Ajoy Ghosh - Academia.edu (original) (raw)

Papers by Ajoy Ghosh

Research paper thumbnail of Roles of Prostaglandin E2 and Histamine in Angiogenesis in Inflammatory Granulation Tissue

Ensho Saisei, 2003

Page 1. 炎症・再生 Vol.23 No.1 2003 84 Mini Review Roles of Prostaglandin E2 and Histamine in Angiogen... more Page 1. 炎症・再生 Vol.23 No.1 2003 84 Mini Review Roles of Prostaglandin E2 and Histamine in Angiogenesis in Inflammatory Granulation Tissue The progress of chronic and proliferative inflammation de-pends on angiogenesis1). ...

Research paper thumbnail of On Implementation of Trajectory Correction System on a Routinely Used Artillery Rocket

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2006

Research paper thumbnail of Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats

Journal of Pharmacology and Experimental Therapeutics, Nov 1, 2000

Research paper thumbnail of Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice

The Journal of experimental medicine, Jan 15, 2002

We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine... more We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase-deficient (HDC(-/-)) mice, mast cell-deficient mice (WBB6F1-W/W(V)), and their corresponding wild-type mice (HDC(+/+) and WBB6F(1)(+/+)). In HDC(+/+) mice, subcutaneous implantation of a cotton thread in the dorsum induced granulation tissue formation with angiogenesis, while the topical injection of anti-vascular endothelial growth factor (VEGF) IgG strongly suppressed them. In HDC(-/-) mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC(+/+) mice. The topical injection of histamine or the H(2) agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC(-/-) mice. There was no significant difference in the granulation tissue formation and angiogenesis between WBB6F1-W/W(V) and WBB6F1(+/+) mice. In addition, macrophages in the granulation tissue were ...

Research paper thumbnail of Trajectory Modeling of a Parafoil in Motion Using Analytically Derived Stability Derivative at High Angle of Attack

19th AIAA Aerodynamic Decelerator Systems Technology Conference and Seminar, 2007

Parafoil and payload system are light weight, fly at low speed and provides soft landing capabili... more Parafoil and payload system are light weight, fly at low speed and provides soft landing capability. The parafoil-payload system flight dynamics requires a 9-DOF model unlike the 6-DOF model, since this system is a two-body dynamic system. This paper attempts to ...

Research paper thumbnail of Flight Path Prediction of an Artillery Shell Using Feed Forward Neural Networks

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2005

An attempt has been made to predict flight path (trajectory) of an artillery shell using feed for... more An attempt has been made to predict flight path (trajectory) of an artillery shell using feed forward neural networks. The proposed neural models are trained with simulated flight data of a routinely used artillery shell. These trained neural models have been used to predict ...

Research paper thumbnail of Estimation of Drag Coefficient from Flight Data of a Cargo Shell

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2006

Two schemes to extract drag coefficient, CD, by processing radar tracked trajectories of artiller... more Two schemes to extract drag coefficient, CD, by processing radar tracked trajectories of artillery shell in motion have been proposed. Flight trajectories of artillery shell are considered. During design, development and validation of new artillery ammunition, a large number of these ...

Research paper thumbnail of Wind Tunnel Study of a Grid Fin Stabilized Guided Projectile

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2008

Research paper thumbnail of Cascade Fins: An Alternate Tail Stabilization Unit

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2008

Research paper thumbnail of 5-Degree-of-Freedom Dynamic Rig for Wind Tunnel Tests of Aerospace Vehicles

AIAA Atmospheric Flight Mechanics Conference, 2009

Research paper thumbnail of Technique to Improve Precision of Kinetic Energy Projectiles Through Motion Study

AIAA Atmospheric Flight Mechanics Conference, 2009

Research paper thumbnail of High Angle of Attack Parameter Estimation of Cascaded Fins Using Neural Network

Journal of Aircraft, 2013

Research paper thumbnail of Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H 2 receptors

British Journal of Pharmacology, 2001

Research paper thumbnail of Inhibition by acharan sulphate of angiogenesis in experimental inflammation models

British Journal of Pharmacology, 2002

1 The eects of acharan sulphate, a glycosaminoglycan isolated from the giant African snail Achati... more 1 The eects of acharan sulphate, a glycosaminoglycan isolated from the giant African snail Achatina fulica, on angiogenesis in the granulation tissue were analysed using an air pouch-type carrageenin-induced in¯ammation model in rats and a cotton thread-induced in¯ammation model in mice.

