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Papers by Alexander Melamud
Retina-the Journal of Retinal and Vitreous Diseases, May 30, 2023
Retinal Cases & Brief Reports, Apr 20, 2023
American Journal of Ophthalmology, 2015
To examine the visual outcomes of early intervention in the setting of fundus-obscuring vitreous ... more To examine the visual outcomes of early intervention in the setting of fundus-obscuring vitreous hemorrhage (VH) presumed to be due to posterior vitreous detachment. DESIGN: Retrospective comparative case series. METHODS: All eyes that presented with a fundusobscuring VH, defined as vision of 20/400 or worse and requiring a B-scan at presentation from 2003 to 2013, were evaluated. Eyes with any history of retinopathy, macular degeneration, recent trauma, presentation greater than 2 weeks after onset of symptoms, or follow-up of less than 2 months were excluded. The main outcome measure studied was final best-corrected visual acuity (BCVA) as dependent on the time to surgery. RESULTS: Ninety-two eyes met inclusion criteria with a mean follow-up of 490 days. Initial BCVA was logMAR 2.218 (Snellen equivalent 20/3000-20/4000, range 20/ 400-light perception); final BCVA was 0.318 (Snellen equivalent of 20/40-20/50, range 20/20-light perception, P < .001). Fifty-six patients (60.8%) had either a retinal tear or a retinal detachment. Patients who underwent surgery within 1 week had no significant improvement over all others; however, a significant improvement was found when comparing early vs delayed surgery groups (P < .05). There was a significantly increased risk of developing a macula-off retinal detachment in patients who did not undergo surgery within 1 week of presentation. CONCLUSIONS: Early surgical intervention results in similar visual outcomes compared to a conservative approach. However, early intervention significantly reduces the incidence of severe vision loss related to macula-involving retinal detachment. This study highlights the importance of close follow-up given the high risk of retinal detachment in fundus-obscuring vitreous hemorrhage.
Nepalese Journal of Ophthalmology, 2011
Introduction: Retinal detachment remains one of the most serious complications of cataract surger... more Introduction: Retinal detachment remains one of the most serious complications of cataract surgery. Treatment of this condition has represented a challenge for vitreoretinal surgeons. Scleral buckle (SB) surgery is one of the treatment options in pseudophakic and aphakic retinal detachment (RD). Aims: To find out the anatomical and visual outcome of SB in pseudophakic and aphakic RD. Subjects and methods: Retrospective case series of 46 consecutive eyes of 46 patients with RD (38 pseudophakic and 8 aphakic eyes) that had undergone conventional SB surgery were reviewed from patient files. Postoperative retinal status at 3 weeks, 6 weeks and 3 months were recorded to see the anatomical success rate after retinal reattachment surgery. Best corrected visual acuity (BCVA) at 3 months follow-up was noted. Results: The mean age of the patients was 54.28 ± 13.49 years. Forty eyes (86.9 %) had primary attachment by 6 weeks duration. Five eyes had undergone repeat surgery within a six-week du...
Investigative Ophthalmology & Visual Science, 2013
Ophthalmic Surgery, Lasers and Imaging Retina
Digital Journal of Ophthalmology
We present a novel case of a 67-year-old man who developed a full-thickness macular hole in the p... more We present a novel case of a 67-year-old man who developed a full-thickness macular hole in the presence of a microbubble after repair of rhegmatogenous retinal detachment.
