Ali Meriçli - Academia.edu (original) (raw)
Papers by Ali Meriçli
Proceedings, 2018
Colchicum pusillum Sieber is a plant from Colchicaceae family that particularly rich in tropoloni... more Colchicum pusillum Sieber is a plant from Colchicaceae family that particularly rich in tropolonic alkaloids, colchicine. The aim of the study is to determine the apoptosis induction effect of Colchicum pusillum extract in Colo-741, metastatic colon cancer cells and if so, to determine by which apoptotic pathway. Colchicum pusillum was collected and extracted with ethanol. Apoptotic activities of Colchicum pusillum were investigated by immunocytochemistry using antibodies directed against to caspase-3, cytochrome-c and FasLigand (FasL) in Colo-741 cells. Immunocytochemical staining results stated that Colchicum pusillum extract at 20 µg/mL dose, increased caspase-3 and FasL activity significantly but was not able to activate cytochrome-c activity. The results suggested that Colchicum pusillum extract induced apoptosis in metastatic colon cancer cells via extrinsic apoptotic pathway.
Phytochemistry, 1988
Abstract The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lact... more Abstract The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lactones, including a new elamanolide and four new eudesmanolides. The structures of the new compounds were elucidated by chemical transformations and ...
Zeitschrift für Naturforschung C, 2012
From the roots of Aconitum vulparia Rchb., collected in Prüm (Germany), a new norditerpenoid alka... more From the roots of Aconitum vulparia Rchb., collected in Prüm (Germany), a new norditerpenoid alkaloid, named alexhumboldtine, has been isolated along with the known norditerpenoid alkaloids lappaconitine, anthranoyllycoctonine, lycoctonine, puberaconitine, ajacine, and septentriodine. The structure of alexhumboldtine was established on the basis of 1H, 13C, DEPT, homonuclear 1H COSY, NOESY, HSQC, and HMBC NMR studies. From the aerial parts of the plant another norditerpenoid alkaloid, aconorine, has been isolated
Thrombosis Research, 2011
Helvetica Chimica Acta, 2007
Helvetica Chimica Acta, 2006
Chemistry of Natural Compounds, 2012
0009-3130/12/4803-0525 2012 Springer Science+Business Media, Inc. 1) Istanbul University, Faculty... more 0009-3130/12/4803-0525 2012 Springer Science+Business Media, Inc. 1) Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, 34116 Beyazit, Istanbul, Turkey, e-mail: alimer@istanbul.edu.tr; 2) Suleyman Demirel University, Faculty of Science and Literature, Department of Botany, Isparta, Turkey; 3) Saarland University, Institute of Pharmaceutical Biology, P. O. 151150, 66041, Saarbrucken, Germany. Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, p. 471. Original article submitted January 24, 2011. Chemistry of Natural Compounds, Vol. 48, No. 3, July, 2012 [Russian original No. 3, May–June, 2012]
Chemistry of Natural Compounds, 2006
From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lyco... more From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lycoctonine, anthranoyllycoctonine, delsemine A, delsemine B, N-acetyldelectine and a diterpenoid alkaloid septatisine were isolated.
Records of Natural Products
Proceedings
Opuntia ficus indica L. fruit (cactus pear) seed oil is used in traditional and complementary the... more Opuntia ficus indica L. fruit (cactus pear) seed oil is used in traditional and complementary therapies for its numerous health benefits. The aim of this study was to analyse of the fatty acid content and apoptotic induction effects of spiny and thornless Opuntia ficus indica L. seed (CPS) oils. Spiny and thornless Opuntia ficus indica L. seed oils obtained by supercritical CO2 extraction method and analyzed by GC-MS. Different concentrations of almond oils were incubated for 24 h and 48 h with Colo-320 and Colo-741 cells. Cell growth and cytotoxicity were measured by MTT assays. TUNEL assay was used to detect DNA fragmentation in both cell lines. Linoleic acid was dominant fatty acid followed by oleic acid, palmitic acid and elaidic acid in both type of seed oil. In MTT, spiny CPS oil was found to be active against Colo-320 and Colo-741 cells with 1:16 dilution for 48 h. Also, 1:8 and 1:16 dilutions of thornless CPS oil showed significant reduction in the number of viable cells in ...
