Alexey Pavlichenko - Academia.edu (original) (raw)

Papers by Alexey Pavlichenko

Research paper thumbnail of Assessment of environmental and economic efficiency of iron ore breaking technology using emulsion explosives

Geotehnіchna mehanіka, 2014

методика расчета параметров буровзрывных работ при ведении очистных работ на шахтах Криворожского... more методика расчета параметров буровзрывных работ при ведении очистных работ на шахтах Криворожского бассейна и ЧАО «Запорожский железорудный комбинат», за счет установленного коэффициента относительной мощности взрывчатого вещества типа Украинит-ПМ-2Б. Предложена технология ведения очистных работ для отбойки руды при камерных системах разработки для залежей мощностью более 5 м с применением эмульсионных взрывчатых веществ, предусматривающая бурение нисходящих вееров эксплуатационных скважин в направлении нижележащих буровых горизонтов. Выполнена эколого-экономическая оценка эффективности внедрения предлагаемой технологии отбойки руды в очистных камерах. Выявлены закономерности изменения индекса опасности вредных веществ при использовании тротилосодержащих и эмульсионных взрывчатых веществ в зависимости от расстояния до источника выброса. Внедрение предлагаемой технологии позволит снизить себестоимость 1 т руды до 15% на одну выемочную единицу. Ключевые слова: тротилосодержащие и эмульсионные взрывчатые вещества, экологическая безопасность, технология отбойки руды.

Research paper thumbnail of Effects of diet on the gut microbiome in patients with depression

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022

OBJECTIVE To investigate the effects of diet on the gut microbiota and to assess the relationship... more OBJECTIVE To investigate the effects of diet on the gut microbiota and to assess the relationship of these factors with depression. MATERIAL AND METHODS Microorganisms that predominate in depressed patients were identified and associations of the identified organisms with the patients' diet were performed. Fourteen depressed patients and 14 healthy volunteers with the same socio-demographic parameters were included in the study. The Hamilton Depression Scale, Generalized Anxiety Disorder Questionnaire, and the Center for Epidemiologic Studies Questionnaire were used. RESULTS Erysipelatoclostridium and Clostridium innocuum species were 11.3 and 14.4 times higher in depressed patients compared with healthy controls. Fusicatenibacter saccharivorans, Faecalibacterium prausnitzii and Roseburia faecis species, as well as members of the genus Roseburia were statistically significantly more abundant in the healthy volunteers group (6.5, 2.14, 8.75 and 5.2 times more frequently compared to patients). The presence of these microorganisms was correlated with dietary components. CONCLUSION Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.

Research paper thumbnail of Plasma levels of neurotrophic factors are not associated with the severity of depression

Consortium Psychiatricum, 2021

Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depre... more Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be useful as an objective diagnosis of the disease and predicting the severity of the pathology. We determined plasma concentrations of the monoamine neurotransmitters serotonin and dopamine, and neurotrophic factors involved in neurogenesis (BDNF, CDNF and neuropeptide Y) in depressed patients and healthy volunteers with the same socio-demographic parameters using enzyme immunoassay and mass spectrometry. All study participants were administered the Hamilton Depression Scale (HAMD), the Generalized Anxiety Disorder Questionnaire (GAD-7), and the Center for Epidemiological Studies (CES-D). The cumulative scores on the three scales examined were significantly higher in depressed patients than ...

Research paper thumbnail of Negative Symptoms of Schizophrenia: New Prospects of Cariprazine Treatment

Consortium Psychiatricum, 2020

Background. Cariprazine is a new piperazine derivative atypical antipsychotic, like aripiprazole ... more Background. Cariprazine is a new piperazine derivative atypical antipsychotic, like aripiprazole and brexpiprazole. It has been approved for treating schizophrenia in many countries and has recently been included on the List of Essential Medicines in Russia. Unlike most other atypical antipsychotics, it shows high in vivo occupancy of dopamine D2 and D3 receptors at clinically relevant doses. In animal models, cariprazine has demonstrated dopamine D3 receptor- dependent pro-cognitive and anti-anhedonic effects, suggesting its potential for treating negative symptoms. This review summarizes the efficacy of cariprazine in the treatment of negative symptoms of schizophrenia. Methods. A literature search of databases covering international and Russian journals, for articles published between 1st January 2010 and 1stJune 2020. Results. Cariprazine demonstrated at least comparable efficacy in the treatment of schizophrenia symptoms to active comparators including risperidone, olanzapine o...

Research paper thumbnail of Results of the COVID-19 mental health international for the health professionals (COMET-HP) study: depression, suicidal tendencies and conspiracism

Social Psychiatry and Psychiatric Epidemiology

Introduction The current study aimed to investigate the rates of anxiety, clinical depression, an... more Introduction The current study aimed to investigate the rates of anxiety, clinical depression, and suicidality and their changes in health professionals during the COVID-19 outbreak.

