Muhanna Al-Muhanna - Academia.edu (original) (raw)

Papers by Muhanna Al-Muhanna

Research paper thumbnail of Drug delivery dosage forms made of tailor-made natural polysaccharides

Tailor-Made Polysaccharides in Drug Delivery

Research paper thumbnail of Synthesis of tailor-made polysaccharides: An overview

Research paper thumbnail of Identification of natural flavonoids as novel EGFR inhibitors using DFT, molecular docking, and molecular dynamics

New Journal of Chemistry

The quantum mechanical descriptors from DFT, molecular docking, molecular dynamics, and NCIplot m... more The quantum mechanical descriptors from DFT, molecular docking, molecular dynamics, and NCIplot methodology have been utilized to find a potential anti-EGFR flavonoid.

Research paper thumbnail of 3-Substituted-2-oxindole derivatives: Design, synthesis and their anti-tuberculosis and radical scavenging dual-action studies

Journal of Molecular Structure, 2022

Research paper thumbnail of Cover Image

Journal of the Association for Information Science and Technology, 2022

Research paper thumbnail of Nanogenerators Theories and Applications

Nanogenerators, May 16, 2022

Research paper thumbnail of Toward allogenizing a xenograft: Xenogeneic cardiac scaffolds recellularized with human-induced pluripotent stem cells do not activate human naïve neutrophils

Journal of Biomedical Materials Research Part B, Oct 7, 2021

The limited availability of human donor organs suitable for transplantation has resulted in ever-... more The limited availability of human donor organs suitable for transplantation has resulted in ever-increasing patient waiting lists globally. Xenotransplantation is considered a potential option, but is yet to reach clinical practice. Although remarkable progress has been made in overcoming immunological rejection, issues with functionality are still to be resolved. Bioengineering approaches have been used to create cardiac tissues with optimized functions. The use of decellularized xenogeneic cardiac tissues seeded with donor-derived cardiac cells may prove to be a viable strategy as supporting structures of the native tissue such as vasculature can be utilized. Here we used sequential perfusion to decellularize adult rat hearts. The acellular scaffolds were reseeded with human endothelial cells, human fibroblasts, human mesenchymal stem cells, and cardiac cells derived from human-induced pluripotent stem cells. The ability of the resultant recellularized rat scaffolds to activate human naïve neutrophils in vitro was investigated to measure xenogeneic recognition. Our results demonstrate that in contrast to cadaveric xenogeneic hearts, acellular and recellularized xenogeneic scaffolds did not activate human naïve neutrophils and suggest that decellularization removes the xenogeneic antigens that lead to human naïve neutrophil activation thus allowing human cells to populate the now "allogenized" xenogeneic scaffolds.

Research paper thumbnail of Associates of thioalkyl derivatives of 2-arylaminopyrimidine with hydroxyapatite-based nanocomposites

Russian Journal of General Chemistry, 2016

Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the... more Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the composites of hydroxyapatite (HA) covered with nanoparticles of magnetite as well as compositions of magnetite, gold and silver. The thioalkyl-substituted derivatives of 2-arylaminopyrimidine, structural analogs of antitumor drug Imatinib containing one or two SH groups and capable to chemisorption on hydroxyapatite and its nanocomposites, have been synthesized. Two-component Fe 3 O 4 (HA) and three-component Fe 3 O 4 (HA)Au and Fe 3 O 4 (HA)Ag composites have been found the most promising as nanocarriers of bioactive compounds.

Research paper thumbnail of Cover Image

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2022

Research paper thumbnail of Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus

PLOS ONE

The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the Togavir... more The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the Togaviridae family’s Alphavirus genus. An epidemic was observed among French troops stationed in the Central African Republic, most likely caused by the SFV virus. The two transmembrane proteins El and E2 and the peripheral protein E3 make up the viral spike protein. The virus binds to the host cell and is internalized via endocytosis; endosome acidification causes the E1/E2 heterodimer to dissociate and the E1 subunits to trimerize. Lupenone was evaluated against the E1 spike protein of SFV in this study based on state-of-the-art cheminformatics approaches, including molecular docking, molecular dynamics simulation, and binding free energy calculation. The molecular docking study envisaged major interactions of Lupenone with binding cavity residues involved non-bonded van der Waal’s and Pi-alkyl interactions. Molecular dynamic simulation of a time scale 200 ns corroborated interaction pattern ...

