Alikhan Raza - Academia.edu (original) (raw)

Papers by Alikhan Raza

Research paper thumbnail of Von Willebrand disease, angiodysplasia and atorvastatin

British Journal of Haematology, 2010

Research paper thumbnail of The use of intravenous iron in patients with cancer related anaemia: don’t overlook iron deficiency anaemia in colorectal cancer - response to Fitzgerald et al

British Journal of Haematology, 2008

Intravenous iron has become the standard of care in patients with renal failure receiving treatme... more Intravenous iron has become the standard of care in patients with renal failure receiving treatment with erythropoiesis stimulating agents (ESAs) to treat true and functional iron deficiency and to prevent its development in haemodialysis patients. In cancer-related anaemia, several recently published, randomised studies suggested that intravenous iron improved haemoglobin response rates in ESA-treated patients compared to those treated with oral iron or placebo. The data supporting the efficacy of intravenous iron instead of oral iron in this setting are increasingly persuasive but larger randomised trials are needed before definitive recommendations are made.

Research paper thumbnail of Lower limb contrast venography: a modified technique for use in thromboprophylaxis clinical trials for the accurate evaluation of deep vein thrombosis

British Journal of Radiology, 2007

Research paper thumbnail of Variations in Lower Limb Venous Anatomy: Implications for US Diagnosis of Deep Vein Thrombosis

Radiology, 2003

Guarantor of integrity of entire study, P.S.S.; study concepts and design, D.J.Q., R.A., P.S.S.; ... more Guarantor of integrity of entire study, P.S.S.; study concepts and design, D.J.Q., R.A., P.S.S.; literature research, D.J.Q., R.A., P.S.S.; clinical studies, all authors; data acquisition, D.J.Q., R.A., P.S.S.; data analysis/interpretation, D.J.Q., R.A.; statistical analysis, R.A.; manuscript preparation, definition of intellectual content, and revision/review, D.J.Q., R.A., P.S.S.; manuscript editing and final version approval, all authors.

Research paper thumbnail of The use of intravenous iron in patients with cancer-related anaemia

British Journal of Haematology, 2008

Intravenous iron has become the standard of care in patients with renal failure receiving treatme... more Intravenous iron has become the standard of care in patients with renal failure receiving treatment with erythropoiesis stimulating agents (ESAs) to treat true and functional iron deficiency and to prevent its development in haemodialysis patients. In cancer-related anaemia, several recently published, randomised studies suggested that intravenous iron improved haemoglobin response rates in ESA-treated patients compared to those treated with oral iron or placebo. The data supporting the efficacy of intravenous iron instead of oral iron in this setting are increasingly persuasive but larger randomised trials are needed before definitive recommendations are made.

Research paper thumbnail of Epidemiology of Venous Thromboembolism in Cardiorespiratory and Infectious Disease

American Journal of Medicine, 2008

Venous thromboembolic complications-deep vein thrombosis and pulmonary embolism-occur in a signif... more Venous thromboembolic complications-deep vein thrombosis and pulmonary embolism-occur in a significant proportion of hospitalized medical patients. The incidence in acutely ill medical patients is 10%-40%, equivalent to that seen in general surgical patients. Prophylaxis is effective and well tolerated, yet remains under-prescribed in medical wards. Current recommendations for prophylaxis are generalized and do not specifically address many patient groups. Data on the prevalence in patients with chronic obstructive pulmonary disease, heart failure, and infectious diseases are limited. However, studies on large numbers of hospitalized patients with these admission diagnoses have provided important information on incidence, and the efficacy of thromboprophylaxis. This review summarizes current knowledge of the epidemiology of venous thromboembolism in patients with chronic obstructive pulmonary disease, heart failure, and infectious diseases, and highlights the benefits of, and needs for, appropriate prophylaxis in these groups. Increased awareness of the prevalence of thrombosis in the major subgroups of medical inpatients should improve the prescribing of prophylaxis and prevent potentially avoidable and costly complications.

Research paper thumbnail of Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness: Analysis of the MEDENOX Study

Archives of Internal Medicine, 2004

Background: There is limited information about risk factors for venous thromboembolism (VTE) in a... more Background: There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients.

