Alexander Shtemenko - Academia.edu (original) (raw)
Papers by Alexander Shtemenko
Chemistry Journal of Moldova, 2007
The interaction of cis-Re2(RCOO)2Cl4, trans-Re2(RCOO)2Cl4, Re2(RCOO)3Cl3 and Re2(RCOO)4Cl2 (where... more The interaction of cis-Re2(RCOO)2Cl4, trans-Re2(RCOO)2Cl4, Re2(RCOO)3Cl3 and Re2(RCOO)4Cl2 (where R - alkyl group) with 1,3,5-triphenylverdazyle radical in 1,2-dichlorethane was investigated. It is discovered, that gradual substitution of halogenide ligands by carboxylates in dirhenium(III) clusters led to slowing down of reaction with a radical due to different influence of these ligands on parameters of rhenium - rhenium bond. Presented data showed perspectivity of Re26+-substances applications as therapeutic agents due to their low toxicity and antiradical properties that occured by δ-component of quadruple Re-Re bond electron transition.
![Research paper thumbnail of Crystal structure of di-μ-isobutyrato-κ4O:O′-bis[cis-dichlorido(dimethyl sulfoxide-κS)rhenium(III)]](https://attachments.academia-assets.com/111453477/thumbnails/1.jpg)
](Acta Crystallographica Section E Crystallographic Communications, 2015
The title compound, [Re2(C3H7COO)2Cl4{(CH3)2SO}2], comprises binuclear complex molecules [Re—Re =... more The title compound, [Re2(C3H7COO)2Cl4{(CH3)2SO}2], comprises binuclear complex molecules [Re—Re = 2.24502 (13) Å] involvingcis-oriented double carboxylate bridges, four equatorial chloride ions and two weakly bonded O atoms from dimethyl sulfoxide ligands in the axial positions at the ReIIIatoms. In the crystal, molecules are linked into corrugated layers parallel to (101) by very weak C—H...Cl and C—H...O hydrogen-bonding interactions. C—H...Cl hydrogen bonding provides the links between layers to consolidate a three-dimensional framework.
ScienceRise: Biological Science, 2020
The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- ... more The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- and trans-diadamanthylcarboxylates of dirhenium(III) alone and together with cisplatin in form of nanobins.Materials and methods. Model of tumor growth, Guerin’s carcinoma; intraperitoneal administration of cisplatin, dirhenium(III) compounds in liposomes and of binary liposomes, containing both cytostatics; volumes and final weights of tumors were measured.Results. In vivo antitumor properties of two dirhenium(III) dicarboxylates with 1-adamantanecarboxylic acid moieties as ligands with cis- (I) and trans- (II) orientation of the carboxylic groups around a cluster fragment alone and together with cisplatin were presented; an attempt to understand differences in a possible mechanism of anticancer activity of the substances were undertaken. Antiradical and DNA-binding properties of I and II were the matter of consideration.Conclusions. Cis- and trans- compounds of dirhenium I and II had c...
Journal of Inorganic Biochemistry, 2021
The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), ... more The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G-quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer - melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also strong stabilization activity to HTelo21 quadruplex. At the same time, the compounds do not show any stabilization activity for ds26 DNA, which suggests unique mechanisms of molecular DNA recognition for these complexes.
Acta Chimica Slovenica, 2020
Present work reports the synthesis of zirconium phosphate nanoparticles containing dirhenium(III)... more Present work reports the synthesis of zirconium phosphate nanoparticles containing dirhenium(III) substance bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III) with formula cis-Re 2 (C(CH 3) 3 COO) 2 Cl 4 • 2DMSO (I) and θ-zirconium phosphate with formula θ-Zr(HPO 4) 2 • 6H 2 O (ZrP). The intercalation process was monitored by EAS. Due to the spectral characteristics of the quadruple bond the conclusion was made that the obtained intercalated compounds had cis-configuration of ligands around cluster dirhenium fragment. The proposed mechanism of intercalation includes the substitution of the axial ligands of I by phosphate groups of ZrP first on the surface of ZrP, than in the inner layers. Two received products of the intercalation were characterized by SEM, XRPD, FT-IR, TGA analysis witnessing about successful intercalation process. The formation of new phases with interlayer distances of 10.53-16.6 Å was found, the average size of obtained platelets was 100-200 nm.
