Ahmet Hüseyin Acar - Academia.edu (original) (raw)

Papers by Ahmet Hüseyin Acar

Research paper thumbnail of Thymus vulgaris, Alpinia officinarum and dried root of Urtica dioica, approved for use in the management of external haemorrhage and surgical bleeding by the Turkish Ministry

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma ... more Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic...

Research paper thumbnail of Como podría la información multimedia sobre la cirugía de implantes dentales afectar al nivel de ansiedad de los pacientes

Antecedentes: Evaluar los efectos de las diferentes tecnicas de educacion del paciente sobre los ... more Antecedentes: Evaluar los efectos de las diferentes tecnicas de educacion del paciente sobre los niveles de ansiedad antes y despues de la cirugia de implantes dentales. Material y Metodos: Sesenta pacientes fueron asignados al azar en tres grupos; cada uno contenia 20 pacientes; [Grupo 1, informacion basica dada verbalmente, con detalles de operacion y recuperacion; grupo 2 (grupo de estudio), informacion basica dada verbalmente con detalles de procedimientos operativos y recuperacion, y viendo una pelicula sobre cirugia de implante unico]; y un grupo de control [informacion basica dada verbalmente "pero estaba desprovista de los detalles de los procedimientos operativos y la recuperacion"]. Los niveles de ansiedad se evaluaron utilizando el Inventario de Ansiedad de Spielberger State-Trait (STAI) y la Escala de Ansiedad Dental Modificada (MDAS). El dolor se evaluo utilizando una escala analogica visual (VAS). Resultados: Se observaron los cambios mas significativos en el...

Research paper thumbnail of How could multimedia information about dental implant surgery effects patients anxiety level?

Medicina Oral Patología Oral y Cirugia Bucal, 2016

Research paper thumbnail of Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Experimental and Therapeutic Medicine, 2017

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma ... more Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.

Research paper thumbnail of Comparison of laser and ozone treatments on oral mucositis in an experimental model

Lasers in medical science, 2017

Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, dri... more Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth ...

Research paper thumbnail of Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Drug Design, Development and Therapy, 2015

Research paper thumbnail of The efficacy of hyaluronic acid in postextraction sockets of impacted third molars: A pilot study

Nigerian Journal of Clinical Practice

Research paper thumbnail of Alveolar Osteitis İnsidansı: 324 Hastanın Geriye Dönük İncelenmesi

Research paper thumbnail of Bone decortication rate and guided bone regeneration under an occlusive titanium dome: Micro- CT analysis

Annals of Medical Research, 2018

We aimed to evaluate how the rate of bone decortication influences guided bone regeneration. Mate... more We aimed to evaluate how the rate of bone decortication influences guided bone regeneration. Material and Methods: Twenty-four titanium domes were placed bilaterally on the parietal bones of sixteen New Zealand rabbits after drilling the bone with a small round burr to induce bleeding from the marrow space (Group A: one hole; Group B: three holes; Group C: nine holes), while the bone surface was left intact at the control sites (Control group). Each group included six samples. Bone decortication rates were approximately 4% in group A, 12% in group B, and 36% in group C. All rabbits were killed after a 12week bone-healing period, and results were evaluated by micro-CT. Results: Both newly generated tissue formation and mineralized bone formation were higher in all experimental groups than in the control group (P < 0.05), increasing in proportion to the increasing number of holes to a peak in Group C. Conclusion: Bone decortication improves mineralized bone and newly regenerated augmented tissue during guided bone regeneration. Bone decortication can be used as an integral part of guided bone regeneration procedures. Also more bone decortication rate seems to be more effective.

