Md. Qamrul Ahsan - Academia.edu (original) (raw)

Papers by Md. Qamrul Ahsan

Indian Journal of Pharmaceutical Sciences, 2006

Three extracts of Hibiscus rosasinensis Linn. have been prepared and evaluated for hypotensive ac... more Three extracts of Hibiscus rosasinensis Linn. have been prepared and evaluated for hypotensive activity. Hydroalcoholic extract was found to exhibit prominent activity when compared to the reference standard minoxidil. In an attempt to isolate the active constituents responsible for this activity from hydroalcoholic extract, five new phytoconstituents were isolated and their structures were elucidated from spectral evidence (IR, NMR and Mass). Hypotensive activity of these isolated compounds was also studied.

International Journal

The purpose of the study was to formulate immediate release tablets using various types of disint... more The purpose of the study was to formulate immediate release tablets using various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to investigate the effect of mode of incorporation of ...

Salbutamol sulphate, a bronchodilator drug for asthma, was encapsulated by (W/O) emulsion-solvent... more Salbutamol sulphate, a bronchodilator drug for asthma, was encapsulated by (W/O) emulsion-solvent-evaporation technique using kollidon ® SR as coating polymeric material to prolong the therapeutic duration of the drug. Four different concentrations of talc were used as additives to see the changes in drug release pattern from the compressed microcapsules. Scanning electron microscopy (SEM) was performed to study the size and surface morphology of prepared microcapsules. UV-spectrophotometric method was applied to calculate the drug loading efficiency and the performance of the prepared dosage form was evaluated in terms of in-vitro dissolution studies according to USP XXX paddle method (type 2) in 400 ml distilled water (pH 7.4) for 8 hours at 37 0 ± 5 0 C temperature at 50 rpm. Release of salbutamol sulphate from the compressed microcapsules was found to follow Higuchi mechanism (R 2 =0.99). Korsmeyer equation was used to calculate the release exponent value (n) which indicates the...

Indian journal of pharmaceutical sciences, 2011

The objectives of the study were to formulate hydroxypropyl methyl cellulose-based controlled rel... more The objectives of the study were to formulate hydroxypropyl methyl cellulose-based controlled release matrix tablets for theophylline with varying drug:polymer ratios (1:1 and 1:2) and differing tablet hardness (5, 6 and 7 kg/cm(2)), and to evaluate the tablet's physico-chemical properties such as hardness, uniformity of weight, friability, drug content and in vitro drug release. Initially, granules were made by wet granulation technique and evaluated for angle of repose, bulk density, tapped density, bulkiness, compressibility index and hausner ratio. The results indicate good flow property of the granules and thus, the evaluated tablet physical properties were within the acceptable limits. The FT-IR study for the F-6 formulation showed that there was no interaction between the drug and the polymer. In vitro release studies were performed using Disso-2000 (paddle method) in 900 ml of pH 7.4 at 50 rpm. The result indicated that at high drug:polymer ratio (1:2) and hardness value...

The aim of the present study was to improve the solubility and dissolution rate of a poorly water... more The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Clonazepam was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxomer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37° C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure Clonazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. Solid dispersions prepared with PEG-6000, Poloxomer showed the highest improvement in wettability and dissolution rate of Clonazepam. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, clonazepam.

The aim of the present study was to improve the sol ubility and dissolution rate of a poorly wate... more The aim of the present study was to improve the sol ubility and dissolution rate of a poorly water-solu ble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Clonazepam was used as a model drug to evaluate its release characteristics from differen t matrices. Solid dispersions were prepared by using polyethyle ne glycol 6000 (PEG- 6000), HPMC, HPC and Poloxomer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1: 8, 1:10). The solid dispersions were prepared by so lvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was u sed as dissolution medium in each dissolution baske t at a temperature of 37° C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pu re Clonazepam and the dispersion of the drug in the po lymers considerably enhanced the dissolutio...

Brazilian Journal of Pharmaceutical Sciences, 2010

Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxy... more Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxypropyl methylcellulose (Surelease®: HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease®/ hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The release of metoprolol succinate from coated pellets was decreased with increased coating load of polymer. The optimized formulation was obtained by 3² full factorial design. The release profile revealed that the optimized formulation follows zero order release kinetics. The stability data showed no interaction for storage at 25ºC and 60% relative humidity.

1Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 2D... more 1Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 2Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 3Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 4Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 5Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh.

The purpose of the study was to formulate matrix systems for oral sustained release drug delivery... more The purpose of the study was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropylmethylcellulose (Methocel K100LV, K4M, K15M, and K100M CR), in order to investigate the effect of various grades of these polymer on release mechanism from matrix tablets. Ciprofloxacin Hydrochloride was used as a model drug to evaluate its release characteristics from different matrices. HPMC matrix tablets of Ciprofloxacin Hydrochloride using various HPMC grades, lactose were prepared by direct compression process. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml 0.1 N HCl, and distilled water. Drug release was analyzed according to their kinetic models. A One way analysis of variance (ANOVA) was used to interpret the result. Statistically significant differences were found among the drug release profile from different matrices. At a fixed polymer level, drug ...

The present study was conducted based on the traditional uses of Blumea densiflora and to evaluat... more The present study was conducted based on the traditional uses of Blumea densiflora and to evaluate in-vivo analgesic, antipyretic, antidiarrheal and anxiolytic activities. Analgesic effect was assessed using Eddy’s hot plate models and antipyretic activity was determined by Brewer’s yeast-induced pyrexia in mice. The ethanol extract of B. densiflora (400mg/Kg, b.wt.) significantly (P˂0.05) decreased latency time in the hot plate method and it also reduced rectal body temperature in Brewer’s yeast-induced pyrexia at the dose of 500mg/Kg body weight of plant extract. The antidiarrheal effect was studied in mice against castor oil induced diarrhea at the dose of 500mg/Kg body weight. The ethanolic extract of Blumea densiflora (EEBD) reduces the number of the faces. The anxiolytic activity was evaluated by open field test, hole cross test and swing test. The result showed that EEBD (500mg/Kg b.wt.) decreases the number of field cross, hole cross and swing which was statistically signifi...

Pharmaceutical and Biological Evaluations, 2015

Objective: In the present study an attempt has been made to evaluate the effect of hydrophilic po... more Objective: In the present study an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from effervescent floating tablets delivery system. Methods: Floating tablets of Amlodipine besylate were developed in eight different formulations (F1 to F8) by direct compression process using different grade of polymers i.e. Eudragit-L-100, Kollidone SR, Methocel K4, Methocel K15 and effervescent agents such as sodium bicarbonate, citric acid. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. Release kinetics of this drug from these sustained release floating tablets in chloride buffer using USP paddle method-2 with sinker for 8 hours were studied. The release mechanism was explored and explained with zero order, first order, Higuchi, Korsmeyer and Hixson crowell equation. Results: The formulations were found to have floating lag time less than 1min. Statisticall...

European Scientific Journal, Aug 30, 2014

PURPOSE: The present work reports the study of different proportion of Lamivudine: Methocel K15M ... more PURPOSE: The present work reports the study of different proportion of Lamivudine: Methocel K15M formulations, inorder to investigation the effect of polymer proportion and diluent on the drug release mechanism. Lamivudine, an anti-HIV agent, was used as a model drug to evaluate its release characteristics from different matrices. METHOD: Matrix tablets of Lamivudine were prepared by direct compression process using methocel K15M CR polymer. In vitro release studies were performed using US Pharmacopeia type 1 apparatus (basket method) in 900 mL of pH 6.8 phosphate buffer at 100 rpm for 8 hours (Initial 2 hours in simulated gastric fluid (pH 1.2)). Scanning Electron Microscopy (SEM) was used to evaluate and surface properties of the matrices. Drug release was analyzed according to their kinetic models. A one-way analysis of variance (ANOVA) was used to interpret the results. RESULTS: Statistically significant differences were found among the drug release profile from different formulations. Higher proportion of polymeric content (25 to 30% of the total tablet weight) in the matrix, release was lower proportion of polymeric content (10% of the total tablet weight), the rate of drug release was elevated. Two formulations showed drug release is more controlled. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer and Hixon-Crowell equations. CONCLUSION: The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug. By suitable modulation could be developed controlled delivery of such type of drug.

