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Papers by Khalid Al Mohammed

Surgical Neurology International, 2021

Background: Extra-axial cerebral cavernous hemangiomas particularly those found in the sellar reg... more Background: Extra-axial cerebral cavernous hemangiomas particularly those found in the sellar region, are extremely rare. Their clinical manifestations and imaging characteristics can mimic those of a pituitary adenoma thus making preoperative diagnosis difficult. Few cases are reported in the literature. We present a case, along with a comprehensive review of the literature regarding specific aspects of diagnosis and management of all similarly reported rare cases. Case Description: We present the clinical, radiological, and operative data of a rare case of a large intrasellar cavernous hemangioma in a 49-year-old female patient presented with headache and diminution of vision, which was diagnosed intraoperatively during an endonasal endoscopic transsphenoidal approach. Subtotal debulking was performed with immediate postoperative clinical improvement. The patient was then referred for radiotherapy and maintained her clinical improvement since then. Conclusion: Neurosurgeons should...

International Journal of Environmental Analytical Chemistry

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020

Introduction: Toxoplasmosis is the disease which is caused by the protozoan parasite Toxoplasma g... more Introduction: Toxoplasmosis is the disease which is caused by the protozoan parasite Toxoplasma gondii (T. gondii), which has the ability to infect all warm-blooded animals. Several molecular techniques for the diagnosis of Toxoplasma gondii includes normal and Real Time Polymerase Chain Reaction (RT-PCR), and gene sequencing. Aim: To apply Loop-Mediated Isothermal Amplification (LAMP) for the diagnosis of T. gondii infections in urine and blood samples from female population in Saudi Arabia. Materials and Methods: In this cross-sectional study, genomic DNA was extracted from 22 blood and urine samples (11 each), two LAMP assays based on B1 and Surface Antigen 2 (SAG2) genes of T. gondii was performed. Conventional PCR was done for the LAMP product followed by sequencing to confirm the specificity of LAMP method. Statistical Package for the Social Sciences (SPSS) version 20.0 was used to summarise continuous and categorical variables. Results: From 22 samples, 17 samples were LAMP p...

Journal of Food & Nutritional Disorders, 2014

Olive Cake Reduce Lipid Peroxidation Associated with Antioxidant Defense in Red Blood Cell and He... more Olive Cake Reduce Lipid Peroxidation Associated with Antioxidant Defense in Red Blood Cell and Heart, in Rats Fed a Cholesterol-Enriched Diet Background: In Mediterranean areas, the olive oil industry produces substantial amounts of by-products, with one of the most important being the olive cake (OC). OC is the solid residue obtained after oil extraction. We hypothesized that administration of OC would prevented hypercholesterolemia and oxidative stress in rats fed a cholesterol-rich diets. Methods: Male Wistar rats (n=24) weighing 45 ± 5 g were divided into four groups fed diet with 1% cholesterol (HC) and supplemented or not with OC at 2.5%, 5% and 7.5% (OC2.5- HC, OC5-HC and OC7.5-HC or HC, respectively) for 28 days. Results: Compared with the HC group, serum total cholesterol values were respectively lower in the OC2.5-HC, OC5-HC and OC7.5-HC groups. Red Blood cells (RBC) thiobarbituric acid reactive substances (TBARS) were 1.3-fold lower in the OC7.5- HC group. In heart, TBARS concentration was significantly lower. In RBC, superoxide dismutase (SOD) activity was 1.13- fold increased in the OC5-HC group. Glutathione peroxidase (GSH-Px) activity was higher in all the OC groups. Glutathione reductase (GSSH-Red) activity was 2.3-fold higher in the OC5- HC and OC7.5-HC. Catalase activity was 1.3-fold increased in the OC2.5-HC and OC5-HC groups. Liver SOD and GSH-Px activities were significantly higher in all groups consumed the OC. Catalase activity was 1.5- fold increased in the OC7.5-HC group. In heart, SOD activity was significantly higher in all OC groups. Conclusion: It appears that olive cake attenuates hypercholesterolemia induced by cholesterol-enriched diet. In addition, olive cake may reduce lipid peroxidation associated with antioxidant defense in RBC and heart, compared to other tissues, in particular liver.

International Journal of Surgery Case Reports, 2020

Highlights • Only 15 cases of clinically diagnosed hemorrhagic colloid cysts were reported in the... more Highlights • Only 15 cases of clinically diagnosed hemorrhagic colloid cysts were reported in the literature and 5 more cases on autopsy.• The benefits of excellent visualization and minimally invasive access through the dilated ventricular system are offered by the endoscopic approach.• Open microsurgical technique is the best choice for hemorrhagic colloid cysts.

