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Alice Xu

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Papers by Alice Xu

Research paper thumbnail of The Impact of C1 Anterior Arch Preservation on Spine Stability After Odontoidectomy: Systematic Review and Meta-Analysis

Research paper thumbnail of Three-Dimensional Skull Model for Endoscopic Skull Base Surgical Training

Research paper thumbnail of Primary Dural Repair via an Endoscopic Endonasal Corridor: Preliminary Development of a 3D-Printed Model for Training

Journal of Neurological Surgery Part B: Skull Base, 2021

Objectives Endonasal suturing is an investigational method for dural repair that has been reporte... more Objectives Endonasal suturing is an investigational method for dural repair that has been reported to decrease the incidence of cerebrospinal fluid fistula. This method requires handling of single-shaft instrumentation in the narrow endonasal corridor. In this study, we designed a low-cost, surgical model using three-dimensional (3D) printing technology to simulate dural repair through the endonasal corridor and subsequently assess the utility of the model for surgical training. Methods Using an Ultimaker 2+ printer, a 3D-printed replica of the cranial base and nasal cavity was fitted with tissue allograft to recapitulate the dural layer. Residents, fellows, and attending surgeons were asked to place two sutures using a 0-degree endoscope and single-shaft needle driver. Task completion time was recorded. Participants were asked to fill out a Likert scale questionnaire after the experiment. Results Twenty-six participants were separated into groups based on their prior endoscope expe...

Research paper thumbnail of Image Processing-based Method for Automatic Design of Patient-Specific Cranial Implant for Additive Manufacturing

Procedia Manufacturing, 2021

Decompressive craniectomy (DC) is a surgical procedure where a portion of the skull (flap) is rem... more Decompressive craniectomy (DC) is a surgical procedure where a portion of the skull (flap) is removed to relieve the built-up pressure from the patient’s brain due to swelling of the brain tissue after a traumatic injury to the head. Subsequently, another surgical procedure called cranioplasty is carried out to fix an implant or bone flap in patients who have undergone DC. In this paper, an automatic design methodology for additive manufacturing of a PSCI (patient-specific cranial implant) has been proposed. The input is the DICOM digital data from a CT scan and the output is the STL file geometry of the cranial implant. The proposed method has been tested and validated using real de-identified DICOM data, and the resultant implant was 3D printed and fit to the skull of a cadaver. The key contribution made in this paper is the complete automation of the design of a PSCI based on the skull’s unique geometry using a combination of image-processing and computational geometry techniques...

Research paper thumbnail of Risk of Infection Associated with Transmucosal Placement of Instrumentation in Clean-Contaminated Field: Systematic Analysis

World Neurosurgery, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Early Investigation Assessing the Feasibility of Electrospinning of Cyanoacrylate Glue for Endonasal Skull Base Repair

30th Annual Meeting North American Skull Base Society, 2020

Research paper thumbnail of The Impact of C1 Anterior Arch Preservation on Spine Stability After Odontoidectomy: Systematic Review and Meta-Analysis

Research paper thumbnail of Three-Dimensional Skull Model for Endoscopic Skull Base Surgical Training

Research paper thumbnail of Primary Dural Repair via an Endoscopic Endonasal Corridor: Preliminary Development of a 3D-Printed Model for Training

Journal of Neurological Surgery Part B: Skull Base, 2021

Objectives Endonasal suturing is an investigational method for dural repair that has been reporte... more Objectives Endonasal suturing is an investigational method for dural repair that has been reported to decrease the incidence of cerebrospinal fluid fistula. This method requires handling of single-shaft instrumentation in the narrow endonasal corridor. In this study, we designed a low-cost, surgical model using three-dimensional (3D) printing technology to simulate dural repair through the endonasal corridor and subsequently assess the utility of the model for surgical training. Methods Using an Ultimaker 2+ printer, a 3D-printed replica of the cranial base and nasal cavity was fitted with tissue allograft to recapitulate the dural layer. Residents, fellows, and attending surgeons were asked to place two sutures using a 0-degree endoscope and single-shaft needle driver. Task completion time was recorded. Participants were asked to fill out a Likert scale questionnaire after the experiment. Results Twenty-six participants were separated into groups based on their prior endoscope expe...

Research paper thumbnail of Image Processing-based Method for Automatic Design of Patient-Specific Cranial Implant for Additive Manufacturing

Procedia Manufacturing, 2021

Decompressive craniectomy (DC) is a surgical procedure where a portion of the skull (flap) is rem... more Decompressive craniectomy (DC) is a surgical procedure where a portion of the skull (flap) is removed to relieve the built-up pressure from the patient’s brain due to swelling of the brain tissue after a traumatic injury to the head. Subsequently, another surgical procedure called cranioplasty is carried out to fix an implant or bone flap in patients who have undergone DC. In this paper, an automatic design methodology for additive manufacturing of a PSCI (patient-specific cranial implant) has been proposed. The input is the DICOM digital data from a CT scan and the output is the STL file geometry of the cranial implant. The proposed method has been tested and validated using real de-identified DICOM data, and the resultant implant was 3D printed and fit to the skull of a cadaver. The key contribution made in this paper is the complete automation of the design of a PSCI based on the skull’s unique geometry using a combination of image-processing and computational geometry techniques...

Research paper thumbnail of Risk of Infection Associated with Transmucosal Placement of Instrumentation in Clean-Contaminated Field: Systematic Analysis

World Neurosurgery, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Early Investigation Assessing the Feasibility of Electrospinning of Cyanoacrylate Glue for Endonasal Skull Base Repair

30th Annual Meeting North American Skull Base Society, 2020

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