Research paper thumbnail of Prevalence of Elongated Styloid Process and Eagle Syndrome in East Eagean Population

Bezmialem Science, 2019

Objective: In this study; we aimed to evaluate the prevalence, clinical and radiographic findings... more Objective: In this study; we aimed to evaluate the prevalence, clinical and radiographic findings of elongated styloid process (SP) and Eagle syndrome (ES) in Eastern Aegean Turkish population. Methods: Recordings of 3678 patients over 18 years of age were examined who were admitted to Afyon Kocatepe University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, between July 1 and December 31, 2014. Length, elongation type, calcification shape, single or double sided appearance of SP and clinical findings were recorded. Results: In 258 patients (112 male, 146 female), SP were found to be elongated (7.01%). In 9 patients (3 male, 6 female) (0.24%), symptoms were considered as ES. There was no difference between age, sex and elongated SP (p>0.05). Conclusion: The elongation of the SP may cause a variety of clinical symptoms. This situation may be confused with many other clinical problems. Elongated SP or ES which can be detected in panoramic radiographs should be consulted with the ear-nose-throat clinic.

Research paper thumbnail of The investigation of effects of proton pump inhibitors (PPI) using on maxillary bone mineral density

Annals of Medical Research, 2018

Proton pump inhibitors (PPI) have been widely used throughout the world. The effects of the PPIs ... more Proton pump inhibitors (PPI) have been widely used throughout the world. The effects of the PPIs on bone mineral density (BMD) is important for oral surgeons. The aim of this study was evaluate alterations in bone mineral density in patients using PPI. Material and Methods: A total of 92 patients were enrolled in the study and were separated into 4 groups (24 in control group, 22 in Lansoprazole group, 24 in Pantoprazole group and 22 in Esomeprazole group). Hounsfield Unit scores were measuredseparately of the incisor, canine, premolar, molar and tubule regions in the jaws with computed tomography. The measurement area in the dental regions was defined as an area of 2mm2 at least 2mm from the apex of the teeth. All data were collected and statistically analysed. Results: There was no significant difference between the groups in respect of mean age. There were no significant differences between the control and the study groups. Also no significant difference was found among the study groups. Conclusion: These data revealed that there were no correlations between decreased maxillary bone mineral density and proton pump inhibitor use. Further studies with more extensive samples should take into consideration drug doses and the period of use.

Research paper thumbnail of Is Counterclockwise Rotation With Double Jaw Orthognathic Surgery Stable in the Long-Term in Hyperdivergent Class III Patients?

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Jan 15, 2018

To evaluate the long-term postsurgical stability of counterclockwise rotation of the occlusal pla... more To evaluate the long-term postsurgical stability of counterclockwise rotation of the occlusal plane (OP) in double-jaw orthognathic surgery in patients with hyperdivergent Class III malocclusion. This retrospective cohort study evaluated the postsurgical stability of orthognathic surgery in patients with skeletal Class III malocclusion and counterclockwise rotation of the maxillomandibular complex with an OP change of at least -2°. Patients were evaluated with lateral cephalometric analysis before surgery, immediately after surgery, and at longest follow-up. The primary predictor variable was the change in angle of the OP and the Frankfort horizontal (FH) after surgery. The primary outcome variable was stability of the OP at longest follow-up. Other study variables were age, gender, and the following cephalometric measurements: mandibular plane angle; gonial angle; angle formed by the sella, nasion, and B point; maxillary height; angle of the palatal plane to the line connecting the...

Research paper thumbnail of Comparison of a new flap design with the routinely used triangular flap design in third molar surgery

International Journal of Oral and Maxillofacial Surgery, 2015

The aim of this study is to introduce a new flap design in the surgical removal of impacted mandi... more The aim of this study is to introduce a new flap design in the surgical removal of impacted mandibular third molars-a lingually based triangular flapand to compare this flap design with the routinely used triangular flap. This randomized, prospective, split-mouth study involved 22 patients with impacted bilateral mandibular third molars that were symmetrically positioned, mesially angulated, and retained in bone. The impacted teeth were removed in two sessions, using two different flap designs: the new alternative flap and the traditional triangular flap. Postoperative complications (pain, swelling, trismus, alveolar osteitis, and wound dehiscence) were recorded on days 2, 7, 14, and 21. The data obtained were analysed using the x 2 test, the Mann-Whitney U-test, and Pearson's correlation. In terms of the severity of postoperative facial swelling and trismus, there were no statistically significant differences between the flap designs (P > 0.05). The alternative flap exhibited higher pain scores at 12 h post-surgery (P < 0.05). In addition, the alternative flap group exhibited less wound dehiscence, although this was not statistically significant. Moreover, all wound dehiscence in this group occurred on sound bone. In conclusion, these results show that this new flap design is preferable to the routinely used flap for impacted third molar surgery.

