Zeynep Aki - Profile on Academia.edu (original) (raw)
Papers by Zeynep Aki
Turkish journal of haematology : official journal of Turkish Society of Haematology, Jan 5, 2003
Hypercalcemia is common in some lymphoproliferative disorders such as myeloma or T- cell leukaemi... more Hypercalcemia is common in some lymphoproliferative disorders such as myeloma or T- cell leukaemialymphoma, but is rarely described in B-cell chronic lymphocytic leukaemia (CLL). A CLL patient who have been presented with multiple pathological fractures and widespread osteolytic lesions is reported. He was a 74 year old male with fractures of his bilateral humerus and radii and multiple osteolytic lesions of skull, fibula, femur and costals. On his admission to the hospital for the fractures he has been diagnosed as CLL. Hypercalcemia has also been documented. All the disorders that could be the reason of hypercalcemia have been ruled out. The open biopsy of bone marrow showed lymphocytic infiltration in which increased number of prolymphocytes are observed. Hypercalcemia arising in a patient with CLL may indicate a negative prognosis.
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism
The American journal of gastroenterology, 1996
Minerva medica, 2012
Pulmonary function tests (PFT) have an important role in the assessment of pulmonary and nonpulmo... more Pulmonary function tests (PFT) have an important role in the assessment of pulmonary and nonpulmonary complications of hematopoetic stem cell transplantation (HSCT). In this study the relationship between PFTs and DLCOadj values and the complications of HSCT was investigated. The possible role of iron overload in the deterioration of the PFTs after HSCT was also searched. One hundred and fifty one patients who had undergone allogeneic HSCT between years 2003 through 2008, and had the records of PFTs prior to and at 1, 3, 6, 9 and 12 months after transplantation were included in the study. Prospectively collected data of these patients were analysed retrospectively. Although no significant difference was identified in other PFT parameters, a significant decrease in DLCOadj was determined after 1st and 3rd months of HSCT. A significant correlation was found between pretransplant DLCOadj value <%70 and sinusoidal obstruction syndrome (SOS) (P=0.001, r=0.323), but in multivariate ana...
Gazi Medical Journal, 2015
Amaç: Çalışmamızda, Gazi Üniversitesi Tıp Fakültesi Hastanesi Kök Hücre Nakil Birimi (KHNB)'nde, ... more Amaç: Çalışmamızda, Gazi Üniversitesi Tıp Fakültesi Hastanesi Kök Hücre Nakil Birimi (KHNB)'nde, eğitimi takiben klorheksidinli swap-stick ile pansuman ve klorheksidin emdirilmiş transparan örtü kullanımı gibi önlemlerin kan dolaşımı enfeksiyonlarının (KDE) insidansına olan etkisinin gösterilmesi amaçlanmıştır. Gereç ve Metod: Kateter ilişkili kan dolaşımı enfeksiyonları (KİKDE) sürveyansı enfeksiyon kontrol hemşireleri tarafından aktif prospektif olarak gerçekleştirilmiştir. 1 Mart 2011 ile 31 Aralık 2011 tarihleri birinci dönem olarak kabul edilmiştir. Birinci dönemde yüksek enfeksiyon oranları görülmesi üzerine personel eğitimi, klorheksidinli swap-stick ve klorheksidin emdirilmiş transparan örtü kullanımı gibi enfeksiyon kontrol önlemleri uygulamaya konulmuştur. Uygulama sonrası, 1 Ocak 2012 ile 31 Ekim 2012 tarihleri ise 2. dönem olarak kabul edilmiştir. İki dönemdeki KİKDE oranları ve insidans dansitesi ki-kare testi kullanılarak karşılaştırılmıştır. Mikroorganizmalar da ayrıca kayıt edilmiştir. Bulgular: Birinci dönemde 329 hastada toplam 51 KDE tanısı konmuştur. Bunların % 62.7'sinin kateter kaynaklı olduğu tespit edilmiştir. İkinci dönemde ise 371 hastada toplam 29 KDE tanısı konmuş, enfeksiyonların % 27.3'ü kateter ilişkili olarak bulunmuştur. Uygulama öncesi dönemde KDE için insidans dansitesi 1000 günde 17.24 iken sonraki dönemde 1000 günde 8.3 olarak bulunmuştur (p=0.001). Her iki dönemde de en sık izole edilen etken KNS'ler olmuştur. Üreyen mikroorganizmalar karşılaştırıldığında toplamda gram pozitif mikroorganizmalarda anlamlı azalma saptanmıştır (p=0.006). Sonuç: Çalışmamızın sonucunda, eğitim, klorheksidinli swap-stick uygulaması ve klorheksidin emdirilmiş transparan örtü kullanımı gibi enfeksiyon kontrol önlemlerinin KDE ve özellikle KİKDE insidansında belirgin azalma sağladığı tespit edilmiştir. Bu azalma, başlıca gram pozitif mikroorganizmalarla gelişen infeksiyonlardaki azalmaya bağlı olarak ortaya çıkmıştır.
