Alan Edwards - Academia.edu (original) (raw)

Papers by Alan Edwards

Research paper thumbnail of Petroleum fuel containing tertiary alkanolamine ester

Research paper thumbnail of Trenchless Rehabilitation in the Tidal zone Rehabilitation of Sewer Systems in Coastal Communities

Proceedings of the Water Environment Federation, 2005

Research paper thumbnail of Production of float glass having an oxidized metal-modified surface

Research paper thumbnail of Load-lifting mast especially adapted for use with automatically-guided vehicles

Research paper thumbnail of Functional outcomes of MPFL reconstruction vs. graft tissue placement

The Iowa orthopaedic journal, 2014

The medial patellofemoral ligament (MPFL) is essential for the maintenance of correct biomechanic... more The medial patellofemoral ligament (MPFL) is essential for the maintenance of correct biomechanical function of the knee. Reconstruction of the MPFL is commonly used in the restoration of patellofemoral stability after traumatic lateral subluxation of the patella. Although a method to accurately determine the MPFL's insertion point has been described, it remains unclear if anatomic placement of MPFL graft tissue is essential for preservation of knee function after MPFL reconstruction. Thus, the purpose of this study was to determine the importance of anatomic placement of MPFL graft tissue for the preservation of knee function following MPFL reconstruction operations. Twenty-seven subjects who underwent MPFL reconstruction operations were retrospectively analyzed. Postoperative radiographs were reviewed. Measurements were taken, and the placement of each patient's MPFL graft tissue was determined to be anatomic or non-anatomic based on radiographic methods previously describ...

Research paper thumbnail of Ehlers-Danlos syndrome with vertebral artery aneurysm

Proceedings of the Royal Society of Medicine, Jan 7, 1969

Research paper thumbnail of Inhaled sodium cromoglycate in children with asthma

Thorax, 2002

We note with interest the further correspondence concerning the systematic review of inhaled sodi... more We note with interest the further correspondence concerning the systematic review of inhaled sodium cromoglycate as maintenance therapy in children with asthma 1 from Professor M Silverman 2 and Dr G Laszlo. 3 Professor Silverman asked the authors to carry out separate calculations of the size of the treatment effect between inhaled sodium cromoglycate and placebo for school children and preschool children. The results of these calculations show that the mean difference

Research paper thumbnail of Treatment of asthma in childhood

Respiratory Medicine, 1995

Research paper thumbnail of Retracted and replaced: Sodium cromoglicate: an ineffective drug or meta-analysis misused?

Pharmaceutical Statistics, 2007

The following article from Pharmaceutical Statistics, Sodium cromoglicate: an ineffective drug or... more The following article from Pharmaceutical Statistics, Sodium cromoglicate: an ineffective drug or meta-analysis misused? by M. T. Stevens, A. M. Edwards, J. B. L. Howell published online on 15 March 2007 in Wiley InterScience (www.interscience.wiley.com), has been retracted by agreement between the author, the journal Editor in Chief, Steven Julious, and John Wiley & Sons, Ltd. The retraction has been agreed because the article is not yet ready for publication and an early version without revisions was published in error. Replacement article pending. Copyright (c) 2007 John Wiley & Sons, Ltd.

Research paper thumbnail of A major breakpoint cluster domain in murine radiation-induced acute myeloid leukemia

Molecular Carcinogenesis, 2002

Cytogenetic and molecular studies have provided evidence of the clustering of chromosome 2 deleti... more Cytogenetic and molecular studies have provided evidence of the clustering of chromosome 2 deletion breakpoints in radiation-induced murine acute myeloid leukemia (AML). Moreover, clustering occurs in at least two fragile domains rich in telomere-like arrays. Here we describe a physical map of the distal breakpoint cluster and confirm the presence of inverted head-to-head telomeric sequence arrays. These potentially recombinogenic sequences were not, however, the direct focus for post-irradiation chromosome breakage in AML. Instead, the two arrays bordered a 2.5-kb sequence with properties expected of a nuclear matrix attachment region (MAR). The putative MAR co-localized in the fragile domain with genes important to the hemopoietic system (leukocyte tyrosine kinase, zinc finger protein 106, erythrocyte protein band 4.2, and beta(2)-microglobulin (beta2m)); the beta2m subdomain was a particular focus of breakage. On the basis of these and other data, we suggest that AML-associated chromosome 2 fragility in the mouse is a consequence of domain-specific fragility in genomic domains containing numerous genes critical to the hemopoietic system. Recorded with the permission of the controller of Her Majesty's Stationery Office. Published by Wiley-Liss, Inc.

