Lutfi Alia - Academia.edu (original) (raw)
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Papers by Lutfi Alia
BMC urology, Jun 15, 2024
Medicus
Fractal analysis is an objective approach that in oncopathology is one of the important fields of... more Fractal analysis is an objective approach that in oncopathology is one of the important fields of application. In this study is present fractal methodologies at histological level that have been successfully applied to characterize pathological features and able to perform differential diagnosis and prognosis in oncopathology. The basic principles and prospects of fractal geometry in pathology are promising. In particular, fractal analysis is emerging as a powerful tool to perform differential diagnosis and prognosis of the patients in cancer and other malignancies as well to improve the effectiveness and safety of patient care. All fractal objects have Fractal Dimension FDs, commonly calculated with box counting. Morphometry, the measure of shapes of the structures, can be added to every imaging technique in order to obtain objective indexes. In this field, fractal analysis has been applied to histopathology, cytopathology, and electron microscopy with great success. Performing fra...
Medicus
It is an urgent need to improve early diagnosis of ESCC, because is one of the most aggressive ca... more It is an urgent need to improve early diagnosis of ESCC, because is one of the most aggressive cancer. The quantitative image analysis can aid in the identification of ESCC. Despite much research effort, the major prognostic factor of ESCC remains the pathological stage of the disease as defined by the TNM classification, whereas tumour grading is of limited value in this respect, mainly due to its low reproducibility. A better means for disease prognostication based on improved understanding of the pathogenetic mechanisms is urgently required. Materials and methods: The material of the present study was derived from a series of 1876 oesophageal surgical specimens taken from a total of 700 patients, who underwent oesophageal resection for an invasive ESCC in Anyang Tumour Hospital, Henan Province of China. Among. The cases of ESCC, previously subjected to extensive testing for Human Papillomavirus (HPV) involvement and expression of p53 gene. All cases are analysed by histopathology...
Medicus
Who faces a neoplastic disease is more bewildered than in the past, in spite of the improvement o... more Who faces a neoplastic disease is more bewildered than in the past, in spite of the improvement of the possibility of cure and priority attributed to this subject by the health institutions and medicine, compared to few decades ago. Nevertheless, disorientation is increasing due to many factors, also beyond those of the scientific and welfare context of cancer and is related to the general background of crisis. The landscape of crisis involves the changes occurring in both epistemic and contextual values, and methodology of science at large, as well as those particular of the medical field, including oncology. The perceived loss of reliability of universal laws and the limits of general theories, in favor of the conception that elementary events concurr to outcomes, makes the scientific appraisal more probabilistic than deterministic. This framework of “complexity” is characterized by non-linearity in the causal links, the opacity of the investigated subject, and the emergence of th...
BMC urology, Jun 15, 2024
Medicus
Fractal analysis is an objective approach that in oncopathology is one of the important fields of... more Fractal analysis is an objective approach that in oncopathology is one of the important fields of application. In this study is present fractal methodologies at histological level that have been successfully applied to characterize pathological features and able to perform differential diagnosis and prognosis in oncopathology. The basic principles and prospects of fractal geometry in pathology are promising. In particular, fractal analysis is emerging as a powerful tool to perform differential diagnosis and prognosis of the patients in cancer and other malignancies as well to improve the effectiveness and safety of patient care. All fractal objects have Fractal Dimension FDs, commonly calculated with box counting. Morphometry, the measure of shapes of the structures, can be added to every imaging technique in order to obtain objective indexes. In this field, fractal analysis has been applied to histopathology, cytopathology, and electron microscopy with great success. Performing fra...
Medicus
It is an urgent need to improve early diagnosis of ESCC, because is one of the most aggressive ca... more It is an urgent need to improve early diagnosis of ESCC, because is one of the most aggressive cancer. The quantitative image analysis can aid in the identification of ESCC. Despite much research effort, the major prognostic factor of ESCC remains the pathological stage of the disease as defined by the TNM classification, whereas tumour grading is of limited value in this respect, mainly due to its low reproducibility. A better means for disease prognostication based on improved understanding of the pathogenetic mechanisms is urgently required. Materials and methods: The material of the present study was derived from a series of 1876 oesophageal surgical specimens taken from a total of 700 patients, who underwent oesophageal resection for an invasive ESCC in Anyang Tumour Hospital, Henan Province of China. Among. The cases of ESCC, previously subjected to extensive testing for Human Papillomavirus (HPV) involvement and expression of p53 gene. All cases are analysed by histopathology...
Medicus
Who faces a neoplastic disease is more bewildered than in the past, in spite of the improvement o... more Who faces a neoplastic disease is more bewildered than in the past, in spite of the improvement of the possibility of cure and priority attributed to this subject by the health institutions and medicine, compared to few decades ago. Nevertheless, disorientation is increasing due to many factors, also beyond those of the scientific and welfare context of cancer and is related to the general background of crisis. The landscape of crisis involves the changes occurring in both epistemic and contextual values, and methodology of science at large, as well as those particular of the medical field, including oncology. The perceived loss of reliability of universal laws and the limits of general theories, in favor of the conception that elementary events concurr to outcomes, makes the scientific appraisal more probabilistic than deterministic. This framework of “complexity” is characterized by non-linearity in the causal links, the opacity of the investigated subject, and the emergence of th...