Research paper thumbnail of Benefits of deep-vein thrombosis prophylaxis in the nonsurgical patients: The MEDENOX trial

Seminars in Hematology, 2001

Research paper thumbnail of Benefits of deep-vein thrombosis prophylaxis in the nonsurgical patient: The MEDENOX trial

Seminars in Hematology, 2001

Research paper thumbnail of Fatal pulmonary embolism in hospitalised patients: a necropsy review

Journal of Clinical Pathology, 2004

Aims: To carry out a retrospective review of all postmortem reports during the period 1991 to 200... more Aims: To carry out a retrospective review of all postmortem reports during the period 1991 to 2000 at King's College Hospital, London, as an extension of a previous analysis performed for the period 1965 to 1990. Methods: The number of deaths resulting from necropsy confirmed fatal pulmonary embolism in hospitalised patients was determined, and a limited analysis of the clinical characteristics of those patients who died was performed. Results: During the 10 year period, 16 104 deaths occurred and 6833 (42.4%) necropsies were performed. The outcome measure, fatal pulmonary embolism, was recorded as cause of death in 265 cases (3.9% of all necropsies; 5.2% of adult cases). No deaths from pulmonary embolism occurred in patients under 18 years of age; 80.0% occurred in patients older than 60 years. Of the fatal emboli, 214 of 265 (80.8%) occurred in patients who had not undergone recent surgery. Of these patients, 110 (51.4%) had suffered an acute medical illness in the six weeks before death, most often an acute infectious episode (26 cases). Conclusions: Thromboembolic events remain a relatively common cause of death in hospitalised patients and appear to occur more frequently in non-surgical than in surgical patients.

Research paper thumbnail of Extended thromboprophylaxis in general surgery reduces the risk of thromboembolism: a meta-analysis: ASGBI: General 07-18

British Journal of Surgery, 2009

Aims: Major general surgical operations, especially for malignancy, are associated with a high ri... more Aims: Major general surgical operations, especially for malignancy, are associated with a high risk of venous thrombo-embolic (VTE) complications, of which about 40 per cent occur after discharge. In this systematic review we examine the value of extended thrombo-prophylaxis.Methods: Three randomized, controlled trials, which studied 1 week versus 4 weeks of thromboprophylaxis (TP) with low molecular weight heparin (LMWH), were included in the analysis. We used RevMan (Version 4.1.1, Oxford & England 2000) to perform the meta-analysis using fixed odds ratio (OR) to compare groups. All patients undergoing venography were considered and only objectively confirmed VTE events were included in the efficacy analysis. All patients randomized to prolonged prophylaxis and who received a dose of study drug were considered in the safety analysis.Results: A total of 683 patients were randomized to receive LMWH for 1 week (333 patients) or 4 weeks (350 patients). Total VTE events occurred in 16 (4.8 per cent) patients in the extended group and 40 (11.4 per cent) in the control group (OR = 0.39, 95 per cent CI 0.21–0.71; P = 0.002). The risk of bleeding was 3.5 per cent in both groups (OR 0.99, 95 per cent CI 0.47–2.06; P = 1).Conclusions: Extended TP results in significant reduction of the risk of developing VTE in patients undergoing major general surgical operations without any increase in the risk of bleeding.

Research paper thumbnail of Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients

Thrombosis and Haemostasis, 2005

Hospitalizedp atientsw ith acute medicalc onditionsa re at significantriskofvenous thromboembolis... more Hospitalizedp atientsw ith acute medicalc onditionsa re at significantriskofvenous thromboembolism (VTE): approximately 10-30% of general medical patients mayd evelop deep-vein thrombosis or pulmonaryembolism, andthe latter is aleading contributortodeaths in hospital. Despite consensus-group recommendations that at-riskm edical patients should receive thromboprophylaxis, there is currentlyn oc onsensusa st o which patients areatrisk,and manypatientsmay not receiveappropriate thromboprophylaxis.This paperreviews evidence for the risk of VTE associated with differentmedical conditions and riskfactors, and presents arisk-assessment modelfor risk stratification in medical patients. Medicalconditionsassociated with

Research paper thumbnail of Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness Analysis of the MEDENOX Study

Background: There is limited information about risk factors for venous thromboembolism (VTE) in a... more Background: There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients.