In this study, the methanol extract of leaf of Sarcochlamys pulcherrima Gaudich (SPME) was invest... more In this study, the methanol extract of leaf of Sarcochlamys pulcherrima Gaudich (SPME) was investigated for anti-diarrheal, antimicrobial and membrane stabilizing activities. Test for anti-diarrheal activity was carried out by castor oil-induced diarrhea in mice. During antimicrobial assay test by agar disc diffusion method, the plant extract showed strong activity against Bacillus megaterium (zone of inhibition = 22.0 mm) and Candida albicans (zone of inhibition = 17.0 mm). The MICs of the sample were 250 µg/ml against Bacillus cereus, B. subtilis, Escherichia coli, Aspergillus niger and Microsporum sp. In membrane stabilizing activity test, the crude methanol extract at 500 µg/ml inhibited the heat-induced haemolysis of RBCs by 47.77% whereas the standard acetyl salicylic acid (ASA) demonstrated 81.72% inhibition of haemolysis. Preliminary phytochemical screening revealed that the crude extract contains reducing sugar, glycosides, alkaloids, flavonoids and saponins.

Bangladesh Pharmaceutical Journal, 2015

The crude methanol extract of seed of Senna obtusifolia Linn. has been investigated for anxiolyti... more The crude methanol extract of seed of Senna obtusifolia Linn. has been investigated for anxiolytic, antiatherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. The anxiolytic activity was examined in mice by using the hole cross and open field test (OFT). The anti-atherothrombosis activity was evaluated and compared with that of standard streptokinase. The membrane stabilizing activity was tested by using hypotonic solution- and heat-induced hemolysis of human erythrocyte. The plant extract was also assessed for anti-diabetic activity through in vitro ?-amylase inhibitory potential. The ?-amylase inhibitory activity of S. obtusifolia was measured using the starch-iodine method. The crude extract of S. obtusifolia showed moderate anxiolytic activity. In the in-vitro anti-atherothrombosis test, the extract exhibited mild activity as compared to the standard, streptokinase (81.53%). In membrane stabilizing activity test, the plant extract at 1.0 mg/ml inhibited ...

Dhaka University Journal of Pharmaceutical Sciences, 2015

The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected ... more The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected to preliminary screenings for phytoconstituents and antipyretic, analgesic and anti-inflammatory activities. Antipyretic activity was assessed by the yeast-induced hyperthermia in mice. The analgesic property was evaluated by formalin-induced writhing test. Acetyl salicylic acid (ASA) was used as standard for in-vitro anti-inflammatory activity test. In yeast-induced pyrexia, the crude extract demonstrated a significant (p=0.05) reduction in body temperature of mice after elevation by the administration of yeast. These effects were pronounced at the 2nd and 3rd h of post-treatment with the extract. BLME exhibited a dose-dependent analgesic activity with 39.13% and 56.52% protection at 200-and 400-mg/kg, b.w., respectively as compared to 76.09% revealed by the standard diclofenac sodium. In the anti-inflammatory test, the crude extract at 400 ?g/ml displayed 62.40% inhibition of protein d...

International Journal of Pharmaceutical and Life Sciences, 2012

We have done research work in lab to find out proper formulation of immediate release tablet by u... more We have done research work in lab to find out proper formulation of immediate release tablet by using of various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to examine the effect of mode of absorption of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to estimate its release pattern from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50% and 80% of the drug release (T 25 %, T 50 %, T 80 %) was used to evaluate the dissolution results. A One way analysis of variance (ANOVA) was used to recognize the result. Statistically significant differences were found among the drug release profile from all the formulations except mode of addition of crosspovidone. At a fixed amount of disintegrants, extragranular mode of addition seemed to be the best mode of incorporation. The best release was achieved with the sodium carboxymethylcellulose and sodium starch glycolate containing formulations. The T 50 and T 80 values were analytical of the fact that the drug release was faster from tablet formulations containing carboxymethylcellulose and sodium starch glycolate. The drug release was very much negligible difference by the mode of crospovidone addition. Two formulations found very small T 50 and T 80 values indicating very much faster release. From the all formulations corresponded extragranular mode of addition could be the best mode of incorporation. The drug release was unaffected by the mode of crospovidone addition. The mode of incorporation of disintegrants suggested enchancing the release of poor soluble drugs.