Turkish Journal of Chemistry
... 17/3. Spectral findings showed the suggested structure for aconasutine (1). Table 1. x H and ... more ... 17/3. Spectral findings showed the suggested structure for aconasutine (1). Table 1. x H and 13 C-NMR data of Aconasutine Position % iac 1 3.72 m ... 3.41 s 58.5 q 16'OMe 3.38 s 56.8 q 18'OMe 3.28 s 59.4 q Acknowledgements One of us (AHM) thanks Alexander von Humboldt ...
Scientia Pharmaceutica
From the aerial parts of Delphinium staphisagria L. (Ranunculaceae) we report here the isolation ... more From the aerial parts of Delphinium staphisagria L. (Ranunculaceae) we report here the isolation and identification of five diterpenoid alkaloids, chellespontine (1), neoline (2), delphisine (3), delphidine (4) and delstaphisagnine (5). Compounds 1 and 2 are reported for the first time from this plant. All the compounds were identified by a comparison of their physical and spectroscopic data (IR, 1H, 13C, DEPT NMR) and TLC behavior with those of authentic samples.
Acta Pharmaceutica Sciencia
Die Pharmazie, 2000
Isolation and identification of six diterpenoid alkaloids, from Aconitum anthora L. are described... more Isolation and identification of six diterpenoid alkaloids, from Aconitum anthora L. are described. All proton detected 2D NMR techniques have been used for unambiguous 1H and 13C chemical shift assignments of guan-fu-base-Y (6). This is the first investigation of the diterpenoid alkaloids of this plant species.
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2003
ChemInform, 2003
From the aerial parts of Consolida scleroclada (Boiss.) Schrod. collected in Turkey, a new diterp... more From the aerial parts of Consolida scleroclada (Boiss.) Schrod. collected in Turkey, a new diterpenoid alkaloid named willipelletierine has been isolated along with the known diterpenoid alkaloids aconitine, lapaconidine, and delcosine. The structure for willipelletierine was established on the basis 1H, 13C, DEPT, homonuclear 1H COSY, HETCOR and NOESY NMR studies.
ChemInform, 2000
Further Diterpenoid Alkaloids from Consolida stenocarpa-[isolation and structure confirmation of ... more Further Diterpenoid Alkaloids from Consolida stenocarpa-[isolation and structure confirmation of known C 20 diterpenoid alkaloids (hetisine, hetisinone, stenocarpine) and C 19 norditerpenoid alkaloid ajadelphinine].
Proceedings, 2018
Colchicum pusillum Sieber is a plant from Colchicaceae family that particularly rich in tropoloni... more Colchicum pusillum Sieber is a plant from Colchicaceae family that particularly rich in tropolonic alkaloids, colchicine. The aim of the study is to determine the apoptosis induction effect of Colchicum pusillum extract in Colo-741, metastatic colon cancer cells and if so, to determine by which apoptotic pathway. Colchicum pusillum was collected and extracted with ethanol. Apoptotic activities of Colchicum pusillum were investigated by immunocytochemistry using antibodies directed against to caspase-3, cytochrome-c and FasLigand (FasL) in Colo-741 cells. Immunocytochemical staining results stated that Colchicum pusillum extract at 20 µg/mL dose, increased caspase-3 and FasL activity significantly but was not able to activate cytochrome-c activity. The results suggested that Colchicum pusillum extract induced apoptosis in metastatic colon cancer cells via extrinsic apoptotic pathway.
Phytochemistry, 1988
Abstract The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lact... more Abstract The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lactones, including a new elamanolide and four new eudesmanolides. The structures of the new compounds were elucidated by chemical transformations and ...
Zeitschrift für Naturforschung C, 2012
From the roots of Aconitum vulparia Rchb., collected in Prüm (Germany), a new norditerpenoid alka... more From the roots of Aconitum vulparia Rchb., collected in Prüm (Germany), a new norditerpenoid alkaloid, named alexhumboldtine, has been isolated along with the known norditerpenoid alkaloids lappaconitine, anthranoyllycoctonine, lycoctonine, puberaconitine, ajacine, and septentriodine. The structure of alexhumboldtine was established on the basis of 1H, 13C, DEPT, homonuclear 1H COSY, NOESY, HSQC, and HMBC NMR studies. From the aerial parts of the plant another norditerpenoid alkaloid, aconorine, has been isolated
Thrombosis Research, 2011
Helvetica Chimica Acta, 2007
Helvetica Chimica Acta, 2006
Chemistry of Natural Compounds, 2012
0009-3130/12/4803-0525 2012 Springer Science+Business Media, Inc. 1) Istanbul University, Faculty... more 0009-3130/12/4803-0525 2012 Springer Science+Business Media, Inc. 1) Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, 34116 Beyazit, Istanbul, Turkey, e-mail: alimer@istanbul.edu.tr; 2) Suleyman Demirel University, Faculty of Science and Literature, Department of Botany, Isparta, Turkey; 3) Saarland University, Institute of Pharmaceutical Biology, P. O. 151150, 66041, Saarbrucken, Germany. Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, p. 471. Original article submitted January 24, 2011. Chemistry of Natural Compounds, Vol. 48, No. 3, July, 2012 [Russian original No. 3, May–June, 2012]
Chemistry of Natural Compounds, 2006
From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lyco... more From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lycoctonine, anthranoyllycoctonine, delsemine A, delsemine B, N-acetyldelectine and a diterpenoid alkaloid septatisine were isolated.