Research paper thumbnail of Anxiety, Depression and Suicidality in Healthcare Workers during the COVID-19 Pandemic: The Russian Study Sample of the COMET-G Project

Psychiatria Danubina, Sep 1, 2022

Research paper thumbnail of Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder

Biomedicines

Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors c... more Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors causing the pathogenesis of MDD include gut microbiota (GM), which interacts with the host through the gut–brain axis. In previous studies of GM in MDD patients, 16S rRNA sequencing was used, which provided information about composition but not about function. In our study, we analyzed whole metagenome sequencing data to assess changes in both the composition and functional profile of GM. We looked at the GM of 36 MDD patients, compared with that of 38 healthy volunteers. Comparative taxonomic analysis showed decreased abundances of Faecalibacterium prausnitzii, Roseburia hominis, and Roseburia intestinalis, and elevated abundances of Escherichia coli and Ruthenibacterium lactatiformans in the GM of MDD patients. We observed decreased levels of bacterial genes encoding key enzymes involved in the production of arginine, asparagine, glutamate, glutamine, melatonin, acetic, butyric and conj...

Research paper thumbnail of The Relationship Between Laboratory and Clinical Indicators in Diagnosing and Treating of Bipolar Disorder

Psychiatria Danubina, Apr 11, 2018

Research paper thumbnail of Multi-center validation of the Russians version of the diagnostic interview for psychoses

European Psychiatry, 2019

Research paper thumbnail of Impact of COVID-19 pandemic on anxiety, depression and distress – online survey results amid the pandemic in Russia

Consortium Psychiatricum, 2020

Background. In 2020, the COVID-19 pandemic evoked a variety of research into the virus and its ef... more Background. In 2020, the COVID-19 pandemic evoked a variety of research into the virus and its effects on mental health. A variety of mental health and psychological problems have been reported: stress, anxiety, depressive symptoms, insomnia, denial, stigma, anger and fear. Objectives. To assess the level of anxiety, depression and distress in the general population during the lockdown in Russia and to reveal factors associated with distress. Methods. An online survey was carried out from 22-27 April 2020 (the fourth week of lockdown) among the general population (mostly Moscow residents). The survey questions covered general information about people's social and demographic characteristics, experience of COVID-19, health condition (physical and mental), attitudes and views on the pandemic, and the need for psychological support. The survey included the Hospital Anxiety and Depression Scale (HADS) and evaluation of the preceding week's subjective distress level using a visual numeric scale (from 0 to 10). We also asked respondents to specify the causes of distress, adopted from the WHO information sheet relating to the major psychological challenges of the COVID-19 pandemic. Results. In total, 352 responses were collected (men = 74, women = 278; age (M ± SD) = 36.81 ± 11.36 y.o.). Most respondents (n = 225, 63.92%) did not have any personal experience of the coronavirus infection. Normal levels of anxiety and depression scores were prevalent in the sample. Higher than normal levels of HADS anxiety/ depression (> 7 scores) were observed in 105 (29.83%) and 59 (16.76%) respondents, respectively; mean (95% CI) scores for HADS anxiety/depression were 6.23 [5.77, 6.68] /4.65 [4.22, 5.08] (women) and 4.20 [3.32, 5.09] /3.46 [2.63, 4.29] (men), respectively. The leading causes of distress were: 1) the risk of financial problems in the future (n = 267, 76.3%); 2) violation of plans and the disruption to normal life (n = 235, 67.1%; and n = 240, 68.6%, respectively); 3) the health of elderly or chronically diseased relatives (n = 205, 58.6%) and 4) being in self-isolation (n = 186, 53.1%).

Research paper thumbnail of Clinical staging in panic disorder and agoraphobia

European Psychiatry, 2016

There is an increasing literature about the implementation of the staging model in many mental di... more There is an increasing literature about the implementation of the staging model in many mental disorders. According to this approach, there are four stages of a psychiatric disorder: prodromal stage, acute manifestations, residual phase, chronic. In this study, we empirically investigate whether additional clinical variables such as clinical manifestations and comorbid disorders may be useful to modify the staging model to panic disorder (PD).We distinguished inpatient sample (n = 79) with a diagnosis of “panic disorder” according to the DSM-IV criteria. We propose that the inclusion of prodromal stage of PD does not make clinical sense since the different unspecific neurotic symptoms may proceed to a variety of anxiety and depressive disorders. First stage was characterized by the situationally predisposed panic attacks (PA) with both somatic and cognitive symptoms. Comorbid disorders included somatoform disorders and generalized anxiety disorder (GAD). During second stage individu...

Research paper thumbnail of Multi-centre clinical assessment of the Russian language version of the Diagnostic Interview for Psychoses

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018

Цель исследования. Диагностическое интервью для психозов (ДИП) разработано с целью повышения каче... more Цель исследования. Диагностическое интервью для психозов (ДИП) разработано с целью повышения качества диагностики психотических расстройств. Настоящее исследование-апробация ДИП в России с оценкой валидности и надежности русскоязычной версии. Материал и методы. 98 больных с психотическими расстройствами (89 видеозаписей) исследовались 12 интервьюерами с помощью русскоязычной версии ДИП на базе семи клинических центров шести городов Российской Федерации. Для определения межэкспертной надежности оценки ДИП 32 случаев из рандомизированной выборки, выставленные 9 интервьюерами, сравнивались с оценками ДИП исследователей, анализировались коэффициенты общего парного согласия и каппа Коэна. Валидность рассчитывалась на основании сравнения оценок ДИП интервьюеров и 62 тех же самых клинических случаев из базы семейного исследования шизофрении Западной Австралии в качестве золотого стандарта. Результаты и заключение. Средняя продолжительность интервью составила 47±21 мин. Статистика каппа продемонстрировала значительное и почти полное согласие для большинства пунктов ДИП (84,54%) и значительноедля диагнозов МКБ-10 с применением компьютерного диагностического алгоритма ДИП (κ=0,68; 95% ДИ 0,53, 0,93). Степень согласия на основании клинических выводов исследователей была существенно ниже (κ=0,31; 95% ДИ 0,06, 0,56). согласие при оценке аффективных и позитивных симптомов было статистически значимо выше, чем негативных (F(2,44)=20,72, p<0,001, η 2 =0,485). Диагностическая валидность русскоязычной версии ДИП была подтверждена совпадением 73% (45/62) диагнозов на основе ДИП и базы Семейного исследования шизофрении Западной Австралии. В рамках несовпадения диагнозов в 80 случаях с диагнозом «F20 Шизофрения» в медицинской документации соответствовали диагнозы F20, выставленные исследователями только у 68 пациентов, и в 62 случаях-F20 на основании компьютерных выводов ДИП. Процесс оценки пунктов ДИП показал низкий и умеренный уровень затруднений интервьюеров. Результаты исследования подтверждают надежность и валидность русскоязычной версии ДИП при оценке психотических расстройств. ДИП может быть рекомендован как важный диагностический ресурс для использования в образовательном процессе, клинической практике и исследованиях. Ключевые слова: диагностическое интервью для психозов (ДИП), валидность, надежность, психиатрический диагноз, психотические расстройства, шизофрения. Multi-center clinical assessment of the Russian language version of the Diagnostic Interview for Psychoses

Research paper thumbnail of The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study

Research paper thumbnail of Symptomatic Profi le of Cariprazine in the Context of ICD-11 Domains for Schizophrenia: Review of Clinically Oriented Studies

INTRODUCTION: One of the innovations in the ICD-11grouping "Schizophrenia and Other Primary ... more INTRODUCTION: One of the innovations in the ICD-11grouping "Schizophrenia and Other Primary Psychotic Disorders" is the implementation of six symptom domains intended to improve diagnostics and treatment of these mental conditions in clinical practice. In this respect, evaluation of the eff ects of various psychotropic drugs, primarily antipsychotic agents, on the specifi ed psychotic symptom domains is a critical task. The antipsychotic agent cariprazine, registered in many countries worldwide (including Russia) for schizophrenia treatment, was selected as the psychotropic drug model for the purposes of the present review. METHODS: For the purposes of this review the MEDLINE, Cochrane Central Register of Controlled Trials, and PubMed databases were searched for randomized controlled trials comparing cariprazine with a placebo, or a placebo and one or several antipsychotic agents, and that was performed within the period from January 2014 to March 2021. RESULTS: Cariprazin...

Research paper thumbnail of Results of the COVID-19 mental health international for the general population (COMET-G) study

European Neuropsychopharmacology, 2021

There are few published empirical data on the effects of COVID-19 on mental health, and until now... more There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them.