International Journal of Pharmaceutical and Life Sciences, 2012

In order to investigate the effect of polymers on release mechanism of poorly soluble drugs from ... more In order to investigate the effect of polymers on release mechanism of poorly soluble drugs from solid dispersions, Clonazepam was used as a model drug for these purposes. Five types of solid dispersions were prepared using polyethylene glycol 6000 (PEG- 6000), Kollicoat IR, Kollidon VA 64 and Poloxomer in different drug-tocarrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solvent evaporation method was used for preparation of solid dispersions. The in-vitro dissolution study with temperature of 37° C and a paddle method, 100 rpm was used in 1000 ml of distilled water as dissolution medium in each dissolution basket for the pure drug and solid dispersions. For pure Clonazepam showed very slow dissolution rate and the solid dispersion considerably enhanced the dissolution rate. Decreased crystalline and increased amorphous fraction of the drug was probably done by wettability and dispersibility. The highest improvement in wettability and dissolution rate of Clonazepam was observed in PEG...

International Journal of Pharmaceutical and Life Sciences, 2012

Drug design through computer, a recent, very effective technique in modern arena. Now a days Comp... more Drug design through computer, a recent, very effective technique in modern arena. Now a days Computer Aided Drug Design (CADD) technologies are used in nanotechnology, molecular biology, biochemistry etc. The main benefit of the CADD is cost effective in research and development of drugs. There are wide ranges of software are used in CADD, Grid computing, window based general PBPK/PD modeling software, PKUDDS for structure based drug design,APIS, JAVA, Perl and Python, CADD as well as software including software libraries. There are different techniques used in CADD visualization, homology, molecular dynamic, energy minimization molecular docking, QSAR etc. Computer aided drug design is applicable in Cancer disease, transportation of drug to specific site in body, data collections and storages of organics and biologicals. Conformational properties and energetics of small molecules and DNA cleavage, molecular diagnostics based on fluorescences are focusing using this technique. DOI: ...

ijpijournals.com

ABSTRACT: Purpose: The present work reports, an attempt was made to formulate matrix systems for ... more ABSTRACT: Purpose: The present work reports, an attempt was made to formulate matrix systems for oral sustained release drug delivery systems using different grades of hydroxypropyl methylcellulose (E50, K100LV, Methocel K4M, K15M), in order to ...

jpsr.pharmainfo.in

PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained r... more PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropyl methylcellulose (Methocel K4M, K15M, K100M and K100LV), in order to investigate the effect of various ...

Indian Journal of Pharmaceutical Sciences, 2006

Three extracts of Hibiscus rosasinensis Linn. have been prepared and evaluated for hypotensive ac... more Three extracts of Hibiscus rosasinensis Linn. have been prepared and evaluated for hypotensive activity. Hydroalcoholic extract was found to exhibit prominent activity when compared to the reference standard minoxidil. In an attempt to isolate the active constituents responsible for this activity from hydroalcoholic extract, five new phytoconstituents were isolated and their structures were elucidated from spectral evidence (IR, NMR and Mass). Hypotensive activity of these isolated compounds was also studied.

International Journal

The purpose of the study was to formulate immediate release tablets using various types of disint... more The purpose of the study was to formulate immediate release tablets using various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to investigate the effect of mode of incorporation of ...

Salbutamol sulphate, a bronchodilator drug for asthma, was encapsulated by (W/O) emulsion-solvent... more Salbutamol sulphate, a bronchodilator drug for asthma, was encapsulated by (W/O) emulsion-solvent-evaporation technique using kollidon ® SR as coating polymeric material to prolong the therapeutic duration of the drug. Four different concentrations of talc were used as additives to see the changes in drug release pattern from the compressed microcapsules. Scanning electron microscopy (SEM) was performed to study the size and surface morphology of prepared microcapsules. UV-spectrophotometric method was applied to calculate the drug loading efficiency and the performance of the prepared dosage form was evaluated in terms of in-vitro dissolution studies according to USP XXX paddle method (type 2) in 400 ml distilled water (pH 7.4) for 8 hours at 37 0 ± 5 0 C temperature at 50 rpm. Release of salbutamol sulphate from the compressed microcapsules was found to follow Higuchi mechanism (R 2 =0.99). Korsmeyer equation was used to calculate the release exponent value (n) which indicates the...

