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Papers by Ahmad Jalilvand

Hormozgan Medical Journal, 2020

Background: Improving the quality of life in osteoporotic women is one of the crucial goals of he... more Background: Improving the quality of life in osteoporotic women is one of the crucial goals of health systems. Hence, recognizing the factors affecting the quality of life in such patients is an important issue. The body mass index (BMI) seems to be capable of affecting quality of life. Besides, BMI is a quantitative index simple to measure. Objectives: The purpose of this study was to examine the impact of BMI on quality of life in a group of osteoporotic women. Methods: One hundred osteoporotic women aged 50 - 60 participated in this descriptive-analytical study. These women were referring to the internal clinic of Mousavi Hospital of Zanjan. The body mass index was calculated after measuring both height and weight. Based on the BMI, the patients were divided into three groups: BMI < 18.5 underweight, 18.5 ≤ BMI < 25 normal and BMI ≥ 25 overweight. The short form 36 (SF-36) questionnaire was employed for measuring the quality of life. Given the normal distribution of data, o...

Archives of Iranian medicine, 2022

BACKGROUND Few studies have been performed to investigate the association between vitamin D and r... more BACKGROUND Few studies have been performed to investigate the association between vitamin D and respiratory problems in premature neonates. METHODS In this cohort study, a low serum level of vitamin D was considered as exposure and respiratory problems and associated interventions were considered as outcome. All patients were followed during their hospital stay. All preterm neonates admitted to the neonatal intensive care unit of a general hospital in Iran during one-year period from January 2018 were enrolled in this study. Serum vitamin D level was measured in the first 24 hours of life by liquid chromatography-spectrometry. Then, respiratory complications were compared between neonates with and without vitamin D insufficiency. RESULTS Among the 113 preterm newborns, 65 (58%) had a low and 48 (42%) had a normal level of vitamin D who were classified into two groups I and II, respectively. Respiratory distress syndrome (RDS) and requirement for surfactant administration was found i...

Photodiagnosis and Photodynamic Therapy, 2022

Cystic echinococcosis, a zoonotic parasitic infection, is a major public health and economic conc... more Cystic echinococcosis, a zoonotic parasitic infection, is a major public health and economic concern, with worldwide distribution. The development of sensitive diagnostic methods for hydatid disease is important. We designed a highly sensitive nano-biosensor for the diagnosis of hydatid cyst based on gold nanoparticles (AuNPs). AuNPs were synthesized. Echinococcus granulosus antigen was coated on the ELISA microwells. Then, the E. granulosus IgG antibody was added to the microwells. After incubation and washing, the Ag-Ab complex was incubated with a human IgG HRP-conjugated antibody. Then, the synthesized AuNPs and tetramethylbenzidine (TMB), as a chromogenic substrate of HRP, were added to the reaction. Finally, the absorption rate was measured by spectrophotometry. The results showed that the enzyme peroxide and TMB change the color of the reaction from red to yellow by oxidizing AuNPs. The sensitivity and specificity of the designed method were investigated. The linear equation and regeneration of nanobiosensor designed for red color Y = 0.0312X + 0.649, R2 9962 and for yellow color Y = 0.013X + 0.398, R2 9851 were determined. The limit of detection of the designed nanobiosensor was 0.001 μg mL-1. The results confirmed that the designed nanobiosensor was completely specific for the detection of E. granulosus antibody.

Journal of Research in Medical Sciences, 2021

Background: Evaluation of insulin-like growth factor-1 (IGF-1) association with retinopathy of pr... more Background: Evaluation of insulin-like growth factor-1 (IGF-1) association with retinopathy of prematurity (ROP) is our object. Materials and Methods: This study was conducted on IGF-1 levels of 40 neonates <34 weeks gestational age and 2000 g at 1st week and 4–6 weeks after birth. All participants were evaluated for ROP after 31 weeks of gestation. Results: IGF-1 levels showed a significant difference between neonates ≤1500 and 1500–2000 g (1 and 4–6 weeks, P = 0.008, P = 0.039, respectively). No significant association was found between IGF-1 and ROP. Conclusion: Finding a meaningful association between IGF-1 and ROP requires consideration of factors affecting the IGF-1.

