Alexandre Abadie - Academia.edu (original) (raw)

Papers by Alexandre Abadie

Research paper thumbnail of Qrkey: Simply and Securely Controlling Swarm Robots

Swarm robotics is a research field on robotic collaboration where large number of robots are depl... more Swarm robotics is a research field on robotic collaboration where large number of robots are deployed to complete collective real-world tasks. Progress made in the field now tends to be democratized through swarm deployments such that users with different background can learn, program, conduct research or just play with them. One of the main challenges for swarm operators though is to keep the infrastructure at reasonable complexity, maintenance level, and price, to allow occasional users to interact with many robots smoothly. In this paper, we present Qrkey, an open-source library which provides an engaging, accessible and trustworthy user experience to control and track robots in a swarm. After a detailed presentation of the primitives and the protocol proposed by Qrkey, we discuss the security concerns raised by this solution. Finally, we conclude by giving Qrkey limitations and possible future work.

Research paper thumbnail of RobOTAP: Over-the-Air Programming of Robotic Swarms

Research paper thumbnail of Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation

Springer eBooks, 2011

Movement disorders in patients with Parkinson's disease may require functional surgery, when medi... more Movement disorders in patients with Parkinson's disease may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient's location of electrode contacts and clinical scores. Three motor and three neuropsychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuropsychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.

Research paper thumbnail of CLARCS, a C++ Library for Automated Registration and Comparison of Surfaces: Medical Applications

In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registr... more In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registration and Comparison of Surfaces) library. This library allows some basic and high level processing on free-form surfaces, represented as point sets or meshes. Three methods are the "building bricks" of CLARCS; they allow (i) the rigid/affine/nonlinear registration of two point sets, (ii) the computation of the midsagittal plane of one point set, (iii) the computation of a mean point set from several point sets, and the variability around this mean. These methods are all based on a common methodological framework, in which the point sets/meshes are represented either as a Gaussian mixture model or as a draw of such a model. We propose some applications of the methods implemented in CLARCS on different sets of medical data.

Research paper thumbnail of Post-operative assessment in Deep Brain Stimulation based on multimodal images: registration workflow and validation

Proceedings of SPIE, Feb 26, 2009

Object Movement disorders in Parkinson disease patients may require functional surgery, when medi... more Object Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing a digital Atlas gathering patient's location of electrodes and contacts for post operative assessment. Materials and Method 12 patients who had undergone bilateral STN DBS have participated to the study. Contacts on post-operative CT scans were automatically localized, based on black artefacts. For each patient, post operative CT images were rigidly registered to pre operative MR images. Then, pre operative MR images were registered to a MR template (super-resolution Collin27 average MRI template). This last registration was the combination of global affine, local affine and local non linear registrations, respectively. Four different studies were performed in order to validate the MR patient to template registration process, based on anatomical landmarks and clinical scores (i.e., Unified Parkinson's disease rating Scale). Visualisation software was developed for displaying into the template images the stimulated contacts represented as cylinders with a colour code related to the improvement of the UPDRS. Results The automatic contact localization algorithm was successful for all the patients. Validation studies for the registration process gave a placement error of 1.4 +/-0.2 mm and coherence with UPDRS scores. Conclusion The developed visualization tool allows post-operative assessment for previous interventions. Correlation with additional clinical scores will certainly permit to learn more about DBS and to better understand clinical side-effects.

Research paper thumbnail of An Open Experimental Platform for Ranging, Proximity and Contact Event Tracking using Ultra-Wide-Band and Bluetooth Low-Energy

The need for cheaper and more precise localisation techniques has recently amplified. The initial... more The need for cheaper and more precise localisation techniques has recently amplified. The initial approach has been to roll out high-level software running on smartphones and leveraging Bluetooth proximity sensing. However this approach lacks both precision in terms of ranging, and flexibility in terms of experimental framework to fully explore alternative schemes for contact event tracing. In this context, we thus provide openaccess nodes in an open-access experimental platform for ranging and proximity tracking, letting researchers tinker freely with the full software stack on a swarm of multi-radio, low-power devices based on cheap microcontrollers. We provide a tutorial on how to use the platform and open source code building blocks to to program the devices, bare-metal. We then report on initial measurements we have performed using the platform. Perspectives with our platform include applicability studies and comparative evaluation for a large variety of localisation schemes combining the use of Ultra-Wide Band and Bluetooth Low-Energy for better precision and smaller energy budgets-and the use of complementary mechanism guaranteeing privacy protection, able to run directly on-board cheap IoT microcontrollers.