Research paper thumbnail of CCDC 929733: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 929732: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050135: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050134: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050133: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Improved Solid-State Photomechanical Materials by Fluorine Substitution of 9-Anthracene Carboxylic Acid

Chemistry of Materials, 2014

ABSTRACT Four fluorinated derivatives of 9-anthracene carboxylic acid (9AC), a molecule that show... more ABSTRACT Four fluorinated derivatives of 9-anthracene carboxylic acid (9AC), a molecule that shows a reversible photomechanical response in its crystal form, have been synthesized and characterized. The spectroscopic properties and crystal structures of 4-fluoro-9-anthracene carboxylic acid (4F-9AC), 2-fluoro-9-anthracene carboxylic acid (2F-9AC), 10-fluoro-9-anthracene carboxylic acid (10F-9AC), and 2,6-difluoro-9-anthracene carboxylic acid (2,6DF-9AC) are all very similar to those of 9AC. However, their photomechanical properties vary widely. 405 nm light was used to induce [4 + 4] photodimerization and a mechanical response in crystalline microneedles and ribbons. Both the photodimer dissociation rate and the mechanical recovery varied by more than an order of magnitude, with 4F-9AC exhibiting the most rapid recovery time, on the order of 30 s. Nanoindentation measurements show that this crystal has a slightly reduced elastic modulus and a significantly reduced hardness, making it less brittle than the 9AC crystal. Large 4F-9AC crystals remain intact after irradiation, without fragmenting, while microneedles can undergo more than 100 mechanical bending cycles. Given the similarity of the crystal packing in all five molecules, the improved photomechanical properties must arise from subtle changes in intermolecular interactions or possibly differences in disorder. These results demonstrate that it is possible to significantly improve the properties of photomechanical materials through small modifications of the molecular structure. ■ INTRODUCTION Photons can be transformed into mechanical motion by photochemical reactions in which molecules change shape or bonding configuration. If photochemically reactive molecules are organized, for example in a molecular crystal or a liquid crystalline polymer, then each photochemical reaction can "push" in the same direction. The sum of many such displacements, on the angstrom scale, can result in a large total displacement on the scale of micrometers or more. This is the origin of photomechanical effects in molecular materials.

Research paper thumbnail of Chemical reaction method for growing photomechanical organic microcrystals

Research paper thumbnail of A high-efficient method for generating radially and azimuthally polarized Bessel beams using biaxial crystals

Optics Communications, 2012

ABSTRACT As was shown previously, in propagation of a circularly polarized Bessel light beam alon... more ABSTRACT As was shown previously, in propagation of a circularly polarized Bessel light beam along the optical axes of a biaxial crystal, there takes place the conversion of the order of Bessel function. In this paper, a new result is presented which is obtained by varying the polarization state of an input beam. Namely, a linearly polarized beam can be transformed into a beam with the radial or azimuthal polarization state. At that the order-transformation also occurs. The switching between radial and azimuthal polarization states of the output beam is performed by the proper switching between two orthogonal linear polarization states of the input beam. The efficiency of polarization conversion is high and can be practically full at an appropriate choice of the cone angle of the input beam or crystal length.

Research paper thumbnail of Energy flow patterns in an optical field formed by a superposition of evanescent Bessel light beams

Journal of Optics-nouvelle Revue D Optique - J OPT, 2011

A theory of the generation of a superposition of evanescent Bessel light beams (BLBs) at the boun... more A theory of the generation of a superposition of evanescent Bessel light beams (BLBs) at the boundary of two dielectrics is developed, the conditions of total internal reflection being fulfilled. Correct analytical expressions are obtained for the field formed inside a medium having a lower refractive index. The longitudinal and transversal (azimuthal and radial) energy flow densities near the boundary have been calculated and analyzed. Our study demonstrates that it is feasible to use a superposition of evanescent BLBs as a virtual tip for near-field optical microscopy with a sub-wave resolution and for optical tweezing.