To describe the correlation between coma, a higher order optical aberration, and monocular diplop... more To describe the correlation between coma, a higher order optical aberration, and monocular diplopia in three eyes
Investigative Ophthalmology & Visual Science, 2011
Investigative Ophthalmology & Visual Science, 2017
Ocular Immunology and Inflammation, 2017
Journal of VitreoRetinal Diseases, 2017
Purpose: To identify risk factors associated with endophthalmitis after pars plana vitrectomy (PP... more Purpose: To identify risk factors associated with endophthalmitis after pars plana vitrectomy (PPV) surgery. Methods: All eyes that presented with endophthalmitis after PPV from 2005 to 2015 in a community-based vitreoretinal subspecialty practice were evaluated using a retrospective nested case–control study. Exclusion criteria were presentation more than 6 weeks post-PPV, less than 3 months of follow-up, history of globe trauma, age less than 18, and history of trabeculectomy surgery. Controls were randomly selected among a population of patients who underwent PPV and did not develop endophthalmitis. Univariate and multivariate regression analyses were performed to evaluate the following perioperative risk factors: use of sclerotomy suture, use of subconjunctival antibiotics, use of endotamponade, presence of postoperative hypotony, and the use of small- versus large-gauge vitrectomy. Results: Thirty-two patients and 150 controls met inclusion criteria. The average time to presentation with endophthalmitis was 5 days after PPV. Endotamponade usage was the only variable that had significant impact on the risk of developing endophthalmitis in univariate and multivariate analyses. The odds ratio of disease in patients with endotamponade over patients without endotamponade was 0.15 (95% confidence interval: 0.06-40); thus, the odds of disease for patients with endotamponade were 85% lower than those without endotamponade. Median visual acuity significantly improved from 20 of 8000 at the time of diagnosis with endophthalmitis to 20 of 50 at 1-year follow-up (P < .001). Conclusion: The use of intraocular endotamponade may reduce the rate of endophthalmitis after PPV surgery.
American journal of ophthalmology, Jan 14, 2016
To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination w... more To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral-suturing of posterior chamber lens (PCIOL). Retrospective comparative case series. All eyes presented with aphakia, luxated, or subluxated posterior chamber intraocular lens (IOL) following complicated cataract surgery, trauma, or spontaneous dislocation. Eyes involving visually significant macular pathology; past retinal detachment; follow up of less than six months; and surgeries requiring the removal of an ACIOL were excluded. The main outcomes measured were final best visual acuity (BCVA) and surgical complication rates. 57 eyes met inclusion criteria with a median follow-up of 13.2 months. Initial median BCVA for ACIOL patients was logMAR 1.301(Snellen equivalent 20/400 range 20/20- light perception); final median BCVA was logMAR 0.477 (Snellen equivalent of 20/60 range 20/20 - light perception, p < 0.00...
Ophthalmology, 2015
Objective-To evaluate the association of subretinal hyper-reflective material (SHRM) with visual ... more Objective-To evaluate the association of subretinal hyper-reflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar in the Comparison of Age related Macular Degeneration Treatments Trials (CATT) Design-Prospective cohort study within a randomized clinical trial. Participants-The 1185 participants in CATT. Methods-Participants were randomly assigned to ranibizumab or bevacizumab treatment monthly or as-needed. Masked readers graded scar and GA on fundus photography and fluorescein angiography images, SHRM on time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width
Retina, 2015
Purpose: To evaluate whether patients with macular pucker (epiretinal membrane [ERM]) and good pr... more Purpose: To evaluate whether patients with macular pucker (epiretinal membrane [ERM]) and good preoperative visual acuity (20/50 or better) benefit from small-gauge pars plana vitrectomy with membrane peeling. Methods: Retrospective chart review of eyes undergoing small-gauge pars plana vitrectomy for ERM. Inclusion criterion was impaired visual acuity (20/50 or better) due to ERM. Exclusion criteria were preoperative visual acuity of 20/60 or worse, previous surgery (other than uncomplicated cataract surgery), and any documented evidence of macular or corneal disease that would limit visual potential. The main outcome measure was final visual acuity. Secondary outcomes included the role of internal limiting membrane peeling, and the effect of preoperative cystoid macular edema and internal limiting membrane peeling on visual acuity. Results: One hundred and forty eyes met inclusion criteria of which 94% underwent 25-gauge vitrectomy (remainder had 23-gauge). There was a statistically significant improvement in final vision with the mean preoperative visual acuity of 0.305 logMAR (20/40) and 1-year visual acuity of 0.250 logMAR (20/35) (P = 0.0167). Cataract formation in phakic patients had a significant effect on the final visual outcome. Fifty-six of 63 patients (89%) in the phakic cohort developed a visually significant cataract by study end. The mean time to recommendation of cataract surgery was 8.4 months. Thirty-eight eyes (27%) had preoperative cystoid macular edema. Fifty-nine eyes (42%) underwent internal limiting membrane peeling. Neither one of these secondary outcome measures had a significant effect on the final visual outcome. Conclusion: Pars plana vitrectomy is both efficacious and safe an option for patients with ERMs and good preoperative vision. Eyes with an ERM and vision 20/50 or better had a statistically significant improvement in the final visual outcome after small-gauge pars plana vitrectomy surgery. As with large-gauge vitrectomy, cataract formation occurred in most phakic eyes within the first year after surgery.