Preventive Care In Nursing and Midwifery Journal, 2019

Background: Health Information Technology (HIT) has the potential for improving the quality, safe... more Background: Health Information Technology (HIT) has the potential for improving the quality, safety, and efficiency of healthcare and nurses are the largest group of HIT users. Objectives: Therefore, the present study mainly aimed to investigate the use of HIT by nurses in healthcare. Methods: This cross-sectional and descriptive-analytical study was conducted in four educational and treatment centers of Zanjan University of Medical Sciences in 2019. A researcher-made questionnaire was used for data collection, the validity and reliability of which were confirmed by experts' approval and Cronbach's test (0.84). Eventually, the data were analyzed by R and Rstudio statistical Software, and Chisquare test was used to examine the relationship between the variables. Results: The most commonly used HITs among nurses were the hospital information system (100%), picture archiving and communication system (83.2%), as well as tele-nursing (76%) and mobile-health (64.9%). However, none of the nurses used a radio frequency identification system (0%) in nursing care. Conclusion: The findings of this study revealed that although the application of HITs presents potential benefits in improving healthcare quality, their features are not used completely in nursing care.

Molecular biology research communications, 2019

Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both g... more Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its association with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in CRC patients. Fifty formalin-fixed paraffin-embedded cancerous and adjacent healthy tissues obtained from CRC patient were investigated. Genomic DNA was isolated using a FFPE commercial DNA extraction kit. The methylation status was evaluated by methylation specific PCR. Genotyping of MTHFR C677T polymorphism was performed using PCR-RFLP technique. Statistical analysis was done by GraphPad Prism 8. Results indicated that the frequency of methylated DACT2 gene was significantly higher in cancerous tissue relative to adjacent healt...

Pediatria Polska, 2021

Aim of the study: An inverse correlation between excessive body weight and response to cholecalci... more Aim of the study: An inverse correlation between excessive body weight and response to cholecalciferol in vitamin D deficiency (VDD) has been reported but no adjusted or conventional dose and treatment period has universally been recommended by the paediatric guidelines for obese children. In this study, we explored the efficacy of vitamin D supplementation in treatment of children with VDD based on their body mass index (BMI) and different levels of initial serum 25(OH)D. Material and methods: In a single-centre, prospective, open label non-randomized trial in 255 subjects, baseline serum 25(OH)D was measured and different doses of oral D3 prescribed accordingly. Serum D 3 was measured at the end of the treatment period. All statistical analyses were conducted using the statistical package SPSS and p values less than 0.05 considered statistically significant. Results: The response rate to vitamin D supplementation was associated with the patients' BMI characteristics. 25(OH)D levels normalized in 97.7% and 92.7% of the non-obese and obese subjects, respectively. In subjects with BMI ≥ 85 th percentile, there was a lower increase in vitamin D levels after treatment than those with a BMI < 85 th percentile. Evaluating the efficacy of the therapeutic dosage of cholecalciferol as per different categories of vitamin D levels, we observed the highest increase in the level of serum D 3 in the severely deficient D 3 category of both obese and non-obese groups. Conclusions: There is an inverse correlation between high Body Mass Index and response to treatment with vitamin D supplementation, suggesting a higher dose of vitamin D for the optimal treatment of vitamin D deficiency in obese children.

Journal of Advances in Medical and Biomedical Research, 2019

Background & Objective: Molybdenum trioxide nanoparticles (MoO3 NPs) have widespread applications... more Background & Objective: Molybdenum trioxide nanoparticles (MoO3 NPs) have widespread applications in industries. However, the toxic and non-toxic effects of MoO3 NPs have not been fully investigated yet. In this study, effects of MoO3 NPs on ovary function of female rats were studied. Materials & Methods: In this study, 21 female rats were randomly divided into three groups (n=7): the first group did not receive any treatment, the second one received normal saline, and the third group received 5 mg/kg MoO3 NPs in normal saline via intraperitoneal injection during a period of 28 days. Serum concentrations of estrogen, progesterone, luteinizing hormone, and follicle stimulating hormone were measured. Also, changes of ovaries, uterine weights, uterine, and length of uterine horns were studied. Results: The serum level of estrogen in the MoO3 NPs exposed group was significantly attenuated; those of luteinizing hormones and follicle stimulating hormone were elevated while progesterone level change was insignificant. The weights of the right ovary and the uterine body decreased significantly in the exposed group. Conclusion: Our data showed that MoO3 nanoparticle exposure could cause an imbalance of sex hormones and decrease in body and ovarian weights in thefemale rats.

Acta Cytologica, 2013

Introduction: In this study, we evaluate the distribution of 24 human papillomavirus (HPV) genoty... more Introduction: In this study, we evaluate the distribution of 24 human papillomavirus (HPV) genotypes in a cohort of 3,381 cytologically screened women from a rural area of northwest Germany, in correlation to cytological diagnoses and histological outcomes. Materials and Methods: We present a retrospective study in which the HPV-genotyping results of women who attended the German cervical screening program were correlated to cytological diagnosis and histological outcome. Results: HPV genotyping showed marked differences among cervical lesions. Although HPV-51 was common in all cervical lesions, it was rarely detected as single-type HPV infection in high-grade cervical intraepithelial neoplasia (CIN)3 (2/118 cases). HPV-16 and 18 were more common in CIN3 (57.6%) than in CIN2 (21.8%), but they were absent in 42.4% of all CIN3 lesions in our cohort. Discussion: Our data show that HPV-16, HPV-31, HPV-51, HPV-53 and HPV-42 are the most prevalent HPV types in the different cervical lesio...

Introduction: vitamin D affects the function of most of the cells in the body, including myocytes... more Introduction: vitamin D affects the function of most of the cells in the body, including myocytes and endothelial cells, and also affects platelet function. This study aims to evaluate the relation between vitamin D deficiency and in-hospital and 6-month outcomes of patients with the acute coronary syndrome.Methods: This was a prospective cohort study of patients admitted to Mousavi hospital with the diagnosis of acute coronary syndrome. A venous blood sample obtained from patients at the time of admission and 25-hydroxyvitamin D, lipid profile, and hs-troponin-I levels were measured. After coronary angiography, the severity of the coronary artery stenosis was calculated by the syntax score. Patients also evaluated in-hospital outcomes and even followed up for 6-month results.Results: Totally, 204 patients were included in the study. The mean ± SD of age was 60 ± 11.6-year-old. The overall vitamin D deficiency was 80.9%. There was no association between vitamin D deficiency and in-h...

BMC Cancer, 2021

Background The association between specific bacteria and colorectal cancer (CRC) has been propose... more Background The association between specific bacteria and colorectal cancer (CRC) has been proposed. Only a few studies have, however, investigated this relationship directly in colorectal tissue with conflicting results. So, we aimed to quantitate Streptococcus gallolyticus, Fusobacterium spp, Enterococcus faecalis and enterotoxigenic Bacteroides fragilis (ETBF) in formalin-fixed and paraffin-embedded (FFPE) colorectal tissue samples of Iranian CRC patients and healthy controls. Methods A total of 80 FFPE colorectal tissue samples of CRC patients (n = 40) and healthy controls (n = 40) were investigated for the presence and copy number of above bacterial species using quantitative PCR. Relative quantification was determined using ΔΔCT method and expressed as relative fold difference compared to reference gene. Results Relative abundance and copy number of E. faecalis and ETBF were significantly higher in CRC samples compared to control group. E. faecalis was more prevalent than ETBF ...

Background: head injuries (HI) are considered as a major public health concern across the world. ... more Background: head injuries (HI) are considered as a major public health concern across the world. This study aims to explore the incidence rate and spatial distribution of HI incidence at rural district levels in Zanjan province, Iran from 2014-2018.Materials & Methods: This study was a cross-sectional and geospatial analysis of head injury incidence pattern in rural areas at Zanjan province, Iran. Data were collected from nine hospital information system databases. Age-adjusted incidence rate and three different spatial analysis methods (Spatial autocorrelation, hotspot analysis and Anselin Local Moran's I) were used to detect the potential high-risk areas of HI incidence in the study area.Results: 4562 patients were registered at Zanjan hospitals due to HI from 2014-2018. The age-adjusted incidence rate of HI was 429 cases (95% CI, 418,443) per 100,000 person which increased from 74 cases in 2014 to 86 cases in 2018, (an 18% increase, P<0001). The highest incidence rate obse...

Archives of Iranian medicine, 2018

BACKGROUND Reduction in the level of tissue decorin is a hallmark of many types of cancer includi... more BACKGROUND Reduction in the level of tissue decorin is a hallmark of many types of cancer including breast carcinoma. However, reduced decorin expression has also been reported in several types of benign tumors to the extent that it has been proposed as a tissue marker to differentiate malignant from benign tumors. The aim of this study was to investigate the potential role of plasma decorin to distinguish breast cancer from fibroadenoma, the second most common type of benign tumor, after fibrocystic disease. METHODS From 35 patients recruited in this study, 24 were affected with invasive ductal carcinoma, either grade II (n = 14) or grade III (n = 10). The other 11 patients had fibroadenoma lesions in their breasts. Tissue decorin mRNA and protein levels were assessed with real-time qPCR and Immunohistochemical analysis. ELISA was employed to measure plasma levels of decorin. RESULTS The mean plasma decorin in cancer patients was measured to be 5.42 ± 1.83 ng/mL while fibroadenoma ...

مقدمه: پارگی زودرس کیسه آب از مشکلات شایع مامایی است که تشخیص صحیح آن امری ضروری در روند درمان و ... more مقدمه: پارگی زودرس کیسه آب از مشکلات شایع مامایی است که تشخیص صحیح آن امری ضروری در روند درمان و پیشگیری پیامدهای نامطلوب بارداری است. مطالعه حاضر با هدف بررسی صحت تشخیصی کراتینین و گنادوتروپین (βHCG) ترشحات موکوس سرویکس در شناسایی آبریزش زنان باردار انجام شد. روش‌کار: این مطالعه آیندهنگر در سال 96-1367 بر روی 150 زنان باردار 37-24 هفته مشکوک به PPROM انجام گرفت. افراد در دو گروه کیسه آب پاره (تست پولینگ و فرن هر دو مثبت) و گروه کنترل (تست پولینگ و فرن هر دو منفی و AFI نرمال) قرار گرفتند. جهت اندازه‌گیری میزان کراتینین از روش Automated Analyzer و با دستگاه Prestige و برای اندازه‌گیری میزان βHCG از روش Chemi-luminescence Signal Band و با دستگاه Abbott استفاده شد. با استفاده از منحنی راک، نقطه برش و صحت تشخیصی برای دو تست اندازه‌گیری شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد. یافته‌ها: در تشخیص پارگی کیسه آب بیشترین حساسیت و ویژگی کراتینین در نقطه برش 135/0 و برای βHCG در نقطه برش 78/26 به‌دست آمد که حساسیت، ویژگی، ارزش اخباری مثبت و منفی و دقت کلی برای کراتینین به‌ترتیب 7/91%...

Advances in Human Biology, 2019

Objectives: The present study aimed at assessing the prevalence of cervical cancer and premaligna... more Objectives: The present study aimed at assessing the prevalence of cervical cancer and premalignant lesions of the cervix in patient referred to colposcopy unit in Zanjan, and to determine what extent colposcopy is conducted based on the scientific indications. Materials and Methods: In this registry-based cross-sectional study, all women who were referred to the Colposcopy unit of Zanjan Ayatollah-Mousavi Hospital to undergo colposcopy during 2012–2017 were studied. The required data were collected from the registered medical records in the Pathology Department of the hospital. The Bethesda System Terminology was used for classifying premalignant cervical lesions. Results: In the present study, the most common abnormal clinical signs were abnormal vaginal bleeding, whereas atypical squamous cells of undetermined significance (39.5%) remained the most common abnormal Pap smear test result. The clinical appearance of the cervix in 104 patients (62.3%) showed cervical erosion. The res...

Journal of Advances in Medical and Biomedical Research, 2021

10.30699/jambs.29.136.263 Background & Objective: Stroke is the second leading cause of mortality... more 10.30699/jambs.29.136.263 Background & Objective: Stroke is the second leading cause of mortality and the third leading cause of morbidity worldwide. This study aimed to examine the spatial-temporal distribution of stroke in rural districts,

Preventive Care In Nursing and Midwifery Journal, 2021

Background: Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, it i... more Background: Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, it is important to predict the future consequences of the disease in patients who have recovered. Objectives: We sought to determine the relationship between troponin-I level and 6-month clinical consequences (i.e., re-infarction, death, re-angiography and coronary artery bypass grafting) in patients with acute coronary syndrome (ACS). Methods: This prospective cross-sectional study was performed among 60 patients with ACS admitted to Ayatollah Mousavi Hospital in Zanjan, Iran. The participants were chosen using the convenience sampling method. Troponin-I level in these patients was initially evaluated. Afterwards, they were followed up for six months in terms of clinical consequences. A checklist was prepared to collect the required data. The receiver operating characteristic (ROC) analysis was conducted to determine the predictive power of high-sensitivity troponin I for the mentioned consequences. Iodine index was calculated to determine the cutoff point for this enzyme in order to predict the consequences. Results: In general, 66.2% of the participants were male and the mean age was 60.46 ± 12.78 years. We found that 21.2% of the participants experienced one of the four clinical consequences in the follow-up period of 6 months. The sub-curved surface was calculated to be 0.705 for the prediction of consequences. The cutoff point for the prediction of consequences was 32.5; the negative predictive value for the cutoff point was 32.5, which was equal to 89.8%. Conclusion: Troponin-I has an acceptable predictive power to identify 6-month consequences of ACS. Moreover, considering the negative predictive value of troponin-I, it is recommended to use this biomarker in patients with ACS. In addition, healthcare providers should pay more attention to the follow-up of patients after discharge and design preventive programs.

International Journal of Cancer, 2021

Policymakers require estimates of the future number of cancer patients in order to allocate finit... more Policymakers require estimates of the future number of cancer patients in order to allocate finite resources to cancer prevention, treatment and palliative care. We examine recent cancer incidence trends in Iran and present predicted incidence rates and new cases for the entire country for the year 2025. We developed a method for approximating population‐based incidence from the pathology‐based data series available nationally for the years 2008 to 2013, and augmented this with data from the Iranian National Population‐based Cancer Registry (INPCR) for the years 2014 to 2016. We fitted time‐linear age‐period models to the recent incidence trends to quantify the future cancer incidence burden to the year 2025, delineating the contribution of changes due to risk and those due to demographic change. The number of new cancer cases is predicted to increase in Iran from 112 000 recorded cases in 2016 to an estimated 160 000 in 2025, a 42.6% increase, of which 13.9% and 28.7% were attributed to changes in risk and population structure, respectively. In terms of specific cancers, the greatest increases in cases are predicted for thyroid (113.8%), prostate (66.7%), female breast (63.0%) and colorectal cancer (54.1%). Breast, colorectal and stomach cancers were the most common cancers in Iran in 2016 and are predicted to remain the leading cancers nationally in 2025. The increasing trends in incidence of most common cancers in Iran reinforce the need for the tailored design and implementation of effective national cancer control programs across the country.

Journal of Advances in Medical and Biomedical Research, 2020

10.30699/jambs.28.127.90 Background & Objective: Cardiovascular diseases (CVDs) are the most comm... more 10.30699/jambs.28.127.90 Background & Objective: Cardiovascular diseases (CVDs) are the most common chronic diseases and the leading cause of death in the world and in Iran. The aim of this study was to explore the geographical epidemiology of CVDs in the province of Zanjan, Iran. Materials & Methods: This cross-sectional study was carried out at Zanjan University of Medical Sciences. Patients with a discharge diagnosis of CVDs (I00-I99 group of ICD-10 codes) who were hospitalized from 2012-2019 were selected as a study sample. All spatial analyses were performed in ArcGIS 10.7, and descriptive analysis was conducted by R (v3.6.0) and RStudio (v1.2.1335) software. Results: The ischemic heart disease subgroup accounted for the majority of CVD cases (43.8%), while acute rheumatic fever (0.03%) was the least common contributor to CVD. Men had a higher rate of CVD (53.1%) than women (46.9%). The mean age of all CVD subgroups was 56.88 years, and the mean length of stay of all CVD subgroups was 114.2 hours. Zanjan city (57.4%) had the greatest incidence rate of CVDs in Zanjan province, Iran. Conclusion: Geographical epidemiology studies can identify the pattern of CVD distribution in different areas and can be helpful in preventing CVDs. A spatialtemporal pattern of CVD distribution provides crucial information for health development planning in Iran. The findings of this study provide useful information for health authorities in Ayatollah Mousavi Zanjan, Iran, to plan CVD prevention programs.