Ahmed Bekhit - Academia.edu (original) (raw)

Papers by Ahmed Bekhit

This is an open-source, empirical data-driven, virtual building energy analysis and retrofit targ... more This is an open-source, empirical data-driven, virtual building energy analysis and retrofit targeting tool. The open-source tool will provide a fully-automated, "no-cost/no-touch" approach to screen large volumes of buildings for operational improvement and equipment upgrade opportunities and quantify associated potential energy and cost savings.

Nature, 2009

Whereas drugs are intended to be selective, at least some bind to several physiologic targets, ex... more Whereas drugs are intended to be selective, at least some bind to several physiologic targets, explaining both side effects and efficacy. As many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here, we compared 3,665 FDA-approved and investigational drugs against hundreds of targets, defining each target by its ligands. Chemical similarities between drugs and ligand sets predicted thousands of unanticipated associations. Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2022

The article has been withdrawn at the request of the editor of the journal Anti-Inflammatory- Ant... more The article has been withdrawn at the request of the editor of the journal Anti-Inflammatory- Anti-Allergy Agents in Medicinal Chemistry. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the a...

World Journal of Gastroenterology, 2020

BACKGROUND The current coronavirus disease 2019 (COVID-19) pandemic has affected routine endoscop... more BACKGROUND The current coronavirus disease 2019 (COVID-19) pandemic has affected routine endoscopy service across the gastroenterology community. This led to the suspension of service provision for elective cases. AIM To assess the potential barriers for resuming the endoscopy service in Egypt. METHODS A national online survey, four domains, was disseminated over a period of 4 wk in August 2020. The primary outcome of the survey was to determine the impact of the COVID-19 pandemic on the endoscopy service and barriers to the full resumption of a disabled center(s). RESULTS A hundred and thirteen Egyptian endoscopy centers participated in the survey. The waiting list was increased by ≥ 50% in 44.9% of areas with clusters of COVID-19 cases (n = 49) and in 35.5% of areas with sporadic cases (n = 62). Thirty nine (34.8%) centers suffered from staff shortage, which was considered a barrier against service resumption by 86.4% of centers in per-protocol analysis. In multivariate analysis, the burden of cases in the unit locality, staff shortage/recovery and the availability of separate designated rooms for COVID-19 cases could markedly affect the resumption of endoscopy practice (P = 0.029, < 0.001 and 0.02, respectively) and Odd’s ratio (0.15, 1.8 and 0.16, respectively). CONCLUSION The COVID-19 pandemic has led to restrictions in endoscopic volumes. The staff shortage/recovery and the availability of COVID-19 designed rooms are the most important barriers against recovery. Increasing working hours and dividing endoscopy staff into teams may help to overcome the current situation.

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020

In late 2019, a novel coronavirus, now designated SARS-CoV-2, emerged and was identified as the c... more In late 2019, a novel coronavirus, now designated SARS-CoV-2, emerged and was identified as the cause of an outbreak of acute respiratory illness in Wuhan, a city in China, named as COVID-19. Since then the waves of the virus exponentially hit many countries around the globe with high rates of spread associated with variable degrees of morbidity and mortality. The WHO announced the pandemic state of the infection in March 2020 and by June 1st 2020 more than 6 million individuals and more than 370 thousands case fatalities were documented worldwide. In this article, we discussed many aspects regarding this emerged infection based on the available evidence aiming to help clinician to improve not only their knowledge but also their practices toward this infection.

Journal of Veterinary Medical Research, 2008

Alexandria Journal of Veterinary Sciences, 2019

ADP-ribosylation factor-guanine nucleotide exchange factors (ARF-GEFs) act as key regulators of v... more ADP-ribosylation factor-guanine nucleotide exchange factors (ARF-GEFs) act as key regulators of vesicle trafficking in all eukaryotes. In Arabidopsis, there are eight ARF-GEFs, including three members of the GBF1 subfamily and five members of the BIG subfamily. These ARF-GEFs have different subcellular localizations and regulate different trafficking pathways. Until now, the roles of these BIG-subfamily ARF-GEFs have not been fully revealed. Here, analysis of the BIGs expression patterns showed that BIG3 and BIG5 have similar expression patterns. big5-1 displayed a dwarf growth and big3-1 big5-1 double mutant showed more severe defects, indicating functional redundancy between BIG3 and BIG5. Moreover, both big5-1 and big3-1 big5-1 exhibited a reduced sensitivity to Brassinosteroid (BR) treatment. Brefeldin A (BFA)-induced BR receptor Brassinosteroid insensitive 1 (BRI1) aggregation was reduced in big5-1 mutant, indicating that the action of BIG5 is required for BRI1 recycling. Furthermore, BR-induced dephosphorylation of transcription factor BZR1 was decreased in big3-1 big5-1 double mutants. The introduction of the gain-of-function of BZR1 mutant BZR1-1D in big3-1 big5-1 mutants can partially rescue the big3-1 big5-1 growth defects. Our findings revealed that BIG5 functions redundantly with BIG3 in plant growth and gravitropism, and BIG5 participates in BR signal transduction pathway through regulating BRI1 trafficking.

Alexandria Journal of Veterinary Sciences, 2018

Gallibacterium anatis and Mycoplasma gallisepticum are bacterial pathogens affecting the respirat... more Gallibacterium anatis and Mycoplasma gallisepticum are bacterial pathogens affecting the respiratory tract of broiler chickens. Tracking the mixed experimental infection effect with G. anatis and M. gallisepticum in broiler chickens regarding clinical signs, performance, PM and histopathological lesions was the aim of this work. Birds inoculated with G. anatis (G2) or M. gallisepticum (G4) alone showed less severe clinical signs and gross pathological lesions in the respiratory tract. While, co-infection with G. anatis and M. gallisepticum (G3) exaggerated the clinical signs like rales, sneezing, nasal discharge, coughing, lacrimation and open mouth breathing and also gross and microscopical lesions which appeared as severe conjunctivitis with hemorrhagic congestive tracheitis, pneumonia and hyperplasia of the epithelium lining of trachea as compared to other groups which were infected with single pathogen or control negative group (G1). In conclusion, G. anatis produce less severe clinical signs and lesions regarding respiratory system than coinfection with M. gallisepticum which may be a most important factor enhancing the pathogenicity of G. anatis under field conditions.

Journal of South Asian Association of Pediatric Dentistry, 2022

new classification system for better grading of paramolar tubercles specifically for primary mola... more new classification system for better grading of paramolar tubercles specifically for primary molars based on the classification given by Turner and Katich (Table 2). 13 Kazak et al. used cone-beam computed tomography (CBCT) for the evaluation of paramolar tubercle in permanent molars in turkish population and found the existence of independent root canals in paramolar tubercles. 13 These morphological variations and complex internal anatomy in parastyle make it pernitent for the clinicians to be aware of such uncommon deviations. The present case series aims to report the presence of parastyle in deciduous molars in four North Indian children and its occurrence in one of the siblings. Case 1 A six-year-old North Indian girl reported with her elder sibling for routine dental checkup to the Department of Pediatric Dentistry. Her medical and dental histories were non-significant and there was no sign of any systemic disease or syndrome. There was no reported history of orofacial trauma. Extraoral examination revealed no abnormalities. Intra oral examination revealed mixed dentition with no softtissue abnormalities. There were mild stains present and no evidence of caries except a restoration in 53. Morphological alterations were found to be present bilaterally on mesiobuccal cusps in maxillary primary first molars. The primary right maxillary first molar (54) showed a cusp-like projection which was conical in shape with its base near the gingival margin and its apex pointing occlusally, the cusp was separated by a deep developmental groove.