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Papers by Ahmed Mohamed
MOH Journal of Medical Case Reports, 2024
Acute myeloid leukemia (AML) can initially present with extramedullary manifestations, including ... more Acute myeloid leukemia (AML) can initially present with extramedullary manifestations, including leukemia cutis (LC), which is a rare and challenging diagnosis. LC often presents as erythematous or violaceous nodules, plaques, or papules, and its nonspecific clinical appearance can lead to diagnostic delays. We report the case of a 29-year-old man who presented with a painful ulcer on his right anterior leg. The initial clinical evaluation did not suggest a hematologic malignancy, and the diagnosis was elusive. Histopathological examination of the skin biopsy revealed atypical infiltrating cells, but the diagnosis remained uncertain until immunohistochemistry (IHC) and molecular testing were performed. The nonspecific clinical and histopathological features complicated the diagnosis of leukemia cutis in this case. IHC analysis and molecular studies played a critical role in identifying the myeloid origin of the infiltrate. The patient was treated with standard induction chemotherapy, consisting of Cytarabine and daunorubicin, followed by consolidation therapy with high-dose Cytarabine. The patient was free of relapse in a threeyear follow-up after treatment. Early recognition and diagnosis are crucial for initiating appropriate therapy, although the prognosis remains poor due to the aggressive nature of the disease.
MOH Journal of Medical Case Reports, 2024
Acute myeloid leukemia (AML) can initially present with extramedullary manifestations, including ... more Acute myeloid leukemia (AML) can initially present with extramedullary manifestations, including leukemia cutis (LC), which is a rare and challenging diagnosis. LC often presents as erythematous or violaceous nodules, plaques, or papules, and its nonspecific clinical appearance can lead to diagnostic delays. We report the case of a 29-year-old man who presented with a painful ulcer on his right anterior leg. The initial clinical evaluation did not suggest a hematologic malignancy, and the diagnosis was elusive. Histopathological examination of the skin biopsy revealed atypical infiltrating cells, but the diagnosis remained uncertain until immunohistochemistry (IHC) and molecular testing were performed. The nonspecific clinical and histopathological features complicated the diagnosis of leukemia cutis in this case. IHC analysis and molecular studies played a critical role in identifying the myeloid origin of the infiltrate. The patient was treated with standard induction chemotherapy, consisting of Cytarabine and daunorubicin, followed by consolidation therapy with high-dose Cytarabine. The patient was free of relapse in a threeyear follow-up after treatment. Early recognition and diagnosis are crucial for initiating appropriate therapy, although the prognosis remains poor due to the aggressive nature of the disease.