Research paper thumbnail of The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism

Pain Research and Management, 2017

Objectives. Nocturnal bruxism can be managed by botulinum toxin (Botox®) in patients who have not... more Objectives. Nocturnal bruxism can be managed by botulinum toxin (Botox®) in patients who have not responded to conservative treatment. The aim of this study was to evaluate the efficacy of botulinum toxin A (BTXA) in the treatment of nocturnal bruxism. Material and Methods. The retrospective study comprised 25 female patients, aged 23–55 years (mean 35.84±8.41 years). All patients received a single injection of BTXA in the right and left masseters. Evaluation was made by Visual Analogue Scale (VAS) values, complaint duration, onset of effect, and duration of effectiveness. Results. BTXA produced significant improvements in pain scores. Only 2 adverse events (8%) were recorded. Conclusion. BTX-A is effective in the treatment of nocturnal bruxism.

Research paper thumbnail of Is Horizontal Mattress Suturing More Effective Than Simple Interrupted Suturing on Postoperative Complications and Primary Wound Healing After Impacted Mandibular Third Molar Surgery?

Journal of Craniofacial Surgery, 2017

The aim of this clinical study was to compare the influence of 2 different suturing techniques on... more The aim of this clinical study was to compare the influence of 2 different suturing techniques on postoperative complications and wound healing after surgical extractions of impacted mandibular third molars. In this randomized split mouth study, 30 patients were examined in whom 60 consecutive surgical extractions of symmetrically positioned impacted mandibular third molars were performed. After the extractions, the surgical flaps were sutured with either the simple interrupted or horizontal mattress suturing technique. Postoperative swelling and trismus were recorded on the 2nd, 7th, and 10th days. Pain was recorded in a 7-day diary and wound dehiscence was recorded on the10th postoperative day. Statistical evaluation of data was made using Mann-Whitney U test and Pearson correlation. There were no statistical differences between the 2 suturing techniques in terms of postoperative pain, trismus, and swelling (P > 0.05). There was significantly less wound dehiscence in the horizontal mattress suturing group than in the simple interrupted suturing group (P: 0017). According to the results of this study, the horizontal mattress suturing technique is more effective than the simple interrupted suturing technique on wound healing after impacted mandibular third molar surgery, although it does not decrease the levels of pain, trismus, and swelling.

Research paper thumbnail of Is More Cortical Bone Decortication Effective on Guided Bone Augmentation?

Journal of Craniofacial Surgery, 2016

This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guid... more This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guided bone augmentation. A total of 16 New Zealand rabbits and 32 titanium domes were used. No cortical bone decortication was applied to the control group and in the study groups, the cortical bones were decorticated with a round burr (Group A: 1 hole with bleeding, Group B: 5 holes with bleeding, Group C: a thin layer of compact bone was completely removed with no bleeding). Then 2 titanium domes were placed on the calvarium of each rabbit with hydroxyapatite/beta-tricalcium phosphate. After 3 months, the animals were sacrificed and specimens were sent for histological and histomorphometric analysis. Histological and histomorphometric analysis showed that bone decortication with burr significantly increased new bone regeneration in all the experimental groups compared with the control group (P <0.05). No statistically significant difference was determined between the study groups. In conclusion, CBD, which has no negative impact on surgery, has a positive effect on guided bone augmentation. However, a greater amount of CBD does not have a greater effect.

Research paper thumbnail of Alveolar Osteitis İnsidansı: 324 Hastanın Geriye Dönük İncelenmesi

Turkiye Klinikleri Dis Hekimligi Bilimleri Dergisi, 2014

Research paper thumbnail of An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery

Nigerian Journal of Clinical Practice, 2016

The aim of the present study was to assess whether the use of platelet-rich fibrin (PRF) decrease... more The aim of the present study was to assess whether the use of platelet-rich fibrin (PRF) decreased the pain, swelling, and trismus levels of postoperative third molar surgery. Materials and Methods: In a double-blinded, split-mouth randomized study, thirty patients (6 male/24 female, mean age 20.32 years) with bilateral symmetric impacted third molars were enrolled in this study to receive surgery. The PRF mass was randomly placed in one of the extraction sockets, whereas the other socket was left without treatment. The outcome variables were pain, maximum mouth opening (trismus), swelling (edema), and the presence of dry socket which were measured using a 10-point visual analog scale, manual calipers, and 3dMD facial imaging system which was used for the 1 st time in the third molar surgery. Results: Statistical analyses revealed that there were no significant differences between the control and study groups regarding postoperative pain, swelling, and trismus (P > 0.05). Conclusion: The results of this study suggest that PRF was not observed to have a positive effect on postoperative discomfort, so even though, PRF is presumed to have positive effects on healing and recovery processes.

Research paper thumbnail of Bone regeneration by low-level laser therapy and low-intensity pulsed ultrasound therapy in the rabbit calvarium

Archives of Oral Biology, 2016

We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (... more We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS), alone and in combination, in triggering new bone formation. Sixteen New Zealand white rabbits were given two calvarial defects by using a 6-mm trephine bur, then divided into four treatment groups: control, LLLT, LIPUS, and LLLT+LIPUS. The LLLT and LIPUS groups were treated three times a week for two weeks. The LLLT+LIPUS group received each treatment on the same day, 12h apart, three days a week for two weeks. The animals were sacrificed after three weeks. LLLT and LIPUS, alone and in combination, enhanced new bone formation in comparison to the untreated controls after three weeks (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05); the combined therapy did not produce an additive effect. Our results demonstrate the efficacy of LLLT or LIPUS in triggering bone regeneration. Therapeutic dose and duration requires further study.

Research paper thumbnail of Mandibular bone mineral density in patients with Behçet’s disease

Therapeutics and Clinical Risk Management, 2015

Objectives: Behçet's disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patient... more Objectives: Behçet's disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD. Materials and methods: The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0-5, 6-10, and .10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique. Results: The mean mandibular body BMD values were 1.294±0.21 g/cm 2 in the control group and 1.216±0.22 g/cm 2 in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree. Conclusion: The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.

Research paper thumbnail of Thymus vulgaris, Alpinia officinarum and dried root of Urtica dioica, approved for use in the management of external haemorrhage and surgical bleeding by the Turkish Ministry

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma ... more Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic...

Research paper thumbnail of Como podría la información multimedia sobre la cirugía de implantes dentales afectar al nivel de ansiedad de los pacientes

Antecedentes: Evaluar los efectos de las diferentes tecnicas de educacion del paciente sobre los ... more Antecedentes: Evaluar los efectos de las diferentes tecnicas de educacion del paciente sobre los niveles de ansiedad antes y despues de la cirugia de implantes dentales. Material y Metodos: Sesenta pacientes fueron asignados al azar en tres grupos; cada uno contenia 20 pacientes; [Grupo 1, informacion basica dada verbalmente, con detalles de operacion y recuperacion; grupo 2 (grupo de estudio), informacion basica dada verbalmente con detalles de procedimientos operativos y recuperacion, y viendo una pelicula sobre cirugia de implante unico]; y un grupo de control [informacion basica dada verbalmente "pero estaba desprovista de los detalles de los procedimientos operativos y la recuperacion"]. Los niveles de ansiedad se evaluaron utilizando el Inventario de Ansiedad de Spielberger State-Trait (STAI) y la Escala de Ansiedad Dental Modificada (MDAS). El dolor se evaluo utilizando una escala analogica visual (VAS). Resultados: Se observaron los cambios mas significativos en el...

Research paper thumbnail of How could multimedia information about dental implant surgery effects patients anxiety level?

Medicina Oral Patología Oral y Cirugia Bucal, 2016

Research paper thumbnail of Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Experimental and Therapeutic Medicine, 2017

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma ... more Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.

Research paper thumbnail of Comparison of laser and ozone treatments on oral mucositis in an experimental model

Lasers in medical science, 2017

Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, dri... more Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth ...