Research paper thumbnail of Validation de la segmentation des ganglions de la base sur un template IRM 3 Tesla

Neurochirurgie, Dec 1, 2010

... version française english version rss feed. inserm-00616982, version 1. Validation de laSegme... more ... version française english version rss feed. inserm-00616982, version 1. Validation de laSegmentation des Ganglions de la Base sur un Template IRM 3 Tesla. ...

Research paper thumbnail of Automatic computation of electrode trajectories for Deep Brain Stimulation: a hybrid symbolic and numerical approach

International Journal of Computer Assisted Radiology and Surgery, Aug 25, 2011

Research paper thumbnail of New Results - Image Segmentation, Registration and Analysis

Research paper thumbnail of Une plateforme logicielle de neurochirurgie assistée par l’image

Neurochirurgie, Dec 1, 2010

National audienc

Research paper thumbnail of An Open Experimental Platform for Ranging, Proximity and Contact Event Tracking using Ultra-Wide-Band and Bluetooth Low-Energy

IEEE INFOCOM 2021 - IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS), 2021

Research paper thumbnail of Anatomo-Clinical Atlases in SubThalamic Deep Brain Stimulation : correlating clinical data and electrode contacts coordinates

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital Atlases gathering patient's location of electrode contacts and clinical scores. Our anatomo-clinical atlases were assessed using non-supervised classification to extract clusters and create rules for finding the optimum site for therapeutic STN DBS.

Research paper thumbnail of CLARCS, a C++ Library for Automated Registration and Comparison of Surfaces: Medical Applications

In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registr... more In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registration and Comparison of Surfaces) library. This library allows some basic and high level processing on free-form surfaces, represented as point sets or meshes. Three methods are the "building bricks" of CLARCS; they allow (i) the rigid/affine/non-linear registration of two point sets, (ii) the computation of the mid-sagittal plane of one point set, (iii) the computation of a mean point set from several point sets, and the variability around this mean. These methods are all based on a common methodological framework, in which the point sets/meshes are represented either as a Gaussian mixture model or as a draw of such a model. We propose some applications of the methods implemented in CLARCS on different sets of medical data.

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales : mise en place et validation des chaînes de recalage

Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps a... more Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow Résumé La stimulation cérébrale profonde (SCP) est une technique neurochirurgicale utilisée pour traiter les troubles moteurs, dont la maladie de Parkinson. Le traitement consiste à implanter au coeur du cerveau, dans les noyaux gris centraux, des électrodes qui diminueront de façon spectaculaire les tremblements par l'intermédiaire d'une stimulation électrique hautefréquence. Cette étude préliminaire décrit les différentes étapes de la construction d'un atlas numérique anatomoclinique pour une évaluation post-opératoire de la SCP, dans un cadre d'outil d'aide à la compréhension. La première version inclut 25 patients, qui furent reliés à un code couleur représentant l'amélioration clinique globale du patient (score UPDRS (Unified Parkinson's disease rating Scale) pour évaluer l'évolution de la maladie de Parkinson). La projection de tous les plots stimulés sur cet atlas a permis au neurochirurgien d'évaluer qualitativement les précédentes implantations.

Research paper thumbnail of Validation de la Segmentation des Ganglions de la Base sur un Template IRM 3 Tesla

... version française english version rss feed. inserm-00616982, version 1. Validation de laSegme... more ... version française english version rss feed. inserm-00616982, version 1. Validation de laSegmentation des Ganglions de la Base sur un Template IRM 3 Tesla. ...