Ophthalmic surgery, lasers & imaging retina, 2015
A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surger... more A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surgery, with retinal hemorrhages and vascular changes in the absence of pain or significant inflammation. She had undergone uncomplicated 25-gauge pars plana vitrectomy for epiretinal membrane with presenting visual acuity of 20/40- and significant distortion. Vitreous culture revealed Staphylococcus epidermidis. Final visual acuity was no light perception with persistent pain, and the patient ultimately underwent enucleation. Although rarely, acute-onset postoperative endophthalmitis can present as retinal vasculitis with intraretinal hemorrhages and mild inflammation. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:393-395.].
Ophthalmic surgery, lasers & imaging retina, 2015
A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surger... more A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surgery, with retinal hemorrhages and vascular changes in the absence of pain or significant inflammation. She had undergone uncomplicated 25-gauge pars plana vitrectomy for epiretinal membrane with presenting visual acuity of 20/40- and significant distortion. Vitreous culture revealed Staphylococcus epidermidis. Final visual acuity was no light perception with persistent pain, and the patient ultimately underwent enucleation. Although rarely, acute-onset postoperative endophthalmitis can present as retinal vasculitis with intraretinal hemorrhages and mild inflammation. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:393-395.].
Retina-the Journal of Retinal and Vitreous Diseases, May 30, 2023
Retinal Cases & Brief Reports, Apr 20, 2023
American Journal of Ophthalmology, 2015
To examine the visual outcomes of early intervention in the setting of fundus-obscuring vitreous ... more To examine the visual outcomes of early intervention in the setting of fundus-obscuring vitreous hemorrhage (VH) presumed to be due to posterior vitreous detachment. DESIGN: Retrospective comparative case series. METHODS: All eyes that presented with a fundusobscuring VH, defined as vision of 20/400 or worse and requiring a B-scan at presentation from 2003 to 2013, were evaluated. Eyes with any history of retinopathy, macular degeneration, recent trauma, presentation greater than 2 weeks after onset of symptoms, or follow-up of less than 2 months were excluded. The main outcome measure studied was final best-corrected visual acuity (BCVA) as dependent on the time to surgery. RESULTS: Ninety-two eyes met inclusion criteria with a mean follow-up of 490 days. Initial BCVA was logMAR 2.218 (Snellen equivalent 20/3000-20/4000, range 20/ 400-light perception); final BCVA was 0.318 (Snellen equivalent of 20/40-20/50, range 20/20-light perception, P < .001). Fifty-six patients (60.8%) had either a retinal tear or a retinal detachment. Patients who underwent surgery within 1 week had no significant improvement over all others; however, a significant improvement was found when comparing early vs delayed surgery groups (P < .05). There was a significantly increased risk of developing a macula-off retinal detachment in patients who did not undergo surgery within 1 week of presentation. CONCLUSIONS: Early surgical intervention results in similar visual outcomes compared to a conservative approach. However, early intervention significantly reduces the incidence of severe vision loss related to macula-involving retinal detachment. This study highlights the importance of close follow-up given the high risk of retinal detachment in fundus-obscuring vitreous hemorrhage.