Research paper thumbnail of Von Willebrand disease, angiodysplasia and atorvastatin

British Journal of Haematology, 2010

Research paper thumbnail of The use of intravenous iron in patients with cancer related anaemia: don’t overlook iron deficiency anaemia in colorectal cancer - response to Fitzgerald et al

British Journal of Haematology, 2008

Intravenous iron has become the standard of care in patients with renal failure receiving treatme... more Intravenous iron has become the standard of care in patients with renal failure receiving treatment with erythropoiesis stimulating agents (ESAs) to treat true and functional iron deficiency and to prevent its development in haemodialysis patients. In cancer-related anaemia, several recently published, randomised studies suggested that intravenous iron improved haemoglobin response rates in ESA-treated patients compared to those treated with oral iron or placebo. The data supporting the efficacy of intravenous iron instead of oral iron in this setting are increasingly persuasive but larger randomised trials are needed before definitive recommendations are made.

Research paper thumbnail of Lower limb contrast venography: a modified technique for use in thromboprophylaxis clinical trials for the accurate evaluation of deep vein thrombosis

British Journal of Radiology, 2007

Research paper thumbnail of Variations in Lower Limb Venous Anatomy: Implications for US Diagnosis of Deep Vein Thrombosis

Radiology, 2003

Guarantor of integrity of entire study, P.S.S.; study concepts and design, D.J.Q., R.A., P.S.S.; ... more Guarantor of integrity of entire study, P.S.S.; study concepts and design, D.J.Q., R.A., P.S.S.; literature research, D.J.Q., R.A., P.S.S.; clinical studies, all authors; data acquisition, D.J.Q., R.A., P.S.S.; data analysis/interpretation, D.J.Q., R.A.; statistical analysis, R.A.; manuscript preparation, definition of intellectual content, and revision/review, D.J.Q., R.A., P.S.S.; manuscript editing and final version approval, all authors.

Research paper thumbnail of The use of intravenous iron in patients with cancer-related anaemia

British Journal of Haematology, 2008

Intravenous iron has become the standard of care in patients with renal failure receiving treatme... more Intravenous iron has become the standard of care in patients with renal failure receiving treatment with erythropoiesis stimulating agents (ESAs) to treat true and functional iron deficiency and to prevent its development in haemodialysis patients. In cancer-related anaemia, several recently published, randomised studies suggested that intravenous iron improved haemoglobin response rates in ESA-treated patients compared to those treated with oral iron or placebo. The data supporting the efficacy of intravenous iron instead of oral iron in this setting are increasingly persuasive but larger randomised trials are needed before definitive recommendations are made.

Research paper thumbnail of Epidemiology of Venous Thromboembolism in Cardiorespiratory and Infectious Disease

American Journal of Medicine, 2008

Venous thromboembolic complications-deep vein thrombosis and pulmonary embolism-occur in a signif... more Venous thromboembolic complications-deep vein thrombosis and pulmonary embolism-occur in a significant proportion of hospitalized medical patients. The incidence in acutely ill medical patients is 10%-40%, equivalent to that seen in general surgical patients. Prophylaxis is effective and well tolerated, yet remains under-prescribed in medical wards. Current recommendations for prophylaxis are generalized and do not specifically address many patient groups. Data on the prevalence in patients with chronic obstructive pulmonary disease, heart failure, and infectious diseases are limited. However, studies on large numbers of hospitalized patients with these admission diagnoses have provided important information on incidence, and the efficacy of thromboprophylaxis. This review summarizes current knowledge of the epidemiology of venous thromboembolism in patients with chronic obstructive pulmonary disease, heart failure, and infectious diseases, and highlights the benefits of, and needs for, appropriate prophylaxis in these groups. Increased awareness of the prevalence of thrombosis in the major subgroups of medical inpatients should improve the prescribing of prophylaxis and prevent potentially avoidable and costly complications.

Research paper thumbnail of Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness: Analysis of the MEDENOX Study

Archives of Internal Medicine, 2004

Background: There is limited information about risk factors for venous thromboembolism (VTE) in a... more Background: There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients.