Research paper thumbnail of Negative symptoms of schizophrenia: the conceptualization and pathophysiological mechanisms. Part 1

Research paper thumbnail of A synopsis of original research projects published in scientific database in the Russian Federation

Asian Journal of Psychiatry, 2015

The Russian Federation had until recently five state research psychiatric centers and more than 4... more The Russian Federation had until recently five state research psychiatric centers and more than 40 psychiatry departments at medical institutions (Pavlichenko and Smirnova, 2012). However, a major reform in 2014 led to consolidation, i.e. of three former research institutes in Moscow now comprise the Federal Medical Research Center of Psychiatry and Addictions, which is now the largest such institution in the Federation. Although consolidation resulted in fewer thesis committees in psychiatry, the overriding objective was to optimize funding, and make psychiatry research in Russia more competitive. During 2000-2011, 2.6% of all medical dissertations in Russia were defended on the specialty of ''Psychiatry'' (Evdokimov and Chehlaty, 2012), to a total of 1449 dissertations. There was a mean of 121 AE 5 monographs per year, including 19 AE 1 (16%) dissertations of Doctoral Degree in Medicine, and 102 AE 5 Candidate of Medical Science (PhD) dissertations. The peak output of dissertations was in 2004-2005 (R 2 = 0.76, p < 0.001). Overall, a third of dissertations were prepared within two research disciplines (specialties). The candidate must complete the monograph, as well as an inventory patent, and publish full-length papers in journals approved by the Supreme Attestation Commission of the Russian Federation. Since 2013, the standard has entailed two papers for a PhD degree, ten for a Doctoral degree in Medicine (2013).

Research paper thumbnail of A synopsis of recent papers published in psychiatric journals in the Russian Federation

Asian Journal of Psychiatry, 2012

Four influential papers that have appeared recently in the main psychiatric journals from Russia ... more Four influential papers that have appeared recently in the main psychiatric journals from Russia are summarized. The first paper examines socio-demographic profile and clinical manifestations and data of people with mental disorders attending the private psychiatric clinics. It was seen that about 50% of private mental health settings&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; patients had never consulted a public psychiatric service before seeking help at private psychiatric clinics. Private mental health services have proven their effectiveness in the treatment of non-psychotic disorders and intervention in early onset psychoses. The second paper describes neuropsychological and evolutionary approaches in understanding the comorbidity between depressive and anxiety disorders. It suggests that if anxiety disorder manifests as the first diagnosis, it is more likely that the person will have depression than vice versa. The next article concludes that there is a specific vulnerability of different groups of somatically ill patients to particular mental disorders: cancer is mainly associated with dissociative disorders and asthenia; patients with cardiac disorders are more likely to have comorbid anxiety disorders, hypochondriasis and severe depression. Patients with dermatological illnesses are more likely to have obsessive-compulsive disorder, delusional disorder and mild depression. The last paper discusses some social-psychological and neuro-immunological parameters of people with &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;dangerous&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; professions. Using mathematical method, the authors created a model that can decrease the negative influence of work-related extreme factors.

Research paper thumbnail of Effect of cariprazine on the 6 domains of schizophrenia in ICD-11: a narrative review

Consortium Psychiatricum, 2022

One of the innovations in the ICD-11 section "schizophrenia and other primary psychotic diso... more One of the innovations in the ICD-11 section "schizophrenia and other primary psychotic disorders" is the implementation of 6 additional domains, which should improve the diagnosis and treatment of these conditions. Cariprazine is a new atypical antipsychotic with a predominant affinity for D3 receptors, which is registered in Russia for the treatment of schizophrenia, mania, mixed and depressive episodes in bipolar I disorder. In modern algorithms for the treatment of schizophrenia with the dominance of negative disorders, pharmacotherapy is recommended to start with cariprazine, as the drug that has the best evidence base in the treatment of the ICD-11 "negative symptoms" domain. Cariprazine has been shown to be effective against the symptoms of the ICD-11 "positive symptoms" domain and can be considered the drug of choice in the treatment of first and multiple episodes of illness, disorganized thinking and disturbed behavior in the form of aggression...

Research paper thumbnail of Interactions between Anxiety Levels and Life Habits Changes in General Population during the Pandemic Lockdown: Decreased Physical Activity, Falling Asleep Late and Internet Browsing about COVID-19 Are Risk Factors for Anxiety, whereas Social Media Use Is not

Psychiatria Danubina, 2021

The COVID-19 pandemic has substantially contributed to increased anxiety rates among the general ... more The COVID-19 pandemic has substantially contributed to increased anxiety rates among the general population worldwide. Pandemic-related health anxiety and worries about getting COVID-19 can lead to generalized anxiety and anxiety somatization, which, together with insalubrious daily life habits, are risk factors of worsening somatic health in people with SARS-Cov-2 infection. The current study is a part of the COMET-G project (40 countries, n=55589; approved by the Ethics Committee of the Aristotle University of Thessaloniki), which represents an intermediate analysis of data collected anonymously via online links from a national sample of the Russian general population (n=9936, 31.09±12.16 y.o., 58.7% females) to estimate anxiety using STAI-S and self-reported changes in anxiety and life habits (physical activity, nutrition and weight, internet use, sleep) during the lockdown. All statistical calculations (descriptive statistics, between group comparisons using chi-square test, MAN...