Nepalese Journal of Ophthalmology, 2011
Introduction: Retinal detachment remains one of the most serious complications of cataract surger... more Introduction: Retinal detachment remains one of the most serious complications of cataract surgery. Treatment of this condition has represented a challenge for vitreoretinal surgeons. Scleral buckle (SB) surgery is one of the treatment options in pseudophakic and aphakic retinal detachment (RD). Aims: To find out the anatomical and visual outcome of SB in pseudophakic and aphakic RD. Subjects and methods: Retrospective case series of 46 consecutive eyes of 46 patients with RD (38 pseudophakic and 8 aphakic eyes) that had undergone conventional SB surgery were reviewed from patient files. Postoperative retinal status at 3 weeks, 6 weeks and 3 months were recorded to see the anatomical success rate after retinal reattachment surgery. Best corrected visual acuity (BCVA) at 3 months follow-up was noted. Results: The mean age of the patients was 54.28 ± 13.49 years. Forty eyes (86.9 %) had primary attachment by 6 weeks duration. Five eyes had undergone repeat surgery within a six-week du...
Investigative Ophthalmology & Visual Science, 2013
Ophthalmic Surgery, Lasers and Imaging Retina
Digital Journal of Ophthalmology
We present a novel case of a 67-year-old man who developed a full-thickness macular hole in the p... more We present a novel case of a 67-year-old man who developed a full-thickness macular hole in the presence of a microbubble after repair of rhegmatogenous retinal detachment.
To describe the correlation between coma, a higher order optical aberration, and monocular diplop... more To describe the correlation between coma, a higher order optical aberration, and monocular diplopia in three eyes
Investigative Ophthalmology & Visual Science, 2011
Investigative Ophthalmology & Visual Science, 2017
Ocular Immunology and Inflammation, 2017
Journal of VitreoRetinal Diseases, 2017
Purpose: To identify risk factors associated with endophthalmitis after pars plana vitrectomy (PP... more Purpose: To identify risk factors associated with endophthalmitis after pars plana vitrectomy (PPV) surgery. Methods: All eyes that presented with endophthalmitis after PPV from 2005 to 2015 in a community-based vitreoretinal subspecialty practice were evaluated using a retrospective nested case–control study. Exclusion criteria were presentation more than 6 weeks post-PPV, less than 3 months of follow-up, history of globe trauma, age less than 18, and history of trabeculectomy surgery. Controls were randomly selected among a population of patients who underwent PPV and did not develop endophthalmitis. Univariate and multivariate regression analyses were performed to evaluate the following perioperative risk factors: use of sclerotomy suture, use of subconjunctival antibiotics, use of endotamponade, presence of postoperative hypotony, and the use of small- versus large-gauge vitrectomy. Results: Thirty-two patients and 150 controls met inclusion criteria. The average time to presentation with endophthalmitis was 5 days after PPV. Endotamponade usage was the only variable that had significant impact on the risk of developing endophthalmitis in univariate and multivariate analyses. The odds ratio of disease in patients with endotamponade over patients without endotamponade was 0.15 (95% confidence interval: 0.06-40); thus, the odds of disease for patients with endotamponade were 85% lower than those without endotamponade. Median visual acuity significantly improved from 20 of 8000 at the time of diagnosis with endophthalmitis to 20 of 50 at 1-year follow-up (P < .001). Conclusion: The use of intraocular endotamponade may reduce the rate of endophthalmitis after PPV surgery.
American journal of ophthalmology, Jan 14, 2016
To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination w... more To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral-suturing of posterior chamber lens (PCIOL). Retrospective comparative case series. All eyes presented with aphakia, luxated, or subluxated posterior chamber intraocular lens (IOL) following complicated cataract surgery, trauma, or spontaneous dislocation. Eyes involving visually significant macular pathology; past retinal detachment; follow up of less than six months; and surgeries requiring the removal of an ACIOL were excluded. The main outcomes measured were final best visual acuity (BCVA) and surgical complication rates. 57 eyes met inclusion criteria with a median follow-up of 13.2 months. Initial median BCVA for ACIOL patients was logMAR 1.301(Snellen equivalent 20/400 range 20/20- light perception); final median BCVA was logMAR 0.477 (Snellen equivalent of 20/60 range 20/20 - light perception, p < 0.00...
