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Akid Mostofa

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Papers by Akid Mostofa

Research paper thumbnail of Delineating the mechanistic relevance of the TP53 gene and its mutational impact on gene expression and patients’ survival in bladder cancer

Research paper thumbnail of A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer

Research paper thumbnail of Comparative Study to Evaluate the Effect of Tamsulosin and Solifenacin on DJ Stent Related Symptoms

Acta Scientific Otolaryngology

Research paper thumbnail of A Comparative Study between Transrectal Ultrasound Guided 6-Core and 12-Core Prostate Biopsy for Detection of Prostate Cancer

Global Academic Journal of Medical Sciences

Background: Prostate cancer is common in urological practice. Diagnosis of prostate cancer depend... more Background: Prostate cancer is common in urological practice. Diagnosis of prostate cancer depends on biopsy of the prostate. For the last two decade TRUS guided 6 core (sextant) biopsy is being considered as standard for prostate biopsy. Various studies in different countries showed the drawback of sextant biopsy. The debate remains alive on number of biopsy core which is appropriate for obtaining representative tissue. Moreover, more number of needle biopsy may be associated with more complication. Methods: In this hospital based Quasi experimental study, a total of 50 patients were allocated into two groups by purposive sampling technique where 6 core prostate biopsy in one group and 12 core biopsy in another group. Baseline demographic and clinical data were recorded. Post procedural morbidity & histopathological findings were recorded. All the collected data were compiled. Further Statistical analyses of the results were obtained by using Microsoft Xcel, 2010 and web based comp...

Research paper thumbnail of Comparative Study to Evaluate Surgical Outcome and Donor Site Morbidity of Buccal Versus Lingual Mucosa Graft in Anterior Urethroplasty

SAS Journal of Medicine

Background: Stricture urethra is a frequent urological problem and substitution urethroplasty is ... more Background: Stricture urethra is a frequent urological problem and substitution urethroplasty is the standard treatment for longer (>2 cm) urerthral strictures, multiple urethral strictures and recurrent strictures. Currently, buccal mucosa graft (BMG) is the preferred donor site for substitution urethroplasty which is associated with donor site morbidities. The mucosa covering the lateral and undersurface of the tongue is identical to the rest of the lining of oral cavity and seems to be associated with less risk of donor site complications. The aim of the study was to compare the surgical outcome and donor site morbidity of buccal versus lingual mucosa graft in anterior urethroplasty. Methods: A prospective experimental study was done in the department of Urology Dhaka Medical College Hospital during the period of April 2017 to September 2018. Total 54 Patients were included by purposive sampling for the study as per inclusion and exclusion Criteria. Patients were than allocate...

Research paper thumbnail of Outcome of Surgical Repair of Vesicovaginal Fistula-A Comparative Study between Transabdominal and Transvaginal Route

Scholars Journal of Applied Medical Sciences

Background: The management of VVF involves a multi-modal technique. Surgical repair remains the t... more Background: The management of VVF involves a multi-modal technique. Surgical repair remains the treatment of choice for VVF. The repair could be undertaken through the transabdominal or transvaginal route. Although the vaginal route was the commonest route employed in the repair of VVF, it is clearly associated with post-operative incontinence, high recurrence and low success rate. Objectives: To compare the outcomes of surgical repair of vesicovaginal fistula between transabdominal and transvaginal Route. Methods: This prospective comparative study intended to compare the outcomes between surgical repair of vesicovaginal fistula- between transabdominal and transvaginal route. A total of 50 cases of VVF patient planned for surgical repair of VVF in Dhaka Medical College Hospital from April 2017 to September 2018, included in this study according to the inclusion and exclusion criteria. Cases were randomly allocated to group A (Transabdominal repair of VVF) and group B (Transvaginal ...

Research paper thumbnail of Surgical Outcome of Penile Fracture Management in a Tertiary Level Hospital in Bangladesh

SAS Journal of Surgery

Background: Fracture of the penis is a urological emergency which occurs as a result of abrupt tr... more Background: Fracture of the penis is a urological emergency which occurs as a result of abrupt trauma to an erect penis. Immediate surgical repair is the standard of care and is superior to non- operative management due to excellent long term outcomes. Objective: The aim of this study was to investigate surgical and functional outcomes in patients who underwent penile fracture repair. Methods: A cross sectional descriptive study was conducted during the period of July 2017-June 2018 to find out the pattern of surgical management of fracture penis among the patients admitted in the urology department of Dhaka Medical College Hospital. A total 50 patients of fracture patients were selected purposively. Outcome of surgical management was investigated by using semi structured and International Index of erectile function questionnaire. Results: The study reveals that the mean age of the patients were 34.26±9.96 (range: 18–65), predominantly married (70%). The mean follow-up period was 12...