Research paper thumbnail of Magnetic Langmuir-Blodgett Films with Gluing Properties

Physics, Chemistry and Applications of Nanostructures, 2011

Research paper thumbnail of Drug delivery dosage forms made of tailor-made natural polysaccharides

Tailor-Made Polysaccharides in Drug Delivery

Research paper thumbnail of Synthesis of tailor-made polysaccharides: An overview

Research paper thumbnail of Identification of natural flavonoids as novel EGFR inhibitors using DFT, molecular docking, and molecular dynamics

New Journal of Chemistry

The quantum mechanical descriptors from DFT, molecular docking, molecular dynamics, and NCIplot m... more The quantum mechanical descriptors from DFT, molecular docking, molecular dynamics, and NCIplot methodology have been utilized to find a potential anti-EGFR flavonoid.

Research paper thumbnail of 3-Substituted-2-oxindole derivatives: Design, synthesis and their anti-tuberculosis and radical scavenging dual-action studies

Journal of Molecular Structure, 2022

Research paper thumbnail of Cover Image

Journal of the Association for Information Science and Technology, 2022

Research paper thumbnail of Nanogenerators Theories and Applications

Nanogenerators, May 16, 2022

Research paper thumbnail of Toward allogenizing a xenograft: Xenogeneic cardiac scaffolds recellularized with human-induced pluripotent stem cells do not activate human naïve neutrophils

Journal of Biomedical Materials Research Part B, Oct 7, 2021

The limited availability of human donor organs suitable for transplantation has resulted in ever-... more The limited availability of human donor organs suitable for transplantation has resulted in ever-increasing patient waiting lists globally. Xenotransplantation is considered a potential option, but is yet to reach clinical practice. Although remarkable progress has been made in overcoming immunological rejection, issues with functionality are still to be resolved. Bioengineering approaches have been used to create cardiac tissues with optimized functions. The use of decellularized xenogeneic cardiac tissues seeded with donor-derived cardiac cells may prove to be a viable strategy as supporting structures of the native tissue such as vasculature can be utilized. Here we used sequential perfusion to decellularize adult rat hearts. The acellular scaffolds were reseeded with human endothelial cells, human fibroblasts, human mesenchymal stem cells, and cardiac cells derived from human-induced pluripotent stem cells. The ability of the resultant recellularized rat scaffolds to activate human naïve neutrophils in vitro was investigated to measure xenogeneic recognition. Our results demonstrate that in contrast to cadaveric xenogeneic hearts, acellular and recellularized xenogeneic scaffolds did not activate human naïve neutrophils and suggest that decellularization removes the xenogeneic antigens that lead to human naïve neutrophil activation thus allowing human cells to populate the now "allogenized" xenogeneic scaffolds.

Research paper thumbnail of Associates of thioalkyl derivatives of 2-arylaminopyrimidine with hydroxyapatite-based nanocomposites

Russian Journal of General Chemistry, 2016

Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the... more Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the composites of hydroxyapatite (HA) covered with nanoparticles of magnetite as well as compositions of magnetite, gold and silver. The thioalkyl-substituted derivatives of 2-arylaminopyrimidine, structural analogs of antitumor drug Imatinib containing one or two SH groups and capable to chemisorption on hydroxyapatite and its nanocomposites, have been synthesized. Two-component Fe 3 O 4 (HA) and three-component Fe 3 O 4 (HA)Au and Fe 3 O 4 (HA)Ag composites have been found the most promising as nanocarriers of bioactive compounds.

Research paper thumbnail of Cover Image

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2022

Research paper thumbnail of Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus

PLOS ONE

The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the Togavir... more The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the Togaviridae family’s Alphavirus genus. An epidemic was observed among French troops stationed in the Central African Republic, most likely caused by the SFV virus. The two transmembrane proteins El and E2 and the peripheral protein E3 make up the viral spike protein. The virus binds to the host cell and is internalized via endocytosis; endosome acidification causes the E1/E2 heterodimer to dissociate and the E1 subunits to trimerize. Lupenone was evaluated against the E1 spike protein of SFV in this study based on state-of-the-art cheminformatics approaches, including molecular docking, molecular dynamics simulation, and binding free energy calculation. The molecular docking study envisaged major interactions of Lupenone with binding cavity residues involved non-bonded van der Waal’s and Pi-alkyl interactions. Molecular dynamic simulation of a time scale 200 ns corroborated interaction pattern ...

