Ahmad Ramdan - Academia.edu (original) (raw)
Papers by Ahmad Ramdan
Sport Mont
Patellofemoral pain syndrome (PFPS) is a common source of knee problems found mostly in physicall... more Patellofemoral pain syndrome (PFPS) is a common source of knee problems found mostly in physically active young adults. Causative factors are multifactorial, including lower extremity weakness, especially quadriceps muscles. Conservative treatment of PFPS consists mainly of knee bracing and knee taping combined with physical therapy. This study was aimed to analyse the outcome comparison between knee bracing and knee taping in combination with rehabilitative exercise for PFPS management. A prospective study was performed involving twenty-five bas- ketball players suffering from PFPS, aged 19–30 years old with regular practice sessions. The subjects were each grouped randomly into a taping or a bracing group. Follow-up evaluations in term of Kujala patellofemoral score were done in the 1 st , 2 nd , and 4 th weeks after treatment. Unpaired t-test and chi-square were used to analyse the difference between both groups in pre- and post-intervention. Baseline characteristics of each grou...
Cermin Dunia Kedokteran, Jun 1, 2018
Global journal for research analysis, 2017
To explores the potential role of plasma vitamin D level and VDR gene polymorphisms in susceptibi... more To explores the potential role of plasma vitamin D level and VDR gene polymorphisms in susceptibility to tuberculo sis (TB) in the West Java population, Indonesia. A case-control study was performed on 53 Spinal TB patients, 53 Pulmonary TB patients and 53 healthy controls. Plasma Vitamin D levels were analyzed by ELISA, genetic polymorphisms of VDR gene (TaqI, FokI, BsmI, ApaI) were analyzed using PCR-RFLP and sequencing, There was a signi cant difference (p<0.01) of plasma vitamin D level among all groups. Genotype analysis of VDR gene polymorphismFok1, Bsml, Apal and Taql has shown no signi cant difference in all group (p>0.01). The combination of vitamin D de ciency and VDR gene polymorphism Fok1 in FF genotype were contributing factors to the susceptibility of spinal tuberculosis in the West Java population, Indonesia.
Global Medical & Health Communication (GMHC), 2020
Clinical intervention has a central role in the outcome of spondylitis tuberculosis cases. Surgic... more Clinical intervention has a central role in the outcome of spondylitis tuberculosis cases. Surgical procedures indicate to prevent neurological collapse, preservation of stability, and early mobilization. The study aims to analyze the outcome of surgical intervention in spinal tuberculosis by using a transpedicular approach. This research was a retrospective study on the Department of Orthopaedics and Traumatology in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2016–2018. There were 64 subjects in this study; 35 were male, and 29 were female, ages ranged 21–60 years with a follow-up period of 12 months to 18 months. A more common site of tubercular lesion was at the thoracal lesion (44%). In this research, the patients were preoperatively categorized by the American Spinal Injury Association (ASIA) Impairment Assessment. Among them four were ASIA-A, 10 were ASIA-B, 30 were ASIA-C, 15 were ASIA-D, and five were ASIA-E. After the operative procedure, two patients wer...
Nyeri pinggang bawah merupakan keluhan umum yang sering diderita oleh perawat di rumah sakit. Has... more Nyeri pinggang bawah merupakan keluhan umum yang sering diderita oleh perawat di rumah sakit. Hasil kajian teoritis nyeri pinggang bawah dipengaruhi oleh faktor eksternal dan faktor internal, yaitu aktifitas pekerjaan, umur, jenis kelamin, indeks massa tubuh.Faktor eksternal dan faktor internal merupakan masalah yang akan diteliti melalui metode kuantitatif dengan rancangan kasus kontrol. Analisa data yang digunakan adalah analisis bivariabel dengan chi-square dan analisis multivariabel dengan menggunakan analisis regresi logistik. Hasil penelitian ini membuktikan adanya variabel usia, indek massa tubuh, lama pekerjaan, aktivitas mengangkat pasien, aktivitas mendorong pasien serta berat badan pasien diatas 50 kg memiliki korelasi yang signifikan dengan kejadian nyeri pinggang bawah. Analisis multivariabel menunjukan bahwa lama/masa kerja, umur, dan lokasi tempat bekerja menjadi faktor yang dapat memprediksi kejadian nyeri pinggang bawah. Berdasarkan hasil penelitian tersebut, disara...
