Ali Othmane - Academia.edu (original) (raw)

Papers by Ali Othmane

Research paper thumbnail of Optimized biosensing interface of bacteria-based microsensor for heavy metals detection

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Research paper thumbnail of Elaboration et étude impédimétrique des électrodes d'or fonctionnalisées par des cyclames mono-N-fonctionnalisés

ABSTRACT communication par affiche

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Research paper thumbnail of Legionella pneumophila detection by Electrochemical Impedance Spectroscopy (présentation orale)

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Research paper thumbnail of Surface Modification with an Antithrombin-Heparin Complex for Anticoagulation: a Voltammetry Study of Cell Adhesion on a Model Surface

Journal of Communications Engineering and Networks, 2014

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Research paper thumbnail of Développement et évaluation d’un micro-biocapteur pour l’immunodétection en temps réel de Legionella pneumophila dans les prélèvements environnementaux

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Research paper thumbnail of 361-11 Zanina proof

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Research paper thumbnail of BBEN-D-12-00207

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Research paper thumbnail of Optimization of physicochemical parameters of a multilayered polyelectrolyte film deposition with Love wave and AFM for bacteria based detection of heavy metal

A biosensor based on Escherichia coli Bacteria for determination of heavy metal ions with an acou... more A biosensor based on Escherichia coli Bacteria for determination of heavy metal ions with an acoustic Love wave device and Polydimethylsiloxane (PDMS) microfluidic network has been previously developed, that provides fast detection of toxic chemical compounds. Bacteria were immobilized on the transducer coated with self-assembled molecular multilayers of polyelectrolytes. In this study, we emphasize Love wave and AFM-based complementary characterization methods, which allowed an optimization of some physicochemical parameters of polyelectrolyte solutions, such as pH, ionic strength or molecular weight, in order to increase the immobilization of bacteria as well as the sensor lifetime. For instance, an increase density of bacteria was observed when using alternative pH of 9 for cationic solution.

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Research paper thumbnail of Love wave bacterial biosensors for the detection of heavy metal toxicity in liquid medium

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Research paper thumbnail of Electrochemical impedance spectroscopy as a highly sensitive tool for a dynamic interaction study between heparin and antithrombin: a novel antithrombin sensor

Talanta, Jan 15, 2011

Specific recognition between two biological partners is widely exploited in biosensors nowadays. ... more Specific recognition between two biological partners is widely exploited in biosensors nowadays. To explore this avenue, a novel biosensor for antithrombin (AT) detection was constructed. Heparin was used as the affinity ligand. A well-known acrylic monomer (butyl methacrylate) was polymerized and grafted onto the heparin polysaccharide by the use of ceric ammonium nitrate as a redox initiator in aqueous nitric acid medium. Polymers were deposited as a thin layer onto surface of stainless steel electrode (SS316L). The obtained polymers were studied by Fourier transform infrared spectroscopy (FTIR) and analyzed by differential scanning calorimetry (DSC). Moreover, the films were characterized by electrochemical impedance spectroscopy (EIS), contact-angle measurements and AFM. EIS was used to study the biosensor affinity to AT and the relationship between functionalization growth of modified electrode and the response of the sensor. The proposed approach appears to be simple, sensitiv...

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Research paper thumbnail of A Hybrid System Based on an Electronic Nose Coupled with an Electronic Tongue for the Characterization of Moroccan Waters

Abstract: A hybrid multisensor system combined with multivariate analysis was applied to the char... more Abstract: A hybrid multisensor system combined with multivariate analysis was applied to the characterization of different kinds of Moroccan waters. The proposed hybrid system based on an electronic nose coupled with an electronic tongue consisted of metal oxide semiconductors and potentiometric sensors respectively. Five Taguchi Gas Sensors were implemented in the electronic nose for the discrimination between mineral, natural, sparkling, river and tap waters. Afterwards, the electronic tongue, based on series of Ion-Selective-Electrodes was applied to the analysis of the same waters. Multisensor responses obtained from the waters were processed by two chemometrics: Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA). PCA results using electronic nose data depict all of the potable water samples in a separate group from the samples that were originated from river. Furthermore, PCA and LDA analysis on electronic tongue data permitted clear and rapid recognizing...

