Ali Elmabsout - Academia.edu (original) (raw)

Papers by Ali Elmabsout

European journal of medical and health sciences, Mar 5, 2023

Background: There is an effort made to improve drug prescribing practices in developing countries... more Background: There is an effort made to improve drug prescribing practices in developing countries. The aim of present work was to comparing prescribing indicators, patient care, and missing information on prescriptions and identifying and assessing drug use patterns in three polyclinics in Benghazi city, Libya. Methods: In this descriptive cross section study a random sample of 1522 prescriptions were selected from three polyclinics include Ras-Ebida, Khalid Ibn-Elwalid and Al-Kish, over 4 months (July-October 2020). The data was collected through predesigned questionnaire. The prescriptions were analyzed for the following indicators: prescribing indicators, patientcare indicators and drug-use indicators. Results: A total of 1522 prescriptions (average = 507.3/clinic) were collected from the three polyclinics including 2329 prescribed (average = 1.4/prescription) items. Percentage of drugs prescribed with generic name was 0.0%, the percentage of prescriptions with antibiotics was 46.3%. The average of prescriptions of injections was 0.84. The average consultation time is 3.4 min and the average dispensing time was found to be 24 seconds. Major classes of drugs prescribed included analgesics, antibiotics, drugs used in medicine & derma clinics, ophthalmic drugs, minerals & vitamins, anti-inflammatory drugs, antihistaminic and antifungal drugs. The most prescribed analgesic was paracetamol (94.4%) and antibiotic was Augmentin (50.3%). In regarding prescribed drug in medicine clinics was found lisinopril (32.0%) and ophthalmic drug was cusicrom (36.8%). In addition, the majorities of prescribed vitamin were vitamin C (81.0%), for GIT drug was omeprazole (59.3%), and for dermatology was Fucidin (56.3%). While most prescribed antiinflammatory was aspirin (52.4%), antihistaminic was loratidine (97.0%), for antifungal drug was flagyl (58.0%). Conclusion: Despite the efforts being made to improve prescribing habits and to rationalize the use of drugs, the obtained results confirm the deficiencies as reported earlier and suggest that methods of intervention should be initiated to improve prescribing trends in these polyclinics.

Asian Journal of Basic Science & Research, 2023

BMC Genomics, 2013

Background: Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic... more Background: Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic periodontitis. In addition, this bacterium is also involved in the development of cardiovascular disease. The aim of this study was to investigate the effects of P. gingivalis infection on gene and protein expression in human aortic smooth muscle cells (AoSMCs) and its relation to cellular function. Results: AoSMCs were exposed to viable P. gingivalis for 24 h, whereafter confocal fluorescence microscopy was used to study P. gingivalis invasion of AoSMCs. AoSMCs proliferation was evaluated by neutral red assay. Human genome microarray, western blot and ELISA were used to investigate how P. gingivalis changes the gene and protein expression of AoSMCs. We found that viable P. gingivalis invades AoSMCs, disrupts stress fiber structures and significantly increases cell proliferation. Microarray results showed that, a total of 982 genes were identified as differentially expressed with the threshold log2 fold change > |1| (adjust p-value <0.05). Using bioinformatic data mining, we demonstrated that up-regulated genes are enriched in gene ontology function of positive control of cell proliferation and down-regulated genes are enriched in the function of negative control of cell proliferation. The results from pathway analysis revealed that all the genes belonging to these two categories induced by P. gingivalis were enriched in 25 pathways, including genes of Notch and TGF-beta pathways. Conclusions: This study demonstrates that P. gingivalis is able to invade AoSMCs and stimulate their proliferation. The activation of TGF-beta and Notch signaling pathways may be involved in the bacteria-mediated proliferation of AoSMCs. These findings further support the association between periodontitis and cardiovascular diseases.

