Alexandre Cardoso - Academia.edu (original) (raw)
Papers by Alexandre Cardoso
Research Square (Research Square), Apr 10, 2020
Revista Panamericana de Salud Pública
Objective. To investigate the prevalence and risk factors for persistent symptoms up to 12 months... more Objective. To investigate the prevalence and risk factors for persistent symptoms up to 12 months after hospital discharge in COVID-19 survivors. Methods. This prospective cohort study included patients with COVID-19 discharged from a university hospital in Brazil. Follow-up was performed 2, 6, and 12 months after discharge. Lung function tests and chest computed tomography (CT) were performed 2 months after discharge and were repeated if abnormal. The primary outcomes were the symptoms present, work status, and limitations in daily activities. Results. Eighty-eight patients were included. Dyspnea (54.5%), fatigue (50.0%), myalgia, and muscle weakness (46.6%) were the most common symptoms, which decreased over time. Anxiety was frequent (46.6%) and remained unchanged. One year after discharge, 43.2% of the patients reported limitations in daily activities, and 17.6% had not returned to work. Corticosteroid use was significantly associated with dyspnea and limitations in daily activi...
Respirology
Background and objectiveAsthma and chronic obstructive pulmonary disease (COPD) are two prevalent... more Background and objectiveAsthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real‐world setting are unknown. We assessed how the presence/absence of specific TTs relate to the diagnosis and severity of ‘asthma’, ‘COPD’ or ‘asthma + COPD’.MethodsThe authors selected 30 frequently occurring TTs from the NOVELTY study cohort (NOVEL observational longiTudinal studY; NCT02760329), a large (n = 11,226), global study that systematically collects data in a real‐world setting, both in primary care clinics and specialized centres, for patients with ‘asthma’ (n = 5932, 52.8%), ‘COPD’ (n = 3898, 34.7%) or both (‘asthma + COPD’; n = 1396, 12.4%).ResultsThe results indicate that (1) the prevalence of the 30 TTs evaluated v...
Purpose To evaluate the frequency of sleep-disordered breathing (SDB) and predictors of the prese... more Purpose To evaluate the frequency of sleep-disordered breathing (SDB) and predictors of the presence of nocturnal desaturation in adults with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Methods Outpatients with a hemodynamic diagnosis of precapillary pulmonary hypertension who underwent portable polysomnography were evaluated. Diagnosis and severity of SDB were assessed using three well-established respiratory disturbance index (RDI) thresholds: 5.0/h, 15.0/h, and 30.0/h, while nocturnal hypoxemia was defined by the average oxygen saturation (SpO2)
Jornal De Pneumologia, 2001
European Respiratory Journal, 2013
Asthma is a leading cause of respiratory morbidity and mortality worldwide, and its prevalence is... more Asthma is a leading cause of respiratory morbidity and mortality worldwide, and its prevalence is increasing. A significant proportion of patients have poorly controlled asthma, despite treatment with high doses of inhaled and oral drugs. Difficult to treat asthma is defined as asthma uncontrolled with a reliever medication plus two or more controllers medications. Omalizumab is an option for patients with elevated serum levels of IgE with severe allergic asthma. Unfortunatelly, due to its high cost, it is still scarcely used in Brazil. We describe the response to omalizumab in a cohort of difficult to treat asthma patients in Rio de Janeiro, Brazil. Fifty patients are currently under omalizumab treatment. All of them, also with high doses of inhaled corticosteroids and long acting bronchodilators. The mean age of the cohort is 55 yrs, 78% are women, and 58% have moderate to severe obstruction in spirometry. Astma control improved and hospitalization rates was significantly reduced ...
Jornal Brasileiro de Pneumologia, 2021
Jornal Brasileiro de Pneumologia, 2020
The pharmacological management of asthma has changed considerably in recent decades, as it has co... more The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lung function, and adverse treatment effects). That requires an approach that is personalized in terms of the pharmacological treatment, patient education, written action plan, training in correct inhaler use, and review of the inhaler technique at each office visit. A panel of 22 pulmonologists was invited to perform a critical review of recent evidence of pharmacological treatment of asthma and to prepare this set of recommendations, a treatment guide tailored to use in Brazil. The topics or questions related to the most significant changes in concepts, and consequently in the manageme...
