Sumaiya Alam - Academia.edu (original) (raw)
Papers by Sumaiya Alam
Bangladesh Journal of Nuclear Medicine
Familial hypocalciuric hypercalcemia (FHH) is a rare, lifelong, benign condition with an autosoma... more Familial hypocalciuric hypercalcemia (FHH) is a rare, lifelong, benign condition with an autosomal dominant pattern of inheritance. FHH is clinically distinguished by mild to moderate PTH-dependent hypercalcemia and normal to significantly reduced urinary calcium excretion despite elevated serum calcium. FHH is usually caused by a heterozygous loss-of-function mutation in the calcium-sensing receptor gene (CASR). It should be differentiated from primary hyperparathyroidism (PHPT). The reported case of a 10-year-old girl presented with symptomatic hypercalcemia, elevated intact parathyroid hormone, and a vitamin D deficiency. 99mTc-Sestamibi scan failed to detect any abnormalities, but high-resolution ultrasound (HRUS) of the neck revealed a right inferior parathyroid adenoma, which was excised with a focused parathyroidectomy. Although the patient’s calcium and iPTH levels normalized initially, they started rising within a few days. Bangladesh J. Nuclear Med. 26(1): 62-65, 2023
Clinical Phytoscience, 2020
Context Cuscuta reflexa (C. reflexa) Roxb. (Convolvulaceae) has medicinal properties for the effe... more Context Cuscuta reflexa (C. reflexa) Roxb. (Convolvulaceae) has medicinal properties for the effective management of several aliments including diabetes mellitus, inflammation, and gastric ulcer. Objective The present investigation focuses on the antidiabetic potential of C. reflexa leaves methanol extract in alloxan-induced diabetic rats. Materials and methods The antidiabetic activity of C. reflexa leaves methanol extract (CRME) was evaluated using alloxan-induced diabetes in Wistar albino rats. The duration of the study was 45 days. Diabetic model was developed by i.p. administration of alloxan monohydrate (120 mg/kg). Ingestion of CRME (100, 200, and 400 mg/kg/day) and standard (gliclazide, 10 mg/kg/day) was done via oral route from the day of diabetes induction and continued up to 45 days. The effect of CRME was investigated by evaluating the blood glucose concentrations, HbA1C, insulin, lipid profile and liver function test. Further, the protective potentials of CRME were stud...
Oriental Pharmacy and Experimental Medicine, 2019
The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobi... more The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO 4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p < 0.001) inhibition activity as 40.67%, 53.11% and 62.03% for 250 and 500 mg/kg b.w. dose and standard drug respectively. In castor oil-induced diarrhea, the percentage inhibition of defection for 250 and 500 mg/kg b.w. dose were 41.67% and 59.72%, respectively, whereas in gut motility test, 500 mg/kg b.w. dose showed remarkable (30.45%) depletion of BaSO 4 transit. The tested plant extract have potential analgesic, anti-inflammatory, anti-diarrhoeal and antimicrobial properties which may conclude the extract as a potential source of phytomedicine.