Acta Crystallographica Section C Structural Chemistry, 2020
Anion...π interactions are newly recognized weak supramolecular forces which are relevant to many... more Anion...π interactions are newly recognized weak supramolecular forces which are relevant to many types of electron-deficient aromatic substrates. Being less competitive with respect to conventional hydrogen bonding, anion...π interactions are only rarely considered as a crystal-structure-defining factor. Their significance dramatically increases for polyoxometalate (POM) species, which offer extended oxide surfaces for maintaining dense aromatic/inorganic stacks. The structures of tetrakis(caffeinium) μ12-silicato-tetracosa-μ2-oxido-dodecaoxidododecatungsten trihydrate, (C8H11N4O2)4[SiW12O40]·3H2O, (1), and tris(theobrominium) μ12-phosphato-tetracosa-μ2-oxido-dodecaoxidododecatungsten ethanol sesquisolvate, (C7H9N4O2)3[PW12O40]·1.5C2H5OH, (2), support the utility of anion...π interactions as a special kind of supramolecular synthon controlling the structures of ionic lattices. Both caffeinium [(HCaf)+ in (1)] and theobrominium cations [(HTbr)+ in (2)] reveal double stacking pattern...
Journal of Raman Spectroscopy, 2017
![Research paper thumbnail of Face-to-face stacking of caffeinium and [PMVI12O40]3− ions: A synthon for crystal engineering with purine bases](https://attachments.academia-assets.com/107451881/thumbnails/1.jpg)
](Inorganic Chemistry Communications, 2018
Weak anion-π bonding dominates interaction of caffeinium and [PM 12 O 40 ] 3− (M = Mo, W) ions an... more Weak anion-π bonding dominates interaction of caffeinium and [PM 12 O 40 ] 3− (M = Mo, W) ions and favors assembly of high-symmetry non-covalent frameworks.
Ukrainian Chemistry Journal, 2019
Using the method of differential thermal analysis and the method of isothermal effects, we invest... more Using the method of differential thermal analysis and the method of isothermal effects, we investigated the thermal transformations of the inter-calation products of representatives of dirhenium(III) complexes of all structural types into the interlayer space of zirconium phosphate. Each of the samples was heated in the temperature range from 40 to 500 C. On the obtained thermograms of the samples, two main endothermic effects were observed, the first of which corresponds to the separation of water of crystallization from zirconium phosphate, and the second to the thermal transformations of dirhe-nium(III) complexes. The first weight loss for all intercalation products was 8.87–9.80%, that is, the percentage of water in the post samples was the same. The weight loss corresponding to the thermal transformation of dirhenium(III) complexes in the obtained nanoparticles was 6.15–11.24 and 12.30–29.90 % for molar ratios of the substance / zirco-nium phosphate, respectively, 1:30 and 1:5,...
Odesa National University Herald. Chemistry, 2019
Ukrainian Chemistry Journal, 2019
Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to... more Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectroscopy (EAS) is a reliable method of investigation to study the hydrolysis of rhenium (III) complex compounds. This conclusion is based on the fact that in the systems with halide and carboxylic ligands, each of the five structural types can be clearly identified by the EAS in the region of both d–d* electron transition and charge transfer transition of L*Hal ®Re type. It is shown that with the increase in the length of the alkyl group and in its branching, the hydrolysis rate decreases, as a result of a change in the positive inductive effect of these groups and, consequently, an increase in the strengthening of quadruple Re–Re bond. In add...
Chemistry & Chemical Technology, 2011
Influence of complex compounds of nickel(II), copper(II) and zinc(II) with nitrogen containing li... more Influence of complex compounds of nickel(II), copper(II) and zinc(II) with nitrogen containing ligands on conductivity of bilayer lipid membranes (BLMs) was studied. The role of conditions (pH, metal and ligand concentration) on complex formation and interaction with BLMs was evaluated. Composition and form of complex ions in solution which maximally change conductivity have been calculated. Relationship between the complex form predominant in the solution and BLM conductivity indicated that complex ions influence mostly depended on surrounding ligands and did not depend on the nature of the central atom. Permeability coefficients for complex ions which maximally changed BLM conductivity were calculated.