Research paper thumbnail of Dissociation of CO2+2 ions into CO+ and O+ fragments

The Journal of Chemical Physics, 1983

Dissociative ionization of CO2 is further studied by the bombardment of 1-MeV He+ ions. The coinc... more Dissociative ionization of CO2 is further studied by the bombardment of 1-MeV He+ ions. The coincident detection of CO+ and O+ fragment pairs confirms the dissociative channel CO22+↠CO++O++6.0 eV which is the principal contributor to the ion yield. (AIP)

Research paper thumbnail of Fantasy and Early Phases of Self-Representation

Journal of Analytical Psychology, 1972

Research paper thumbnail of Immunosuppressant drugs in the treatment of allergic eye disease: do they have potential usage?

Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 2003

The conjunctivae of the eye are exposed to the same wide spectrum of airborne allergens as is the... more The conjunctivae of the eye are exposed to the same wide spectrum of airborne allergens as is the nasal and bronchial mucosa, and also exhibit the same inflammatory allergic responses as these other body surfaces. Immediate and late responses to allergens and delayed hypersensitivity reactions have all been described with the involvement of mast cells, eosinophils, neutrophils, macrophages and T lymphocytes and the numerous mediators released by these cells. The inflammatory conditions that result from these reactions are classified as acute allergic conjunctivitis, seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis and giant papillary conjunctivitis [1, 2]. Acute, seasonal and perennial allergic conjunctivitis are relatively mild conditions, can occur at any age, and are usually caused by exposure to allergens of plant or animal origin such as grass or tree pollens and house dust mite. The predominant inflammatory cells are mast cells and eosinophils. Vernal keratoconjunctivitis and atopic keratoconjunctivitis are, as the names imply, more severe inflammatory conditions involving the deeper layers of the eye. Vernal keratoconjunctivitis usually presents in boys less than 10 years of age. The symptoms are severe and distressing, intense itching, photophobia, blepharospasm and the production of thick tenacious mucus making it difficult to open the eyes in the mornings. The condition is characterized by subepithelial accumulations of lymphoid tissue forming papillary hypertrophic swellings – ‘cobblestones’. There is also infiltration with eosinophils, mast cells, macrophages and lymphocytes suggesting that both mast cell-IgE-and lymphocyte-mediated reactions are involved. Corneal erosion with plaques of mucus and fibrin preventing re-formation of the epithelium can occur and the resultant scarring is sight threatening. Atopic keratoconjunctivitis has a similar profile of inflammation to the vernal type but primarily affects young adults. Corneal ulceration and scarring can occur as can the development of keratoconus, which may require the patient to wear contact lenses to correct sight. Giant papillary conjunctivitis occurs in eyes in which the conjunctival surface is in contact with foreign material such as contact lenses. Clinically it has similar features to vernal keratoconjunctivitis. The treatment of acute allergic, seasonal allergic and perennial allergic conjunctivitis consists of avoidance of the responsible allergen where possible and the application of antihistamine and anti-inflammatory eyedrops. Antihistamine eyedrops are effective in relieving the itching, oedema and hyperaemia associated with immediate hypersensitivity responses. For more prolonged use, eyedrops containing one of the chromones, sodium cromoglycate or nedocromil sodium, have proven efficacy and safety. In cases of vernal and atopic keratoconjunctivitis, although the chromones can be of benefit in both, it is usually necessary to resort to prolonged treatment with topical corticosteroids. However, long-term topical corticosteroids, as in other clinical situations can result in serious adverse events. Ocular hypertension or glaucoma can affect up to 20% of patients and longer administration can result in cataracts plus the possibility of enhancing infection, in particular herpes simplex keratitis. Although topical corticosteroids are nearly always needed to treat vernal and atopic keratoconjunctivitis, the amount used and the length of treatment can often be reduced by the concomitant use of topical chromones. It would therefore be a major advance if an alternative antiinflammatory agent to corticosteroids became available, particularly if it had equivalent efficacy and without the long-term side-effects. In this issue of the journal, Sengoku et al. [3] from the Medicinal Biology Research Laboratories of Fujisawa Pharmaceutical Co. Ltd. in Japan report on a series of animal experiments in models of allergic eye disease using the immunosuppressant drug tacrolimus hydrate, also known as FK506. Tacrolimus hydrate is a macrolide extracted from the soil bacterium Streptomyces tsukubaensis [4]. It was developed originally as an immunosuppressant and is used worldwide to prevent liver and kidney allograft rejection. More recently, it has been approved in a number of countries as a topical skin ointment for the treatment of moderate to severe atopic dermatitis in adults. Sengoku et al. [3] report the effects of tacrolimus in animal models of late and delayed hypersensitivity reactions in the eye. A late response in rats and guinea pigs was induced by the topical application of egg albumin solution 2 weeks after the animals had been sensitized by intra-peritoneal injection of egg. Delayed responses were induced in rats, guinea pigs and rabbits by the injection of purified protein derivative into the palpebral conjunctivae 2 weeks after sensitization with subcutaneous injections of…