Research paper thumbnail of <title>Post-operative assessment in Deep Brain Stimulation based on multimodal images: registration workflow and validation</title>

Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 2009

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing a digital Atlas gathering patient's location of electrodes and contacts for post operative assessment.

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales: mise en place et validation des chaînes de recalage

Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps a... more Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow Résumé La stimulation cérébrale profonde (SCP) est une technique neurochirurgicale utilisée pour traiter les troubles moteurs, dont la maladie de Parkinson. Le traitement consiste à implanter au coeur du cerveau, dans les noyaux gris centraux, des électrodes qui diminueront de façon spectaculaire les tremblements par l'intermédiaire d'une stimulation électrique hautefréquence. Cette étude préliminaire décrit les différentes étapes de la construction d'un atlas numérique anatomoclinique pour une évaluation post-opératoire de la SCP, dans un cadre d'outil d'aide à la compréhension. La première version inclut 25 patients, qui furent reliés à un code couleur représentant l'amélioration clinique globale du patient (score UPDRS (Unified Parkinson's disease rating Scale) pour évaluer l'évolution de la maladie de Parkinson). La projection de tous les plots stimulés sur cet atlas a permis au neurochirurgien d'évaluer qualitativement les précédentes implantations.

Research paper thumbnail of Une plateforme logicielle de neurochirurgie assistée par l’image

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales : mise en place et validation des chaînes de recalage Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus. This paper describes successive steps for constructing a digital atlas gathering patient's location of electrodes and contacts for post operative assessment. Visualisation software was developed for displaying

Research paper thumbnail of Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation

Lecture Notes in Computer Science, 2011

Movement disorders in patients with Parkinson's disease may require functional surgery, when medi... more Movement disorders in patients with Parkinson's disease may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient's location of electrode contacts and clinical scores. Three motor and three neuropsychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuropsychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.

Research paper thumbnail of Qrkey: Simply and Securely Controlling Swarm Robots

Swarm robotics is a research field on robotic collaboration where large number of robots are depl... more Swarm robotics is a research field on robotic collaboration where large number of robots are deployed to complete collective real-world tasks. Progress made in the field now tends to be democratized through swarm deployments such that users with different background can learn, program, conduct research or just play with them. One of the main challenges for swarm operators though is to keep the infrastructure at reasonable complexity, maintenance level, and price, to allow occasional users to interact with many robots smoothly. In this paper, we present Qrkey, an open-source library which provides an engaging, accessible and trustworthy user experience to control and track robots in a swarm. After a detailed presentation of the primitives and the protocol proposed by Qrkey, we discuss the security concerns raised by this solution. Finally, we conclude by giving Qrkey limitations and possible future work.

Research paper thumbnail of RobOTAP: Over-the-Air Programming of Robotic Swarms

Research paper thumbnail of Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation

Springer eBooks, 2011

Movement disorders in patients with Parkinson's disease may require functional surgery, when medi... more Movement disorders in patients with Parkinson's disease may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient's location of electrode contacts and clinical scores. Three motor and three neuropsychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuropsychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.

Research paper thumbnail of CLARCS, a C++ Library for Automated Registration and Comparison of Surfaces: Medical Applications

In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registr... more In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registration and Comparison of Surfaces) library. This library allows some basic and high level processing on free-form surfaces, represented as point sets or meshes. Three methods are the "building bricks" of CLARCS; they allow (i) the rigid/affine/nonlinear registration of two point sets, (ii) the computation of the midsagittal plane of one point set, (iii) the computation of a mean point set from several point sets, and the variability around this mean. These methods are all based on a common methodological framework, in which the point sets/meshes are represented either as a Gaussian mixture model or as a draw of such a model. We propose some applications of the methods implemented in CLARCS on different sets of medical data.