BMC Pulmonary Medicine, 2015
Jornal de Pneumologia, 1999
Biotehnologija u stocarstvu, 2011
This paper analyzes the present state of sheep farming in Serbia and provide guidance for sustain... more This paper analyzes the present state of sheep farming in Serbia and provide guidance for sustainable development in the future. It also discusses the challenges of the modern age that may affect the viability of sheep production. Today in Serbia grows less than 1.5 million sheep. In terms of breed structures, most of the population makes indigenous Pramenka sheep (80%), while the remaining 20% are: Tsigai, Merinolandschaf, Ile de France, Pirot improved, Mis sheep, and other less important population, as well as the crossbreed with foreign and local domestic sheep. However, due to the intense process of industrialization, from the second half of the twentieth century until today there is a trend of depopulation, demographic discharge of the village, which has resulted in reducing the farms so that the number of sheep in the past two decades fell by about 30%. The greatest reduction in the number of sheep registered in the nineties. After stabilization, a large decrease in the number...
BMC Pulmonary Medicine, 2016
Brazilian Journal of Medical and Biological Research, 2005
With the aim of investigating the presence of latent inflammatory process in the lungs of patient... more With the aim of investigating the presence of latent inflammatory process in the lungs of patients with Crohn's disease, 15 patients with Crohn's disease were evaluated by spirometry, the methacholine challenge test, induced sputum, and skin tests for inhaled antigens. Serum IgE, erythrocyte sedimentation rate and hematocrit were also determined. The patients were compared with 20 healthy controls by the Mann-Whitney and Fisher exact tests. Their respiratory physical examination was normal. None had a personal or family history of clinical atopy. None had a previous history of pulmonary disease, smoking or toxic bronchopulmonary exposure. None had sinusitis, migraine, diabetes mellitus, or cardiac failure. Four (26.6%) of the patients with Crohn's disease had a positive methacholine challenge test whereas none of the 20 controls had a positive methacholine test (P = 0.026, Fisher exact test). Patients with Crohn's disease had a higher level of lymphocytes in induced sputum than controls (mean 14.59%, range 3.2-50 vs 5.46%, 0-26.92%, respectively; P = 0.011, Mann-Whitney test). Patients with Crohn's disease and a positive methacholine challenge test had an even higher percentage of lymphocytes in induced sputum compared with patients with Crohn's disease and a negative methacholine test (mean 24.88%, range 12.87-50 vs 10.48%, 3.2-21.69%; P = 0.047, Mann-Whitney test). The simultaneous findings of bronchopulmonary lymphocytosis and bronchial hyperresponsiveness in patients with Crohn's disease were not reported up to now. These results suggest that patients with Crohn's disease present a subclinical inflammatory process despite the absence of pulmonary symptoms.
A43. INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS, 2010
A43 INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS Session / Sunday,... more A43 INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS Session / Sunday, May 16/8:15 AM-4:00 PM / Area G, Hall G (First Level), Morial Convention Center ... Intrabronchial Instillation Of Bone Marrow Derived Mononuclear Cells In ...
2013 XV Symposium on Virtual and Augmented Reality, 2013
Jornal Brasileiro de …, 2009
Community-acquired pneumonia continues to be the acute infectious disease that has the greatest m... more Community-acquired pneumonia continues to be the acute infectious disease that has the greatest medical and social impact regarding morbidity and treatment costs. Children and the elderly are more susceptible to severe complications, thereby justifying the fact that the ...
Jornal Brasileiro de Pneumologia, 2009
A pneumonia adquirida na comunidade mantém-se como a doença infecciosa aguda de maior impacto méd... more A pneumonia adquirida na comunidade mantém-se como a doença infecciosa aguda de maior impacto médico-social quanto à morbidade ea custos relacionados ao tratamento. Os grupos etários mais suscetíveis de complicações graves situam-se entre os extremos de idade, ...
Jornal Brasileiro de Pneumologia, 2009
Corrêa, Ricardo de Amorim; Lundgren, Fernando Luiz Cavalcanti; Pereira-Silva, Jorge Luiz; Silva, ... more Corrêa, Ricardo de Amorim; Lundgren, Fernando Luiz Cavalcanti; Pereira-Silva, Jorge Luiz; Silva, Rodney Luiz Frare e; Cardoso, Alexandre Pinto; Lemos, Antônio Carlos Moreira; Rossi, Flávia; Michel, Gustavo; Ribeiro, Liany; Cavalcanti, Manuela Araújo de Nóbrega; ...