Surgical Neurology International, 2021

Background: Extra-axial cerebral cavernous hemangiomas particularly those found in the sellar reg... more Background: Extra-axial cerebral cavernous hemangiomas particularly those found in the sellar region, are extremely rare. Their clinical manifestations and imaging characteristics can mimic those of a pituitary adenoma thus making preoperative diagnosis difficult. Few cases are reported in the literature. We present a case, along with a comprehensive review of the literature regarding specific aspects of diagnosis and management of all similarly reported rare cases. Case Description: We present the clinical, radiological, and operative data of a rare case of a large intrasellar cavernous hemangioma in a 49-year-old female patient presented with headache and diminution of vision, which was diagnosed intraoperatively during an endonasal endoscopic transsphenoidal approach. Subtotal debulking was performed with immediate postoperative clinical improvement. The patient was then referred for radiotherapy and maintained her clinical improvement since then. Conclusion: Neurosurgeons should...

International Journal of Environmental Analytical Chemistry

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020

Introduction: Toxoplasmosis is the disease which is caused by the protozoan parasite Toxoplasma g... more Introduction: Toxoplasmosis is the disease which is caused by the protozoan parasite Toxoplasma gondii (T. gondii), which has the ability to infect all warm-blooded animals. Several molecular techniques for the diagnosis of Toxoplasma gondii includes normal and Real Time Polymerase Chain Reaction (RT-PCR), and gene sequencing. Aim: To apply Loop-Mediated Isothermal Amplification (LAMP) for the diagnosis of T. gondii infections in urine and blood samples from female population in Saudi Arabia. Materials and Methods: In this cross-sectional study, genomic DNA was extracted from 22 blood and urine samples (11 each), two LAMP assays based on B1 and Surface Antigen 2 (SAG2) genes of T. gondii was performed. Conventional PCR was done for the LAMP product followed by sequencing to confirm the specificity of LAMP method. Statistical Package for the Social Sciences (SPSS) version 20.0 was used to summarise continuous and categorical variables. Results: From 22 samples, 17 samples were LAMP p...

Journal of Food & Nutritional Disorders, 2014

Olive Cake Reduce Lipid Peroxidation Associated with Antioxidant Defense in Red Blood Cell and He... more Olive Cake Reduce Lipid Peroxidation Associated with Antioxidant Defense in Red Blood Cell and Heart, in Rats Fed a Cholesterol-Enriched Diet Background: In Mediterranean areas, the olive oil industry produces substantial amounts of by-products, with one of the most important being the olive cake (OC). OC is the solid residue obtained after oil extraction. We hypothesized that administration of OC would prevented hypercholesterolemia and oxidative stress in rats fed a cholesterol-rich diets. Methods: Male Wistar rats (n=24) weighing 45 ± 5 g were divided into four groups fed diet with 1% cholesterol (HC) and supplemented or not with OC at 2.5%, 5% and 7.5% (OC2.5- HC, OC5-HC and OC7.5-HC or HC, respectively) for 28 days. Results: Compared with the HC group, serum total cholesterol values were respectively lower in the OC2.5-HC, OC5-HC and OC7.5-HC groups. Red Blood cells (RBC) thiobarbituric acid reactive substances (TBARS) were 1.3-fold lower in the OC7.5- HC group. In heart, TBARS concentration was significantly lower. In RBC, superoxide dismutase (SOD) activity was 1.13- fold increased in the OC5-HC group. Glutathione peroxidase (GSH-Px) activity was higher in all the OC groups. Glutathione reductase (GSSH-Red) activity was 2.3-fold higher in the OC5- HC and OC7.5-HC. Catalase activity was 1.3-fold increased in the OC2.5-HC and OC5-HC groups. Liver SOD and GSH-Px activities were significantly higher in all groups consumed the OC. Catalase activity was 1.5- fold increased in the OC7.5-HC group. In heart, SOD activity was significantly higher in all OC groups. Conclusion: It appears that olive cake attenuates hypercholesterolemia induced by cholesterol-enriched diet. In addition, olive cake may reduce lipid peroxidation associated with antioxidant defense in RBC and heart, compared to other tissues, in particular liver.

International Journal of Surgery Case Reports, 2020

Highlights • Only 15 cases of clinically diagnosed hemorrhagic colloid cysts were reported in the... more Highlights • Only 15 cases of clinically diagnosed hemorrhagic colloid cysts were reported in the literature and 5 more cases on autopsy.• The benefits of excellent visualization and minimally invasive access through the dilated ventricular system are offered by the endoscopic approach.• Open microsurgical technique is the best choice for hemorrhagic colloid cysts.