Clinical Phytoscience, 2016
Background: Phytochemical derived from plant consisting of phenols and flavonoids possess antioxi... more Background: Phytochemical derived from plant consisting of phenols and flavonoids possess antioxidant properties, which are useful to scavenge reactive oxygen species (ROS). The aim of the work is to ascertain the level of antioxidant, cytotoxic, anti-microbial properties and in vivo analgesic and anti-inflammatory activity of methanolic extracts of Pouzolzia zeylanica (L.) Benn. Methods: The present study was conducted to evaluate antioxidant, cytotoxic, anti-microbial potential, analgesic and anti-inflammatory activity of methanol extracts of Pouzolzia zeylanica (L) Benn. using DPPH (1,1-diphenyl-2picrylhydrazyl) scavenging assay, cupric reducing antioxidant capacity, nitric oxide scavenging assay, ferric reducing antioxidant power, total antioxidant capacity, determination of total phenol and flavonoid contents and cytotoxic activity test using brine shrimp lethality bioassay whereas antimicrobial activity was evaluated against some potent Gram positive and Gram negative bacteria by disc diffusion method, anti-inflammatory and analgesic activity were determined by Xylene-induced ear edema and acetic acid induced writhing method respectively. Results: Preliminary phytochemical study revealed the presence of alkaloid and flavonoids in the extract. The tested fraction showed significant antioxidant activities in the assay compared to the reference ascorbic acid in a dose dependent manner. In DPPH radical scavenging assay, the IC50 value of the crude methanol extract was 485.223 μg/mL, whereas IC50 value for the reference ascorbic acid was 34.88 μg/mL. In case of nitric oxide scavenging assay, the IC50 value of the extract was 76.737 μg/mL, whereas IC50 value for the reference ascorbic acid was 51.078 μg/mL. Moreover, at 200 μg/mL extract concentration, lower grade total antioxidant activity (160.813 ± 0.653 mg/g equivalent to ascorbic acid) was observed. Furthermore, extract showed good cupric reducing power and ferric reducing power capability. In addition, significant amount of flavonoids and low phenols content were obtained from the extract. In case of cytotoxicity test the crude extract showed a significant activity compared to the standard vincristine sulfate. In essence the tested extract exhibited moderate antibacterial activity which reveals that Pouzolzia zeylanica (L) Benn. might be a source of antimicrobial agent. In case of anti-inflammatory and analgesic activity the tested extracts showed dose dependent significant inhibition (78.86 and 21.95 % at 500 mg/kg doses). Conclusions: Further study on different solvent extracts of Pouzolzia zeylanica (L.) Benn. would be carried out to elucidate the active principles for its outmost activity.
This paper reports a study has been designed to formulate and to offer a comparison of various pa... more This paper reports a study has been designed to formulate and to offer a comparison of various parameters of combination dose of Paracetamol (500 mg) and Ibuprofen (200 mg). A combined solid dosage form of Paracetamol (500mg) and Ibuprofen (200mg) is formulated and tested by analytical parameters.We use Nuromol (Paracetamol 500 mg and Ibuprofen 200 mg; Reckitt Benckiser Healthcare, UK) as a vendor drug for the purpose to cure from mild to moderately severe pain as a new combination dosage regimen in Bangladesh. Initially combined dosage regimen was prepared using six different formulas and formulated drugs are tested for checking all parameters as with supplied reference drugs. The assay is carried out by employing HPLC system with UV detection at 222 nm.There after each formulation had been subjected to preformulation and postformulation studies. The tablet mass is evaluated by assessing various compressional parameter such as angle of repose, bulk density, tapped density, Hausner's ratio and compressibility index. All the results are met the specifications and this results indicated that this new formulation have good flow properties. Various kinetic models were employed for the application of in vitro release profile assessment. The hardness of the tablet is found 4.3 to 6 kg, friability of the tablet is found 0.25 to 0.63%, disintegration time for the core tablet and the coated tablet are found 40 seconds and 1.30 seconds respectively. The results also show that the presence of active components in the formulated tablets are 100.31% Paracetamol and 101.12% Ibuprofen. We observed the potencies of the Paracetamol are 103.36% and 99.29% for Ibuprofen. All results of post formulation parameters were according to pharmacopoeias and within acceptable range. Based on fundamental comparative behavior of drug dissolution it can be concluded that release profile of all six batches under investigation was compatible with reference drug. In this present study as the newly formulated combination dosages regimen has met all the acceptance criteria and complied with the pharmacopoeial specifications and reference standard this formulation can be adapted as commercial preparation in Bangladesh for treatment of mild to moderately severe pain for post-operative patients.
Clinical Phytoscience
An amendment to this paper has been published and can be accessed via the original article.