The relation between plasminogen activator inhibitor activity and disease activation in acute myeloblastic leukaemia patients
Clinical and Laboratory Haematology, 2006
Coagulation and fibrinolytic abnormalities are common in patients with acute myeloblastic leukaem... more Coagulation and fibrinolytic abnormalities are common in patients with acute myeloblastic leukaemia (AML) like other forms of leukaemias. In this study, we investigated if total plasminogen activator inhibitor (PAI) activity, which is believed to increase in initial diagnosis and relapse in AML patients could be accepted as a relapse criterion or not. Total of 34 AML patients and 18 healthy volunteers were included in this study. The patients' diagnosis were based on clinical criteria as well as morphological, cytochemical, immunuphenotypic examinations of peripheral blood and bone marrow specimens. Total PAI activity was measured with Dade Behring Bericrom PAI reagent in BCS system. Total PAI activity was higher than 3.5 U/ml in 11 AML patients while it was normal (0.3-3.5 U/ml) in control group (P < 0.01). There was no significant difference in total PAI activity between AML subgroups (P > 0.05). We found significant difference in total PAI activity between patients who have active disease and remission. In conclusion, the total PAI activity could be accepted as a relapse and an initial diagnosis criterion of AML patients during follow up.
BT-online: an innovated and promising computer assisted transfusion system
Medical Science Monitor, 2008
Errors in the transfusion process are common. These errors encompass a spectrum of events ranging... more Errors in the transfusion process are common. These errors encompass a spectrum of events ranging from incorrect transfusion to administration of infected blood products. To overcome these complications, we developed a new blood management software system - the BT-Online system - to decrease erroneous transfusions that are mostly human based. Like previously developed transfusion safety systems, this program uses handheld devices to improve the safety of bedside practices. The BT-online system consists of 3 main structures: (1) the personal digital assistant, (2) the equipment and software (user interface), and (3) the relational database and a web service providing communication of a security-layered database with other personal digital assistants. This system has many features including the ability at the bedside to check the complete patient history and requested tests and blood products, the ability to conduct simultaneous multiple procedures, the ability to transmit results to ...
Gazi Medical Journal, 1998
Gazi Medical Journal, 1996
Gazi Medical Journal, 1996
Gazi Medical Journal, 1998
The Comparison of The Effect of Somatostatin and SMS 201-995 on Enzym Change Following Endoscopic... more The Comparison of The Effect of Somatostatin and SMS 201-995 on Enzym Change Following Endoscopic Retrograde Cholangiopancreotography
Comparison of pulmonary and extra pulmonary characteristics in allogeneic hematopoietic stem cell transplantation recipients with healthy controls
Background: Limited number of studies reported reduction in exercise capacity, muscle strength an... more Background: Limited number of studies reported reduction in exercise capacity, muscle strength and abnormalities in lung functions in allogeneic hematopoetik stem cell transplantation (allo-HSCT) recipients. However, pulmonary and extrapulmonary characteristics in allo-HSCT recipients have not been compared with healthy controls so far. Aim: To compare submaximal exercise capacity, pulmonary functions, respiratory and peripheral muscle strength, dyspnea and fatigue perception and depression in allo-HSCT recipients with healthy controls. Methods: Forty patients (41.55±12.03 years) previously underwent allo-HSCT (>100 days status post transplantation) and 30 controls (45.77±10.02 years) were compared. Functional exercise capacity using 6-minute walk test (6MWT), respiratory muscle strength (MIP, MEP) using a mouth pressure device, peripheral muscles strength using dynamometer, dyspnea using Modified Medical Research Council (MMRC) dyspnea scale, fatigue using Fatigue Impact Scale (...
