Ali Raza - Academia.edu (original) (raw)
Papers by Ali Raza
Molecular Microbiology Research, 2013
Mastitis is one of the major problematic diseases of dairy animals throughout the world which is ... more Mastitis is one of the major problematic diseases of dairy animals throughout the world which is associated with different etiological agents but Staphylococcus aureus is one of the major causes which are responsible for this dairy scourge. Biofilm production by the microorganisms is considered an important virulence factor responsible for adhesion of these microorganisms with living or non-living surfaces. Staphylococcus aureus isolates which produce biofilm lead to chronic mastitis in dairy animals. The intramammary infection due to biofilm producer S. aureus is difficult to treat even with intra-mammary antibiotics so proper considerations should be given to the infections produced by biofilm producing bacteria. Development of an effective vaccination against the bacteria which produce biofilm may provide success to control such type of perilous infections.
International Journal of Molecular Medical Science, 2013
Entamoeba histolytica has diverse distribution and is a substantial risk in almost all the countr... more Entamoeba histolytica has diverse distribution and is a substantial risk in almost all the countries where barrier between human feces, food and water source are ordinary. There are at least 8 different amoebas that live in the human intestinal lumen however those are generally accepted as commensals except for E. histolytica. The parasite imposes a major threat to public health in most parts of world and has re-emerged in some previously dormant areas as it is categorized as second leading cause of death from parasitic disease worldwide. In most of E. histolytica infection, symptoms remain absent or very mild whereas most frequent clinical manifestation are colitis and liver abscess due to amoebic infection. Laboratory diagnosis of amoebiasis is usually made on the basis of microscopical and serological methods Nitromidazole derivatives like metronidazole, tinidazole and ornidazole are considered as foundation stone of the treatment for amoebiasis. Lack of effective vaccination is one of the major hurdles for the control of amoebiasis that may prevent transmission of the parasite and or at least progression of the infected individuals into active invasive disease. The aim of this article is to comprehensively review the epidemiology, disease pathology and treatment of this parasitic zoonotic disease. Keywords Amoebiasis; Entamoeba histolytica; Food and water borne; Parasitic disease .
ep.liu.se
Quality of Service delivery in health sector is the most ignored area in Pakistan. Process incons... more Quality of Service delivery in health sector is the most ignored area in Pakistan. Process inconsistencies generally have not been perceived as a major problem in public health facility in a typical developing country like Pakistan. The study will analyze the outcomes of process improvement in public health care facility resulting in achieving patient satisfaction. This study comprises of three sequential phases. First phase consists of identifying discrepancies between Quality of Services and its effects on Patient Satisfaction. Second phase will deal with understanding determinants of inconsistencies in health care system, particularly in terms of process performance. Finally a strategy will be evolved on the basis of research with a view to reduce process deficiencies and to evaluate existing inconsistencies.
The Open Orthopaedics …, 2009
We present a unique prospective study to estimate the median sustained stage-related improvement ... more We present a unique prospective study to estimate the median sustained stage-related improvement in pain and hand function in patients with trapezio-metacarpal joint osteoarthritis after administration of a single corticosteroid injection. Response to the corticosteroid injection was assessed using Disability of Arm Shoulder and Hand (DASH) and Visual Analogue Scale (VAS) pain scores. Self assessment scores revealed a reduction in pain and improvement in hand function. All patients reported a significant improvement in pain and hand function (p ≤ 0.05), regardless of the disease stage. Additionally, we observed a marked difference in the duration of improvement in hand function between early and late stages of the disease (p = 0.0046). In conclusion, it is possible to predict the period of symptomatic improvement at each of the four radiological stages of the disease. This would allow the treating clinician to judge the outcome of treatment with reasonable accuracy.
The American Journal of Cardiology, 2001
Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein (LDL)... more Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein (LDL) cholesterol-lowering activity. We conducted 2 dose-ranging studies. In the first study, after a 6-week dietary run-in, 142 moderately hypercholesterolemic patients were randomized equally to receive double-blind placebo or rosuvastatin 1, 2.5, 5, 10, 20, or 40 mg or open-label atorvastatin 10 or 80 mg once daily for 6 weeks; in the second study, conducted to extend the rosuvastatin dose range, 64 patients were randomized to double-blind, once-daily placebo or rosuvastatin 40 or 80 mg (1:1:2 ratio) for 6 weeks. Data from both studies were combined for analysis of lipid effects. No statistical comparison of atorvastatin arms with placebo or rosuvastatin was performed. Rosuvastatin was associated with highly significant dose-dependent reductions in LDL cholesterol compared with placebo (p <0.001); decreases ranged from 34% (1 mg) to 65% (80 mg). Linear regression analysis indi-cated an additional 4.5% LDL cholesterol reduction for each doubling of the rosuvastatin dose. Across the dose range, approximately 90% of LDL cholesterol reduction occurred within the first 2 weeks of treatment. Significant, dose-dependent reductions in total cholesterol and apolipoprotein B with rosuvastatin were also observed (p <0.001). High-density lipoprotein cholesterol increases and triglyceride reductions were consistently observed and statistically significant at some dose levels. All lipid ratios were significantly reduced at all rosuvastatin dose levels (p <0.001). Adverse events were similar across placebo and active treatments. No significant increases in alanine aminotransferase or creatine kinase were seen in any patient. Over 6 weeks, rosuvastatin produced large, rapid, dose-dependent LDL cholesterol reductions and was well tolerated in hypercholesterolemic patients. ᮊ2001
Molecular Microbiology Research, 2013
Mastitis is one of the major problematic diseases of dairy animals throughout the world which is ... more Mastitis is one of the major problematic diseases of dairy animals throughout the world which is associated with different etiological agents but Staphylococcus aureus is one of the major causes which are responsible for this dairy scourge. Biofilm production by the microorganisms is considered an important virulence factor responsible for adhesion of these microorganisms with living or non-living surfaces. Staphylococcus aureus isolates which produce biofilm lead to chronic mastitis in dairy animals. The intramammary infection due to biofilm producer S. aureus is difficult to treat even with intra-mammary antibiotics so proper considerations should be given to the infections produced by biofilm producing bacteria. Development of an effective vaccination against the bacteria which produce biofilm may provide success to control such type of perilous infections.