Research Square (Research Square), Apr 10, 2020
Revista Panamericana de Salud Pública
Objective. To investigate the prevalence and risk factors for persistent symptoms up to 12 months... more Objective. To investigate the prevalence and risk factors for persistent symptoms up to 12 months after hospital discharge in COVID-19 survivors. Methods. This prospective cohort study included patients with COVID-19 discharged from a university hospital in Brazil. Follow-up was performed 2, 6, and 12 months after discharge. Lung function tests and chest computed tomography (CT) were performed 2 months after discharge and were repeated if abnormal. The primary outcomes were the symptoms present, work status, and limitations in daily activities. Results. Eighty-eight patients were included. Dyspnea (54.5%), fatigue (50.0%), myalgia, and muscle weakness (46.6%) were the most common symptoms, which decreased over time. Anxiety was frequent (46.6%) and remained unchanged. One year after discharge, 43.2% of the patients reported limitations in daily activities, and 17.6% had not returned to work. Corticosteroid use was significantly associated with dyspnea and limitations in daily activi...
Respirology
Background and objectiveAsthma and chronic obstructive pulmonary disease (COPD) are two prevalent... more Background and objectiveAsthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real‐world setting are unknown. We assessed how the presence/absence of specific TTs relate to the diagnosis and severity of ‘asthma’, ‘COPD’ or ‘asthma + COPD’.MethodsThe authors selected 30 frequently occurring TTs from the NOVELTY study cohort (NOVEL observational longiTudinal studY; NCT02760329), a large (n = 11,226), global study that systematically collects data in a real‐world setting, both in primary care clinics and specialized centres, for patients with ‘asthma’ (n = 5932, 52.8%), ‘COPD’ (n = 3898, 34.7%) or both (‘asthma + COPD’; n = 1396, 12.4%).ResultsThe results indicate that (1) the prevalence of the 30 TTs evaluated v...
Purpose To evaluate the frequency of sleep-disordered breathing (SDB) and predictors of the prese... more Purpose To evaluate the frequency of sleep-disordered breathing (SDB) and predictors of the presence of nocturnal desaturation in adults with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Methods Outpatients with a hemodynamic diagnosis of precapillary pulmonary hypertension who underwent portable polysomnography were evaluated. Diagnosis and severity of SDB were assessed using three well-established respiratory disturbance index (RDI) thresholds: 5.0/h, 15.0/h, and 30.0/h, while nocturnal hypoxemia was defined by the average oxygen saturation (SpO2)
Jornal De Pneumologia, 2001
European Respiratory Journal, 2013
Asthma is a leading cause of respiratory morbidity and mortality worldwide, and its prevalence is... more Asthma is a leading cause of respiratory morbidity and mortality worldwide, and its prevalence is increasing. A significant proportion of patients have poorly controlled asthma, despite treatment with high doses of inhaled and oral drugs. Difficult to treat asthma is defined as asthma uncontrolled with a reliever medication plus two or more controllers medications. Omalizumab is an option for patients with elevated serum levels of IgE with severe allergic asthma. Unfortunatelly, due to its high cost, it is still scarcely used in Brazil. We describe the response to omalizumab in a cohort of difficult to treat asthma patients in Rio de Janeiro, Brazil. Fifty patients are currently under omalizumab treatment. All of them, also with high doses of inhaled corticosteroids and long acting bronchodilators. The mean age of the cohort is 55 yrs, 78% are women, and 58% have moderate to severe obstruction in spirometry. Astma control improved and hospitalization rates was significantly reduced ...
Jornal Brasileiro de Pneumologia, 2021
Jornal Brasileiro de Pneumologia, 2020
The pharmacological management of asthma has changed considerably in recent decades, as it has co... more The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lung function, and adverse treatment effects). That requires an approach that is personalized in terms of the pharmacological treatment, patient education, written action plan, training in correct inhaler use, and review of the inhaler technique at each office visit. A panel of 22 pulmonologists was invited to perform a critical review of recent evidence of pharmacological treatment of asthma and to prepare this set of recommendations, a treatment guide tailored to use in Brazil. The topics or questions related to the most significant changes in concepts, and consequently in the manageme...