International Journal of Diagnostic Imaging, 2014
Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with bro... more Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with broad spectrum antibiotics. Transthoracic echocardiography was performed to explain the origin of the fever and a huge mass was detected in the left atrium. Cardiac magnetic resonance imaging was performed and reported as intracardiac thrombus. Patient was referred to surgery. Culture of the surgical material favored to Aspergillus fumigates. Voriconazole treatment was started and patient recovered. The authors report overlapping two different clinical situations, intracardiac thrombus and fungal infective endocarditis.
Gazi Medical Journal, 1996
Maximal exercise capacity and quality of life in allogeneic hematopoietic stem cell transplantation recipients
Physiotherapists
Gazi Medical Journal, 1998
Lenfoma Tedavisinde Kök Hücre Nakli
Turkiye Klinikleri Tıbbi Onkoloji Ozel Dergisi, 2009
Comparison of pulmonary and extra pulmonary characteristics in allogeneic hematopoietic stem cell transplantation recipients with healthy controls
European Respiratory Journal, Sep 1, 2014
European Respiratory Journal, Sep 1, 2013
Gazi Medical Journal, 1996
Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion
Canadian Journal of Ophthalmology Journal Canadien D Ophtalmologie, Aug 1, 2007
Turkish journal of haematology : official journal of Turkish Society of Haematology, Jan 5, 2003
Hypercalcemia is common in some lymphoproliferative disorders such as myeloma or T- cell leukaemi... more Hypercalcemia is common in some lymphoproliferative disorders such as myeloma or T- cell leukaemialymphoma, but is rarely described in B-cell chronic lymphocytic leukaemia (CLL). A CLL patient who have been presented with multiple pathological fractures and widespread osteolytic lesions is reported. He was a 74 year old male with fractures of his bilateral humerus and radii and multiple osteolytic lesions of skull, fibula, femur and costals. On his admission to the hospital for the fractures he has been diagnosed as CLL. Hypercalcemia has also been documented. All the disorders that could be the reason of hypercalcemia have been ruled out. The open biopsy of bone marrow showed lymphocytic infiltration in which increased number of prolymphocytes are observed. Hypercalcemia arising in a patient with CLL may indicate a negative prognosis.
Re: Alvarez et al., "Improvement of Thrombocytopenia due to Hypersplenism
The American journal of gastroenterology, 1996
Minerva medica, 2012
Pulmonary function tests (PFT) have an important role in the assessment of pulmonary and nonpulmo... more Pulmonary function tests (PFT) have an important role in the assessment of pulmonary and nonpulmonary complications of hematopoetic stem cell transplantation (HSCT). In this study the relationship between PFTs and DLCOadj values and the complications of HSCT was investigated. The possible role of iron overload in the deterioration of the PFTs after HSCT was also searched. One hundred and fifty one patients who had undergone allogeneic HSCT between years 2003 through 2008, and had the records of PFTs prior to and at 1, 3, 6, 9 and 12 months after transplantation were included in the study. Prospectively collected data of these patients were analysed retrospectively. Although no significant difference was identified in other PFT parameters, a significant decrease in DLCOadj was determined after 1st and 3rd months of HSCT. A significant correlation was found between pretransplant DLCOadj value <%70 and sinusoidal obstruction syndrome (SOS) (P=0.001, r=0.323), but in multivariate ana...