Indian journal of pharmaceutical sciences, 2011

The objectives of the study were to formulate hydroxypropyl methyl cellulose-based controlled rel... more The objectives of the study were to formulate hydroxypropyl methyl cellulose-based controlled release matrix tablets for theophylline with varying drug:polymer ratios (1:1 and 1:2) and differing tablet hardness (5, 6 and 7 kg/cm(2)), and to evaluate the tablet's physico-chemical properties such as hardness, uniformity of weight, friability, drug content and in vitro drug release. Initially, granules were made by wet granulation technique and evaluated for angle of repose, bulk density, tapped density, bulkiness, compressibility index and hausner ratio. The results indicate good flow property of the granules and thus, the evaluated tablet physical properties were within the acceptable limits. The FT-IR study for the F-6 formulation showed that there was no interaction between the drug and the polymer. In vitro release studies were performed using Disso-2000 (paddle method) in 900 ml of pH 7.4 at 50 rpm. The result indicated that at high drug:polymer ratio (1:2) and hardness value...

The aim of the present study was to improve the solubility and dissolution rate of a poorly water... more The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Clonazepam was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxomer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37° C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure Clonazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. Solid dispersions prepared with PEG-6000, Poloxomer showed the highest improvement in wettability and dissolution rate of Clonazepam. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, clonazepam.

The aim of the present study was to improve the sol ubility and dissolution rate of a poorly wate... more The aim of the present study was to improve the sol ubility and dissolution rate of a poorly water-solu ble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Clonazepam was used as a model drug to evaluate its release characteristics from differen t matrices. Solid dispersions were prepared by using polyethyle ne glycol 6000 (PEG- 6000), HPMC, HPC and Poloxomer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1: 8, 1:10). The solid dispersions were prepared by so lvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was u sed as dissolution medium in each dissolution baske t at a temperature of 37° C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pu re Clonazepam and the dispersion of the drug in the po lymers considerably enhanced the dissolutio...

Brazilian Journal of Pharmaceutical Sciences, 2010

Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxy... more Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxypropyl methylcellulose (Surelease®: HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease®/ hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The release of metoprolol succinate from coated pellets was decreased with increased coating load of polymer. The optimized formulation was obtained by 3² full factorial design. The release profile revealed that the optimized formulation follows zero order release kinetics. The stability data showed no interaction for storage at 25ºC and 60% relative humidity.

1Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 2D... more 1Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 2Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 3Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 4Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh, 5Department of pharmacy, Southern University Bangladesh, Chittagong-PIN Code 4000, Bangladesh.

The purpose of the study was to formulate matrix systems for oral sustained release drug delivery... more The purpose of the study was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropylmethylcellulose (Methocel K100LV, K4M, K15M, and K100M CR), in order to investigate the effect of various grades of these polymer on release mechanism from matrix tablets. Ciprofloxacin Hydrochloride was used as a model drug to evaluate its release characteristics from different matrices. HPMC matrix tablets of Ciprofloxacin Hydrochloride using various HPMC grades, lactose were prepared by direct compression process. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml 0.1 N HCl, and distilled water. Drug release was analyzed according to their kinetic models. A One way analysis of variance (ANOVA) was used to interpret the result. Statistically significant differences were found among the drug release profile from different matrices. At a fixed polymer level, drug ...

The present study was conducted based on the traditional uses of Blumea densiflora and to evaluat... more The present study was conducted based on the traditional uses of Blumea densiflora and to evaluate in-vivo analgesic, antipyretic, antidiarrheal and anxiolytic activities. Analgesic effect was assessed using Eddy’s hot plate models and antipyretic activity was determined by Brewer’s yeast-induced pyrexia in mice. The ethanol extract of B. densiflora (400mg/Kg, b.wt.) significantly (P˂0.05) decreased latency time in the hot plate method and it also reduced rectal body temperature in Brewer’s yeast-induced pyrexia at the dose of 500mg/Kg body weight of plant extract. The antidiarrheal effect was studied in mice against castor oil induced diarrhea at the dose of 500mg/Kg body weight. The ethanolic extract of Blumea densiflora (EEBD) reduces the number of the faces. The anxiolytic activity was evaluated by open field test, hole cross test and swing test. The result showed that EEBD (500mg/Kg b.wt.) decreases the number of field cross, hole cross and swing which was statistically signifi...

Pharmaceutical and Biological Evaluations, 2015

Objective: In the present study an attempt has been made to evaluate the effect of hydrophilic po... more Objective: In the present study an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from effervescent floating tablets delivery system. Methods: Floating tablets of Amlodipine besylate were developed in eight different formulations (F1 to F8) by direct compression process using different grade of polymers i.e. Eudragit-L-100, Kollidone SR, Methocel K4, Methocel K15 and effervescent agents such as sodium bicarbonate, citric acid. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. Release kinetics of this drug from these sustained release floating tablets in chloride buffer using USP paddle method-2 with sinker for 8 hours were studied. The release mechanism was explored and explained with zero order, first order, Higuchi, Korsmeyer and Hixson crowell equation. Results: The formulations were found to have floating lag time less than 1min. Statisticall...