Indonesian Journal of Cancer, 2020
Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the sp... more Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the spine. It is estimated to be 2% to 12% in incidence from various series. The use of neoadjuvant and adjuvant chemotherapy for chondrosarcomas is controversial. Low- and intermediate-grade chondrosarcomas respond poorly to chemotherapy. Although not much data on the efficacy of chemotherapy in the treatment of high-grade chondrosarcomas, it should be considered in any young patient with a high-grade tumor. Radiation is recommended when anything other than wide excision is performed for chondrosarcoma of any grade.Case Presentation: A 24-year old female presented to the clinic with a chief complaint of persistent low back pain and a lump in her back. Initially, the lump was the size of a tennis ball three years ago. At the time of the examination, the lump was at the size of a volleyball about 65 x 63 x 58 centimeters. Systemic and general examinations were unremarkable. There were no comorb...
Majalah Kedokteran Bandung, 2020
Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, inc... more Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, including iron, are crucial in the body's defense mechanism. Iron modulates the activation of IFN-γ, which in turn will activate the macrophages. This study explores the effect of iron supplementation given with anti-tuberculosis drug therapy on the IFN-γ level in tuberculosis spondylitis patients. This was a single-blind randomized control trial study at Dr. Hasan Sadikin General Hospital Bandung, from December 2018 to March 2019, using the consecutive sampling approach. Thirty-four respondents with category 1 TB spondylitis and an sTfR level of> 21.7 pg /µL were recruited and randomized into control and experimental groups. The control group (n=17) was treated with 2 RHZE for 2 months while the experimental group (n=17) received 2 RHZE and iron tablet for 2 months. An increase in the IFN-γ level of the experimental group was observed from an average of 21.7 pg/ml before therapy to ...
(JOINTS) Journal Orthopaedi and Traumatology Surabaya, 2019
Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating ... more Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK.Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression.Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between grou...
Jurnal Anestesi Perioperatif, 2020
Preoperative anti-tuberculosis (TB) drugs play a role in surgery of TB spondylitis patients to pr... more Preoperative anti-tuberculosis (TB) drugs play a role in surgery of TB spondylitis patients to prevent transmission in the operating room, reduce inflammatory processes and prevent relapse. Currently, there is no study on effects of preoperative anti TB drugs administration duration on the spinal TB patients surgical outcome at Dr. Hasan Sadikin General Hospital (RSHS). This study used retrospective method by analyzing medical record data of TB spondylitis patients operated at RSHS, January 2014-May 2018. Based on the preoperative TB drugs duration, patients were divided into 2 groups: preoperative TB drugs group <2 and 2-4 weeks. Data analyzed were identity, duration of preoperative TB drugs administration, preoperative neurologic grade, preoperative CRP and ESR level, and postoperative data at 2 month follow up consisted of neurologic grade, postoperative CRP and ESR levels. The 58 patients consisted of 25 males and 33 females, Kolmogorov-Smirnov test showed a significant difference (p<0.05) in postoperative neurologic grade between preoperative TB drugs administration <2 vs 2-4 weeks. Unpaired T-Test showed postoperative CRP and ESR levels were significant (p<0.05). Postoperative neurologic grade in the preoperative TB drugs <2 weeks group was better vs the 2-4 week group. Operative procedure is more important in TB spondylitis patients treatment compared to a prolonged preoperative TB drugs administration.
Jurnal Anestesi Perioperatif, 2020
Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in... more Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in TB patients, causes a poor outcome, reccurency, and treatment failure. Iron supplements on TB patients with iron deficiency will activate macrophage-derived monocytes (MDM) and interferon-gamma (IFN-γ), with a positive feedback mechanism pushing interleukin-12 (IL-12). This study is a single-blind randomized control trial comparing the effectivity of preoperative iron supplementation in IL-12 level between two different groups in Dr. Hasan Sadikin General Hospital Bandung, conducted from November 2018 until March 2019. Respondents are those having Spondylitis TB, with sTfR > 21,7 pg/mL and IL-12 <41 pg/mL, intensive phase antituberculosis drugs category 1. The experimental group, comprised 17 respondents, was treated with 2RHZE and 357mg iron (III) hidroxy polymaltosa. The control group was treated with 2RHZE. The sTfR and IL-12 levels were performed before and after treatment. The increase of IL-12 in the experimental group was +364,53% higher than in the control group (p<0.05). The decrease of sTfR in the experimental group was-60,68% higher than in the control group (p<0.05). The result of the Pearson correlation test was a coefficient correlation of-0,73, this showed that a decrease in the sTfR level correlated with an increase in the Il-12 level. Iron supplement in Spondylitis TB with iron deficiency in the experimental group increases the IL-12 level. Preoperative iron supplementation on spondylitis TB with iron deficiency, increases the immune system with higher levels of IL-12.