![Research paper thumbnail of Synthesis of Novel Tetracarboxylato Dirhenium(III) Compounds and Crystal Structure of [Re2(1-Adamantylcarboxylate)4Cl2] · 4 CHCl3](https://attachments.academia-assets.com/107451877/thumbnails/1.jpg)
](Zeitschrift für Naturforschung B, 2001
The coordination compounds o f the general formula Re2 (L)4X2 (X = Cl, Br; L = 1 -adamantyl-carbo... more The coordination compounds o f the general formula Re2 (L)4X2 (X = Cl, Br; L = 1 -adamantyl-carboxylate and 1 -adamantylacetate) have been prepared and characterized by means of UV-VIS spectroscopy (20000 cm-1 , δ → δ*). The crystal and molecular structure of Re2(AdCOO)4Cl2 · 4 CHCl3 solvate was determined by X-ray diffraction. The units Re2(AdCOO)4Cl2 adopt a centrosymmetric dinuclear array with each metal atom coordinated in a distorted octahedron comprising one rhenium and one chlorine atoms (Re-Cl 2.505(2) Å) and four carboxylate oxygen atoms in the equatorial plane. The rhenium-rhenium separation of 2.2300(5) Å corresponds to quadruple bond between the metal atoms. All R e-0 bonds have an almost uniform length (2.017(4) -2.032(4) Å) and do not differ essentially from the parameters reported for related compounds. The closest environment of the Re2(AdCOO)4Cl2 molecules in the crystal comprises weak Cl---HC hydrogen bonds with the chloroform molecules and significantly shortened ...
Journal of Inorganic Biochemistry, 2017
A series of N-alkylaminoferrocene-based prodrugs were prepared A derivative with an N-propargyl... more A series of N-alkylaminoferrocene-based prodrugs were prepared A derivative with an N-propargyl residue was found to have the optimal properties The optimized prodrug exhibited relatively low lipophilicity and high water solubility The activity of the prodrug in selected cancer cell lines was in the range of 15-31 µM The optimized prodrug exhibited high antitumor activity in vivo (rat, T8 carcinoma).
New J. Chem., 2016
In order to obtain unknown thermodynamic properties, such as enthalpy of formation, of trans-tetr... more In order to obtain unknown thermodynamic properties, such as enthalpy of formation, of trans-tetrachlorodi-μ-carboxylate dirhenium(iii) (trans-[Re2Cl4(RCOO)2] (R = C2H5; C3H7; (CH3)2CH; (CH3)3C)), exothermic reactions of burning in oxygen were investigated.
![Research paper thumbnail of Crystal structure of bis(ethylenedithio)tetrathiafulvalenium μ2-acetato-bis[tribromidorhenate(III)] 1,1,2-trichloroethane hemisolvate](https://attachments.academia-assets.com/107451850/thumbnails/1.jpg)
](Acta Crystallographica Section E Crystallographic Communications, 2016
The asymmetric unit of the title salt, (C10H8S8)[Re2Br6(CH3COO)]·0.5C2H3Cl3, contains one bis(eth... more The asymmetric unit of the title salt, (C10H8S8)[Re2Br6(CH3COO)]·0.5C2H3Cl3, contains one bis(ethylenedithio)tetrathiafulvalene (ET) radical cation, one μ2-acetato-bis[tribromidorhenate(III)] anion and a 1,1,2-trichloroethane molecule with half-occupancy disordered about a twofold rotation axis. The tetrathiafulvalene fragment adopts an almost planar configuration typical of the ET radical cation. The C atoms of both ethylenedithio fragments in the cation are disordered over two orientations with occupancy factors 0.65:0.35 and 0.77:0.23. In the anion, six Br atoms and a μ2-acetate ligand form a strongly distorted cubic O2Br6coordination polyhedron around the Re2dinuclear centre. In the crystal, centrosymmetrically related ET cations and Re2O2Br6anions are linked into dimers by π–π stacking interactions [centroid-to-centroid distance = 3.826 (8) Å] and by pairs of additional Re...Br contacts [3.131 (3) Å], respectively. The dimers are further packed into a three-dimensional network ...