Clinical Phytoscience
An amendment to this paper has been published and can be accessed via the original article.
Bangladesh Journal of Nuclear Medicine
Familial hypocalciuric hypercalcemia (FHH) is a rare, lifelong, benign condition with an autosoma... more Familial hypocalciuric hypercalcemia (FHH) is a rare, lifelong, benign condition with an autosomal dominant pattern of inheritance. FHH is clinically distinguished by mild to moderate PTH-dependent hypercalcemia and normal to significantly reduced urinary calcium excretion despite elevated serum calcium. FHH is usually caused by a heterozygous loss-of-function mutation in the calcium-sensing receptor gene (CASR). It should be differentiated from primary hyperparathyroidism (PHPT). The reported case of a 10-year-old girl presented with symptomatic hypercalcemia, elevated intact parathyroid hormone, and a vitamin D deficiency. 99mTc-Sestamibi scan failed to detect any abnormalities, but high-resolution ultrasound (HRUS) of the neck revealed a right inferior parathyroid adenoma, which was excised with a focused parathyroidectomy. Although the patient’s calcium and iPTH levels normalized initially, they started rising within a few days. Bangladesh J. Nuclear Med. 26(1): 62-65, 2023
Clinical Phytoscience, 2020
Context Cuscuta reflexa (C. reflexa) Roxb. (Convolvulaceae) has medicinal properties for the effe... more Context Cuscuta reflexa (C. reflexa) Roxb. (Convolvulaceae) has medicinal properties for the effective management of several aliments including diabetes mellitus, inflammation, and gastric ulcer. Objective The present investigation focuses on the antidiabetic potential of C. reflexa leaves methanol extract in alloxan-induced diabetic rats. Materials and methods The antidiabetic activity of C. reflexa leaves methanol extract (CRME) was evaluated using alloxan-induced diabetes in Wistar albino rats. The duration of the study was 45 days. Diabetic model was developed by i.p. administration of alloxan monohydrate (120 mg/kg). Ingestion of CRME (100, 200, and 400 mg/kg/day) and standard (gliclazide, 10 mg/kg/day) was done via oral route from the day of diabetes induction and continued up to 45 days. The effect of CRME was investigated by evaluating the blood glucose concentrations, HbA1C, insulin, lipid profile and liver function test. Further, the protective potentials of CRME were stud...
Oriental Pharmacy and Experimental Medicine, 2019
The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobi... more The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO 4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p < 0.001) inhibition activity as 40.67%, 53.11% and 62.03% for 250 and 500 mg/kg b.w. dose and standard drug respectively. In castor oil-induced diarrhea, the percentage inhibition of defection for 250 and 500 mg/kg b.w. dose were 41.67% and 59.72%, respectively, whereas in gut motility test, 500 mg/kg b.w. dose showed remarkable (30.45%) depletion of BaSO 4 transit. The tested plant extract have potential analgesic, anti-inflammatory, anti-diarrhoeal and antimicrobial properties which may conclude the extract as a potential source of phytomedicine.