Research paper thumbnail of Post-operative assessment in Deep Brain Stimulation based on multimodal images: registration workflow and validation

Proceedings of SPIE, Feb 26, 2009

Object Movement disorders in Parkinson disease patients may require functional surgery, when medi... more Object Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing a digital Atlas gathering patient's location of electrodes and contacts for post operative assessment. Materials and Method 12 patients who had undergone bilateral STN DBS have participated to the study. Contacts on post-operative CT scans were automatically localized, based on black artefacts. For each patient, post operative CT images were rigidly registered to pre operative MR images. Then, pre operative MR images were registered to a MR template (super-resolution Collin27 average MRI template). This last registration was the combination of global affine, local affine and local non linear registrations, respectively. Four different studies were performed in order to validate the MR patient to template registration process, based on anatomical landmarks and clinical scores (i.e., Unified Parkinson's disease rating Scale). Visualisation software was developed for displaying into the template images the stimulated contacts represented as cylinders with a colour code related to the improvement of the UPDRS. Results The automatic contact localization algorithm was successful for all the patients. Validation studies for the registration process gave a placement error of 1.4 +/-0.2 mm and coherence with UPDRS scores. Conclusion The developed visualization tool allows post-operative assessment for previous interventions. Correlation with additional clinical scores will certainly permit to learn more about DBS and to better understand clinical side-effects.

Research paper thumbnail of An Open Experimental Platform for Ranging, Proximity and Contact Event Tracking using Ultra-Wide-Band and Bluetooth Low-Energy

The need for cheaper and more precise localisation techniques has recently amplified. The initial... more The need for cheaper and more precise localisation techniques has recently amplified. The initial approach has been to roll out high-level software running on smartphones and leveraging Bluetooth proximity sensing. However this approach lacks both precision in terms of ranging, and flexibility in terms of experimental framework to fully explore alternative schemes for contact event tracing. In this context, we thus provide openaccess nodes in an open-access experimental platform for ranging and proximity tracking, letting researchers tinker freely with the full software stack on a swarm of multi-radio, low-power devices based on cheap microcontrollers. We provide a tutorial on how to use the platform and open source code building blocks to to program the devices, bare-metal. We then report on initial measurements we have performed using the platform. Perspectives with our platform include applicability studies and comparative evaluation for a large variety of localisation schemes combining the use of Ultra-Wide Band and Bluetooth Low-Energy for better precision and smaller energy budgets-and the use of complementary mechanism guaranteeing privacy protection, able to run directly on-board cheap IoT microcontrollers.

Research paper thumbnail of Validation de la segmentation des ganglions de la base sur un template IRM 3 Tesla

Neurochirurgie, Dec 1, 2010

... version française english version rss feed. inserm-00616982, version 1. Validation de laSegme... more ... version française english version rss feed. inserm-00616982, version 1. Validation de laSegmentation des Ganglions de la Base sur un Template IRM 3 Tesla. ...

Research paper thumbnail of Automatic computation of electrode trajectories for Deep Brain Stimulation: a hybrid symbolic and numerical approach

International Journal of Computer Assisted Radiology and Surgery, Aug 25, 2011

Research paper thumbnail of New Results - Image Segmentation, Registration and Analysis

Research paper thumbnail of Une plateforme logicielle de neurochirurgie assistée par l’image

Neurochirurgie, Dec 1, 2010

National audienc

Research paper thumbnail of An Open Experimental Platform for Ranging, Proximity and Contact Event Tracking using Ultra-Wide-Band and Bluetooth Low-Energy

IEEE INFOCOM 2021 - IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS), 2021

Research paper thumbnail of Anatomo-Clinical Atlases in SubThalamic Deep Brain Stimulation : correlating clinical data and electrode contacts coordinates

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital Atlases gathering patient's location of electrode contacts and clinical scores. Our anatomo-clinical atlases were assessed using non-supervised classification to extract clusters and create rules for finding the optimum site for therapeutic STN DBS.