European Scientific Journal, Aug 30, 2014

PURPOSE: The present work reports the study of different proportion of Lamivudine: Methocel K15M ... more PURPOSE: The present work reports the study of different proportion of Lamivudine: Methocel K15M formulations, inorder to investigation the effect of polymer proportion and diluent on the drug release mechanism. Lamivudine, an anti-HIV agent, was used as a model drug to evaluate its release characteristics from different matrices. METHOD: Matrix tablets of Lamivudine were prepared by direct compression process using methocel K15M CR polymer. In vitro release studies were performed using US Pharmacopeia type 1 apparatus (basket method) in 900 mL of pH 6.8 phosphate buffer at 100 rpm for 8 hours (Initial 2 hours in simulated gastric fluid (pH 1.2)). Scanning Electron Microscopy (SEM) was used to evaluate and surface properties of the matrices. Drug release was analyzed according to their kinetic models. A one-way analysis of variance (ANOVA) was used to interpret the results. RESULTS: Statistically significant differences were found among the drug release profile from different formulations. Higher proportion of polymeric content (25 to 30% of the total tablet weight) in the matrix, release was lower proportion of polymeric content (10% of the total tablet weight), the rate of drug release was elevated. Two formulations showed drug release is more controlled. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer and Hixon-Crowell equations. CONCLUSION: The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug. By suitable modulation could be developed controlled delivery of such type of drug.

In this study, the methanol extract of leaf of Sarcochlamys pulcherrima Gaudich (SPME) was invest... more In this study, the methanol extract of leaf of Sarcochlamys pulcherrima Gaudich (SPME) was investigated for anti-diarrheal, antimicrobial and membrane stabilizing activities. Test for anti-diarrheal activity was carried out by castor oil-induced diarrhea in mice. During antimicrobial assay test by agar disc diffusion method, the plant extract showed strong activity against Bacillus megaterium (zone of inhibition = 22.0 mm) and Candida albicans (zone of inhibition = 17.0 mm). The MICs of the sample were 250 µg/ml against Bacillus cereus, B. subtilis, Escherichia coli, Aspergillus niger and Microsporum sp. In membrane stabilizing activity test, the crude methanol extract at 500 µg/ml inhibited the heat-induced haemolysis of RBCs by 47.77% whereas the standard acetyl salicylic acid (ASA) demonstrated 81.72% inhibition of haemolysis. Preliminary phytochemical screening revealed that the crude extract contains reducing sugar, glycosides, alkaloids, flavonoids and saponins.

Bangladesh Pharmaceutical Journal, 2015

The crude methanol extract of seed of Senna obtusifolia Linn. has been investigated for anxiolyti... more The crude methanol extract of seed of Senna obtusifolia Linn. has been investigated for anxiolytic, antiatherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. The anxiolytic activity was examined in mice by using the hole cross and open field test (OFT). The anti-atherothrombosis activity was evaluated and compared with that of standard streptokinase. The membrane stabilizing activity was tested by using hypotonic solution- and heat-induced hemolysis of human erythrocyte. The plant extract was also assessed for anti-diabetic activity through in vitro ?-amylase inhibitory potential. The ?-amylase inhibitory activity of S. obtusifolia was measured using the starch-iodine method. The crude extract of S. obtusifolia showed moderate anxiolytic activity. In the in-vitro anti-atherothrombosis test, the extract exhibited mild activity as compared to the standard, streptokinase (81.53%). In membrane stabilizing activity test, the plant extract at 1.0 mg/ml inhibited ...