Clinical Phytoscience, 2016
Background: Phytochemical derived from plant consisting of phenols and flavonoids possess antioxi... more Background: Phytochemical derived from plant consisting of phenols and flavonoids possess antioxidant properties, which are useful to scavenge reactive oxygen species (ROS). The aim of the work is to ascertain the level of antioxidant, cytotoxic, anti-microbial properties and in vivo analgesic and anti-inflammatory activity of methanolic extracts of Pouzolzia zeylanica (L.) Benn. Methods: The present study was conducted to evaluate antioxidant, cytotoxic, anti-microbial potential, analgesic and anti-inflammatory activity of methanol extracts of Pouzolzia zeylanica (L) Benn. using DPPH (1,1-diphenyl-2picrylhydrazyl) scavenging assay, cupric reducing antioxidant capacity, nitric oxide scavenging assay, ferric reducing antioxidant power, total antioxidant capacity, determination of total phenol and flavonoid contents and cytotoxic activity test using brine shrimp lethality bioassay whereas antimicrobial activity was evaluated against some potent Gram positive and Gram negative bacteria by disc diffusion method, anti-inflammatory and analgesic activity were determined by Xylene-induced ear edema and acetic acid induced writhing method respectively. Results: Preliminary phytochemical study revealed the presence of alkaloid and flavonoids in the extract. The tested fraction showed significant antioxidant activities in the assay compared to the reference ascorbic acid in a dose dependent manner. In DPPH radical scavenging assay, the IC50 value of the crude methanol extract was 485.223 μg/mL, whereas IC50 value for the reference ascorbic acid was 34.88 μg/mL. In case of nitric oxide scavenging assay, the IC50 value of the extract was 76.737 μg/mL, whereas IC50 value for the reference ascorbic acid was 51.078 μg/mL. Moreover, at 200 μg/mL extract concentration, lower grade total antioxidant activity (160.813 ± 0.653 mg/g equivalent to ascorbic acid) was observed. Furthermore, extract showed good cupric reducing power and ferric reducing power capability. In addition, significant amount of flavonoids and low phenols content were obtained from the extract. In case of cytotoxicity test the crude extract showed a significant activity compared to the standard vincristine sulfate. In essence the tested extract exhibited moderate antibacterial activity which reveals that Pouzolzia zeylanica (L) Benn. might be a source of antimicrobial agent. In case of anti-inflammatory and analgesic activity the tested extracts showed dose dependent significant inhibition (78.86 and 21.95 % at 500 mg/kg doses). Conclusions: Further study on different solvent extracts of Pouzolzia zeylanica (L.) Benn. would be carried out to elucidate the active principles for its outmost activity.
This paper reports a study has been designed to formulate and to offer a comparison of various pa... more This paper reports a study has been designed to formulate and to offer a comparison of various parameters of combination dose of Paracetamol (500 mg) and Ibuprofen (200 mg). A combined solid dosage form of Paracetamol (500mg) and Ibuprofen (200mg) is formulated and tested by analytical parameters.We use Nuromol (Paracetamol 500 mg and Ibuprofen 200 mg; Reckitt Benckiser Healthcare, UK) as a vendor drug for the purpose to cure from mild to moderately severe pain as a new combination dosage regimen in Bangladesh. Initially combined dosage regimen was prepared using six different formulas and formulated drugs are tested for checking all parameters as with supplied reference drugs. The assay is carried out by employing HPLC system with UV detection at 222 nm.There after each formulation had been subjected to preformulation and postformulation studies. The tablet mass is evaluated by assessing various compressional parameter such as angle of repose, bulk density, tapped density, Hausner's ratio and compressibility index. All the results are met the specifications and this results indicated that this new formulation have good flow properties. Various kinetic models were employed for the application of in vitro release profile assessment. The hardness of the tablet is found 4.3 to 6 kg, friability of the tablet is found 0.25 to 0.63%, disintegration time for the core tablet and the coated tablet are found 40 seconds and 1.30 seconds respectively. The results also show that the presence of active components in the formulated tablets are 100.31% Paracetamol and 101.12% Ibuprofen. We observed the potencies of the Paracetamol are 103.36% and 99.29% for Ibuprofen. All results of post formulation parameters were according to pharmacopoeias and within acceptable range. Based on fundamental comparative behavior of drug dissolution it can be concluded that release profile of all six batches under investigation was compatible with reference drug. In this present study as the newly formulated combination dosages regimen has met all the acceptance criteria and complied with the pharmacopoeial specifications and reference standard this formulation can be adapted as commercial preparation in Bangladesh for treatment of mild to moderately severe pain for post-operative patients.
Clinical Phytoscience
An amendment to this paper has been published and can be accessed via the original article.
Clinical Phytoscience
An amendment to this paper has been published and can be accessed via the original article.