Research paper thumbnail of A randomized controlled trial on the efficacy of alternative treatment regimens for uncomplicated falciparum malaria in a multidrug-resistant falciparum area of Bangladesh—narrowing the options for the National Malaria Control Programme?

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2001

We performed an open, randomized chemotherapy trial comparing the recommended first-, second-and ... more We performed an open, randomized chemotherapy trial comparing the recommended first-, second-and third-line drug regimens, as well as mefloquine, for uncomplicated falciparum malaria in Bangladesh in 1996-97. The regimens were chloroquine for 3 days (CQ, Group I), quinine sulphate for 3 days followed by single-dose sulfadoxine-pyrimethamine (43 + SP, Group II), quinine for 7 days (47, Group III), and mefloquine 20 mg/kg single dose (MEF, Group Iv). Subjects were symptomatic patients, aged 3 12 years, with parasite density 500-250 OOO/mm' and no history of taking antimalarials during the previous week. Drug administration was supervised and subjects were followed clinically and with blood slides in the hospital for 8 days, then as outpatients on days 14,2 1 and 28. A total of 4 13 subjects (149,145,49 and 70 in Groups I-IV, respectively) completed the study. Early treatment failures (persistent or worsening clinical manifestations by day 3 confirmed with parasitological examinations) occurred only in the chloroquine group. RI1 and RI11 parasitological failures occurred in 56%, 12%, 8% and 14% in Groups I-IV, respectively. There were significantly more clinical and parasitological failures with chloroquine than with Q3 + SP, which we now recommend as a better (but far from ideal) choice for first-line therapy. The alternative compounds show parasitogical evidence of Plasmodium falciparum resistance. Further studies are needed to determine the optimum treatment for malaria in Bangladesh.

Research paper thumbnail of Roles of Prostaglandin E2 and Histamine in Angiogenesis in Inflammatory Granulation Tissue

Ensho Saisei, 2003

Page 1. 炎症・再生 Vol.23 No.1 2003 84 Mini Review Roles of Prostaglandin E2 and Histamine in Angiogen... more Page 1. 炎症・再生 Vol.23 No.1 2003 84 Mini Review Roles of Prostaglandin E2 and Histamine in Angiogenesis in Inflammatory Granulation Tissue The progress of chronic and proliferative inflammation de-pends on angiogenesis1). ...

Research paper thumbnail of On Implementation of Trajectory Correction System on a Routinely Used Artillery Rocket

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2006

Research paper thumbnail of Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats

Journal of Pharmacology and Experimental Therapeutics, Nov 1, 2000

Research paper thumbnail of Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice

The Journal of experimental medicine, Jan 15, 2002

We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine... more We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase-deficient (HDC(-/-)) mice, mast cell-deficient mice (WBB6F1-W/W(V)), and their corresponding wild-type mice (HDC(+/+) and WBB6F(1)(+/+)). In HDC(+/+) mice, subcutaneous implantation of a cotton thread in the dorsum induced granulation tissue formation with angiogenesis, while the topical injection of anti-vascular endothelial growth factor (VEGF) IgG strongly suppressed them. In HDC(-/-) mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC(+/+) mice. The topical injection of histamine or the H(2) agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC(-/-) mice. There was no significant difference in the granulation tissue formation and angiogenesis between WBB6F1-W/W(V) and WBB6F1(+/+) mice. In addition, macrophages in the granulation tissue were ...

Research paper thumbnail of Trajectory Modeling of a Parafoil in Motion Using Analytically Derived Stability Derivative at High Angle of Attack

19th AIAA Aerodynamic Decelerator Systems Technology Conference and Seminar, 2007

Parafoil and payload system are light weight, fly at low speed and provides soft landing capabili... more Parafoil and payload system are light weight, fly at low speed and provides soft landing capability. The parafoil-payload system flight dynamics requires a 9-DOF model unlike the 6-DOF model, since this system is a two-body dynamic system. This paper attempts to ...