Research paper thumbnail of Assessment of environmental and economic efficiency of iron ore breaking technology using emulsion explosives

Geotehnіchna mehanіka, 2014

методика расчета параметров буровзрывных работ при ведении очистных работ на шахтах Криворожского... more методика расчета параметров буровзрывных работ при ведении очистных работ на шахтах Криворожского бассейна и ЧАО «Запорожский железорудный комбинат», за счет установленного коэффициента относительной мощности взрывчатого вещества типа Украинит-ПМ-2Б. Предложена технология ведения очистных работ для отбойки руды при камерных системах разработки для залежей мощностью более 5 м с применением эмульсионных взрывчатых веществ, предусматривающая бурение нисходящих вееров эксплуатационных скважин в направлении нижележащих буровых горизонтов. Выполнена эколого-экономическая оценка эффективности внедрения предлагаемой технологии отбойки руды в очистных камерах. Выявлены закономерности изменения индекса опасности вредных веществ при использовании тротилосодержащих и эмульсионных взрывчатых веществ в зависимости от расстояния до источника выброса. Внедрение предлагаемой технологии позволит снизить себестоимость 1 т руды до 15% на одну выемочную единицу. Ключевые слова: тротилосодержащие и эмульсионные взрывчатые вещества, экологическая безопасность, технология отбойки руды.

Research paper thumbnail of Effects of diet on the gut microbiome in patients with depression

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022

OBJECTIVE To investigate the effects of diet on the gut microbiota and to assess the relationship... more OBJECTIVE To investigate the effects of diet on the gut microbiota and to assess the relationship of these factors with depression. MATERIAL AND METHODS Microorganisms that predominate in depressed patients were identified and associations of the identified organisms with the patients' diet were performed. Fourteen depressed patients and 14 healthy volunteers with the same socio-demographic parameters were included in the study. The Hamilton Depression Scale, Generalized Anxiety Disorder Questionnaire, and the Center for Epidemiologic Studies Questionnaire were used. RESULTS Erysipelatoclostridium and Clostridium innocuum species were 11.3 and 14.4 times higher in depressed patients compared with healthy controls. Fusicatenibacter saccharivorans, Faecalibacterium prausnitzii and Roseburia faecis species, as well as members of the genus Roseburia were statistically significantly more abundant in the healthy volunteers group (6.5, 2.14, 8.75 and 5.2 times more frequently compared to patients). The presence of these microorganisms was correlated with dietary components. CONCLUSION Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.

Research paper thumbnail of Plasma levels of neurotrophic factors are not associated with the severity of depression

Consortium Psychiatricum, 2021

Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depre... more Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be useful as an objective diagnosis of the disease and predicting the severity of the pathology. We determined plasma concentrations of the monoamine neurotransmitters serotonin and dopamine, and neurotrophic factors involved in neurogenesis (BDNF, CDNF and neuropeptide Y) in depressed patients and healthy volunteers with the same socio-demographic parameters using enzyme immunoassay and mass spectrometry. All study participants were administered the Hamilton Depression Scale (HAMD), the Generalized Anxiety Disorder Questionnaire (GAD-7), and the Center for Epidemiological Studies (CES-D). The cumulative scores on the three scales examined were significantly higher in depressed patients than ...

Research paper thumbnail of Negative Symptoms of Schizophrenia: New Prospects of Cariprazine Treatment

Consortium Psychiatricum, 2020

Background. Cariprazine is a new piperazine derivative atypical antipsychotic, like aripiprazole ... more Background. Cariprazine is a new piperazine derivative atypical antipsychotic, like aripiprazole and brexpiprazole. It has been approved for treating schizophrenia in many countries and has recently been included on the List of Essential Medicines in Russia. Unlike most other atypical antipsychotics, it shows high in vivo occupancy of dopamine D2 and D3 receptors at clinically relevant doses. In animal models, cariprazine has demonstrated dopamine D3 receptor- dependent pro-cognitive and anti-anhedonic effects, suggesting its potential for treating negative symptoms. This review summarizes the efficacy of cariprazine in the treatment of negative symptoms of schizophrenia. Methods. A literature search of databases covering international and Russian journals, for articles published between 1st January 2010 and 1stJune 2020. Results. Cariprazine demonstrated at least comparable efficacy in the treatment of schizophrenia symptoms to active comparators including risperidone, olanzapine o...

Research paper thumbnail of Results of the COVID-19 mental health international for the health professionals (COMET-HP) study: depression, suicidal tendencies and conspiracism

Social Psychiatry and Psychiatric Epidemiology

Introduction The current study aimed to investigate the rates of anxiety, clinical depression, an... more Introduction The current study aimed to investigate the rates of anxiety, clinical depression, and suicidality and their changes in health professionals during the COVID-19 outbreak.