Research paper thumbnail of CLARCS, a C++ Library for Automated Registration and Comparison of Surfaces: Medical Applications

In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registr... more In this paper we present the methods implemented in the CLARCS (C++ Library for Automated Registration and Comparison of Surfaces) library. This library allows some basic and high level processing on free-form surfaces, represented as point sets or meshes. Three methods are the "building bricks" of CLARCS; they allow (i) the rigid/affine/non-linear registration of two point sets, (ii) the computation of the mid-sagittal plane of one point set, (iii) the computation of a mean point set from several point sets, and the variability around this mean. These methods are all based on a common methodological framework, in which the point sets/meshes are represented either as a Gaussian mixture model or as a draw of such a model. We propose some applications of the methods implemented in CLARCS on different sets of medical data.

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales : mise en place et validation des chaînes de recalage

Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps a... more Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow Résumé La stimulation cérébrale profonde (SCP) est une technique neurochirurgicale utilisée pour traiter les troubles moteurs, dont la maladie de Parkinson. Le traitement consiste à implanter au coeur du cerveau, dans les noyaux gris centraux, des électrodes qui diminueront de façon spectaculaire les tremblements par l'intermédiaire d'une stimulation électrique hautefréquence. Cette étude préliminaire décrit les différentes étapes de la construction d'un atlas numérique anatomoclinique pour une évaluation post-opératoire de la SCP, dans un cadre d'outil d'aide à la compréhension. La première version inclut 25 patients, qui furent reliés à un code couleur représentant l'amélioration clinique globale du patient (score UPDRS (Unified Parkinson's disease rating Scale) pour évaluer l'évolution de la maladie de Parkinson). La projection de tous les plots stimulés sur cet atlas a permis au neurochirurgien d'évaluer qualitativement les précédentes implantations.

Research paper thumbnail of Validation de la Segmentation des Ganglions de la Base sur un Template IRM 3 Tesla

... version française english version rss feed. inserm-00616982, version 1. Validation de laSegme... more ... version française english version rss feed. inserm-00616982, version 1. Validation de laSegmentation des Ganglions de la Base sur un Template IRM 3 Tesla. ...

Research paper thumbnail of <title>Post-operative assessment in Deep Brain Stimulation based on multimodal images: registration workflow and validation</title>

Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 2009

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS) electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing a digital Atlas gathering patient's location of electrodes and contacts for post operative assessment.

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales: mise en place et validation des chaînes de recalage

Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps a... more Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow Résumé La stimulation cérébrale profonde (SCP) est une technique neurochirurgicale utilisée pour traiter les troubles moteurs, dont la maladie de Parkinson. Le traitement consiste à implanter au coeur du cerveau, dans les noyaux gris centraux, des électrodes qui diminueront de façon spectaculaire les tremblements par l'intermédiaire d'une stimulation électrique hautefréquence. Cette étude préliminaire décrit les différentes étapes de la construction d'un atlas numérique anatomoclinique pour une évaluation post-opératoire de la SCP, dans un cadre d'outil d'aide à la compréhension. La première version inclut 25 patients, qui furent reliés à un code couleur représentant l'amélioration clinique globale du patient (score UPDRS (Unified Parkinson's disease rating Scale) pour évaluer l'évolution de la maladie de Parkinson). La projection de tous les plots stimulés sur cet atlas a permis au neurochirurgien d'évaluer qualitativement les précédentes implantations.

Research paper thumbnail of Une plateforme logicielle de neurochirurgie assistée par l’image

Research paper thumbnail of Analyse post-opératoire en stimulation cérébrale profonde basée sur des images multimodales : mise en place et validation des chaînes de recalage Post-operative analysis in deep brain stimulation based on multimodal images: preliminary steps and validation of the registration workflow

Movement disorders in Parkinson disease patients may require functional surgery, when medical the... more Movement disorders in Parkinson disease patients may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus. This paper describes successive steps for constructing a digital atlas gathering patient's location of electrodes and contacts for post operative assessment. Visualisation software was developed for displaying

Research paper thumbnail of Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation

Lecture Notes in Computer Science, 2011

Movement disorders in patients with Parkinson's disease may require functional surgery, when medi... more Movement disorders in patients with Parkinson's disease may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient's location of electrode contacts and clinical scores. Three motor and three neuropsychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuropsychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.