Research paper thumbnail of Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Drug Design, Development and Therapy, 2015

Research paper thumbnail of The efficacy of hyaluronic acid in postextraction sockets of impacted third molars: A pilot study

Nigerian Journal of Clinical Practice

Research paper thumbnail of Alveolar Osteitis İnsidansı: 324 Hastanın Geriye Dönük İncelenmesi

Research paper thumbnail of Bone decortication rate and guided bone regeneration under an occlusive titanium dome: Micro- CT analysis

Annals of Medical Research, 2018

We aimed to evaluate how the rate of bone decortication influences guided bone regeneration. Mate... more We aimed to evaluate how the rate of bone decortication influences guided bone regeneration. Material and Methods: Twenty-four titanium domes were placed bilaterally on the parietal bones of sixteen New Zealand rabbits after drilling the bone with a small round burr to induce bleeding from the marrow space (Group A: one hole; Group B: three holes; Group C: nine holes), while the bone surface was left intact at the control sites (Control group). Each group included six samples. Bone decortication rates were approximately 4% in group A, 12% in group B, and 36% in group C. All rabbits were killed after a 12week bone-healing period, and results were evaluated by micro-CT. Results: Both newly generated tissue formation and mineralized bone formation were higher in all experimental groups than in the control group (P < 0.05), increasing in proportion to the increasing number of holes to a peak in Group C. Conclusion: Bone decortication improves mineralized bone and newly regenerated augmented tissue during guided bone regeneration. Bone decortication can be used as an integral part of guided bone regeneration procedures. Also more bone decortication rate seems to be more effective.

Research paper thumbnail of Prevalence of Elongated Styloid Process and Eagle Syndrome in East Eagean Population

Bezmialem Science, 2019

Objective: In this study; we aimed to evaluate the prevalence, clinical and radiographic findings... more Objective: In this study; we aimed to evaluate the prevalence, clinical and radiographic findings of elongated styloid process (SP) and Eagle syndrome (ES) in Eastern Aegean Turkish population. Methods: Recordings of 3678 patients over 18 years of age were examined who were admitted to Afyon Kocatepe University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, between July 1 and December 31, 2014. Length, elongation type, calcification shape, single or double sided appearance of SP and clinical findings were recorded. Results: In 258 patients (112 male, 146 female), SP were found to be elongated (7.01%). In 9 patients (3 male, 6 female) (0.24%), symptoms were considered as ES. There was no difference between age, sex and elongated SP (p>0.05). Conclusion: The elongation of the SP may cause a variety of clinical symptoms. This situation may be confused with many other clinical problems. Elongated SP or ES which can be detected in panoramic radiographs should be consulted with the ear-nose-throat clinic.

Research paper thumbnail of The investigation of effects of proton pump inhibitors (PPI) using on maxillary bone mineral density

Annals of Medical Research, 2018

Proton pump inhibitors (PPI) have been widely used throughout the world. The effects of the PPIs ... more Proton pump inhibitors (PPI) have been widely used throughout the world. The effects of the PPIs on bone mineral density (BMD) is important for oral surgeons. The aim of this study was evaluate alterations in bone mineral density in patients using PPI. Material and Methods: A total of 92 patients were enrolled in the study and were separated into 4 groups (24 in control group, 22 in Lansoprazole group, 24 in Pantoprazole group and 22 in Esomeprazole group). Hounsfield Unit scores were measuredseparately of the incisor, canine, premolar, molar and tubule regions in the jaws with computed tomography. The measurement area in the dental regions was defined as an area of 2mm2 at least 2mm from the apex of the teeth. All data were collected and statistically analysed. Results: There was no significant difference between the groups in respect of mean age. There were no significant differences between the control and the study groups. Also no significant difference was found among the study groups. Conclusion: These data revealed that there were no correlations between decreased maxillary bone mineral density and proton pump inhibitor use. Further studies with more extensive samples should take into consideration drug doses and the period of use.

Research paper thumbnail of Is Counterclockwise Rotation With Double Jaw Orthognathic Surgery Stable in the Long-Term in Hyperdivergent Class III Patients?