Pharmaceutical Sciences and Research, 2019
Muscle injuries among athletes require a complete recovery to be able to function optimally as be... more Muscle injuries among athletes require a complete recovery to be able to function optimally as before. However, in spite of implementing the management with PRICE (Protection, Rest, Immobilization, Compression and Elevation), during the recovery processes, fibrotic tissue will be formed, which is an unwanted non-functional muscle. Losartan is a blood pressure-lowering drug which has the inhibitory effect of inhibitory effect of TGF-β cytokines (fibrotic tissue regulators). TGF-β is the key to fibrotic formation and differentiation. Losartan has an effect on decreasing the TGF-β production and it may affect the fibrotic tissue. This research is conducted by an experimental comparative method on the rabbit as study objects. Based on Federer formula sampling, twenty samples totally occurred. The random sampling method is adopted for comparing fibrotic tissue in two different groups (control group and losartan group). Losartan is administered orally. There were significant differences in the proportion of fibrotic tissue between the sample groups. The losartan group showed that the level of fibrotic intensity, distribution, and H-score was decreased compared to the control group. Moreover, the result of Mann Whitney statistic test, for determining the H-score for both groups, showed that p is less than 0.05 (p<0.05), which implies that this research is statistically significant. This research proves that giving Losartan tablets brings a significant impact in reducing the formation of muscle fibrosis in muscle injury grade 1 in gastrocnemius rabbits.
Interdisciplinary Neurosurgery, 2018
Introduction: Tuberculous meningitis (TBM) and tuberculous spondylitis (TBS) are the form of extr... more Introduction: Tuberculous meningitis (TBM) and tuberculous spondylitis (TBS) are the form of extra-pulmonary tuberculosis.
Progress in Orthopedic Science, 2018
Background: Tuberculous infection susceptibility emerges in individuals with low levels of vitami... more Background: Tuberculous infection susceptibility emerges in individuals with low levels of vitamin D. C-reactive protein (CRP) and erythrocyte sediment rate (ESR) are low during the intensive phase of anti-tuberculous drug (ATD) therapy. Cathelicidin, which is induced by vitamin D, has been proven to reduce the inflammatory process. Methods: This single-blind randomized control trial compared the efficacy of vitamin D in lowering CRP and ESR. The research was conducted at the Hasan Sadikin Hospital Outpatient Clinic and the Clinical Pathology Laboratory from March 2017 through August 2017. Tuberculous infected patients enrolled in the study were assigned to one of two groups; one received vitamin D supplementation, the other didn’t received. The Willcoxon statistical test was used to examine the value of CRP in two groups, and the unpaired t-test was used to evaluate ESR values for both groups. Results: The CRP and ESR values in the group receiving vitamin D were significantly lower than in the placebo group (p < 0.05), indicating that vitamin D is beneficial in treating tuberculous infection. Discussion: Vitamin D can increase macrophage activation by increasing cathelicidin, Nitrogen Oxide (NO), and Reactive Oxygen Species (ROS) production. Conclusions: Giving vitamin D3 800 International Units (IU) supplementation increases the efficacy of ATDs in spine tuberculosis treatment.
Majalah Kedokteran Bandung, 2011
Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, ... more Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, koreksi deformitas, dan mengatasi komplikasi neurologis. Data tingkat keberhasilan fusi ini masih belum tersedia. Kendala lain adalah harga instrumentasi bermerek untuk operasi fusi tulang belakang sangat mahal. Penelitian studi kohort retrospektif ini untuk evaluasi keberhasilan fusi tulang belakang pada spondilitis tuberkulosis di Rumah Sakit Dr. Hasan Sadikin, Bandung tahun 2005-2009. Didapatkan 115 kasus spondilitis tuberkulosis yang dioperasi terdiri atas 34 (29,3%) kasus anterior decompresion spinal fusion (ADSF) dan 81 (70,7%) kasus dengan menggunakan instrumentasi posterior. Dari 81 kasus tersebut, terdapat 3, 27, 26, dan 19 orang berturut-turut mengalami fusi tulang belakang setelah 4, 3, 2, dan 1 tahun pascaoperasi. Hanya 6 kasus yang belum mengalami fusi. Tingkat keberhasilan fusi tulang belakang pada kasus spondilitis tuberkulosis terbukti tinggi, 93%. Selain itu, instrumentasi lokal dapat digunakan sebagai alternatif instrumentasi yang bersifat cost effective untuk tindakan operasi fusi tulang belakang pada kasus spondilitis tuberkulosis dengan p=0,63. Sebagai kesimpulan, kasus spondilitis tuberkulosis yang memerlukan tindakan operasi fusi tulang belakang dapat ditangani dengan baik di RS Dr. Hasan Sadikin, dengan tingkat keberhasilan tinggi dan cost effective. [MKB. 2011;43(3):134-9].
Journal of the …, 2011
... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... more ... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... Agus Hadian Rahim, Bambang Tiksnadi, Ahmad Ramdan, Harry Kamijantono, Herry Setiawan, Andreas Vincent Handoyo, Arrio Yusman ...