Research paper thumbnail of Penerapan Model Pembelajaran Inkuiri Terbimbing untuk Meningkatkan Kemampuan Berpikir Kritis Peserta Didik

Research paper thumbnail of Improvement of semen quality after treatment with folic acid and zinc in subfertile men in a tertiary hospital

International journal of reproduction, contraception, obstetrics and gynecology, Mar 25, 2022

Background: The 50% of all male infertility is idiopathic, and there is currently no recognized t... more Background: The 50% of all male infertility is idiopathic, and there is currently no recognized treatment. The effectiveness of a nonprescription nutraceutical comprising eight nutrients on sperm quality in males with idiopathic infertility was studied. The aim of the study was to evaluate improvement of semen quality after treatment with folic acid and zinc in subfertile men. Methods: This prospective observational study was carried out in the infertility unit, department of obstetrics and gynaecology, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, Bangladesh from January 2018 to June 2020. Approval from local ethics committee was obtained for this study. Results: One hundred and twenty-five male subfertile patients were included in this study. Most men, 99 (79.2%) belong to more than 30 years, followed by 26 (20.8%) less than 30 years, range was 25 to 50 years. Mean ± SD age was 35.3±5.1 years. Rapid linear (RL) before treatment were 16.06±14.46 (mean ± SD) and after treatment were 22.82±13.40 (mean ± SD). Slow linear (SL) before treatment were 17.56±12.06 (mean ± SD) and after treatment were 19.75±9.25 (mean ± SD). Non progressive (NP) before treatment were 10.82±8.95 (mean ± SD) and after treatment were 10.12±7.34 (mean ± SD). Morphology of the sperm before treatment were 19.43±15.48 (mean ± SD) and after treatment were 30.18±19.12 (mean ± SD). Conclusions: Our research findings fully correspond to the above research results, so it can be said that treatment of subfertile men with micronutrients like folic acid and zinc sulfate causes increase of semen quality and thus plays a key role in treatment of male subfertility.

Research paper thumbnail of Delineating the mechanistic relevance of the TP53 gene and its mutational impact on gene expression and patients’ survival in bladder cancer

Research paper thumbnail of A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer

Research paper thumbnail of Comparative Study to Evaluate the Effect of Tamsulosin and Solifenacin on DJ Stent Related Symptoms

Acta Scientific Otolaryngology

Research paper thumbnail of A Comparative Study between Transrectal Ultrasound Guided 6-Core and 12-Core Prostate Biopsy for Detection of Prostate Cancer

Global Academic Journal of Medical Sciences

Background: Prostate cancer is common in urological practice. Diagnosis of prostate cancer depend... more Background: Prostate cancer is common in urological practice. Diagnosis of prostate cancer depends on biopsy of the prostate. For the last two decade TRUS guided 6 core (sextant) biopsy is being considered as standard for prostate biopsy. Various studies in different countries showed the drawback of sextant biopsy. The debate remains alive on number of biopsy core which is appropriate for obtaining representative tissue. Moreover, more number of needle biopsy may be associated with more complication. Methods: In this hospital based Quasi experimental study, a total of 50 patients were allocated into two groups by purposive sampling technique where 6 core prostate biopsy in one group and 12 core biopsy in another group. Baseline demographic and clinical data were recorded. Post procedural morbidity & histopathological findings were recorded. All the collected data were compiled. Further Statistical analyses of the results were obtained by using Microsoft Xcel, 2010 and web based comp...

Research paper thumbnail of Comparative Study to Evaluate Surgical Outcome and Donor Site Morbidity of Buccal Versus Lingual Mucosa Graft in Anterior Urethroplasty

SAS Journal of Medicine

Background: Stricture urethra is a frequent urological problem and substitution urethroplasty is ... more Background: Stricture urethra is a frequent urological problem and substitution urethroplasty is the standard treatment for longer (>2 cm) urerthral strictures, multiple urethral strictures and recurrent strictures. Currently, buccal mucosa graft (BMG) is the preferred donor site for substitution urethroplasty which is associated with donor site morbidities. The mucosa covering the lateral and undersurface of the tongue is identical to the rest of the lining of oral cavity and seems to be associated with less risk of donor site complications. The aim of the study was to compare the surgical outcome and donor site morbidity of buccal versus lingual mucosa graft in anterior urethroplasty. Methods: A prospective experimental study was done in the department of Urology Dhaka Medical College Hospital during the period of April 2017 to September 2018. Total 54 Patients were included by purposive sampling for the study as per inclusion and exclusion Criteria. Patients were than allocate...