BMC Pulmonary Medicine, 2015
Jornal de Pneumologia, 1999
Biotehnologija u stocarstvu, 2011
This paper analyzes the present state of sheep farming in Serbia and provide guidance for sustain... more This paper analyzes the present state of sheep farming in Serbia and provide guidance for sustainable development in the future. It also discusses the challenges of the modern age that may affect the viability of sheep production. Today in Serbia grows less than 1.5 million sheep. In terms of breed structures, most of the population makes indigenous Pramenka sheep (80%), while the remaining 20% are: Tsigai, Merinolandschaf, Ile de France, Pirot improved, Mis sheep, and other less important population, as well as the crossbreed with foreign and local domestic sheep. However, due to the intense process of industrialization, from the second half of the twentieth century until today there is a trend of depopulation, demographic discharge of the village, which has resulted in reducing the farms so that the number of sheep in the past two decades fell by about 30%. The greatest reduction in the number of sheep registered in the nineties. After stabilization, a large decrease in the number...
BMC Pulmonary Medicine, 2016
Brazilian Journal of Medical and Biological Research, 2005
With the aim of investigating the presence of latent inflammatory process in the lungs of patient... more With the aim of investigating the presence of latent inflammatory process in the lungs of patients with Crohn's disease, 15 patients with Crohn's disease were evaluated by spirometry, the methacholine challenge test, induced sputum, and skin tests for inhaled antigens. Serum IgE, erythrocyte sedimentation rate and hematocrit were also determined. The patients were compared with 20 healthy controls by the Mann-Whitney and Fisher exact tests. Their respiratory physical examination was normal. None had a personal or family history of clinical atopy. None had a previous history of pulmonary disease, smoking or toxic bronchopulmonary exposure. None had sinusitis, migraine, diabetes mellitus, or cardiac failure. Four (26.6%) of the patients with Crohn's disease had a positive methacholine challenge test whereas none of the 20 controls had a positive methacholine test (P = 0.026, Fisher exact test). Patients with Crohn's disease had a higher level of lymphocytes in induced sputum than controls (mean 14.59%, range 3.2-50 vs 5.46%, 0-26.92%, respectively; P = 0.011, Mann-Whitney test). Patients with Crohn's disease and a positive methacholine challenge test had an even higher percentage of lymphocytes in induced sputum compared with patients with Crohn's disease and a negative methacholine test (mean 24.88%, range 12.87-50 vs 10.48%, 3.2-21.69%; P = 0.047, Mann-Whitney test). The simultaneous findings of bronchopulmonary lymphocytosis and bronchial hyperresponsiveness in patients with Crohn's disease were not reported up to now. These results suggest that patients with Crohn's disease present a subclinical inflammatory process despite the absence of pulmonary symptoms.
A43. INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS, 2010
A43 INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS Session / Sunday,... more A43 INTERESTING CASES IN INTERVENTIONAL PULMONARY: TECHNIQUES AND COMPLICATIONS Session / Sunday, May 16/8:15 AM-4:00 PM / Area G, Hall G (First Level), Morial Convention Center ... Intrabronchial Instillation Of Bone Marrow Derived Mononuclear Cells In ...
2013 XV Symposium on Virtual and Augmented Reality, 2013
Jornal Brasileiro de …, 2009
Community-acquired pneumonia continues to be the acute infectious disease that has the greatest m... more Community-acquired pneumonia continues to be the acute infectious disease that has the greatest medical and social impact regarding morbidity and treatment costs. Children and the elderly are more susceptible to severe complications, thereby justifying the fact that the ...
Jornal Brasileiro de Pneumologia, 2009
A pneumonia adquirida na comunidade mantém-se como a doença infecciosa aguda de maior impacto méd... more A pneumonia adquirida na comunidade mantém-se como a doença infecciosa aguda de maior impacto médico-social quanto à morbidade ea custos relacionados ao tratamento. Os grupos etários mais suscetíveis de complicações graves situam-se entre os extremos de idade, ...
Jornal Brasileiro de Pneumologia, 2009
Corrêa, Ricardo de Amorim; Lundgren, Fernando Luiz Cavalcanti; Pereira-Silva, Jorge Luiz; Silva, ... more Corrêa, Ricardo de Amorim; Lundgren, Fernando Luiz Cavalcanti; Pereira-Silva, Jorge Luiz; Silva, Rodney Luiz Frare e; Cardoso, Alexandre Pinto; Lemos, Antônio Carlos Moreira; Rossi, Flávia; Michel, Gustavo; Ribeiro, Liany; Cavalcanti, Manuela Araújo de Nóbrega; ...