Majalah Kedokteran Bandung, 2021
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Spinal TB is associat... more Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Spinal TB is associated with poor functional outcomes. Histopathological examination requires a long waiting times to obtain the results thus impractical for screening and may delay diagnosis. GeneXpert offers rapid tests for prompt screening and diagnosis. This study aimed to assess the diagnostic accuracy of GeneXpert in patients with spinal TB when compared to the histopathology test as the gold standard. This study was performed on patients in the Spine Clinic of the Department of Orthopedic and Traumatology, Dr. Hasan Sadikin General Hospital Bandung who were diagnosed with spinal TB during the period of May 2019–May 2020. Blood samples were collected from the patients and tested using GeneXpert and histopathological assessment. Results demonstrated 34 patients with a positive result and 6 patients with negative results on both diagnostic methods. Twenty nine out of 40 patients (72.5%) had rifampin-sens...
International Journal of Spine Surgery, 2020
Fibrous dysplasia of the spine in a polyostotic form is very rare, with fewer than 36 cases discu... more Fibrous dysplasia of the spine in a polyostotic form is very rare, with fewer than 36 cases discussed in the literature and there is no such case in Indonesia that has been reported. The aim of this report is to present a case from Indonesia of polyostotic fibrous dysplasia isolated in the spine. We report a case of a 38-year-old Sundanese man with a 1-year history of progressive back pain and weakness of both lower extremities. There was no history leading to infection and no previous trauma. A physical examination revealed kyphoscoliotic deformity, a caf´e au lait spot, tenderness at the thoracolumbar region, and neurological deficits. Laboratory studies were within normal ranges. Plain radiographs showed lytic lesion and kyphoscoliosis. Magnetic resonance imaging showed an endosteal scalloping, infiltrative process, expansion, and destruction in the vertebral bodies from T2 to L5. The findings of an aggressive destructive process was highly suspicious of a malignant process, relying on differential diagnosis and metastases, plasma cell myeloma, bone tumor and chronic infectious spondylitis. Histology revealed an irregularly oriented osteoid without osteoblastic rimming but surrounded by fibroblastic proliferation with a C-shaped sign. Investigations revealed a diagnosis of polyostotic fibrous dysplasia of the thoracolumbar spine in isolation. The patient underwent T5-S1 stabilization and bone grafting. At 1 year postoperative, the patient was asymptomatic; there was no recurrence and minimal neurological deficit with grade II on the modified McCormick scale. A case of the polyostotic form of fibrous dysplasia of the spine in isolation has never been reported in Indonesia. The extreme rarity of this type of presentation can pose a diagnostic dilemma, and in cases isolated to the spine, surgical treatment with posterior stabilization, decompression, and bone grafting gives a good functional outcome.
Majalah Kedokteran Bandung, Sep 20, 2011
Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, ... more Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, koreksi deformitas, dan mengatasi komplikasi neurologis. Data tingkat keberhasilan fusi ini masih belum tersedia. Kendala lain adalah harga instrumentasi bermerek untuk operasi fusi tulang belakang sangat mahal. Penelitian studi kohort retrospektif ini untuk evaluasi keberhasilan fusi tulang belakang pada spondilitis tuberkulosis di Rumah Sakit Dr. Hasan Sadikin, Bandung tahun 2005-2009. Didapatkan 115 kasus spondilitis tuberkulosis yang dioperasi terdiri atas 34 (29,3%) kasus anterior decompresion spinal fusion (ADSF) dan 81 (70,7%) kasus dengan menggunakan instrumentasi posterior. Dari 81 kasus tersebut, terdapat 3, 27, 26, dan 19 orang berturut-turut mengalami fusi tulang belakang setelah 4, 3, 2, dan 1 tahun pascaoperasi. Hanya 6 kasus yang belum mengalami fusi. Tingkat keberhasilan fusi tulang belakang pada kasus spondilitis tuberkulosis terbukti tinggi, 93%. Selain itu, instrumentasi lokal dapat digunakan sebagai alternatif instrumentasi yang bersifat cost effective untuk tindakan operasi fusi tulang belakang pada kasus spondilitis tuberkulosis dengan p=0,63. Sebagai kesimpulan, kasus spondilitis tuberkulosis yang memerlukan tindakan operasi fusi tulang belakang dapat ditangani dengan baik di RS Dr. Hasan Sadikin, dengan tingkat keberhasilan tinggi dan cost effective. [MKB. 2011;43(3):134-9].
Journal of the Indonesian Medical Association, Oct 21, 2011
... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... more ... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... Agus Hadian Rahim, Bambang Tiksnadi, Ahmad Ramdan, Harry Kamijantono, Herry Setiawan, Andreas Vincent Handoyo, Arrio Yusman ...
Sport Mont
Patellofemoral pain syndrome (PFPS) is a common source of knee problems found mostly in physicall... more Patellofemoral pain syndrome (PFPS) is a common source of knee problems found mostly in physically active young adults. Causative factors are multifactorial, including lower extremity weakness, especially quadriceps muscles. Conservative treatment of PFPS consists mainly of knee bracing and knee taping combined with physical therapy. This study was aimed to analyse the outcome comparison between knee bracing and knee taping in combination with rehabilitative exercise for PFPS management. A prospective study was performed involving twenty-five bas- ketball players suffering from PFPS, aged 19–30 years old with regular practice sessions. The subjects were each grouped randomly into a taping or a bracing group. Follow-up evaluations in term of Kujala patellofemoral score were done in the 1 st , 2 nd , and 4 th weeks after treatment. Unpaired t-test and chi-square were used to analyse the difference between both groups in pre- and post-intervention. Baseline characteristics of each grou...
Cermin Dunia Kedokteran, Jun 1, 2018
Global journal for research analysis, 2017
To explores the potential role of plasma vitamin D level and VDR gene polymorphisms in susceptibi... more To explores the potential role of plasma vitamin D level and VDR gene polymorphisms in susceptibility to tuberculo sis (TB) in the West Java population, Indonesia. A case-control study was performed on 53 Spinal TB patients, 53 Pulmonary TB patients and 53 healthy controls. Plasma Vitamin D levels were analyzed by ELISA, genetic polymorphisms of VDR gene (TaqI, FokI, BsmI, ApaI) were analyzed using PCR-RFLP and sequencing, There was a signi cant difference (p<0.01) of plasma vitamin D level among all groups. Genotype analysis of VDR gene polymorphismFok1, Bsml, Apal and Taql has shown no signi cant difference in all group (p>0.01). The combination of vitamin D de ciency and VDR gene polymorphism Fok1 in FF genotype were contributing factors to the susceptibility of spinal tuberculosis in the West Java population, Indonesia.
Global Medical & Health Communication (GMHC), 2020
Clinical intervention has a central role in the outcome of spondylitis tuberculosis cases. Surgic... more Clinical intervention has a central role in the outcome of spondylitis tuberculosis cases. Surgical procedures indicate to prevent neurological collapse, preservation of stability, and early mobilization. The study aims to analyze the outcome of surgical intervention in spinal tuberculosis by using a transpedicular approach. This research was a retrospective study on the Department of Orthopaedics and Traumatology in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2016–2018. There were 64 subjects in this study; 35 were male, and 29 were female, ages ranged 21–60 years with a follow-up period of 12 months to 18 months. A more common site of tubercular lesion was at the thoracal lesion (44%). In this research, the patients were preoperatively categorized by the American Spinal Injury Association (ASIA) Impairment Assessment. Among them four were ASIA-A, 10 were ASIA-B, 30 were ASIA-C, 15 were ASIA-D, and five were ASIA-E. After the operative procedure, two patients wer...
Nyeri pinggang bawah merupakan keluhan umum yang sering diderita oleh perawat di rumah sakit. Has... more Nyeri pinggang bawah merupakan keluhan umum yang sering diderita oleh perawat di rumah sakit. Hasil kajian teoritis nyeri pinggang bawah dipengaruhi oleh faktor eksternal dan faktor internal, yaitu aktifitas pekerjaan, umur, jenis kelamin, indeks massa tubuh.Faktor eksternal dan faktor internal merupakan masalah yang akan diteliti melalui metode kuantitatif dengan rancangan kasus kontrol. Analisa data yang digunakan adalah analisis bivariabel dengan chi-square dan analisis multivariabel dengan menggunakan analisis regresi logistik. Hasil penelitian ini membuktikan adanya variabel usia, indek massa tubuh, lama pekerjaan, aktivitas mengangkat pasien, aktivitas mendorong pasien serta berat badan pasien diatas 50 kg memiliki korelasi yang signifikan dengan kejadian nyeri pinggang bawah. Analisis multivariabel menunjukan bahwa lama/masa kerja, umur, dan lokasi tempat bekerja menjadi faktor yang dapat memprediksi kejadian nyeri pinggang bawah. Berdasarkan hasil penelitian tersebut, disara...
Indonesian Journal of Cancer, 2020
Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the sp... more Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the spine. It is estimated to be 2% to 12% in incidence from various series. The use of neoadjuvant and adjuvant chemotherapy for chondrosarcomas is controversial. Low- and intermediate-grade chondrosarcomas respond poorly to chemotherapy. Although not much data on the efficacy of chemotherapy in the treatment of high-grade chondrosarcomas, it should be considered in any young patient with a high-grade tumor. Radiation is recommended when anything other than wide excision is performed for chondrosarcoma of any grade.Case Presentation: A 24-year old female presented to the clinic with a chief complaint of persistent low back pain and a lump in her back. Initially, the lump was the size of a tennis ball three years ago. At the time of the examination, the lump was at the size of a volleyball about 65 x 63 x 58 centimeters. Systemic and general examinations were unremarkable. There were no comorb...
Majalah Kedokteran Bandung, 2020
Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, inc... more Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, including iron, are crucial in the body's defense mechanism. Iron modulates the activation of IFN-γ, which in turn will activate the macrophages. This study explores the effect of iron supplementation given with anti-tuberculosis drug therapy on the IFN-γ level in tuberculosis spondylitis patients. This was a single-blind randomized control trial study at Dr. Hasan Sadikin General Hospital Bandung, from December 2018 to March 2019, using the consecutive sampling approach. Thirty-four respondents with category 1 TB spondylitis and an sTfR level of> 21.7 pg /µL were recruited and randomized into control and experimental groups. The control group (n=17) was treated with 2 RHZE for 2 months while the experimental group (n=17) received 2 RHZE and iron tablet for 2 months. An increase in the IFN-γ level of the experimental group was observed from an average of 21.7 pg/ml before therapy to ...
(JOINTS) Journal Orthopaedi and Traumatology Surabaya, 2019
Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating ... more Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK.Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression.Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between grou...
Jurnal Anestesi Perioperatif, 2020
Preoperative anti-tuberculosis (TB) drugs play a role in surgery of TB spondylitis patients to pr... more Preoperative anti-tuberculosis (TB) drugs play a role in surgery of TB spondylitis patients to prevent transmission in the operating room, reduce inflammatory processes and prevent relapse. Currently, there is no study on effects of preoperative anti TB drugs administration duration on the spinal TB patients surgical outcome at Dr. Hasan Sadikin General Hospital (RSHS). This study used retrospective method by analyzing medical record data of TB spondylitis patients operated at RSHS, January 2014-May 2018. Based on the preoperative TB drugs duration, patients were divided into 2 groups: preoperative TB drugs group <2 and 2-4 weeks. Data analyzed were identity, duration of preoperative TB drugs administration, preoperative neurologic grade, preoperative CRP and ESR level, and postoperative data at 2 month follow up consisted of neurologic grade, postoperative CRP and ESR levels. The 58 patients consisted of 25 males and 33 females, Kolmogorov-Smirnov test showed a significant difference (p<0.05) in postoperative neurologic grade between preoperative TB drugs administration <2 vs 2-4 weeks. Unpaired T-Test showed postoperative CRP and ESR levels were significant (p<0.05). Postoperative neurologic grade in the preoperative TB drugs <2 weeks group was better vs the 2-4 week group. Operative procedure is more important in TB spondylitis patients treatment compared to a prolonged preoperative TB drugs administration.
Jurnal Anestesi Perioperatif, 2020
Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in... more Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in TB patients, causes a poor outcome, reccurency, and treatment failure. Iron supplements on TB patients with iron deficiency will activate macrophage-derived monocytes (MDM) and interferon-gamma (IFN-γ), with a positive feedback mechanism pushing interleukin-12 (IL-12). This study is a single-blind randomized control trial comparing the effectivity of preoperative iron supplementation in IL-12 level between two different groups in Dr. Hasan Sadikin General Hospital Bandung, conducted from November 2018 until March 2019. Respondents are those having Spondylitis TB, with sTfR > 21,7 pg/mL and IL-12 <41 pg/mL, intensive phase antituberculosis drugs category 1. The experimental group, comprised 17 respondents, was treated with 2RHZE and 357mg iron (III) hidroxy polymaltosa. The control group was treated with 2RHZE. The sTfR and IL-12 levels were performed before and after treatment. The increase of IL-12 in the experimental group was +364,53% higher than in the control group (p<0.05). The decrease of sTfR in the experimental group was-60,68% higher than in the control group (p<0.05). The result of the Pearson correlation test was a coefficient correlation of-0,73, this showed that a decrease in the sTfR level correlated with an increase in the Il-12 level. Iron supplement in Spondylitis TB with iron deficiency in the experimental group increases the IL-12 level. Preoperative iron supplementation on spondylitis TB with iron deficiency, increases the immune system with higher levels of IL-12.