Research paper thumbnail of CCDC 929733: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 929732: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050135: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050134: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of CCDC 1050133: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Improved Solid-State Photomechanical Materials by Fluorine Substitution of 9-Anthracene Carboxylic Acid

Chemistry of Materials, 2014

ABSTRACT Four fluorinated derivatives of 9-anthracene carboxylic acid (9AC), a molecule that show... more ABSTRACT Four fluorinated derivatives of 9-anthracene carboxylic acid (9AC), a molecule that shows a reversible photomechanical response in its crystal form, have been synthesized and characterized. The spectroscopic properties and crystal structures of 4-fluoro-9-anthracene carboxylic acid (4F-9AC), 2-fluoro-9-anthracene carboxylic acid (2F-9AC), 10-fluoro-9-anthracene carboxylic acid (10F-9AC), and 2,6-difluoro-9-anthracene carboxylic acid (2,6DF-9AC) are all very similar to those of 9AC. However, their photomechanical properties vary widely. 405 nm light was used to induce [4 + 4] photodimerization and a mechanical response in crystalline microneedles and ribbons. Both the photodimer dissociation rate and the mechanical recovery varied by more than an order of magnitude, with 4F-9AC exhibiting the most rapid recovery time, on the order of 30 s. Nanoindentation measurements show that this crystal has a slightly reduced elastic modulus and a significantly reduced hardness, making it less brittle than the 9AC crystal. Large 4F-9AC crystals remain intact after irradiation, without fragmenting, while microneedles can undergo more than 100 mechanical bending cycles. Given the similarity of the crystal packing in all five molecules, the improved photomechanical properties must arise from subtle changes in intermolecular interactions or possibly differences in disorder. These results demonstrate that it is possible to significantly improve the properties of photomechanical materials through small modifications of the molecular structure. ■ INTRODUCTION Photons can be transformed into mechanical motion by photochemical reactions in which molecules change shape or bonding configuration. If photochemically reactive molecules are organized, for example in a molecular crystal or a liquid crystalline polymer, then each photochemical reaction can "push" in the same direction. The sum of many such displacements, on the angstrom scale, can result in a large total displacement on the scale of micrometers or more. This is the origin of photomechanical effects in molecular materials.

Research paper thumbnail of Chemical reaction method for growing photomechanical organic microcrystals

Research paper thumbnail of A high-efficient method for generating radially and azimuthally polarized Bessel beams using biaxial crystals

Optics Communications, 2012

ABSTRACT As was shown previously, in propagation of a circularly polarized Bessel light beam alon... more ABSTRACT As was shown previously, in propagation of a circularly polarized Bessel light beam along the optical axes of a biaxial crystal, there takes place the conversion of the order of Bessel function. In this paper, a new result is presented which is obtained by varying the polarization state of an input beam. Namely, a linearly polarized beam can be transformed into a beam with the radial or azimuthal polarization state. At that the order-transformation also occurs. The switching between radial and azimuthal polarization states of the output beam is performed by the proper switching between two orthogonal linear polarization states of the input beam. The efficiency of polarization conversion is high and can be practically full at an appropriate choice of the cone angle of the input beam or crystal length.

Research paper thumbnail of Energy flow patterns in an optical field formed by a superposition of evanescent Bessel light beams

Journal of Optics-nouvelle Revue D Optique - J OPT, 2011

A theory of the generation of a superposition of evanescent Bessel light beams (BLBs) at the boun... more A theory of the generation of a superposition of evanescent Bessel light beams (BLBs) at the boundary of two dielectrics is developed, the conditions of total internal reflection being fulfilled. Correct analytical expressions are obtained for the field formed inside a medium having a lower refractive index. The longitudinal and transversal (azimuthal and radial) energy flow densities near the boundary have been calculated and analyzed. Our study demonstrates that it is feasible to use a superposition of evanescent BLBs as a virtual tip for near-field optical microscopy with a sub-wave resolution and for optical tweezing.

Research paper thumbnail of Magnetic Langmuir-Blodgett Films with Gluing Properties

Physics, Chemistry and Applications of Nanostructures, 2011