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Jan 15, 2018

To evaluate the long-term postsurgical stability of counterclockwise rotation of the occlusal pla... more To evaluate the long-term postsurgical stability of counterclockwise rotation of the occlusal plane (OP) in double-jaw orthognathic surgery in patients with hyperdivergent Class III malocclusion. This retrospective cohort study evaluated the postsurgical stability of orthognathic surgery in patients with skeletal Class III malocclusion and counterclockwise rotation of the maxillomandibular complex with an OP change of at least -2°. Patients were evaluated with lateral cephalometric analysis before surgery, immediately after surgery, and at longest follow-up. The primary predictor variable was the change in angle of the OP and the Frankfort horizontal (FH) after surgery. The primary outcome variable was stability of the OP at longest follow-up. Other study variables were age, gender, and the following cephalometric measurements: mandibular plane angle; gonial angle; angle formed by the sella, nasion, and B point; maxillary height; angle of the palatal plane to the line connecting the...

Research paper thumbnail of Comparison of a new flap design with the routinely used triangular flap design in third molar surgery

International Journal of Oral and Maxillofacial Surgery, 2015

The aim of this study is to introduce a new flap design in the surgical removal of impacted mandi... more The aim of this study is to introduce a new flap design in the surgical removal of impacted mandibular third molars-a lingually based triangular flapand to compare this flap design with the routinely used triangular flap. This randomized, prospective, split-mouth study involved 22 patients with impacted bilateral mandibular third molars that were symmetrically positioned, mesially angulated, and retained in bone. The impacted teeth were removed in two sessions, using two different flap designs: the new alternative flap and the traditional triangular flap. Postoperative complications (pain, swelling, trismus, alveolar osteitis, and wound dehiscence) were recorded on days 2, 7, 14, and 21. The data obtained were analysed using the x 2 test, the Mann-Whitney U-test, and Pearson's correlation. In terms of the severity of postoperative facial swelling and trismus, there were no statistically significant differences between the flap designs (P > 0.05). The alternative flap exhibited higher pain scores at 12 h post-surgery (P < 0.05). In addition, the alternative flap group exhibited less wound dehiscence, although this was not statistically significant. Moreover, all wound dehiscence in this group occurred on sound bone. In conclusion, these results show that this new flap design is preferable to the routinely used flap for impacted third molar surgery.

Research paper thumbnail of The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism

Pain Research and Management, 2017

Objectives. Nocturnal bruxism can be managed by botulinum toxin (Botox®) in patients who have not... more Objectives. Nocturnal bruxism can be managed by botulinum toxin (Botox®) in patients who have not responded to conservative treatment. The aim of this study was to evaluate the efficacy of botulinum toxin A (BTXA) in the treatment of nocturnal bruxism. Material and Methods. The retrospective study comprised 25 female patients, aged 23–55 years (mean 35.84±8.41 years). All patients received a single injection of BTXA in the right and left masseters. Evaluation was made by Visual Analogue Scale (VAS) values, complaint duration, onset of effect, and duration of effectiveness. Results. BTXA produced significant improvements in pain scores. Only 2 adverse events (8%) were recorded. Conclusion. BTX-A is effective in the treatment of nocturnal bruxism.

Research paper thumbnail of Is Horizontal Mattress Suturing More Effective Than Simple Interrupted Suturing on Postoperative Complications and Primary Wound Healing After Impacted Mandibular Third Molar Surgery?

Journal of Craniofacial Surgery, 2017

The aim of this clinical study was to compare the influence of 2 different suturing techniques on... more The aim of this clinical study was to compare the influence of 2 different suturing techniques on postoperative complications and wound healing after surgical extractions of impacted mandibular third molars. In this randomized split mouth study, 30 patients were examined in whom 60 consecutive surgical extractions of symmetrically positioned impacted mandibular third molars were performed. After the extractions, the surgical flaps were sutured with either the simple interrupted or horizontal mattress suturing technique. Postoperative swelling and trismus were recorded on the 2nd, 7th, and 10th days. Pain was recorded in a 7-day diary and wound dehiscence was recorded on the10th postoperative day. Statistical evaluation of data was made using Mann-Whitney U test and Pearson correlation. There were no statistical differences between the 2 suturing techniques in terms of postoperative pain, trismus, and swelling (P > 0.05). There was significantly less wound dehiscence in the horizontal mattress suturing group than in the simple interrupted suturing group (P: 0017). According to the results of this study, the horizontal mattress suturing technique is more effective than the simple interrupted suturing technique on wound healing after impacted mandibular third molar surgery, although it does not decrease the levels of pain, trismus, and swelling.