Pharmaceutical Sciences and Research, 2019
Muscle injuries among athletes require a complete recovery to be able to function optimally as be... more Muscle injuries among athletes require a complete recovery to be able to function optimally as before. However, in spite of implementing the management with PRICE (Protection, Rest, Immobilization, Compression and Elevation), during the recovery processes, fibrotic tissue will be formed, which is an unwanted non-functional muscle. Losartan is a blood pressure-lowering drug which has the inhibitory effect of inhibitory effect of TGF-β cytokines (fibrotic tissue regulators). TGF-β is the key to fibrotic formation and differentiation. Losartan has an effect on decreasing the TGF-β production and it may affect the fibrotic tissue. This research is conducted by an experimental comparative method on the rabbit as study objects. Based on Federer formula sampling, twenty samples totally occurred. The random sampling method is adopted for comparing fibrotic tissue in two different groups (control group and losartan group). Losartan is administered orally. There were significant differences in the proportion of fibrotic tissue between the sample groups. The losartan group showed that the level of fibrotic intensity, distribution, and H-score was decreased compared to the control group. Moreover, the result of Mann Whitney statistic test, for determining the H-score for both groups, showed that p is less than 0.05 (p<0.05), which implies that this research is statistically significant. This research proves that giving Losartan tablets brings a significant impact in reducing the formation of muscle fibrosis in muscle injury grade 1 in gastrocnemius rabbits.
Interdisciplinary Neurosurgery, 2018
Introduction: Tuberculous meningitis (TBM) and tuberculous spondylitis (TBS) are the form of extr... more Introduction: Tuberculous meningitis (TBM) and tuberculous spondylitis (TBS) are the form of extra-pulmonary tuberculosis.
Progress in Orthopedic Science, 2018
Background: Tuberculous infection susceptibility emerges in individuals with low levels of vitami... more Background: Tuberculous infection susceptibility emerges in individuals with low levels of vitamin D. C-reactive protein (CRP) and erythrocyte sediment rate (ESR) are low during the intensive phase of anti-tuberculous drug (ATD) therapy. Cathelicidin, which is induced by vitamin D, has been proven to reduce the inflammatory process. Methods: This single-blind randomized control trial compared the efficacy of vitamin D in lowering CRP and ESR. The research was conducted at the Hasan Sadikin Hospital Outpatient Clinic and the Clinical Pathology Laboratory from March 2017 through August 2017. Tuberculous infected patients enrolled in the study were assigned to one of two groups; one received vitamin D supplementation, the other didn’t received. The Willcoxon statistical test was used to examine the value of CRP in two groups, and the unpaired t-test was used to evaluate ESR values for both groups. Results: The CRP and ESR values in the group receiving vitamin D were significantly lower than in the placebo group (p < 0.05), indicating that vitamin D is beneficial in treating tuberculous infection. Discussion: Vitamin D can increase macrophage activation by increasing cathelicidin, Nitrogen Oxide (NO), and Reactive Oxygen Species (ROS) production. Conclusions: Giving vitamin D3 800 International Units (IU) supplementation increases the efficacy of ATDs in spine tuberculosis treatment.
Majalah Kedokteran Bandung, 2011
Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, ... more Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, koreksi deformitas, dan mengatasi komplikasi neurologis. Data tingkat keberhasilan fusi ini masih belum tersedia. Kendala lain adalah harga instrumentasi bermerek untuk operasi fusi tulang belakang sangat mahal. Penelitian studi kohort retrospektif ini untuk evaluasi keberhasilan fusi tulang belakang pada spondilitis tuberkulosis di Rumah Sakit Dr. Hasan Sadikin, Bandung tahun 2005-2009. Didapatkan 115 kasus spondilitis tuberkulosis yang dioperasi terdiri atas 34 (29,3%) kasus anterior decompresion spinal fusion (ADSF) dan 81 (70,7%) kasus dengan menggunakan instrumentasi posterior. Dari 81 kasus tersebut, terdapat 3, 27, 26, dan 19 orang berturut-turut mengalami fusi tulang belakang setelah 4, 3, 2, dan 1 tahun pascaoperasi. Hanya 6 kasus yang belum mengalami fusi. Tingkat keberhasilan fusi tulang belakang pada kasus spondilitis tuberkulosis terbukti tinggi, 93%. Selain itu, instrumentasi lokal dapat digunakan sebagai alternatif instrumentasi yang bersifat cost effective untuk tindakan operasi fusi tulang belakang pada kasus spondilitis tuberkulosis dengan p=0,63. Sebagai kesimpulan, kasus spondilitis tuberkulosis yang memerlukan tindakan operasi fusi tulang belakang dapat ditangani dengan baik di RS Dr. Hasan Sadikin, dengan tingkat keberhasilan tinggi dan cost effective. [MKB. 2011;43(3):134-9].
Journal of the …, 2011
... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... more ... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... Agus Hadian Rahim, Bambang Tiksnadi, Ahmad Ramdan, Harry Kamijantono, Herry Setiawan, Andreas Vincent Handoyo, Arrio Yusman ...