Research paper thumbnail of Flight Path Prediction of an Artillery Shell Using Feed Forward Neural Networks

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2005

An attempt has been made to predict flight path (trajectory) of an artillery shell using feed for... more An attempt has been made to predict flight path (trajectory) of an artillery shell using feed forward neural networks. The proposed neural models are trained with simulated flight data of a routinely used artillery shell. These trained neural models have been used to predict ...

Research paper thumbnail of Estimation of Drag Coefficient from Flight Data of a Cargo Shell

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2006

Two schemes to extract drag coefficient, CD, by processing radar tracked trajectories of artiller... more Two schemes to extract drag coefficient, CD, by processing radar tracked trajectories of artillery shell in motion have been proposed. Flight trajectories of artillery shell are considered. During design, development and validation of new artillery ammunition, a large number of these ...

Research paper thumbnail of Wind Tunnel Study of a Grid Fin Stabilized Guided Projectile

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2008

Research paper thumbnail of Cascade Fins: An Alternate Tail Stabilization Unit

AIAA Atmospheric Flight Mechanics Conference and Exhibit, 2008

Research paper thumbnail of 5-Degree-of-Freedom Dynamic Rig for Wind Tunnel Tests of Aerospace Vehicles

AIAA Atmospheric Flight Mechanics Conference, 2009

Research paper thumbnail of Technique to Improve Precision of Kinetic Energy Projectiles Through Motion Study

AIAA Atmospheric Flight Mechanics Conference, 2009

Research paper thumbnail of High Angle of Attack Parameter Estimation of Cascaded Fins Using Neural Network

Journal of Aircraft, 2013

Research paper thumbnail of Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H 2 receptors

British Journal of Pharmacology, 2001

Research paper thumbnail of Inhibition by acharan sulphate of angiogenesis in experimental inflammation models

British Journal of Pharmacology, 2002

1 The eects of acharan sulphate, a glycosaminoglycan isolated from the giant African snail Achati... more 1 The eects of acharan sulphate, a glycosaminoglycan isolated from the giant African snail Achatina fulica, on angiogenesis in the granulation tissue were analysed using an air pouch-type carrageenin-induced in¯ammation model in rats and a cotton thread-induced in¯ammation model in mice.

Research paper thumbnail of A randomized controlled trial on the efficacy of alternative treatment regimens for uncomplicated falciparum malaria in a multidrug-resistant falciparum area of Bangladesh—narrowing the options for the National Malaria Control Programme?

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2001

We performed an open, randomized chemotherapy trial comparing the recommended first-, second-and ... more We performed an open, randomized chemotherapy trial comparing the recommended first-, second-and third-line drug regimens, as well as mefloquine, for uncomplicated falciparum malaria in Bangladesh in 1996-97. The regimens were chloroquine for 3 days (CQ, Group I), quinine sulphate for 3 days followed by single-dose sulfadoxine-pyrimethamine (43 + SP, Group II), quinine for 7 days (47, Group III), and mefloquine 20 mg/kg single dose (MEF, Group Iv). Subjects were symptomatic patients, aged 3 12 years, with parasite density 500-250 OOO/mm' and no history of taking antimalarials during the previous week. Drug administration was supervised and subjects were followed clinically and with blood slides in the hospital for 8 days, then as outpatients on days 14,2 1 and 28. A total of 4 13 subjects (149,145,49 and 70 in Groups I-IV, respectively) completed the study. Early treatment failures (persistent or worsening clinical manifestations by day 3 confirmed with parasitological examinations) occurred only in the chloroquine group. RI1 and RI11 parasitological failures occurred in 56%, 12%, 8% and 14% in Groups I-IV, respectively. There were significantly more clinical and parasitological failures with chloroquine than with Q3 + SP, which we now recommend as a better (but far from ideal) choice for first-line therapy. The alternative compounds show parasitogical evidence of Plasmodium falciparum resistance. Further studies are needed to determine the optimum treatment for malaria in Bangladesh.