Research paper thumbnail of Anxiety, Depression and Suicidality in Healthcare Workers during the COVID-19 Pandemic: The Russian Study Sample of the COMET-G Project

Psychiatria Danubina, Sep 1, 2022

Research paper thumbnail of Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder

Biomedicines

Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors c... more Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors causing the pathogenesis of MDD include gut microbiota (GM), which interacts with the host through the gut–brain axis. In previous studies of GM in MDD patients, 16S rRNA sequencing was used, which provided information about composition but not about function. In our study, we analyzed whole metagenome sequencing data to assess changes in both the composition and functional profile of GM. We looked at the GM of 36 MDD patients, compared with that of 38 healthy volunteers. Comparative taxonomic analysis showed decreased abundances of Faecalibacterium prausnitzii, Roseburia hominis, and Roseburia intestinalis, and elevated abundances of Escherichia coli and Ruthenibacterium lactatiformans in the GM of MDD patients. We observed decreased levels of bacterial genes encoding key enzymes involved in the production of arginine, asparagine, glutamate, glutamine, melatonin, acetic, butyric and conj...

Research paper thumbnail of The Relationship Between Laboratory and Clinical Indicators in Diagnosing and Treating of Bipolar Disorder

Psychiatria Danubina, Apr 11, 2018

Research paper thumbnail of Multi-center validation of the Russians version of the diagnostic interview for psychoses

European Psychiatry, 2019

Research paper thumbnail of Impact of COVID-19 pandemic on anxiety, depression and distress – online survey results amid the pandemic in Russia

Consortium Psychiatricum, 2020

Background. In 2020, the COVID-19 pandemic evoked a variety of research into the virus and its ef... more Background. In 2020, the COVID-19 pandemic evoked a variety of research into the virus and its effects on mental health. A variety of mental health and psychological problems have been reported: stress, anxiety, depressive symptoms, insomnia, denial, stigma, anger and fear. Objectives. To assess the level of anxiety, depression and distress in the general population during the lockdown in Russia and to reveal factors associated with distress. Methods. An online survey was carried out from 22-27 April 2020 (the fourth week of lockdown) among the general population (mostly Moscow residents). The survey questions covered general information about people's social and demographic characteristics, experience of COVID-19, health condition (physical and mental), attitudes and views on the pandemic, and the need for psychological support. The survey included the Hospital Anxiety and Depression Scale (HADS) and evaluation of the preceding week's subjective distress level using a visual numeric scale (from 0 to 10). We also asked respondents to specify the causes of distress, adopted from the WHO information sheet relating to the major psychological challenges of the COVID-19 pandemic. Results. In total, 352 responses were collected (men = 74, women = 278; age (M ± SD) = 36.81 ± 11.36 y.o.). Most respondents (n = 225, 63.92%) did not have any personal experience of the coronavirus infection. Normal levels of anxiety and depression scores were prevalent in the sample. Higher than normal levels of HADS anxiety/ depression (> 7 scores) were observed in 105 (29.83%) and 59 (16.76%) respondents, respectively; mean (95% CI) scores for HADS anxiety/depression were 6.23 [5.77, 6.68] /4.65 [4.22, 5.08] (women) and 4.20 [3.32, 5.09] /3.46 [2.63, 4.29] (men), respectively. The leading causes of distress were: 1) the risk of financial problems in the future (n = 267, 76.3%); 2) violation of plans and the disruption to normal life (n = 235, 67.1%; and n = 240, 68.6%, respectively); 3) the health of elderly or chronically diseased relatives (n = 205, 58.6%) and 4) being in self-isolation (n = 186, 53.1%).

Research paper thumbnail of Clinical staging in panic disorder and agoraphobia

European Psychiatry, 2016

There is an increasing literature about the implementation of the staging model in many mental di... more There is an increasing literature about the implementation of the staging model in many mental disorders. According to this approach, there are four stages of a psychiatric disorder: prodromal stage, acute manifestations, residual phase, chronic. In this study, we empirically investigate whether additional clinical variables such as clinical manifestations and comorbid disorders may be useful to modify the staging model to panic disorder (PD).We distinguished inpatient sample (n = 79) with a diagnosis of “panic disorder” according to the DSM-IV criteria. We propose that the inclusion of prodromal stage of PD does not make clinical sense since the different unspecific neurotic symptoms may proceed to a variety of anxiety and depressive disorders. First stage was characterized by the situationally predisposed panic attacks (PA) with both somatic and cognitive symptoms. Comorbid disorders included somatoform disorders and generalized anxiety disorder (GAD). During second stage individu...