Research paper thumbnail of The response of the reticulo-endothelial system to a cancer

British Journal of Surgery, 1966

Research paper thumbnail of Preliminary Report on Transorbital Leucotomy

The British Journal of Psychiatry, 1950

One&amp…

Research paper thumbnail of Coeliac axis compression syndrome

Research paper thumbnail of In vitro stability of a novel compliant poly (carbonate‐urea) urethane to oxidative and hydrolytic stress

Journal of …, 2002

Linear segmented polyurethanes have many uses, mainly because of their mechanical and chemical pr... more Linear segmented polyurethanes have many uses, mainly because of their mechanical and chemical properties, including strength, flexibility, abrasion resistance, ease of handling, and hemocompatibility.1, 2 Because of these characteristics, their use has been rapidly ...

Research paper thumbnail of Petroleum fuel containing tertiary alkanolamine ester

Research paper thumbnail of Trenchless Rehabilitation in the Tidal zone Rehabilitation of Sewer Systems in Coastal Communities

Proceedings of the Water Environment Federation, 2005

Research paper thumbnail of Production of float glass having an oxidized metal-modified surface

Research paper thumbnail of Load-lifting mast especially adapted for use with automatically-guided vehicles

Research paper thumbnail of Functional outcomes of MPFL reconstruction vs. graft tissue placement

The Iowa orthopaedic journal, 2014

The medial patellofemoral ligament (MPFL) is essential for the maintenance of correct biomechanic... more The medial patellofemoral ligament (MPFL) is essential for the maintenance of correct biomechanical function of the knee. Reconstruction of the MPFL is commonly used in the restoration of patellofemoral stability after traumatic lateral subluxation of the patella. Although a method to accurately determine the MPFL's insertion point has been described, it remains unclear if anatomic placement of MPFL graft tissue is essential for preservation of knee function after MPFL reconstruction. Thus, the purpose of this study was to determine the importance of anatomic placement of MPFL graft tissue for the preservation of knee function following MPFL reconstruction operations. Twenty-seven subjects who underwent MPFL reconstruction operations were retrospectively analyzed. Postoperative radiographs were reviewed. Measurements were taken, and the placement of each patient's MPFL graft tissue was determined to be anatomic or non-anatomic based on radiographic methods previously describ...

Research paper thumbnail of Ehlers-Danlos syndrome with vertebral artery aneurysm

Proceedings of the Royal Society of Medicine, Jan 7, 1969

Research paper thumbnail of Inhaled sodium cromoglycate in children with asthma

Thorax, 2002

We note with interest the further correspondence concerning the systematic review of inhaled sodi... more We note with interest the further correspondence concerning the systematic review of inhaled sodium cromoglycate as maintenance therapy in children with asthma 1 from Professor M Silverman 2 and Dr G Laszlo. 3 Professor Silverman asked the authors to carry out separate calculations of the size of the treatment effect between inhaled sodium cromoglycate and placebo for school children and preschool children. The results of these calculations show that the mean difference

Research paper thumbnail of Treatment of asthma in childhood

Respiratory Medicine, 1995

Research paper thumbnail of Retracted and replaced: Sodium cromoglicate: an ineffective drug or meta-analysis misused?