International Journal of Molecular Medical Science, 2013
Entamoeba histolytica has diverse distribution and is a substantial risk in almost all the countr... more Entamoeba histolytica has diverse distribution and is a substantial risk in almost all the countries where barrier between human feces, food and water source are ordinary. There are at least 8 different amoebas that live in the human intestinal lumen however those are generally accepted as commensals except for E. histolytica. The parasite imposes a major threat to public health in most parts of world and has re-emerged in some previously dormant areas as it is categorized as second leading cause of death from parasitic disease worldwide. In most of E. histolytica infection, symptoms remain absent or very mild whereas most frequent clinical manifestation are colitis and liver abscess due to amoebic infection. Laboratory diagnosis of amoebiasis is usually made on the basis of microscopical and serological methods Nitromidazole derivatives like metronidazole, tinidazole and ornidazole are considered as foundation stone of the treatment for amoebiasis. Lack of effective vaccination is one of the major hurdles for the control of amoebiasis that may prevent transmission of the parasite and or at least progression of the infected individuals into active invasive disease. The aim of this article is to comprehensively review the epidemiology, disease pathology and treatment of this parasitic zoonotic disease. Keywords Amoebiasis; Entamoeba histolytica; Food and water borne; Parasitic disease .
ep.liu.se
Quality of Service delivery in health sector is the most ignored area in Pakistan. Process incons... more Quality of Service delivery in health sector is the most ignored area in Pakistan. Process inconsistencies generally have not been perceived as a major problem in public health facility in a typical developing country like Pakistan. The study will analyze the outcomes of process improvement in public health care facility resulting in achieving patient satisfaction. This study comprises of three sequential phases. First phase consists of identifying discrepancies between Quality of Services and its effects on Patient Satisfaction. Second phase will deal with understanding determinants of inconsistencies in health care system, particularly in terms of process performance. Finally a strategy will be evolved on the basis of research with a view to reduce process deficiencies and to evaluate existing inconsistencies.
The Open Orthopaedics …, 2009
We present a unique prospective study to estimate the median sustained stage-related improvement ... more We present a unique prospective study to estimate the median sustained stage-related improvement in pain and hand function in patients with trapezio-metacarpal joint osteoarthritis after administration of a single corticosteroid injection. Response to the corticosteroid injection was assessed using Disability of Arm Shoulder and Hand (DASH) and Visual Analogue Scale (VAS) pain scores. Self assessment scores revealed a reduction in pain and improvement in hand function. All patients reported a significant improvement in pain and hand function (p ≤ 0.05), regardless of the disease stage. Additionally, we observed a marked difference in the duration of improvement in hand function between early and late stages of the disease (p = 0.0046). In conclusion, it is possible to predict the period of symptomatic improvement at each of the four radiological stages of the disease. This would allow the treating clinician to judge the outcome of treatment with reasonable accuracy.
The American Journal of Cardiology, 2001
Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein (LDL)... more Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein (LDL) cholesterol-lowering activity. We conducted 2 dose-ranging studies. In the first study, after a 6-week dietary run-in, 142 moderately hypercholesterolemic patients were randomized equally to receive double-blind placebo or rosuvastatin 1, 2.5, 5, 10, 20, or 40 mg or open-label atorvastatin 10 or 80 mg once daily for 6 weeks; in the second study, conducted to extend the rosuvastatin dose range, 64 patients were randomized to double-blind, once-daily placebo or rosuvastatin 40 or 80 mg (1:1:2 ratio) for 6 weeks. Data from both studies were combined for analysis of lipid effects. No statistical comparison of atorvastatin arms with placebo or rosuvastatin was performed. Rosuvastatin was associated with highly significant dose-dependent reductions in LDL cholesterol compared with placebo (p <0.001); decreases ranged from 34% (1 mg) to 65% (80 mg). Linear regression analysis indi-cated an additional 4.5% LDL cholesterol reduction for each doubling of the rosuvastatin dose. Across the dose range, approximately 90% of LDL cholesterol reduction occurred within the first 2 weeks of treatment. Significant, dose-dependent reductions in total cholesterol and apolipoprotein B with rosuvastatin were also observed (p <0.001). High-density lipoprotein cholesterol increases and triglyceride reductions were consistently observed and statistically significant at some dose levels. All lipid ratios were significantly reduced at all rosuvastatin dose levels (p <0.001). Adverse events were similar across placebo and active treatments. No significant increases in alanine aminotransferase or creatine kinase were seen in any patient. Over 6 weeks, rosuvastatin produced large, rapid, dose-dependent LDL cholesterol reductions and was well tolerated in hypercholesterolemic patients. ᮊ2001