Polyhedron, 2015
Abstract The new fac -[Re(CO) 3 ] + complexes with bidentate ligands (5-phenyl-3-(pyridin-2-yl)-1... more Abstract The new fac -[Re(CO) 3 ] + complexes with bidentate ligands (5-phenyl-3-(pyridin-2-yl)-1,2,4-triazole L1 ; 5-(2-aminophenyl)- 3-(pyridin-2-yl)-1,2,4-triazole L2 ; 5-(2-hydroxyphenyl)-3-(pyridin-2-yl)-1,2,4-triazole L3 ; 5-phenyl-2-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline L4 ) were obtained by refluxing [Re(CO) 5 Br] and the ligand in benzene for 5 h. These complexes were characterized by 1 H NMR, elemental analysis, ESI–mass spectrometry and IR spectra. Molecular structures of two complexes were confirmed by X-ray crystallography. The complexes show luminescence emission with large Stokes shifts ( λ ex = 365 nm, λ em = 506–620 nm).
Journal of Inorganic Biochemistry, 2015
Synthesis and X-ray crystal structure of the dirhenium complex Re 2 (i-C 3 H 7 COO) 4 Cl 2 and it... more Synthesis and X-ray crystal structure of the dirhenium complex Re 2 (i-C 3 H 7 COO) 4 Cl 2 and its interactions with the DNA purine nucleobases,
Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994), 2001
The correlation-regressive and pharmacological analysis of butane acid derivates--ufibrat, Re2(is... more The correlation-regressive and pharmacological analysis of butane acid derivates--ufibrat, Re2(isoC3H7COO)4Cl2Ta[Re2(GABA)2Cl4(H2O)2]Cl2--was made. It is established that among these substances antihypoxic activity on the hypercapnic hypoxic hypoxia have only ufibrat. It decrease mice's temperature of body, increase duration of period to the appearance of sudoms and the life longitudindity at the condition of hypercapnia-hypoxia.
 sesquihydrate](https://attachments.academia-assets.com/107451873/thumbnails/1.jpg)
](Acta crystallographica. Section E, Crystallographic communications, 2015
The structure of the title compound, [Re2Cl6(C3H7NO2)2]·1.5H2O, comprises a dinuclear complex cat... more The structure of the title compound, [Re2Cl6(C3H7NO2)2]·1.5H2O, comprises a dinuclear complex cation [Re-Re = 2.2494 (3) Å] involving cis-oriented double carboxyl-ate bridges, four equatorial chloride ions and two weakly bonded chloride ligands in the axial positions at the two rhenium(III) atoms. In the crystal, two complex mol-ecules and two water mol-ecules constitute hydrogen-bonded dimers, while an extensive hydrogen-bonding network involving the groups of the zwitterionic ligand is important for generation of the framework. An additional partially occupied water molecule is disordered over two sets of sites about a symmetry centre with a site-occupancy ratio of 0.3:0.2.
Chemistry Journal of Moldova, 2007
The interaction of cis-Re2(RCOO)2Cl4, trans-Re2(RCOO)2Cl4, Re2(RCOO)3Cl3 and Re2(RCOO)4Cl2 (where... more The interaction of cis-Re2(RCOO)2Cl4, trans-Re2(RCOO)2Cl4, Re2(RCOO)3Cl3 and Re2(RCOO)4Cl2 (where R - alkyl group) with 1,3,5-triphenylverdazyle radical in 1,2-dichlorethane was investigated. It is discovered, that gradual substitution of halogenide ligands by carboxylates in dirhenium(III) clusters led to slowing down of reaction with a radical due to different influence of these ligands on parameters of rhenium - rhenium bond. Presented data showed perspectivity of Re26+-substances applications as therapeutic agents due to their low toxicity and antiradical properties that occured by δ-component of quadruple Re-Re bond electron transition.
Acta Crystallographica Section E Crystallographic Communications, 2015
The title compound, [Re2(C3H7COO)2Cl4{(CH3)2SO}2], comprises binuclear complex molecules [Re—Re =... more The title compound, [Re2(C3H7COO)2Cl4{(CH3)2SO}2], comprises binuclear complex molecules [Re—Re = 2.24502 (13) Å] involvingcis-oriented double carboxylate bridges, four equatorial chloride ions and two weakly bonded O atoms from dimethyl sulfoxide ligands in the axial positions at the ReIIIatoms. In the crystal, molecules are linked into corrugated layers parallel to (101) by very weak C—H...Cl and C—H...O hydrogen-bonding interactions. C—H...Cl hydrogen bonding provides the links between layers to consolidate a three-dimensional framework.