Research paper thumbnail of Multi-centre clinical assessment of the Russian language version of the Diagnostic Interview for Psychoses

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018

Цель исследования. Диагностическое интервью для психозов (ДИП) разработано с целью повышения каче... more Цель исследования. Диагностическое интервью для психозов (ДИП) разработано с целью повышения качества диагностики психотических расстройств. Настоящее исследование-апробация ДИП в России с оценкой валидности и надежности русскоязычной версии. Материал и методы. 98 больных с психотическими расстройствами (89 видеозаписей) исследовались 12 интервьюерами с помощью русскоязычной версии ДИП на базе семи клинических центров шести городов Российской Федерации. Для определения межэкспертной надежности оценки ДИП 32 случаев из рандомизированной выборки, выставленные 9 интервьюерами, сравнивались с оценками ДИП исследователей, анализировались коэффициенты общего парного согласия и каппа Коэна. Валидность рассчитывалась на основании сравнения оценок ДИП интервьюеров и 62 тех же самых клинических случаев из базы семейного исследования шизофрении Западной Австралии в качестве золотого стандарта. Результаты и заключение. Средняя продолжительность интервью составила 47±21 мин. Статистика каппа продемонстрировала значительное и почти полное согласие для большинства пунктов ДИП (84,54%) и значительноедля диагнозов МКБ-10 с применением компьютерного диагностического алгоритма ДИП (κ=0,68; 95% ДИ 0,53, 0,93). Степень согласия на основании клинических выводов исследователей была существенно ниже (κ=0,31; 95% ДИ 0,06, 0,56). согласие при оценке аффективных и позитивных симптомов было статистически значимо выше, чем негативных (F(2,44)=20,72, p<0,001, η 2 =0,485). Диагностическая валидность русскоязычной версии ДИП была подтверждена совпадением 73% (45/62) диагнозов на основе ДИП и базы Семейного исследования шизофрении Западной Австралии. В рамках несовпадения диагнозов в 80 случаях с диагнозом «F20 Шизофрения» в медицинской документации соответствовали диагнозы F20, выставленные исследователями только у 68 пациентов, и в 62 случаях-F20 на основании компьютерных выводов ДИП. Процесс оценки пунктов ДИП показал низкий и умеренный уровень затруднений интервьюеров. Результаты исследования подтверждают надежность и валидность русскоязычной версии ДИП при оценке психотических расстройств. ДИП может быть рекомендован как важный диагностический ресурс для использования в образовательном процессе, клинической практике и исследованиях. Ключевые слова: диагностическое интервью для психозов (ДИП), валидность, надежность, психиатрический диагноз, психотические расстройства, шизофрения. Multi-center clinical assessment of the Russian language version of the Diagnostic Interview for Psychoses

Research paper thumbnail of The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study

Research paper thumbnail of Symptomatic Profi le of Cariprazine in the Context of ICD-11 Domains for Schizophrenia: Review of Clinically Oriented Studies

INTRODUCTION: One of the innovations in the ICD-11grouping "Schizophrenia and Other Primary ... more INTRODUCTION: One of the innovations in the ICD-11grouping "Schizophrenia and Other Primary Psychotic Disorders" is the implementation of six symptom domains intended to improve diagnostics and treatment of these mental conditions in clinical practice. In this respect, evaluation of the eff ects of various psychotropic drugs, primarily antipsychotic agents, on the specifi ed psychotic symptom domains is a critical task. The antipsychotic agent cariprazine, registered in many countries worldwide (including Russia) for schizophrenia treatment, was selected as the psychotropic drug model for the purposes of the present review. METHODS: For the purposes of this review the MEDLINE, Cochrane Central Register of Controlled Trials, and PubMed databases were searched for randomized controlled trials comparing cariprazine with a placebo, or a placebo and one or several antipsychotic agents, and that was performed within the period from January 2014 to March 2021. RESULTS: Cariprazin...

Research paper thumbnail of Results of the COVID-19 mental health international for the general population (COMET-G) study

European Neuropsychopharmacology, 2021

There are few published empirical data on the effects of COVID-19 on mental health, and until now... more There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them.

