intracranial tumors who were treated in Dr. Hasan Sadikin Hospital, Bandung in the period of February 2014 to February 2015. Samples were taken from peripheral and intracranial serum. The results were analyzed with independent t-test and Pearson correlation test. Significance is defined as p≤0.05 with 95% confidence interval. Results: The results showed that the average Se concentration in peripheral serum was significantly higher than the Se concentration in intracranial serum (95.92±20.95 μg/L and 66.62±22.37 μg/L, respectively). After classifying the subjects into groups based on sex, age, tumor location, and grades, the difference between Se concentrations were still statistically significant (p≤0.05), with the exception of the supratentorial group (p=0.0053). Pearson correlation test showed very-low to medium strength correlations between peripheral and intracranial serum Se concentration in all groups (r=0.16-0.59, p>0.05). Conclusions: A significant difference is seen between the peripheral and intracranial serum Se concentration means in pediatric patients with intracranial tumors, with higher concentrations observed in the peripheral serum. Further studies are required to investigate the roles of Se in the management of pediatric patients with intracranial tumors.

SSRN Electronic Journal, 2019

Interdisciplinary Neurosurgery, 2016

Acute traumatic subdural hematomas (SDHs) are very common. These hematomas are usually neurosurgi... more Acute traumatic subdural hematomas (SDHs) are very common. These hematomas are usually neurosurgical emergencies, although conservative therapy is indicated in certain cases. SDH can increase intracranial pressure (ICP) and compress or stretch the brainstem. Lately, it has been recognized that increased ICP can lead to hemodynamic instability and bradycardia. Bradycardia can be an early warning sign in many neurosurgical conditions. We observed bradycardia in serial cases of the patient without hypertension and bradypnea, classically known as Cushing's triad, in an acute traumatic SDH patients who were receiving conservative treatment and the bradycardia were proved as an early sign of an increasing ICP. The onset of bradycardia can indicate the need for further evaluation from a conservative management strategy to perform definitive surgery treatment.

Surgical Neurology International

Background: With changes in European and the US academia and education systems, research has beco... more Background: With changes in European and the US academia and education systems, research has become a measurement to define academic productivity, as it is a crucial component in the process of becoming a well-trained neurosurgeon. In this recent study, we aimed to reveal the current status and challenges facing neurosurgical research in Indonesia. Methods: An open-access PubMed MEDLINE database search was performed to reveal all articles published by Indonesian Neurosurgeons from 1980 to July 2021. The detail was extracted to the following parameters: academia center or city of the study, year of publication, study type, topic, journal, institution and Q status, first author, article citation, international collaboration, and the working field. These data were processed and examined. Results: During 1980 and July 2021, a total of 242 PubMed-indexed papers were published from Indonesia. The number of publications started increasing significantly from 2010 to 2021, with an average of...

Organoid Technology for Disease Modelling and Personalized Treatment, 2022

International Journal of Integrated Health Sciences, 2016

Objective: The presentation of cystic meningioma in the inter-hemispheric near the falx cerebri i... more Objective: The presentation of cystic meningioma in the inter-hemispheric near the falx cerebri is uncommon. It is difficult to differentiate it from intra-axial tumors, such as gliomas. Therefore, it is likely that it is misdiagnosed as other types of brain tumors. Methods: In this study, we reported a cystic meningioma case in the inter-hemispheric location, showing an intramural nodule on magnetic resonance imaging scans. Results: Patient underwent surgical treatment and pathological section confirmation revealing meningioma. The patient was a middle-age woman and had been misdiagnosed as suffering from glioma followed by slight hemipharesis on the right extremities. Conclusions: Although this is a rare case, it will be good if we always consider cystic meningioma in inter-hemispheric space when diagnosing this type of cystic lesion if the magnetic resonance imaging (MRI) shows a cystic lesion mimicking glioma image presentation. Keywords: Cystic meningioma, interhemispheric spac...

Processes, 2021

Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type... more Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type (large) amino acid transporter 1 (LAT1) on the cancer cell membrane facilitates such a demand, which is limited in normal organs. Therefore, LAT1 overexpression is ideal as a molecular cancer therapeutic target. JPH203, a LAT1-selective non-transportable blocker, had demonstrated LAT1 inhibition in <10 µM IC50 values and effectively suppressed cancer cell growth in studies involving several types of cancer cell lines and tumor xenograft models. A limited phase I clinical trial was performed on five different solid tumors and showed that JPH203 is well-tolerated and has a promising activity for the treatment of bile duct cancer. This review details the development and prospect of JPH203 as a LAT1-targeting cancer therapy.