ScienceRise: Biological Science, 2020
The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- ... more The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- and trans-diadamanthylcarboxylates of dirhenium(III) alone and together with cisplatin in form of nanobins.Materials and methods. Model of tumor growth, Guerin’s carcinoma; intraperitoneal administration of cisplatin, dirhenium(III) compounds in liposomes and of binary liposomes, containing both cytostatics; volumes and final weights of tumors were measured.Results. In vivo antitumor properties of two dirhenium(III) dicarboxylates with 1-adamantanecarboxylic acid moieties as ligands with cis- (I) and trans- (II) orientation of the carboxylic groups around a cluster fragment alone and together with cisplatin were presented; an attempt to understand differences in a possible mechanism of anticancer activity of the substances were undertaken. Antiradical and DNA-binding properties of I and II were the matter of consideration.Conclusions. Cis- and trans- compounds of dirhenium I and II had c...
Journal of Inorganic Biochemistry, 2021
The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), ... more The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G-quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer - melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also strong stabilization activity to HTelo21 quadruplex. At the same time, the compounds do not show any stabilization activity for ds26 DNA, which suggests unique mechanisms of molecular DNA recognition for these complexes.
Acta Chimica Slovenica, 2020
Present work reports the synthesis of zirconium phosphate nanoparticles containing dirhenium(III)... more Present work reports the synthesis of zirconium phosphate nanoparticles containing dirhenium(III) substance bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III) with formula cis-Re 2 (C(CH 3) 3 COO) 2 Cl 4 • 2DMSO (I) and θ-zirconium phosphate with formula θ-Zr(HPO 4) 2 • 6H 2 O (ZrP). The intercalation process was monitored by EAS. Due to the spectral characteristics of the quadruple bond the conclusion was made that the obtained intercalated compounds had cis-configuration of ligands around cluster dirhenium fragment. The proposed mechanism of intercalation includes the substitution of the axial ligands of I by phosphate groups of ZrP first on the surface of ZrP, than in the inner layers. Two received products of the intercalation were characterized by SEM, XRPD, FT-IR, TGA analysis witnessing about successful intercalation process. The formation of new phases with interlayer distances of 10.53-16.6 Å was found, the average size of obtained platelets was 100-200 nm.
Acta Crystallographica Section C Structural Chemistry, 2020
Anion...π interactions are newly recognized weak supramolecular forces which are relevant to many... more Anion...π interactions are newly recognized weak supramolecular forces which are relevant to many types of electron-deficient aromatic substrates. Being less competitive with respect to conventional hydrogen bonding, anion...π interactions are only rarely considered as a crystal-structure-defining factor. Their significance dramatically increases for polyoxometalate (POM) species, which offer extended oxide surfaces for maintaining dense aromatic/inorganic stacks. The structures of tetrakis(caffeinium) μ12-silicato-tetracosa-μ2-oxido-dodecaoxidododecatungsten trihydrate, (C8H11N4O2)4[SiW12O40]·3H2O, (1), and tris(theobrominium) μ12-phosphato-tetracosa-μ2-oxido-dodecaoxidododecatungsten ethanol sesquisolvate, (C7H9N4O2)3[PW12O40]·1.5C2H5OH, (2), support the utility of anion...π interactions as a special kind of supramolecular synthon controlling the structures of ionic lattices. Both caffeinium [(HCaf)+ in (1)] and theobrominium cations [(HTbr)+ in (2)] reveal double stacking pattern...
Journal of Raman Spectroscopy, 2017
Inorganic Chemistry Communications, 2018
Weak anion-π bonding dominates interaction of caffeinium and [PM 12 O 40 ] 3− (M = Mo, W) ions an... more Weak anion-π bonding dominates interaction of caffeinium and [PM 12 O 40 ] 3− (M = Mo, W) ions and favors assembly of high-symmetry non-covalent frameworks.