Gazi Medical Journal, 2015
Amaç: Çalışmamızda, Gazi Üniversitesi Tıp Fakültesi Hastanesi Kök Hücre Nakil Birimi (KHNB)'nde, ... more Amaç: Çalışmamızda, Gazi Üniversitesi Tıp Fakültesi Hastanesi Kök Hücre Nakil Birimi (KHNB)'nde, eğitimi takiben klorheksidinli swap-stick ile pansuman ve klorheksidin emdirilmiş transparan örtü kullanımı gibi önlemlerin kan dolaşımı enfeksiyonlarının (KDE) insidansına olan etkisinin gösterilmesi amaçlanmıştır. Gereç ve Metod: Kateter ilişkili kan dolaşımı enfeksiyonları (KİKDE) sürveyansı enfeksiyon kontrol hemşireleri tarafından aktif prospektif olarak gerçekleştirilmiştir. 1 Mart 2011 ile 31 Aralık 2011 tarihleri birinci dönem olarak kabul edilmiştir. Birinci dönemde yüksek enfeksiyon oranları görülmesi üzerine personel eğitimi, klorheksidinli swap-stick ve klorheksidin emdirilmiş transparan örtü kullanımı gibi enfeksiyon kontrol önlemleri uygulamaya konulmuştur. Uygulama sonrası, 1 Ocak 2012 ile 31 Ekim 2012 tarihleri ise 2. dönem olarak kabul edilmiştir. İki dönemdeki KİKDE oranları ve insidans dansitesi ki-kare testi kullanılarak karşılaştırılmıştır. Mikroorganizmalar da ayrıca kayıt edilmiştir. Bulgular: Birinci dönemde 329 hastada toplam 51 KDE tanısı konmuştur. Bunların % 62.7'sinin kateter kaynaklı olduğu tespit edilmiştir. İkinci dönemde ise 371 hastada toplam 29 KDE tanısı konmuş, enfeksiyonların % 27.3'ü kateter ilişkili olarak bulunmuştur. Uygulama öncesi dönemde KDE için insidans dansitesi 1000 günde 17.24 iken sonraki dönemde 1000 günde 8.3 olarak bulunmuştur (p=0.001). Her iki dönemde de en sık izole edilen etken KNS'ler olmuştur. Üreyen mikroorganizmalar karşılaştırıldığında toplamda gram pozitif mikroorganizmalarda anlamlı azalma saptanmıştır (p=0.006). Sonuç: Çalışmamızın sonucunda, eğitim, klorheksidinli swap-stick uygulaması ve klorheksidin emdirilmiş transparan örtü kullanımı gibi enfeksiyon kontrol önlemlerinin KDE ve özellikle KİKDE insidansında belirgin azalma sağladığı tespit edilmiştir. Bu azalma, başlıca gram pozitif mikroorganizmalarla gelişen infeksiyonlardaki azalmaya bağlı olarak ortaya çıkmıştır.
The relation between plasminogen activator inhibitor activity and disease activation in acute myeloblastic leukaemia patients
Clinical and Laboratory Haematology, 2006
Coagulation and fibrinolytic abnormalities are common in patients with acute myeloblastic leukaem... more Coagulation and fibrinolytic abnormalities are common in patients with acute myeloblastic leukaemia (AML) like other forms of leukaemias. In this study, we investigated if total plasminogen activator inhibitor (PAI) activity, which is believed to increase in initial diagnosis and relapse in AML patients could be accepted as a relapse criterion or not. Total of 34 AML patients and 18 healthy volunteers were included in this study. The patients' diagnosis were based on clinical criteria as well as morphological, cytochemical, immunuphenotypic examinations of peripheral blood and bone marrow specimens. Total PAI activity was measured with Dade Behring Bericrom PAI reagent in BCS system. Total PAI activity was higher than 3.5 U/ml in 11 AML patients while it was normal (0.3-3.5 U/ml) in control group (P < 0.01). There was no significant difference in total PAI activity between AML subgroups (P > 0.05). We found significant difference in total PAI activity between patients who have active disease and remission. In conclusion, the total PAI activity could be accepted as a relapse and an initial diagnosis criterion of AML patients during follow up.