Pharmaceutical Statistics, 2007

The following article from Pharmaceutical Statistics, Sodium cromoglicate: an ineffective drug or... more The following article from Pharmaceutical Statistics, Sodium cromoglicate: an ineffective drug or meta-analysis misused? by M. T. Stevens, A. M. Edwards, J. B. L. Howell published online on 15 March 2007 in Wiley InterScience (www.interscience.wiley.com), has been retracted by agreement between the author, the journal Editor in Chief, Steven Julious, and John Wiley &amp;amp;amp; Sons, Ltd. The retraction has been agreed because the article is not yet ready for publication and an early version without revisions was published in error. Replacement article pending. Copyright (c) 2007 John Wiley &amp;amp;amp; Sons, Ltd.

Research paper thumbnail of A major breakpoint cluster domain in murine radiation-induced acute myeloid leukemia

Molecular Carcinogenesis, 2002

Cytogenetic and molecular studies have provided evidence of the clustering of chromosome 2 deleti... more Cytogenetic and molecular studies have provided evidence of the clustering of chromosome 2 deletion breakpoints in radiation-induced murine acute myeloid leukemia (AML). Moreover, clustering occurs in at least two fragile domains rich in telomere-like arrays. Here we describe a physical map of the distal breakpoint cluster and confirm the presence of inverted head-to-head telomeric sequence arrays. These potentially recombinogenic sequences were not, however, the direct focus for post-irradiation chromosome breakage in AML. Instead, the two arrays bordered a 2.5-kb sequence with properties expected of a nuclear matrix attachment region (MAR). The putative MAR co-localized in the fragile domain with genes important to the hemopoietic system (leukocyte tyrosine kinase, zinc finger protein 106, erythrocyte protein band 4.2, and beta(2)-microglobulin (beta2m)); the beta2m subdomain was a particular focus of breakage. On the basis of these and other data, we suggest that AML-associated chromosome 2 fragility in the mouse is a consequence of domain-specific fragility in genomic domains containing numerous genes critical to the hemopoietic system. Recorded with the permission of the controller of Her Majesty&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s Stationery Office. Published by Wiley-Liss, Inc.

Research paper thumbnail of Dissociation of CO2+2 ions into CO+ and O+ fragments

The Journal of Chemical Physics, 1983

Dissociative ionization of CO2 is further studied by the bombardment of 1-MeV He+ ions. The coinc... more Dissociative ionization of CO2 is further studied by the bombardment of 1-MeV He+ ions. The coincident detection of CO+ and O+ fragment pairs confirms the dissociative channel CO22+↠CO++O++6.0 eV which is the principal contributor to the ion yield. (AIP)

Research paper thumbnail of Fantasy and Early Phases of Self-Representation

Journal of Analytical Psychology, 1972

Research paper thumbnail of Immunosuppressant drugs in the treatment of allergic eye disease: do they have potential usage?

Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 2003

The conjunctivae of the eye are exposed to the same wide spectrum of airborne allergens as is the... more The conjunctivae of the eye are exposed to the same wide spectrum of airborne allergens as is the nasal and bronchial mucosa, and also exhibit the same inflammatory allergic responses as these other body surfaces. Immediate and late responses to allergens and delayed hypersensitivity reactions have all been described with the involvement of mast cells, eosinophils, neutrophils, macrophages and T lymphocytes and the numerous mediators released by these cells. The inflammatory conditions that result from these reactions are classified as acute allergic conjunctivitis, seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis and giant papillary conjunctivitis [1, 2]. Acute, seasonal and perennial allergic conjunctivitis are relatively mild conditions, can occur at any age, and are usually caused by exposure to allergens of plant or animal origin such as grass or tree pollens and house dust mite. The predominant inflammatory cells are mast cells and eosinophils. Vernal keratoconjunctivitis and atopic keratoconjunctivitis are, as the names imply, more severe inflammatory conditions involving the deeper layers of the eye. Vernal keratoconjunctivitis usually presents in boys less than 10 years of age. The symptoms are severe and distressing, intense itching, photophobia, blepharospasm and the production of thick tenacious mucus making it difficult to open the eyes in the mornings. The condition is characterized by subepithelial accumulations of lymphoid tissue forming papillary hypertrophic swellings – ‘cobblestones’. There is also infiltration with eosinophils, mast cells, macrophages and lymphocytes suggesting that both mast cell-IgE-and lymphocyte-mediated reactions are involved. Corneal erosion with plaques of mucus and fibrin preventing re-formation of the epithelium can occur and the resultant scarring is sight threatening. Atopic keratoconjunctivitis has a similar profile of inflammation to the vernal type but primarily affects young adults. Corneal ulceration and scarring can occur as can the development of keratoconus, which may require the patient to wear contact lenses to correct sight. Giant papillary conjunctivitis occurs in eyes in which the conjunctival surface is in contact with foreign material such as contact lenses. Clinically it has similar features to vernal keratoconjunctivitis. The treatment of acute allergic, seasonal allergic and perennial allergic conjunctivitis consists of avoidance of the responsible allergen where possible and the application of antihistamine and anti-inflammatory eyedrops. Antihistamine eyedrops are effective in relieving the itching, oedema and hyperaemia associated with immediate hypersensitivity responses. For more prolonged use, eyedrops containing one of the chromones, sodium cromoglycate or nedocromil sodium, have proven efficacy and safety. In cases of vernal and atopic keratoconjunctivitis, although the chromones can be of benefit in both, it is usually necessary to resort to prolonged treatment with topical corticosteroids. However, long-term topical corticosteroids, as in other clinical situations can result in serious adverse events. Ocular hypertension or glaucoma can affect up to 20% of patients and longer administration can result in cataracts plus the possibility of enhancing infection, in particular herpes simplex keratitis. Although topical corticosteroids are nearly always needed to treat vernal and atopic keratoconjunctivitis, the amount used and the length of treatment can often be reduced by the concomitant use of topical chromones. It would therefore be a major advance if an alternative antiinflammatory agent to corticosteroids became available, particularly if it had equivalent efficacy and without the long-term side-effects. In this issue of the journal, Sengoku et al. [3] from the Medicinal Biology Research Laboratories of Fujisawa Pharmaceutical Co. Ltd. in Japan report on a series of animal experiments in models of allergic eye disease using the immunosuppressant drug tacrolimus hydrate, also known as FK506. Tacrolimus hydrate is a macrolide extracted from the soil bacterium Streptomyces tsukubaensis [4]. It was developed originally as an immunosuppressant and is used worldwide to prevent liver and kidney allograft rejection. More recently, it has been approved in a number of countries as a topical skin ointment for the treatment of moderate to severe atopic dermatitis in adults. Sengoku et al. [3] report the effects of tacrolimus in animal models of late and delayed hypersensitivity reactions in the eye. A late response in rats and guinea pigs was induced by the topical application of egg albumin solution 2 weeks after the animals had been sensitized by intra-peritoneal injection of egg. Delayed responses were induced in rats, guinea pigs and rabbits by the injection of purified protein derivative into the palpebral conjunctivae 2 weeks after sensitization with subcutaneous injections of…

Research paper thumbnail of The response of the reticulo-endothelial system to a cancer

British Journal of Surgery, 1966

Research paper thumbnail of Preliminary Report on Transorbital Leucotomy

The British Journal of Psychiatry, 1950

One&amp…

Research paper thumbnail of Coeliac axis compression syndrome

Research paper thumbnail of In vitro stability of a novel compliant poly (carbonate‐urea) urethane to oxidative and hydrolytic stress

Journal of …, 2002

Linear segmented polyurethanes have many uses, mainly because of their mechanical and chemical pr... more Linear segmented polyurethanes have many uses, mainly because of their mechanical and chemical properties, including strength, flexibility, abrasion resistance, ease of handling, and hemocompatibility.1, 2 Because of these characteristics, their use has been rapidly ...