Research paper thumbnail of Is More Cortical Bone Decortication Effective on Guided Bone Augmentation?

Journal of Craniofacial Surgery, 2016

This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guid... more This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guided bone augmentation. A total of 16 New Zealand rabbits and 32 titanium domes were used. No cortical bone decortication was applied to the control group and in the study groups, the cortical bones were decorticated with a round burr (Group A: 1 hole with bleeding, Group B: 5 holes with bleeding, Group C: a thin layer of compact bone was completely removed with no bleeding). Then 2 titanium domes were placed on the calvarium of each rabbit with hydroxyapatite/beta-tricalcium phosphate. After 3 months, the animals were sacrificed and specimens were sent for histological and histomorphometric analysis. Histological and histomorphometric analysis showed that bone decortication with burr significantly increased new bone regeneration in all the experimental groups compared with the control group (P <0.05). No statistically significant difference was determined between the study groups. In conclusion, CBD, which has no negative impact on surgery, has a positive effect on guided bone augmentation. However, a greater amount of CBD does not have a greater effect.

Research paper thumbnail of Alveolar Osteitis İnsidansı: 324 Hastanın Geriye Dönük İncelenmesi

Turkiye Klinikleri Dis Hekimligi Bilimleri Dergisi, 2014

Research paper thumbnail of An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery

Nigerian Journal of Clinical Practice, 2016

The aim of the present study was to assess whether the use of platelet-rich fibrin (PRF) decrease... more The aim of the present study was to assess whether the use of platelet-rich fibrin (PRF) decreased the pain, swelling, and trismus levels of postoperative third molar surgery. Materials and Methods: In a double-blinded, split-mouth randomized study, thirty patients (6 male/24 female, mean age 20.32 years) with bilateral symmetric impacted third molars were enrolled in this study to receive surgery. The PRF mass was randomly placed in one of the extraction sockets, whereas the other socket was left without treatment. The outcome variables were pain, maximum mouth opening (trismus), swelling (edema), and the presence of dry socket which were measured using a 10-point visual analog scale, manual calipers, and 3dMD facial imaging system which was used for the 1 st time in the third molar surgery. Results: Statistical analyses revealed that there were no significant differences between the control and study groups regarding postoperative pain, swelling, and trismus (P > 0.05). Conclusion: The results of this study suggest that PRF was not observed to have a positive effect on postoperative discomfort, so even though, PRF is presumed to have positive effects on healing and recovery processes.

Research paper thumbnail of Bone regeneration by low-level laser therapy and low-intensity pulsed ultrasound therapy in the rabbit calvarium

Archives of Oral Biology, 2016

We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (... more We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS), alone and in combination, in triggering new bone formation. Sixteen New Zealand white rabbits were given two calvarial defects by using a 6-mm trephine bur, then divided into four treatment groups: control, LLLT, LIPUS, and LLLT+LIPUS. The LLLT and LIPUS groups were treated three times a week for two weeks. The LLLT+LIPUS group received each treatment on the same day, 12h apart, three days a week for two weeks. The animals were sacrificed after three weeks. LLLT and LIPUS, alone and in combination, enhanced new bone formation in comparison to the untreated controls after three weeks (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05); the combined therapy did not produce an additive effect. Our results demonstrate the efficacy of LLLT or LIPUS in triggering bone regeneration. Therapeutic dose and duration requires further study.

Research paper thumbnail of Mandibular bone mineral density in patients with Behçet’s disease

Therapeutics and Clinical Risk Management, 2015

Objectives: Behçet's disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patient... more Objectives: Behçet's disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD. Materials and methods: The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0-5, 6-10, and .10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique. Results: The mean mandibular body BMD values were 1.294±0.21 g/cm 2 in the control group and 1.216±0.22 g/cm 2 in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree. Conclusion: The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.