BT-online: an innovated and promising computer assisted transfusion system
Medical Science Monitor, 2008
Errors in the transfusion process are common. These errors encompass a spectrum of events ranging... more Errors in the transfusion process are common. These errors encompass a spectrum of events ranging from incorrect transfusion to administration of infected blood products. To overcome these complications, we developed a new blood management software system - the BT-Online system - to decrease erroneous transfusions that are mostly human based. Like previously developed transfusion safety systems, this program uses handheld devices to improve the safety of bedside practices. The BT-online system consists of 3 main structures: (1) the personal digital assistant, (2) the equipment and software (user interface), and (3) the relational database and a web service providing communication of a security-layered database with other personal digital assistants. This system has many features including the ability at the bedside to check the complete patient history and requested tests and blood products, the ability to conduct simultaneous multiple procedures, the ability to transmit results to ...
Gazi Medical Journal, 1998
Gazi Medical Journal, 1996
Gazi Medical Journal, 1996
Gazi Medical Journal, 1998
The Comparison of The Effect of Somatostatin and SMS 201-995 on Enzym Change Following Endoscopic... more The Comparison of The Effect of Somatostatin and SMS 201-995 on Enzym Change Following Endoscopic Retrograde Cholangiopancreotography
Comparison of pulmonary and extra pulmonary characteristics in allogeneic hematopoietic stem cell transplantation recipients with healthy controls
Background: Limited number of studies reported reduction in exercise capacity, muscle strength an... more Background: Limited number of studies reported reduction in exercise capacity, muscle strength and abnormalities in lung functions in allogeneic hematopoetik stem cell transplantation (allo-HSCT) recipients. However, pulmonary and extrapulmonary characteristics in allo-HSCT recipients have not been compared with healthy controls so far. Aim: To compare submaximal exercise capacity, pulmonary functions, respiratory and peripheral muscle strength, dyspnea and fatigue perception and depression in allo-HSCT recipients with healthy controls. Methods: Forty patients (41.55±12.03 years) previously underwent allo-HSCT (>100 days status post transplantation) and 30 controls (45.77±10.02 years) were compared. Functional exercise capacity using 6-minute walk test (6MWT), respiratory muscle strength (MIP, MEP) using a mouth pressure device, peripheral muscles strength using dynamometer, dyspnea using Modified Medical Research Council (MMRC) dyspnea scale, fatigue using Fatigue Impact Scale (...
International Journal of Diagnostic Imaging, 2014
Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with bro... more Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with broad spectrum antibiotics. Transthoracic echocardiography was performed to explain the origin of the fever and a huge mass was detected in the left atrium. Cardiac magnetic resonance imaging was performed and reported as intracardiac thrombus. Patient was referred to surgery. Culture of the surgical material favored to Aspergillus fumigates. Voriconazole treatment was started and patient recovered. The authors report overlapping two different clinical situations, intracardiac thrombus and fungal infective endocarditis.
Gazi Medical Journal, 1996
Maximal exercise capacity and quality of life in allogeneic hematopoietic stem cell transplantation recipients
Physiotherapists
Gazi Medical Journal, 1998
Lenfoma Tedavisinde Kök Hücre Nakli
Turkiye Klinikleri Tıbbi Onkoloji Ozel Dergisi, 2009
Comparison of pulmonary and extra pulmonary characteristics in allogeneic hematopoietic stem cell transplantation recipients with healthy controls
European Respiratory Journal, Sep 1, 2014
European Respiratory Journal, Sep 1, 2013
Gazi Medical Journal, 1996
Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion
Canadian Journal of Ophthalmology Journal Canadien D Ophtalmologie, Aug 1, 2007