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Research paper thumbnail of Biocapteurs SH-SAW. ADN et analogues, vers une discrimination de fragments courts et de mutations

Instrumentation Mesure Métrologie, 2013

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Research paper thumbnail of Comparison of polysiloxane films substituted by undecenyl-cyclam and by naphthyl-cyclam for the design of ISFET devices sensitive to Fe3+ ions

Sensors and Actuators B: Chemical, 2014

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Research paper thumbnail of Evaluation of Endothelial Cell Adhesion onto Different Protein/Gold Electrodes by EIS

Macromolecular Bioscience, 2007

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Research paper thumbnail of Aggregation and deformation of red blood cells as probed by a laser light scattering technique in a concentrated suspension: comparison between normal and pathological red blood cells

Changes in aggregability and/or deformability of red blood cells (RBC) can cause severe complicat... more Changes in aggregability and/or deformability of red blood cells (RBC) can cause severe complications in blood circulation. We use a laser light scattering technique, which can distinguish between normal and pathological RBCs by studying the angular distributions of backscattered and transmitted light of concentrated suspensions of RBCs submitted to a simple shear flow. In order to study the deformation, we induced partial rigidity in the RBC membrane, and showed that the gradients of deformation and the relaxation times of normal and partially rigidified RBC membranes can be quantified using a non-Newtonian rheological model. We observe that blood aggregation of patients with `microcirculatory' diseases, such as diabetes, differs from that of healthy individuals.

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Research paper thumbnail of Enhanced bio-inspired microsensor based on microfluidic/bacteria/love wave hybrid structure for continuous control of heavy metals toxicity in liquid medium

Sensors and Actuators B: Chemical, 2014

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Research paper thumbnail of Investigating antibody–antigen binding with atomic force microscopy

Sensors and Actuators B: Chemical, 2002

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Research paper thumbnail of Love Wave Bacterial Biosensors and Microfluidic Network for Detection of Heavy Metal Toxicity

Sensor Letters, 2011

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Research paper thumbnail of Investigating specific antigen/antibody binding with the atomic force microscope

Biomolecular Engineering, 2002

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Research paper thumbnail of Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic substrata

Materials Science and Engineering: C, 2006

... Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic s... more ... Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic substrata. ... a, Laboratoire de Physique et Chimie des Interfaces, Faculté des Sciences de Monastir,Tunisia. b, Laboratoire de Biophysique, Faculté de Médecine de Monastir, Tunisia. ...

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Research paper thumbnail of Optimized biosensing interface of bacteria-based microsensor for heavy metals detection

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Elaboration et étude impédimétrique des électrodes d'or fonctionnalisées par des cyclames mono-N-fonctionnalisés

ABSTRACT communication par affiche

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Legionella pneumophila detection by Electrochemical Impedance Spectroscopy (présentation orale)

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Surface Modification with an Antithrombin-Heparin Complex for Anticoagulation: a Voltammetry Study of Cell Adhesion on a Model Surface

Journal of Communications Engineering and Networks, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Développement et évaluation d’un micro-biocapteur pour l’immunodétection en temps réel de Legionella pneumophila dans les prélèvements environnementaux

Bookmarks Related papers MentionsView impact

Research paper thumbnail of 361-11 Zanina proof

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Research paper thumbnail of BBEN-D-12-00207

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Research paper thumbnail of Optimization of physicochemical parameters of a multilayered polyelectrolyte film deposition with Love wave and AFM for bacteria based detection of heavy metal

A biosensor based on Escherichia coli Bacteria for determination of heavy metal ions with an acou... more A biosensor based on Escherichia coli Bacteria for determination of heavy metal ions with an acoustic Love wave device and Polydimethylsiloxane (PDMS) microfluidic network has been previously developed, that provides fast detection of toxic chemical compounds. Bacteria were immobilized on the transducer coated with self-assembled molecular multilayers of polyelectrolytes. In this study, we emphasize Love wave and AFM-based complementary characterization methods, which allowed an optimization of some physicochemical parameters of polyelectrolyte solutions, such as pH, ionic strength or molecular weight, in order to increase the immobilization of bacteria as well as the sensor lifetime. For instance, an increase density of bacteria was observed when using alternative pH of 9 for cationic solution.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Love wave bacterial biosensors for the detection of heavy metal toxicity in liquid medium

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Electrochemical impedance spectroscopy as a highly sensitive tool for a dynamic interaction study between heparin and antithrombin: a novel antithrombin sensor