European journal of medical and health sciences, Jun 11, 2022

Introduction: Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characteriz... more Introduction: Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions onset in the first 3 years of life. Therefore, the present study aimed to study the clinical features, nutritional status, risk factors, and behaviors of children with autism. Methods: Across section study involved a total of 100 subjects 74 (76%) male and 26 (24%) female. The ages of the children were ranging from 3-17 years old. The self-administration questionnaire containing questions on behavior, health problems, nutritional status, and risk factors was also completed. Bodyweight and height were measured to calculate the BMI percentile. Laboratory tests such as blood glucose and HbA1C, vitamin D were included. Clinical and behavioral information is also involved. All samples were analyzed through either mean ±SEM or Chi-square to determine significant differences. Results: The present study shows that the majority of the children have age 7 years old, and autism increased significantly at ages between 6-10 years (P<0.05). In comparison to females, a male has three times more affected by autism (P=0.000). There were many points identified in the study including autism onset started between 1-3 years, blood groups of parents O+ significant resultant in offspring with O+ blood groups, 20% of subjects have positive family history and consanguinity for each. The behavior of autistic children shows that children like playing with electronic IPAD, dislike hearing crying, and less sleeping hours than normal people but they have similar food attitudes and consumption compared to normal counterparts. Impairment in communication was the most common sign of autism and less like hours for play. Obesity was a common nutritional disorder and food behavior has been seen toward some foods. The common health problems reported were epilepsy, respiratory diseases, constipation, and UTIs. Conclusion: The present study revealed that some behaviors, risk factors, health problems, and abnormal levels of calcium, hemoglobin, and vitamin D were determined. Furthermore, increase body weight some behaviors toward certain types of foods have been identified. This study suggested that routine monitoring of children with autism should include assessment of blood groups, dietary habits, as well as anthropometric measurements.

PLOS ONE, Apr 6, 2023

Undernutrition (stunting, wasting and underweight) among children remains a public health concern... more Undernutrition (stunting, wasting and underweight) among children remains a public health concern in North Africa, especially following recent conflicts in the region. Therefore, this paper systematically reviews and meta-analyses the prevalence of undernutrition among children under five in North Africa to determine whether efforts to reduce undernutrition are on track to achieving the Sustainable Development Goals (SDGs) by 2030. Eligible studies published between 1 st January 2006 and 10 th April 2022 were searched for, using five electronic bibliographic databases (Ovid MEDLINE, Web of Science, Embase (Ovid), ProQuest and CINAHL). The JBI critical appraisal tool was used, and a meta-analysis was conducted using the 'metaprop' command in STATA, to estimate the prevalence of each undernutrition indicator in the seven North African countries (Egypt,

Zenodo (CERN European Organization for Nuclear Research), Apr 30, 2023

Background: Caffeinated beverages include coffee, tea, hot chocolate, soft drinks, and energy dri... more Background: Caffeinated beverages include coffee, tea, hot chocolate, soft drinks, and energy drinks. The main active ingredient in caffeinated beverages is caffeine. Therefore, the aim of the present work was to determine the caffeine contents of the most popular caffeinated hot beverages and their related health problems. Methods: This cross sectional study accrued out a number of café to collect caffeinated hot beverages for determine their caffeine contents by analytical methods. The next second part of this study was done through predesigned questionnaire to study the most consumed beverages and health problems related hot caffeinated beverages consumption. The data was analysis by Chi-square or T test at α<0.05 for statistical differences. Results: The intake volume of one cup of Espesial hot beverages has mean ± SD 87.6±3.7 ml, Espresso 27±7 ml, green tea 138.33±6 ml, red tea 129.3 ± 14 ml, Nescafe 114.33±17ml and coffee 132±34 ml. Similarly, has been estimated for volume intake of homemade hot beverages and found that mean± SD for coffee, cacao and red tea 58.4±6 ml, 61.7±4 ml, and 57.6±7 ml respectively. Green tea contains an averages caffeine 16.5%, red tea 21.9%, cacao 10.4%, Nescafé 32.2%, Expresso 207.3%, Espesial 50.3%, coffee 132.6% and homemade coffee 102.3%. The total volume intake of caffeine based on the type of cup volume purchased form the café shown that the real intake of caffeine in the beverages were as following 23g/138.33 ml drinkable green tea, 28.5g/129.3 ml drinkable red tea, 6.5g/61.7 ml drinkable cacao, 29g/129.3 ml drinkable Nescafe, 56g/27 ml drinkable Expresso, 44g/87.6 ml drinkable Espesial, 175g/132ml drinkable coffee and 60g/58.4 ml drinkable homemade coffee. This result further shown that, highest caffeine intake was found in Expresso (56g/27 ml), coffee (175g/132ml) and homemade coffee (60g/58.4 ml) while the other hot beverage have least amount of caffeine was that cacao 6.5g/61.7ml, and almost similar amounts of caffeine found in green tea, red tea and Nescafe (about 29g/130 ml for each) and the moderate levels of caffeine found in Expresso, 44g/87.6 ml. The symptoms and complication have been reported by one third of the participants were insomnia, nervousness, headache. The positive effect of caffeine intake reported was improved in mood. Conclusion: The present study revealed that, some caffeinated hot beverages contain higher amounts of caffeine and the people should be aware for such products to avoid the negative or positive effect of caffeine.

Journal of Vascular Research, Jul 6, 2010

hibitor also induced expression of atRA-responsive genes. Therefore, atRA-induced CYP26 expressio... more hibitor also induced expression of atRA-responsive genes. Therefore, atRA-induced CYP26 expression accelerated atRA inactivation in AOSMCs, giving rise to an atRA-CYP26 feedback loop. Inhibition of this loop with a CYP26 inhibitor increased retinoid signaling. Conclusion: The results suggest that CYP26 inhibitors may be a therapeutic alternative to exogenous retinoid administration.

European Journal of Theoretical and Applied Sciences

Obesity is recognized as one of the major nutrition related disorders around the world. Eating be... more Obesity is recognized as one of the major nutrition related disorders around the world. Eating behaviours affect caloric intake and are implicated in the development of obesity. Three types of eating behaviours (cognitive restraint (CR), emotional eating (EE) and uncontrolled eating (UE)) have been studied for associations with obesity in various populations. The aim of the present work was to investigate the interactions between eating behavior and age and to determine the influence of gender on this relationship. This study was conducted on 351 volunteers from Benghazi University students and staff, eating behaviours were measured using the revised three-factor eating questionnaire (TFEQ-R18). Anthropometric measurements for all participants included in this study were measured and BMI was calculated. The finding of this study showed that the age was (26.12 ± 7.749), BMI (23.99 ± 5.003), Cognitive Restraint (15.83 ± 3.662), Emotional Eating (6.74 ± 2.028), and Uncontrolled Eating ...

British Journal of Multidisciplinary and Advanced Studies

The psychostimulant substances were used by medical students is a phenomenon partially well-known... more The psychostimulant substances were used by medical students is a phenomenon partially well-known. The aim of present work was to find the prevalence of use and abuse of psychostimulant drugs among medical students. A descriptive cross sectional study was conducted A structured questionnaire about potential use of caffeine, nicotine, and amphetamine as psychostimulant drugs use, was distributed by electronic means (google forms), among medical students from various levels at different faculties from 18 Libyan medical universities. A total of 752 students responded to the study. About 81.6% of respondents were caffeine users, 13.4% smokers and 6.8% were amphetamines consumers. More than 50% of Caffeine consumers reported increase in their caffeine consumption after started their university studies and 66.9% of nicotine consumers reported increase in nicotine consumption after started their university studies while 81.1% of amphetamine consumers reported that taking amphetamine only s...

World Journal of Advanced Research and Reviews

Asian Journal of Medical Sciences

Background: The Dietary Guidelines for Americans (DGA) 2015-2020 supports that healthy eating pat... more Background: The Dietary Guidelines for Americans (DGA) 2015-2020 supports that healthy eating patterns should include a variety of vegetables from all five of the following vegetable subgroups: dark green, red and orange, legumes, starchy, and others. Aims and Objective: To determine the approximate composition and nutritive values of edible portions of different varieties of popular seeds and to identify the heavy metals contents of these seeds. Materials and Methods: Five different seeds were collected from traditional supermarkets in Benghazi. Moisture and Ash contents in the samples were determined by A.O.A.C method. Total fat and the crude protein content in the seed sample were measured by using soxhlet extraction, and the Kjeldahl method of AOAC, respectively. The mineral content in seeds also determined by Atomic Absorption, spectrophotometer. Result: Five different seeds (pumpkin, sunflower, watermelon seeds, corn and chickpea) were analyzed for determination their protein,...

International Journal of Health Sciences and Research, 2021

Background: A cross-sectional study aimed to determine the factors association with repeated weig... more Background: A cross-sectional study aimed to determine the factors association with repeated weight loss attempts, and weight loss maintenance. Methods: The study was conducted in the main public hospitals in Benghazi, Libya. A total sample of 300 participants who suffered from weight gain or/ obesity and had a history of trying of weight loss. The data were collected by using a questionnaire that include all the factors that may affect the weight loss process such as social, psychological, health, factors related to diet , and daily behavior factors. Results: The majority of participants 78% were found at age group between 15-35 years, 81.7% of them were female and 18.3% were male. More than half of participants 56% had less than four times of weight loss attempts, while 43.6% of them had more than four attempts. The repetition of weight loss attempts was associated with genetic, binge eating, tension, anxiety, negative body image, duration of weight loss maintenance, watching TV o...

P. gingivalis were enriched in 25 pathways, including genes of Notch and TGF-beta pathways.

World Journal of Advanced Research and Reviews, 2022

Introduction: Proton pump inhibitors (PPIs) are most prescribed medication classes and have simil... more Introduction: Proton pump inhibitors (PPIs) are most prescribed medication classes and have similar efficacy between generic and brand names. PPIs are used for treatment upper GIT disorders. The aim of the present study was to evaluate the effectiveness and safety of proton pump inhibitors (PPIs). Methods: A cross sectional study conducted randomly on pharmacies, patients and Doctors to collect a data regarding the effectiveness and safely use of PPI through predesigned questionnaire containing information about dosage, types, side effect, effectiveness and safety of PPIs. The collected data was analysis by using Chi-square for determine the significant differences at α < 0.05. Result: The result of present study revealed numbers of points in which the questionnaire were intended for pharmacies, patients and doctors knowledge, effectiveness and safety of PPIs. The data gathered from pharmacy shown PPI dispensed without prescription (P< 0.05) in dose of 20 mg of omeprazole and ...

European Journal of Physical Education and Sport Science, 2021

Background: Individuals who have valuable knowledge on how the importance of adequate and balance... more Background: Individuals who have valuable knowledge on how the importance of adequate and balanced diet and this knowledge will on their behaviors which eventually considered to be more successful in sports life. The present study aims to evaluate the nutrition and nutrients imbalance related to the health knowledge among trainers’ athletes. Methods: The study sample consists of 203 voluntary trainers from the sport clubs and gyms. Modified questionnaire was used in the study and Chi-square and Pearson correlation test was used. Results: Athletes related fields were determined to have the lack of knowledge on nutrition and also nutrients deficit related to ill-health questions. It was more likely the trainers know some aspects of foods and nutrients such as role and sources of some foods, but the overall score showed 40-50% for nutritional knowledge questions. Furthermore, questions related to ill-health showed poor score (< 40%). There was no gender difference in related nutriti...

Cancer is reported to be the second and third leading cause of all deaths in both developed and d... more Cancer is reported to be the second and third leading cause of all deaths in both developed and developing countries respectively. In Libya as well cancer is the second leading cause of all deaths. The purpose of this paper is to identify the nutritional status of female breast cancer patients in Benghazi city of Libya via cross-sectional study using Patient Generated Subjective Global Assessment (PG‐SGA) was carried out on 145 female cancer patients. Only 1.5 % of the subjects were well nourished. 25% of the studied females were severely malnourished; while 73.5 % were either at risk of malnutrition or suspected to develop malnutrition in the future. The mean age of the subjects’ ±SD was 50.8 + 13.5. Living arrangement, income, physical activity levels and body mass index were associated with nutritional status (P < 0.05). All sections of the PG-SGA has a significant statistical positive correlation with its total score (r = 0.54 – 0.93, p < 0.05).It is recommended that publi...

There are several methods can be used to assess nutritional status, among these methods is Body M... more There are several methods can be used to assess nutritional status, among these methods is Body Mass Index (BMI). Therefore this cross-sectional study examined differences in body weight of male and female medical students in relation of socioeconomic variables. The Participants completed the self-administration Questionnaire. Body weights, and height were measured for calculating BMI. A total of 579 students in which 95 (16.4%) and 484 (83.6%) male and female respectively. The mean age of our subject’s ±SD was 21.1 ±1.6 ranged from 21.6 or 20.9 male and female respectively. About 4% of males and 9% of females were underweight, while the percentage of obesity almost same among both genders 37.1%, 36.6 respectively. Based on age classification, we found that the majorities of our participants aged groups 18-24 were obese (64%) whereas those aged group 25 years old and over were normal weight (93%). Classification of body mass index among our medical faculty branches shown significant...

There is an interest in the degree to which feeding practices contribute to early childhood obesi... more There is an interest in the degree to which feeding practices contribute to early childhood obesity. We undertook a systematic review to investigate the effect of demand feeding versus scheduled feeding on obesity in early childhood. A systematic search of electronic databases identified studies relating feeding during early life mainly infancy to episodes of early childhood obesity. Included studies were assessed for quality based on study methodology, validity of dietary assessment, success of follow-up, standardised assessment of obesity. Data from ten cohorts involving 5535 subjects were included. Studies had follow-up of more than 60 %, adjusted statistically for three or more confounders and used standard criteria to determine end points. About half the studies used a validated FFQ, administered the FFQ more than once or had follow-up of one year. Fewer than half the studies involved subjects’ representative of the general population. This systematic review points out the pres...