Research paper thumbnail of Outcome of Surgical Repair of Vesicovaginal Fistula-A Comparative Study between Transabdominal and Transvaginal Route

Scholars Journal of Applied Medical Sciences

Background: The management of VVF involves a multi-modal technique. Surgical repair remains the t... more Background: The management of VVF involves a multi-modal technique. Surgical repair remains the treatment of choice for VVF. The repair could be undertaken through the transabdominal or transvaginal route. Although the vaginal route was the commonest route employed in the repair of VVF, it is clearly associated with post-operative incontinence, high recurrence and low success rate. Objectives: To compare the outcomes of surgical repair of vesicovaginal fistula between transabdominal and transvaginal Route. Methods: This prospective comparative study intended to compare the outcomes between surgical repair of vesicovaginal fistula- between transabdominal and transvaginal route. A total of 50 cases of VVF patient planned for surgical repair of VVF in Dhaka Medical College Hospital from April 2017 to September 2018, included in this study according to the inclusion and exclusion criteria. Cases were randomly allocated to group A (Transabdominal repair of VVF) and group B (Transvaginal ...

Research paper thumbnail of Surgical Outcome of Penile Fracture Management in a Tertiary Level Hospital in Bangladesh

SAS Journal of Surgery

Background: Fracture of the penis is a urological emergency which occurs as a result of abrupt tr... more Background: Fracture of the penis is a urological emergency which occurs as a result of abrupt trauma to an erect penis. Immediate surgical repair is the standard of care and is superior to non- operative management due to excellent long term outcomes. Objective: The aim of this study was to investigate surgical and functional outcomes in patients who underwent penile fracture repair. Methods: A cross sectional descriptive study was conducted during the period of July 2017-June 2018 to find out the pattern of surgical management of fracture penis among the patients admitted in the urology department of Dhaka Medical College Hospital. A total 50 patients of fracture patients were selected purposively. Outcome of surgical management was investigated by using semi structured and International Index of erectile function questionnaire. Results: The study reveals that the mean age of the patients were 34.26±9.96 (range: 18–65), predominantly married (70%). The mean follow-up period was 12...

Research paper thumbnail of Penerapan Model Pembelajaran Inkuiri Terbimbing untuk Meningkatkan Kemampuan Berpikir Kritis Peserta Didik

Research paper thumbnail of Improvement of semen quality after treatment with folic acid and zinc in subfertile men in a tertiary hospital

International journal of reproduction, contraception, obstetrics and gynecology, Mar 25, 2022

Background: The 50% of all male infertility is idiopathic, and there is currently no recognized t... more Background: The 50% of all male infertility is idiopathic, and there is currently no recognized treatment. The effectiveness of a nonprescription nutraceutical comprising eight nutrients on sperm quality in males with idiopathic infertility was studied. The aim of the study was to evaluate improvement of semen quality after treatment with folic acid and zinc in subfertile men. Methods: This prospective observational study was carried out in the infertility unit, department of obstetrics and gynaecology, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, Bangladesh from January 2018 to June 2020. Approval from local ethics committee was obtained for this study. Results: One hundred and twenty-five male subfertile patients were included in this study. Most men, 99 (79.2%) belong to more than 30 years, followed by 26 (20.8%) less than 30 years, range was 25 to 50 years. Mean ± SD age was 35.3±5.1 years. Rapid linear (RL) before treatment were 16.06±14.46 (mean ± SD) and after treatment were 22.82±13.40 (mean ± SD). Slow linear (SL) before treatment were 17.56±12.06 (mean ± SD) and after treatment were 19.75±9.25 (mean ± SD). Non progressive (NP) before treatment were 10.82±8.95 (mean ± SD) and after treatment were 10.12±7.34 (mean ± SD). Morphology of the sperm before treatment were 19.43±15.48 (mean ± SD) and after treatment were 30.18±19.12 (mean ± SD). Conclusions: Our research findings fully correspond to the above research results, so it can be said that treatment of subfertile men with micronutrients like folic acid and zinc sulfate causes increase of semen quality and thus plays a key role in treatment of male subfertility.

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