Talanta, Jan 15, 2011

Specific recognition between two biological partners is widely exploited in biosensors nowadays. ... more Specific recognition between two biological partners is widely exploited in biosensors nowadays. To explore this avenue, a novel biosensor for antithrombin (AT) detection was constructed. Heparin was used as the affinity ligand. A well-known acrylic monomer (butyl methacrylate) was polymerized and grafted onto the heparin polysaccharide by the use of ceric ammonium nitrate as a redox initiator in aqueous nitric acid medium. Polymers were deposited as a thin layer onto surface of stainless steel electrode (SS316L). The obtained polymers were studied by Fourier transform infrared spectroscopy (FTIR) and analyzed by differential scanning calorimetry (DSC). Moreover, the films were characterized by electrochemical impedance spectroscopy (EIS), contact-angle measurements and AFM. EIS was used to study the biosensor affinity to AT and the relationship between functionalization growth of modified electrode and the response of the sensor. The proposed approach appears to be simple, sensitiv...

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Research paper thumbnail of A Hybrid System Based on an Electronic Nose Coupled with an Electronic Tongue for the Characterization of Moroccan Waters

Abstract: A hybrid multisensor system combined with multivariate analysis was applied to the char... more Abstract: A hybrid multisensor system combined with multivariate analysis was applied to the characterization of different kinds of Moroccan waters. The proposed hybrid system based on an electronic nose coupled with an electronic tongue consisted of metal oxide semiconductors and potentiometric sensors respectively. Five Taguchi Gas Sensors were implemented in the electronic nose for the discrimination between mineral, natural, sparkling, river and tap waters. Afterwards, the electronic tongue, based on series of Ion-Selective-Electrodes was applied to the analysis of the same waters. Multisensor responses obtained from the waters were processed by two chemometrics: Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA). PCA results using electronic nose data depict all of the potable water samples in a separate group from the samples that were originated from river. Furthermore, PCA and LDA analysis on electronic tongue data permitted clear and rapid recognizing...

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Research paper thumbnail of Biocapteurs SH-SAW. ADN et analogues, vers une discrimination de fragments courts et de mutations

Instrumentation Mesure Métrologie, 2013

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Research paper thumbnail of Comparison of polysiloxane films substituted by undecenyl-cyclam and by naphthyl-cyclam for the design of ISFET devices sensitive to Fe3+ ions

Sensors and Actuators B: Chemical, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Evaluation of Endothelial Cell Adhesion onto Different Protein/Gold Electrodes by EIS

Macromolecular Bioscience, 2007

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Aggregation and deformation of red blood cells as probed by a laser light scattering technique in a concentrated suspension: comparison between normal and pathological red blood cells

Changes in aggregability and/or deformability of red blood cells (RBC) can cause severe complicat... more Changes in aggregability and/or deformability of red blood cells (RBC) can cause severe complications in blood circulation. We use a laser light scattering technique, which can distinguish between normal and pathological RBCs by studying the angular distributions of backscattered and transmitted light of concentrated suspensions of RBCs submitted to a simple shear flow. In order to study the deformation, we induced partial rigidity in the RBC membrane, and showed that the gradients of deformation and the relaxation times of normal and partially rigidified RBC membranes can be quantified using a non-Newtonian rheological model. We observe that blood aggregation of patients with `microcirculatory' diseases, such as diabetes, differs from that of healthy individuals.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Enhanced bio-inspired microsensor based on microfluidic/bacteria/love wave hybrid structure for continuous control of heavy metals toxicity in liquid medium

Sensors and Actuators B: Chemical, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Investigating antibody–antigen binding with atomic force microscopy

Sensors and Actuators B: Chemical, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Love Wave Bacterial Biosensors and Microfluidic Network for Detection of Heavy Metal Toxicity

Sensor Letters, 2011

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Research paper thumbnail of Investigating specific antigen/antibody binding with the atomic force microscope

Biomolecular Engineering, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic substrata

Materials Science and Engineering: C, 2006

... Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic s... more ... Quantification of the adhesion free energy between bacteria and hydrophobic and hydrophilic substrata. ... a, Laboratoire de Physique et Chimie des Interfaces, Faculté des Sciences de Monastir,Tunisia. b, Laboratoire de Biophysique, Faculté de Médecine de Monastir, Tunisia. ...

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