Records of Natural Products
Proceedings
Opuntia ficus indica L. fruit (cactus pear) seed oil is used in traditional and complementary the... more Opuntia ficus indica L. fruit (cactus pear) seed oil is used in traditional and complementary therapies for its numerous health benefits. The aim of this study was to analyse of the fatty acid content and apoptotic induction effects of spiny and thornless Opuntia ficus indica L. seed (CPS) oils. Spiny and thornless Opuntia ficus indica L. seed oils obtained by supercritical CO2 extraction method and analyzed by GC-MS. Different concentrations of almond oils were incubated for 24 h and 48 h with Colo-320 and Colo-741 cells. Cell growth and cytotoxicity were measured by MTT assays. TUNEL assay was used to detect DNA fragmentation in both cell lines. Linoleic acid was dominant fatty acid followed by oleic acid, palmitic acid and elaidic acid in both type of seed oil. In MTT, spiny CPS oil was found to be active against Colo-320 and Colo-741 cells with 1:16 dilution for 48 h. Also, 1:8 and 1:16 dilutions of thornless CPS oil showed significant reduction in the number of viable cells in ...
Turkish Journal of Chemistry
... 17/3. Spectral findings showed the suggested structure for aconasutine (1). Table 1. x H and ... more ... 17/3. Spectral findings showed the suggested structure for aconasutine (1). Table 1. x H and 13 C-NMR data of Aconasutine Position % iac 1 3.72 m ... 3.41 s 58.5 q 16'OMe 3.38 s 56.8 q 18'OMe 3.28 s 59.4 q Acknowledgements One of us (AHM) thanks Alexander von Humboldt ...
Scientia Pharmaceutica
From the aerial parts of Delphinium staphisagria L. (Ranunculaceae) we report here the isolation ... more From the aerial parts of Delphinium staphisagria L. (Ranunculaceae) we report here the isolation and identification of five diterpenoid alkaloids, chellespontine (1), neoline (2), delphisine (3), delphidine (4) and delstaphisagnine (5). Compounds 1 and 2 are reported for the first time from this plant. All the compounds were identified by a comparison of their physical and spectroscopic data (IR, 1H, 13C, DEPT NMR) and TLC behavior with those of authentic samples.
Acta Pharmaceutica Sciencia
Die Pharmazie, 2000
Isolation and identification of six diterpenoid alkaloids, from Aconitum anthora L. are described... more Isolation and identification of six diterpenoid alkaloids, from Aconitum anthora L. are described. All proton detected 2D NMR techniques have been used for unambiguous 1H and 13C chemical shift assignments of guan-fu-base-Y (6). This is the first investigation of the diterpenoid alkaloids of this plant species.
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2003
ChemInform, 2003
From the aerial parts of Consolida scleroclada (Boiss.) Schrod. collected in Turkey, a new diterp... more From the aerial parts of Consolida scleroclada (Boiss.) Schrod. collected in Turkey, a new diterpenoid alkaloid named willipelletierine has been isolated along with the known diterpenoid alkaloids aconitine, lapaconidine, and delcosine. The structure for willipelletierine was established on the basis 1H, 13C, DEPT, homonuclear 1H COSY, HETCOR and NOESY NMR studies.
ChemInform, 2000
Further Diterpenoid Alkaloids from Consolida stenocarpa-[isolation and structure confirmation of ... more Further Diterpenoid Alkaloids from Consolida stenocarpa-[isolation and structure confirmation of known C 20 diterpenoid alkaloids (hetisine, hetisinone, stenocarpine) and C 19 norditerpenoid alkaloid ajadelphinine].