Ukrainian Chemistry Journal, 2019
Using the method of differential thermal analysis and the method of isothermal effects, we invest... more Using the method of differential thermal analysis and the method of isothermal effects, we investigated the thermal transformations of the inter-calation products of representatives of dirhenium(III) complexes of all structural types into the interlayer space of zirconium phosphate. Each of the samples was heated in the temperature range from 40 to 500 C. On the obtained thermograms of the samples, two main endothermic effects were observed, the first of which corresponds to the separation of water of crystallization from zirconium phosphate, and the second to the thermal transformations of dirhe-nium(III) complexes. The first weight loss for all intercalation products was 8.87–9.80%, that is, the percentage of water in the post samples was the same. The weight loss corresponding to the thermal transformation of dirhenium(III) complexes in the obtained nanoparticles was 6.15–11.24 and 12.30–29.90 % for molar ratios of the substance / zirco-nium phosphate, respectively, 1:30 and 1:5,...
Odesa National University Herald. Chemistry, 2019
Ukrainian Chemistry Journal, 2019
Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to... more Study of hydrolysis of cis-tetrachlorodi-m-carboxylates of dirhenium (III) was carried out due to the electronic adsorption and IR spectroscopy and pHmeter. As a result, itwas shown that the hydrolysis is a multistage process which can be attributed to the reactions of the pseudo-first order. It is also shown that the electronic absorption spectroscopy (EAS) is a reliable method of investigation to study the hydrolysis of rhenium (III) complex compounds. This conclusion is based on the fact that in the systems with halide and carboxylic ligands, each of the five structural types can be clearly identified by the EAS in the region of both d–d* electron transition and charge transfer transition of L*Hal ®Re type. It is shown that with the increase in the length of the alkyl group and in its branching, the hydrolysis rate decreases, as a result of a change in the positive inductive effect of these groups and, consequently, an increase in the strengthening of quadruple Re–Re bond. In add...
Chemistry & Chemical Technology, 2011
Influence of complex compounds of nickel(II), copper(II) and zinc(II) with nitrogen containing li... more Influence of complex compounds of nickel(II), copper(II) and zinc(II) with nitrogen containing ligands on conductivity of bilayer lipid membranes (BLMs) was studied. The role of conditions (pH, metal and ligand concentration) on complex formation and interaction with BLMs was evaluated. Composition and form of complex ions in solution which maximally change conductivity have been calculated. Relationship between the complex form predominant in the solution and BLM conductivity indicated that complex ions influence mostly depended on surrounding ligands and did not depend on the nature of the central atom. Permeability coefficients for complex ions which maximally changed BLM conductivity were calculated.
Zeitschrift für Naturforschung B, 2001
The coordination compounds o f the general formula Re2 (L)4X2 (X = Cl, Br; L = 1 -adamantyl-carbo... more The coordination compounds o f the general formula Re2 (L)4X2 (X = Cl, Br; L = 1 -adamantyl-carboxylate and 1 -adamantylacetate) have been prepared and characterized by means of UV-VIS spectroscopy (20000 cm-1 , δ → δ*). The crystal and molecular structure of Re2(AdCOO)4Cl2 · 4 CHCl3 solvate was determined by X-ray diffraction. The units Re2(AdCOO)4Cl2 adopt a centrosymmetric dinuclear array with each metal atom coordinated in a distorted octahedron comprising one rhenium and one chlorine atoms (Re-Cl 2.505(2) Å) and four carboxylate oxygen atoms in the equatorial plane. The rhenium-rhenium separation of 2.2300(5) Å corresponds to quadruple bond between the metal atoms. All R e-0 bonds have an almost uniform length (2.017(4) -2.032(4) Å) and do not differ essentially from the parameters reported for related compounds. The closest environment of the Re2(AdCOO)4Cl2 molecules in the crystal comprises weak Cl---HC hydrogen bonds with the chloroform molecules and significantly shortened ...
Journal of Inorganic Biochemistry, 2017
A series of N-alkylaminoferrocene-based prodrugs were prepared A derivative with an N-propargyl... more A series of N-alkylaminoferrocene-based prodrugs were prepared A derivative with an N-propargyl residue was found to have the optimal properties The optimized prodrug exhibited relatively low lipophilicity and high water solubility The activity of the prodrug in selected cancer cell lines was in the range of 15-31 µM The optimized prodrug exhibited high antitumor activity in vivo (rat, T8 carcinoma).
New J. Chem., 2016
In order to obtain unknown thermodynamic properties, such as enthalpy of formation, of trans-tetr... more In order to obtain unknown thermodynamic properties, such as enthalpy of formation, of trans-tetrachlorodi-μ-carboxylate dirhenium(iii) (trans-[Re2Cl4(RCOO)2] (R = C2H5; C3H7; (CH3)2CH; (CH3)3C)), exothermic reactions of burning in oxygen were investigated.