Majalah Kedokteran Bandung, 2021
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Spinal TB is associat... more Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Spinal TB is associated with poor functional outcomes. Histopathological examination requires a long waiting times to obtain the results thus impractical for screening and may delay diagnosis. GeneXpert offers rapid tests for prompt screening and diagnosis. This study aimed to assess the diagnostic accuracy of GeneXpert in patients with spinal TB when compared to the histopathology test as the gold standard. This study was performed on patients in the Spine Clinic of the Department of Orthopedic and Traumatology, Dr. Hasan Sadikin General Hospital Bandung who were diagnosed with spinal TB during the period of May 2019–May 2020. Blood samples were collected from the patients and tested using GeneXpert and histopathological assessment. Results demonstrated 34 patients with a positive result and 6 patients with negative results on both diagnostic methods. Twenty nine out of 40 patients (72.5%) had rifampin-sens...
International Journal of Spine Surgery, 2020
Fibrous dysplasia of the spine in a polyostotic form is very rare, with fewer than 36 cases discu... more Fibrous dysplasia of the spine in a polyostotic form is very rare, with fewer than 36 cases discussed in the literature and there is no such case in Indonesia that has been reported. The aim of this report is to present a case from Indonesia of polyostotic fibrous dysplasia isolated in the spine. We report a case of a 38-year-old Sundanese man with a 1-year history of progressive back pain and weakness of both lower extremities. There was no history leading to infection and no previous trauma. A physical examination revealed kyphoscoliotic deformity, a caf´e au lait spot, tenderness at the thoracolumbar region, and neurological deficits. Laboratory studies were within normal ranges. Plain radiographs showed lytic lesion and kyphoscoliosis. Magnetic resonance imaging showed an endosteal scalloping, infiltrative process, expansion, and destruction in the vertebral bodies from T2 to L5. The findings of an aggressive destructive process was highly suspicious of a malignant process, relying on differential diagnosis and metastases, plasma cell myeloma, bone tumor and chronic infectious spondylitis. Histology revealed an irregularly oriented osteoid without osteoblastic rimming but surrounded by fibroblastic proliferation with a C-shaped sign. Investigations revealed a diagnosis of polyostotic fibrous dysplasia of the thoracolumbar spine in isolation. The patient underwent T5-S1 stabilization and bone grafting. At 1 year postoperative, the patient was asymptomatic; there was no recurrence and minimal neurological deficit with grade II on the modified McCormick scale. A case of the polyostotic form of fibrous dysplasia of the spine in isolation has never been reported in Indonesia. The extreme rarity of this type of presentation can pose a diagnostic dilemma, and in cases isolated to the spine, surgical treatment with posterior stabilization, decompression, and bone grafting gives a good functional outcome.
Majalah Kedokteran Bandung, Sep 20, 2011
Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, ... more Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, koreksi deformitas, dan mengatasi komplikasi neurologis. Data tingkat keberhasilan fusi ini masih belum tersedia. Kendala lain adalah harga instrumentasi bermerek untuk operasi fusi tulang belakang sangat mahal. Penelitian studi kohort retrospektif ini untuk evaluasi keberhasilan fusi tulang belakang pada spondilitis tuberkulosis di Rumah Sakit Dr. Hasan Sadikin, Bandung tahun 2005-2009. Didapatkan 115 kasus spondilitis tuberkulosis yang dioperasi terdiri atas 34 (29,3%) kasus anterior decompresion spinal fusion (ADSF) dan 81 (70,7%) kasus dengan menggunakan instrumentasi posterior. Dari 81 kasus tersebut, terdapat 3, 27, 26, dan 19 orang berturut-turut mengalami fusi tulang belakang setelah 4, 3, 2, dan 1 tahun pascaoperasi. Hanya 6 kasus yang belum mengalami fusi. Tingkat keberhasilan fusi tulang belakang pada kasus spondilitis tuberkulosis terbukti tinggi, 93%. Selain itu, instrumentasi lokal dapat digunakan sebagai alternatif instrumentasi yang bersifat cost effective untuk tindakan operasi fusi tulang belakang pada kasus spondilitis tuberkulosis dengan p=0,63. Sebagai kesimpulan, kasus spondilitis tuberkulosis yang memerlukan tindakan operasi fusi tulang belakang dapat ditangani dengan baik di RS Dr. Hasan Sadikin, dengan tingkat keberhasilan tinggi dan cost effective. [MKB. 2011;43(3):134-9].
Journal of the Indonesian Medical Association, Oct 21, 2011
... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... more ... Sebanyak 18 orang belum menunjukkan fusi vertebra pada saat observasi ini selesai dilakukan. ... Agus Hadian Rahim, Bambang Tiksnadi, Ahmad Ramdan, Harry Kamijantono, Herry Setiawan, Andreas Vincent Handoyo, Arrio Yusman ...