Majalah Kedokteran Bandung, 2019

Cerebral contusion is found in 17-34% of traumatic brain injury (TBI) cases. The inertial and con... more Cerebral contusion is found in 17-34% of traumatic brain injury (TBI) cases. The inertial and contact effects responsible for this injury makes the presence and location of contusion almost impossible to detect without appropriate imaging techniques. This study aimed to identify the geometric association between site of impact and cerebral contusion in patients with TBI. Data were collected retrospectively from Dr. Hasan Sadikin Hospital Bandung, Indonesia from January 2016-December 2017. TBI patients were scanned for diagnosis of cerebral contusion on the initial CT scan and the presence of soft tissue swelling as the site of impact. The locations were then geometrically classified into four groups; frontal, right temporoparietal, left temporoparietal, and occipital. Analysis was then performed using the multinomial logistic regression method with α=0.05 and 95% confidence interval (CI). Right temporoparietal contusion was associated with contrecoup impact compared to frontal

Majalah Kedokteran Bandung, 2019

The use of non-human primate (NHP) animal models, which anatomical and physiological similarities... more The use of non-human primate (NHP) animal models, which anatomical and physiological similarities to human, is important for the sake of learning the anatomical properties. This study aimed to characterize the cranial, maxillofacial, and skull base structures of non-human primates as a potential model suitable for a cranial craniotomy model. Adult Macaca fascicularis (MF) skulls classified asspecificpathogen-free for TB, SIV, SV40, Polio, Foamy virus and Herpes B virus from PT Bio Farma (Persero) Animal Lab. Library were used to represent the anatomical model.The open access database from Mammalian Crania Photographic Archive 2 nd Edition (MCPA2) was used for cranial characterization analysis. This study was performed at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital and the Animal Laboratory of PT. Biofarma (Persero) from November 2018 to January 2019. The skull base structures were assessed for its analogies with its human counterpart. Comparison by t-student analysis between male and female skulls shows the mean male cranial length (CL) is greater than in female (116.68 vs 102.50 mm), with p=0.000; the mean male bizygomatic width (BZB) is greater than in female (79.30 vs 69.70 mm) with p=0.001; the mean male posterior cranial breadth (CBN) is greater than in female (63.40 vs 58.79 mm) with p=0.019; and the mean male cranial base length (CBL) is greater than in female (63.32 vs 57.55 mm), with p=0.001. The skull of MF is suitable for Neurosurgery and Neuroscience study since the MF cranial characterization and structure are similar to that of human. Its structure is ideal for performing craniotomy since it has several characteristics such as cranial vault, maxillofacial structure with huge temporal muscle, and skull base structure.

Majalah Kedokteran Bandung, 2019

Amniotic membrane (AM), a hospital waste product, is a potential source for tissue donor. There a... more Amniotic membrane (AM), a hospital waste product, is a potential source for tissue donor. There are several types of AM, namely dried and fresh-AM. AM being challange to be grafted in the clinical application of duramater replacement in neurosurgery cases. This study aimed to characterize the histological properties of dry-lyophilized amniotic membrane, fresh amniotic membrane (AM), and duramater membrane in search for a biologicallyderived material suitable for meninges surface reconstruction. This descriptive study was conducted at the Unit

Interdisciplinary Neurosurgery, 2019

Although an open depressed skull fractures at the anterior cranial fossa is relatively common, co... more Although an open depressed skull fractures at the anterior cranial fossa is relatively common, comorbidity with a progressive vision loss at initial presentation, with acute communicating hydrocephalus is rare. Here we report a rare case of a progressive vision loss presented with communicating hydrocephalus following open depressed skull fractures at a mid-frontobasal. Fragments of skull were extracted and the dural tear was repaired. Within the first post-operative day, the patient already gained full consciousness and his headache was completely resolved. Unfortunately, the ophthalmologic examinations revealed his vision remains impaired. We discussed the pathological mechanisms of a progressive vision loss and acute communicating hydrocephalus in a patient who was diagnosed with traumatic open depressed skull fracture at a mid-frontobasal, with focus on surgical management of this intriguing case. This case makes a strong argument for an early neurosurgical intervention in frontobasal fractures.