Acta Crystallographica Section E Crystallographic Communications, 2016
The asymmetric unit of the title salt, (C10H8S8)[Re2Br6(CH3COO)]·0.5C2H3Cl3, contains one bis(eth... more The asymmetric unit of the title salt, (C10H8S8)[Re2Br6(CH3COO)]·0.5C2H3Cl3, contains one bis(ethylenedithio)tetrathiafulvalene (ET) radical cation, one μ2-acetato-bis[tribromidorhenate(III)] anion and a 1,1,2-trichloroethane molecule with half-occupancy disordered about a twofold rotation axis. The tetrathiafulvalene fragment adopts an almost planar configuration typical of the ET radical cation. The C atoms of both ethylenedithio fragments in the cation are disordered over two orientations with occupancy factors 0.65:0.35 and 0.77:0.23. In the anion, six Br atoms and a μ2-acetate ligand form a strongly distorted cubic O2Br6coordination polyhedron around the Re2dinuclear centre. In the crystal, centrosymmetrically related ET cations and Re2O2Br6anions are linked into dimers by π–π stacking interactions [centroid-to-centroid distance = 3.826 (8) Å] and by pairs of additional Re...Br contacts [3.131 (3) Å], respectively. The dimers are further packed into a three-dimensional network ...
Polyhedron, 2015
Abstract The new fac -[Re(CO) 3 ] + complexes with bidentate ligands (5-phenyl-3-(pyridin-2-yl)-1... more Abstract The new fac -[Re(CO) 3 ] + complexes with bidentate ligands (5-phenyl-3-(pyridin-2-yl)-1,2,4-triazole L1 ; 5-(2-aminophenyl)- 3-(pyridin-2-yl)-1,2,4-triazole L2 ; 5-(2-hydroxyphenyl)-3-(pyridin-2-yl)-1,2,4-triazole L3 ; 5-phenyl-2-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline L4 ) were obtained by refluxing [Re(CO) 5 Br] and the ligand in benzene for 5 h. These complexes were characterized by 1 H NMR, elemental analysis, ESI–mass spectrometry and IR spectra. Molecular structures of two complexes were confirmed by X-ray crystallography. The complexes show luminescence emission with large Stokes shifts ( λ ex = 365 nm, λ em = 506–620 nm).
Journal of Inorganic Biochemistry, 2015
Synthesis and X-ray crystal structure of the dirhenium complex Re 2 (i-C 3 H 7 COO) 4 Cl 2 and it... more Synthesis and X-ray crystal structure of the dirhenium complex Re 2 (i-C 3 H 7 COO) 4 Cl 2 and its interactions with the DNA purine nucleobases,
Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994), 2001
The correlation-regressive and pharmacological analysis of butane acid derivates--ufibrat, Re2(is... more The correlation-regressive and pharmacological analysis of butane acid derivates--ufibrat, Re2(isoC3H7COO)4Cl2Ta[Re2(GABA)2Cl4(H2O)2]Cl2--was made. It is established that among these substances antihypoxic activity on the hypercapnic hypoxic hypoxia have only ufibrat. It decrease mice's temperature of body, increase duration of period to the appearance of sudoms and the life longitudindity at the condition of hypercapnia-hypoxia.
Acta crystallographica. Section E, Crystallographic communications, 2015
The structure of the title compound, [Re2Cl6(C3H7NO2)2]·1.5H2O, comprises a dinuclear complex cat... more The structure of the title compound, [Re2Cl6(C3H7NO2)2]·1.5H2O, comprises a dinuclear complex cation [Re-Re = 2.2494 (3) Å] involving cis-oriented double carboxyl-ate bridges, four equatorial chloride ions and two weakly bonded chloride ligands in the axial positions at the two rhenium(III) atoms. In the crystal, two complex mol-ecules and two water mol-ecules constitute hydrogen-bonded dimers, while an extensive hydrogen-bonding network involving the groups of the zwitterionic ligand is important for generation of the framework. An additional partially occupied water molecule is disordered over two sets of sites about a symmetry centre with a site-occupancy ratio of 0.3:0.2.