Dhaka University Journal of Pharmaceutical Sciences, 2015

The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected ... more The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected to preliminary screenings for phytoconstituents and antipyretic, analgesic and anti-inflammatory activities. Antipyretic activity was assessed by the yeast-induced hyperthermia in mice. The analgesic property was evaluated by formalin-induced writhing test. Acetyl salicylic acid (ASA) was used as standard for in-vitro anti-inflammatory activity test. In yeast-induced pyrexia, the crude extract demonstrated a significant (p=0.05) reduction in body temperature of mice after elevation by the administration of yeast. These effects were pronounced at the 2nd and 3rd h of post-treatment with the extract. BLME exhibited a dose-dependent analgesic activity with 39.13% and 56.52% protection at 200-and 400-mg/kg, b.w., respectively as compared to 76.09% revealed by the standard diclofenac sodium. In the anti-inflammatory test, the crude extract at 400 ?g/ml displayed 62.40% inhibition of protein d...

International Journal of Pharmaceutical and Life Sciences, 2012

We have done research work in lab to find out proper formulation of immediate release tablet by u... more We have done research work in lab to find out proper formulation of immediate release tablet by using of various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to examine the effect of mode of absorption of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to estimate its release pattern from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50% and 80% of the drug release (T 25 %, T 50 %, T 80 %) was used to evaluate the dissolution results. A One way analysis of variance (ANOVA) was used to recognize the result. Statistically significant differences were found among the drug release profile from all the formulations except mode of addition of crosspovidone. At a fixed amount of disintegrants, extragranular mode of addition seemed to be the best mode of incorporation. The best release was achieved with the sodium carboxymethylcellulose and sodium starch glycolate containing formulations. The T 50 and T 80 values were analytical of the fact that the drug release was faster from tablet formulations containing carboxymethylcellulose and sodium starch glycolate. The drug release was very much negligible difference by the mode of crospovidone addition. Two formulations found very small T 50 and T 80 values indicating very much faster release. From the all formulations corresponded extragranular mode of addition could be the best mode of incorporation. The drug release was unaffected by the mode of crospovidone addition. The mode of incorporation of disintegrants suggested enchancing the release of poor soluble drugs.

International Journal of Pharmaceutical and Life Sciences, 2012

In order to investigate the effect of polymers on release mechanism of poorly soluble drugs from ... more In order to investigate the effect of polymers on release mechanism of poorly soluble drugs from solid dispersions, Clonazepam was used as a model drug for these purposes. Five types of solid dispersions were prepared using polyethylene glycol 6000 (PEG- 6000), Kollicoat IR, Kollidon VA 64 and Poloxomer in different drug-tocarrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solvent evaporation method was used for preparation of solid dispersions. The in-vitro dissolution study with temperature of 37° C and a paddle method, 100 rpm was used in 1000 ml of distilled water as dissolution medium in each dissolution basket for the pure drug and solid dispersions. For pure Clonazepam showed very slow dissolution rate and the solid dispersion considerably enhanced the dissolution rate. Decreased crystalline and increased amorphous fraction of the drug was probably done by wettability and dispersibility. The highest improvement in wettability and dissolution rate of Clonazepam was observed in PEG...

International Journal of Pharmaceutical and Life Sciences, 2012

Drug design through computer, a recent, very effective technique in modern arena. Now a days Comp... more Drug design through computer, a recent, very effective technique in modern arena. Now a days Computer Aided Drug Design (CADD) technologies are used in nanotechnology, molecular biology, biochemistry etc. The main benefit of the CADD is cost effective in research and development of drugs. There are wide ranges of software are used in CADD, Grid computing, window based general PBPK/PD modeling software, PKUDDS for structure based drug design,APIS, JAVA, Perl and Python, CADD as well as software including software libraries. There are different techniques used in CADD visualization, homology, molecular dynamic, energy minimization molecular docking, QSAR etc. Computer aided drug design is applicable in Cancer disease, transportation of drug to specific site in body, data collections and storages of organics and biologicals. Conformational properties and energetics of small molecules and DNA cleavage, molecular diagnostics based on fluorescences are focusing using this technique. DOI: ...

ijpijournals.com

ABSTRACT: Purpose: The present work reports, an attempt was made to formulate matrix systems for ... more ABSTRACT: Purpose: The present work reports, an attempt was made to formulate matrix systems for oral sustained release drug delivery systems using different grades of hydroxypropyl methylcellulose (E50, K100LV, Methocel K4M, K15M), in order to ...

jpsr.pharmainfo.in

PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained r... more PURPOSE: The present work reports an attempt was to formulate matrix systems for oral sustained release drug delivery systems using diverse grades of hydroxypropyl methylcellulose (Methocel K4M, K15M, K100M and K100LV), in order to investigate the effect of various ...