Ophthalmology, 2015
Objective-To evaluate the association of subretinal hyper-reflective material (SHRM) with visual ... more Objective-To evaluate the association of subretinal hyper-reflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar in the Comparison of Age related Macular Degeneration Treatments Trials (CATT) Design-Prospective cohort study within a randomized clinical trial. Participants-The 1185 participants in CATT. Methods-Participants were randomly assigned to ranibizumab or bevacizumab treatment monthly or as-needed. Masked readers graded scar and GA on fundus photography and fluorescein angiography images, SHRM on time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width
Retina, 2015
Purpose: To evaluate whether patients with macular pucker (epiretinal membrane [ERM]) and good pr... more Purpose: To evaluate whether patients with macular pucker (epiretinal membrane [ERM]) and good preoperative visual acuity (20/50 or better) benefit from small-gauge pars plana vitrectomy with membrane peeling. Methods: Retrospective chart review of eyes undergoing small-gauge pars plana vitrectomy for ERM. Inclusion criterion was impaired visual acuity (20/50 or better) due to ERM. Exclusion criteria were preoperative visual acuity of 20/60 or worse, previous surgery (other than uncomplicated cataract surgery), and any documented evidence of macular or corneal disease that would limit visual potential. The main outcome measure was final visual acuity. Secondary outcomes included the role of internal limiting membrane peeling, and the effect of preoperative cystoid macular edema and internal limiting membrane peeling on visual acuity. Results: One hundred and forty eyes met inclusion criteria of which 94% underwent 25-gauge vitrectomy (remainder had 23-gauge). There was a statistically significant improvement in final vision with the mean preoperative visual acuity of 0.305 logMAR (20/40) and 1-year visual acuity of 0.250 logMAR (20/35) (P = 0.0167). Cataract formation in phakic patients had a significant effect on the final visual outcome. Fifty-six of 63 patients (89%) in the phakic cohort developed a visually significant cataract by study end. The mean time to recommendation of cataract surgery was 8.4 months. Thirty-eight eyes (27%) had preoperative cystoid macular edema. Fifty-nine eyes (42%) underwent internal limiting membrane peeling. Neither one of these secondary outcome measures had a significant effect on the final visual outcome. Conclusion: Pars plana vitrectomy is both efficacious and safe an option for patients with ERMs and good preoperative vision. Eyes with an ERM and vision 20/50 or better had a statistically significant improvement in the final visual outcome after small-gauge pars plana vitrectomy surgery. As with large-gauge vitrectomy, cataract formation occurred in most phakic eyes within the first year after surgery.
Ophthalmic surgery, lasers & imaging retina, 2015
A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surger... more A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surgery, with retinal hemorrhages and vascular changes in the absence of pain or significant inflammation. She had undergone uncomplicated 25-gauge pars plana vitrectomy for epiretinal membrane with presenting visual acuity of 20/40- and significant distortion. Vitreous culture revealed Staphylococcus epidermidis. Final visual acuity was no light perception with persistent pain, and the patient ultimately underwent enucleation. Although rarely, acute-onset postoperative endophthalmitis can present as retinal vasculitis with intraretinal hemorrhages and mild inflammation. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:393-395.].
Ophthalmic surgery, lasers & imaging retina, 2015
A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surger... more A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surgery, with retinal hemorrhages and vascular changes in the absence of pain or significant inflammation. She had undergone uncomplicated 25-gauge pars plana vitrectomy for epiretinal membrane with presenting visual acuity of 20/40- and significant distortion. Vitreous culture revealed Staphylococcus epidermidis. Final visual acuity was no light perception with persistent pain, and the patient ultimately underwent enucleation. Although rarely, acute-onset postoperative endophthalmitis can present as retinal vasculitis with intraretinal hemorrhages and mild inflammation. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:393-395.].