Research paper thumbnail of Negative symptoms of schizophrenia: the conceptualization and pathophysiological mechanisms. Part 1

Research paper thumbnail of A synopsis of original research projects published in scientific database in the Russian Federation

Asian Journal of Psychiatry, 2015

The Russian Federation had until recently five state research psychiatric centers and more than 4... more The Russian Federation had until recently five state research psychiatric centers and more than 40 psychiatry departments at medical institutions (Pavlichenko and Smirnova, 2012). However, a major reform in 2014 led to consolidation, i.e. of three former research institutes in Moscow now comprise the Federal Medical Research Center of Psychiatry and Addictions, which is now the largest such institution in the Federation. Although consolidation resulted in fewer thesis committees in psychiatry, the overriding objective was to optimize funding, and make psychiatry research in Russia more competitive. During 2000-2011, 2.6% of all medical dissertations in Russia were defended on the specialty of ''Psychiatry'' (Evdokimov and Chehlaty, 2012), to a total of 1449 dissertations. There was a mean of 121 AE 5 monographs per year, including 19 AE 1 (16%) dissertations of Doctoral Degree in Medicine, and 102 AE 5 Candidate of Medical Science (PhD) dissertations. The peak output of dissertations was in 2004-2005 (R 2 = 0.76, p < 0.001). Overall, a third of dissertations were prepared within two research disciplines (specialties). The candidate must complete the monograph, as well as an inventory patent, and publish full-length papers in journals approved by the Supreme Attestation Commission of the Russian Federation. Since 2013, the standard has entailed two papers for a PhD degree, ten for a Doctoral degree in Medicine (2013).

Research paper thumbnail of A synopsis of recent papers published in psychiatric journals in the Russian Federation

Asian Journal of Psychiatry, 2012

Four influential papers that have appeared recently in the main psychiatric journals from Russia ... more Four influential papers that have appeared recently in the main psychiatric journals from Russia are summarized. The first paper examines socio-demographic profile and clinical manifestations and data of people with mental disorders attending the private psychiatric clinics. It was seen that about 50% of private mental health settings&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; patients had never consulted a public psychiatric service before seeking help at private psychiatric clinics. Private mental health services have proven their effectiveness in the treatment of non-psychotic disorders and intervention in early onset psychoses. The second paper describes neuropsychological and evolutionary approaches in understanding the comorbidity between depressive and anxiety disorders. It suggests that if anxiety disorder manifests as the first diagnosis, it is more likely that the person will have depression than vice versa. The next article concludes that there is a specific vulnerability of different groups of somatically ill patients to particular mental disorders: cancer is mainly associated with dissociative disorders and asthenia; patients with cardiac disorders are more likely to have comorbid anxiety disorders, hypochondriasis and severe depression. Patients with dermatological illnesses are more likely to have obsessive-compulsive disorder, delusional disorder and mild depression. The last paper discusses some social-psychological and neuro-immunological parameters of people with &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;dangerous&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; professions. Using mathematical method, the authors created a model that can decrease the negative influence of work-related extreme factors.

Research paper thumbnail of Effect of cariprazine on the 6 domains of schizophrenia in ICD-11: a narrative review

Consortium Psychiatricum, 2022

One of the innovations in the ICD-11 section "schizophrenia and other primary psychotic diso... more One of the innovations in the ICD-11 section "schizophrenia and other primary psychotic disorders" is the implementation of 6 additional domains, which should improve the diagnosis and treatment of these conditions. Cariprazine is a new atypical antipsychotic with a predominant affinity for D3 receptors, which is registered in Russia for the treatment of schizophrenia, mania, mixed and depressive episodes in bipolar I disorder. In modern algorithms for the treatment of schizophrenia with the dominance of negative disorders, pharmacotherapy is recommended to start with cariprazine, as the drug that has the best evidence base in the treatment of the ICD-11 "negative symptoms" domain. Cariprazine has been shown to be effective against the symptoms of the ICD-11 "positive symptoms" domain and can be considered the drug of choice in the treatment of first and multiple episodes of illness, disorganized thinking and disturbed behavior in the form of aggression...

Research paper thumbnail of Interactions between Anxiety Levels and Life Habits Changes in General Population during the Pandemic Lockdown: Decreased Physical Activity, Falling Asleep Late and Internet Browsing about COVID-19 Are Risk Factors for Anxiety, whereas Social Media Use Is not

Psychiatria Danubina, 2021

The COVID-19 pandemic has substantially contributed to increased anxiety rates among the general ... more The COVID-19 pandemic has substantially contributed to increased anxiety rates among the general population worldwide. Pandemic-related health anxiety and worries about getting COVID-19 can lead to generalized anxiety and anxiety somatization, which, together with insalubrious daily life habits, are risk factors of worsening somatic health in people with SARS-Cov-2 infection. The current study is a part of the COMET-G project (40 countries, n=55589; approved by the Ethics Committee of the Aristotle University of Thessaloniki), which represents an intermediate analysis of data collected anonymously via online links from a national sample of the Russian general population (n=9936, 31.09±12.16 y.o., 58.7% females) to estimate anxiety using STAI-S and self-reported changes in anxiety and life habits (physical activity, nutrition and weight, internet use, sleep) during the lockdown. All statistical calculations (descriptive statistics, between group comparisons using chi-square test, MAN...