Research paper thumbnail of Benefits of deep-vein thrombosis prophylaxis in the nonsurgical patients: The MEDENOX trial

Seminars in Hematology, 2001

Research paper thumbnail of Benefits of deep-vein thrombosis prophylaxis in the nonsurgical patient: The MEDENOX trial

Seminars in Hematology, 2001

Research paper thumbnail of Fatal pulmonary embolism in hospitalised patients: a necropsy review

Journal of Clinical Pathology, 2004

Aims: To carry out a retrospective review of all postmortem reports during the period 1991 to 200... more Aims: To carry out a retrospective review of all postmortem reports during the period 1991 to 2000 at King's College Hospital, London, as an extension of a previous analysis performed for the period 1965 to 1990. Methods: The number of deaths resulting from necropsy confirmed fatal pulmonary embolism in hospitalised patients was determined, and a limited analysis of the clinical characteristics of those patients who died was performed. Results: During the 10 year period, 16 104 deaths occurred and 6833 (42.4%) necropsies were performed. The outcome measure, fatal pulmonary embolism, was recorded as cause of death in 265 cases (3.9% of all necropsies; 5.2% of adult cases). No deaths from pulmonary embolism occurred in patients under 18 years of age; 80.0% occurred in patients older than 60 years. Of the fatal emboli, 214 of 265 (80.8%) occurred in patients who had not undergone recent surgery. Of these patients, 110 (51.4%) had suffered an acute medical illness in the six weeks before death, most often an acute infectious episode (26 cases). Conclusions: Thromboembolic events remain a relatively common cause of death in hospitalised patients and appear to occur more frequently in non-surgical than in surgical patients.

Research paper thumbnail of Extended thromboprophylaxis in general surgery reduces the risk of thromboembolism: a meta-analysis: ASGBI: General 07-18

British Journal of Surgery, 2009

Aims: Major general surgical operations, especially for malignancy, are associated with a high ri... more Aims: Major general surgical operations, especially for malignancy, are associated with a high risk of venous thrombo-embolic (VTE) complications, of which about 40 per cent occur after discharge. In this systematic review we examine the value of extended thrombo-prophylaxis.Methods: Three randomized, controlled trials, which studied 1 week versus 4 weeks of thromboprophylaxis (TP) with low molecular weight heparin (LMWH), were included in the analysis. We used RevMan (Version 4.1.1, Oxford & England 2000) to perform the meta-analysis using fixed odds ratio (OR) to compare groups. All patients undergoing venography were considered and only objectively confirmed VTE events were included in the efficacy analysis. All patients randomized to prolonged prophylaxis and who received a dose of study drug were considered in the safety analysis.Results: A total of 683 patients were randomized to receive LMWH for 1 week (333 patients) or 4 weeks (350 patients). Total VTE events occurred in 16 (4.8 per cent) patients in the extended group and 40 (11.4 per cent) in the control group (OR = 0.39, 95 per cent CI 0.21–0.71; P = 0.002). The risk of bleeding was 3.5 per cent in both groups (OR 0.99, 95 per cent CI 0.47–2.06; P = 1).Conclusions: Extended TP results in significant reduction of the risk of developing VTE in patients undergoing major general surgical operations without any increase in the risk of bleeding.

Research paper thumbnail of Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients

Thrombosis and Haemostasis, 2005

Hospitalizedp atientsw ith acute medicalc onditionsa re at significantriskofvenous thromboembolis... more Hospitalizedp atientsw ith acute medicalc onditionsa re at significantriskofvenous thromboembolism (VTE): approximately 10-30% of general medical patients mayd evelop deep-vein thrombosis or pulmonaryembolism, andthe latter is aleading contributortodeaths in hospital. Despite consensus-group recommendations that at-riskm edical patients should receive thromboprophylaxis, there is currentlyn oc onsensusa st o which patients areatrisk,and manypatientsmay not receiveappropriate thromboprophylaxis.This paperreviews evidence for the risk of VTE associated with differentmedical conditions and riskfactors, and presents arisk-assessment modelfor risk stratification in medical patients. Medicalconditionsassociated with

Research paper thumbnail of Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness Analysis of the MEDENOX Study

Background: There is limited information about risk factors for venous thromboembolism (VTE) in a... more Background: There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients.