Ali liu - Academia.edu (original) (raw)
Papers by Ali liu
Frontiers in Aging Neuroscience
Background: More and more elderly patients are being diagnosed with arteriovenous malformation (A... more Background: More and more elderly patients are being diagnosed with arteriovenous malformation (AVM) in this global aging society, while the treatment strategy remains controversial among these aging population. This study aimed to clarify the long-term outcomes of elderly AVMs after different management modalities.Methods: The authors retrospectively reviewed 71 elderly AVMs (>60 years) in two tertiary neurosurgery centers between 2011 and 2019. Patients were divided into four groups: conservation, microsurgery, embolization, and stereotactic radiosurgery (SRS). The perioperative complications, short-term and long-term neurological outcomes, obliteration rates, annualized rupture risk, and mortality rates were compared among different management modalities in the ruptured and unruptured subgroups. Kaplan-Meier survival analysis was employed to compare the death-free survival rates among different management modalities. Logistic regression analyses were conducted to calculate the...
Chinese Neurosurgical Journal
Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in ... more Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological impairment. The registry of Multimodality treatment for brain ArTeriovenous malformation in mainland CHina (MATCH) is a national prospective registry to identify the natural history of AVMs in Asian population; to investigate traditional and emerging hemorrhagic predictors; and to explore the superiority of the multidisciplinary assessment in improving the long-term outcomes. Methods Consecutive AVM patients will be enrolled from 52 participating hospitals in mainland China. Baseline demographic, clinical and imaging data will be collected prospectively. Conservation, microsurgery, embolization, stereotactic radiosurgery (SRS), and multimodal strategies are all included in this study. Patients will be divided into experimental and control group according to whether the treatment protocols are formulated by multidisciplinary team. Neuro...
Frontiers in Oncology
Background and PurposeThe purpose of this study was to identify morphologic and dosimetric featur... more Background and PurposeThe purpose of this study was to identify morphologic and dosimetric features associated with volume reduction velocity for arteriovenous malformation (AVM) after dose-stage stereotactic radiosurgery (DS-SRS).MethodsThirty patients with intracranial AVM were treated with DS fractionated SRS at Beijing Tiantan Hospital from 2011 to 2019. The AVM nidus was automatically segmented from DICOMRT files using the 3D Slicer software. The change in lesion volume was obtained from the decrease in the planning target volume (PTV) between the two treatment sessions. The volume reduction velocity was measured by the change in volume divided by the time interval between treatments. Fourteen morphologic features of AVM prior to treatment were extracted from the PTV using ‘Pyradiomics’ implemented in Python. Along with other dosimetric features, univariate and multivariate analyses were performed to explore predictors of the volume reduction velocity.ResultsAmong the 15 male (...
Magnetic Resonance Imaging
Frontiers in Neurology, 2021
Background and purpose: To evaluate whether a radiosurgery-based arteriovenous malformation (AVM)... more Background and purpose: To evaluate whether a radiosurgery-based arteriovenous malformation (AVM) scale (RBAS) could be used to predict obliteration of brain arteriovenous malformations (bAVMs) supposed for combined endovascular embolization (EMB) and gamma knife surgery (GKS) treatment.Methods: bAVM patients who underwent GKS with or without previous EMB from January 2011 to December 2016 at our institution were retrospectively reviewed. The patients were categorized into a combined treatment group and a GKS group. A 1:1 propensity score matching (PSM) was used to match the two groups. Pre-EMB and pre-GKS RBAS were assessed for every patient. Multivariate analysis was performed to find factors associated with complete obliteration in the combined treatment group. Survival analysis based on sub-groups according to RBAS was performed to compare obliteration rate and find cutoffs for appropriate treatment modalities.Results: A total of 96 patients were involved, and each group compris...
Additional file 1. Contemporary web-based nationwide questionnaire survey on brain arteriovenous ... more Additional file 1. Contemporary web-based nationwide questionnaire survey on brain arteriovenous malformations management in mainland China
Additional file 2: Table S2. Genomic regions explained more than 1% of genetic variance for sperm... more Additional file 2: Table S2. Genomic regions explained more than 1% of genetic variance for sperm motility.
Additional file 1: Table S1. Genomic regions explained more than 1% of genetic variance for the n... more Additional file 1: Table S1. Genomic regions explained more than 1% of genetic variance for the number of sperm cells.
Additional file 4: Table S4. Genomic regions explained more than 1% of genetic variance for total... more Additional file 4: Table S4. Genomic regions explained more than 1% of genetic variance for total morphological abnormalities.
Additional file 3: Table S3. Genomic regions explained more than 1% of genetic variance for progr... more Additional file 3: Table S3. Genomic regions explained more than 1% of genetic variance for progressive motility.
Frontiers in Neurology, 2021
Objective: Whether partial embolization could facilitate the post-stereotactic radiosurgery (SRS)... more Objective: Whether partial embolization could facilitate the post-stereotactic radiosurgery (SRS) obliteration for brain arteriovenous malformations (bAVMs) remains controversial. We performed this study to compare the outcomes of SRS with and without prior embolization for bAVMs.Methods: We retrospectively reviewed the Beijing Tiantan AVMs prospective registration research database from September 2011 to October 2014. Patients were categorized into two groups, combined upfront embolization and SRS (Em+SRS group) and SRS alone (SRS group), and we performed a propensity score matching analysis based on pre-embolization baseline characteristics; the matched groups each comprised 76 patients.Results: The obliteration rate was similar between SRS and Em+SRS (44.7 vs. 31.6%; OR, 1.754; 95% CI, 0.905–3.401; p = 0.096). However, the SRS group was superior to the Em+SRS group in terms of cumulative obliteration rate at a follow-up of 5 years (HR,1.778; 95% CI, 1.017–3.110; p = 0.033). The s...
Stroke and Vascular Neurology, 2020
ObjectiveThe aims of this study are to clarify the long-term outcomes of brainstem arteriovenous ... more ObjectiveThe aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations (AVMs) after different management modalities.MethodsThe authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and 2017. The rupture risk was represented by annualised haemorrhagic rate. Patients were divided into five groups: conservation, microsurgery, embolisation, stereotactic radiosurgery (SRS) and embolisation+SRS. Neurofunctional outcomes were evaluated by the modified Rankin Scale (mRS). Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured cohorts.ResultsAll of 61 brainstem AVMs (12 unruptured and 49 ruptured) were followed up for an average of 4.5 years. The natural annualised rupture risk was 7.3%, and the natural annualised reruptured risk in the ruptured cohort was 8.9%. 13 cases were conservative managed and 48 cases underwent intervention (including 6 mi...
BMC Genomics, 2019
BackgroundIn the pig production industry, artificial insemination (AI) plays an important role in... more BackgroundIn the pig production industry, artificial insemination (AI) plays an important role in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and detecting genetic markers associated with semen traits can help in improving genetic selection for such traits and accelerate genetic progress. In this study, we utilized a weighted single-step genome-wide association study (wssGWAS) procedure to detect genetic regions and further candidate genes associated with semen traits in a Duroc boar population. Overall, the full pedigree consists of 5284 pigs (12 generations), of which 2693 boars have semen data (143,113 ejaculations) and 1733 pigs were genotyped with 50 K single nucleotide polymorphism (SNP) array.ResultsResults show that the most significant genetic regions (0.4 Mb windows) explained approximately 2%~ 6% of the total genetic variances for the studied traits. Totally, the identified significant windows (windows explaining more than 1% of ...
World Neurosurgery, 2019
The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery... more The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery (GKRS) for residual and recurrent nonfunctioning pituitary adenomas (NFPAs) after surgery and the role of GKRS in the management of NFPAs.-METHODS: Between January 2000 and December 2010, 204 patients with residual or recurrent NFPAs undergoing GKRS were enrolled in this study according to the inclusion criteria. The median age of the patients was 48 years (mean, 48 years; range, 14e79 years). The median tumor volume was 3.3 mL (mean, 5.2 mL; range, 0.3e26.4 mL). The median margin dose was 14 Gy (mean, 14 Gy; range, 9e18 Gy). The median maximum dose was 31 Gy (mean, 30 Gy; 20e40 Gy). The median duration of follow-up was 86 months (mean, 88 months; range, 12e213 months).-RESULTS: Of these 204 patients, the latest follow-up magnetic resonance imaging studies showed tumor regression in 102 patients (50%), tumor stability in 81 patients (40%), and tumor enlargement in 21 patients (10%). The tumor control rate of this cohort was 90%. The cumulative progression-free survival at 3, 5, 8, 10, and 15 years was 97%, 95%, 92%, 92%, and 81%, respectively. Thirty-seven patients (18%) developed new-onset hypopituitarism, with 1 patient experiencing panhypopituitarism. Five patients (2.5%) presented with new or worsening visual dysfunction without tumor growth. No new cranial nerve dysfunction was shown and no second brain tumor was identified.-CONCLUSIONS: GKRS provided high tumor control and a low complication rate in our long-term follow-up. We recommend that early GKRS should be considered the routine adjuvant treatment for residual NFPAs approximately 6 months after subtotal surgical resection.
Zhonghua yi xue za zhi
To explore the core controlling genes and their functions and pathways of gamma knife in the trea... more To explore the core controlling genes and their functions and pathways of gamma knife in the treatment of epilepsy in rats. The temporal epilepsy rats induced by stereotactic technique were irradiated with gamma knife. Total RNA samples were isolated at 3 weeks post-irradiation. After hybridization, washing and staining, the probe arrays were scanned to acquire the gene chip data. The functional categories and affected pathways of differentially regulated genes were analyzed. And the gene co-expression network was constructed to determine the core controlling genes. The differentiated genes of normal, epileptic and epileptic rats treated with gamma knife were screened by 1.5-fold method. There were a total of 766 union genes. The differentiated up-regulated and down-regulated genes were obtained. These genes were involved in functional categories such as ion transport (P = 6.85 × 10(-24)), cell adhesion (P = 1.55 × 10(-8)) , response to mechanical stimulus (P = 7.86 × 10(-7)) , potassium ion transport (P = 2.63 × 10(-6)) and such pathways as MAPK signaling (P = 5.55 × 10(-6)), calcium signaling (P = 4.29 × 10(-5)) and TGF-beta signaling (P < 0.01), etc. And the core controlling genes from the gene co-expression network included Arf3, Akap5, Omd and Rtn4r, etc. Gamma knife achieves its antiepileptic effect through modulating target genes involved in different functions and pathways.
Journal of neurosurgery, 2006
The authors sought to assess the clinical effect of Gamma Knife surgery (GKS) for trigeminal schw... more The authors sought to assess the clinical effect of Gamma Knife surgery (GKS) for trigeminal schwannomas. Between December 1994 and December 2003, 69 patients with trigeminal schwannomas underwent GKS, and 58 patients were followed up and reviewed at the Beijing Neurosurgical Institute. The mean target volume was 4.6 cm3. The mean peripheral dose was 13.1 Gy, and the mean central dose was 28.3 Gy. The mean radiological follow-up period was 42.5 months. Radiological follow-up demonstrated near-complete disappearance of the tumors in four patients (6.9%), in 34 patients (58.6%) a reduction was seen, in 16 patients (27.6%) no change was observed, and in four patients (6.9%) an enlargement was revealed. The overall tumor control rate was 93.1%. Improvement of presenting neurological symptoms was observed in 28 patients (48.3%), stabilization of presenting neurological symptoms was observed in 23 patients (39.6%), continued progression of presenting neurological symptoms was observed in ...
Stereotactic and Functional Neurosurgery, 2009
Aims: The aim of this study was to assess the clinical effects of Gamma Knife radiosurgery (GKS) ... more Aims: The aim of this study was to assess the clinical effects of Gamma Knife radiosurgery (GKS) for recurrent and residual meningeal hemangiopericytomas (M-HPC). Methods: Between December 1994 and December 2006, 22 patients with recurrent and residual M-HPC with 58 foci underwent GKS at the Gamma Knife Center of Beijing Neurosurgical Institute. Of these 22 patients, 13 patients (59.1%) were males and 9 patients (40.9%) were females. The mean age was 40.9 years (range 16–64 years). The mean volume of these tumors was 5.4 cm3 (range 0.1–37.2 cm3). The mean tumor margin dose was 13.5 Gy (range 10.0–20.0 Gy). The mean tumor central dose was 28.2 Gy (range 21.8–35.0 Gy). The mean prescription isodose line was 48.4% (range 30.0–70.0%). Results: The mean period of follow-up was 26.0 months (range 5–90 months). Of these 22 patients, intracranial metastases developed in 7 patients (31.8%), extracranial metastases developed in 3 patients (13.6%). Four patients died. The mean life expectancy ...
Journal of neurosurgery, 2014
The aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS)... more The aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS) for patients with neurofibromatosis Type 2 (NF2) and the role of GKS in the management of NF2. From December 1994 through December 2008, a total of 46 patients (21 male, 25 female) with NF2 underwent GKS and follow-up evaluation for at least 5 years at the Gamma Knife Center of the Beijing Neurosurgical Institute. GKS was performed using the Leksell Gamma Knife Models B and C. The mean age of the patients was 30 years (range 13-59 years). A family history of NF2 was found for 9 (20%) patients. The NF2 phenotype was thought to be Wishart for 20 (44%) and Feiling-Gardner for 26 (56%) patients. Among these 46 patients, GKS was performed to treat 195 tumors (73 vestibular schwannomas and 122 other tumors including other schwannomas and meningiomas). For vestibular schwannomas, the mean volume was 5.1 cm(3) (median 3.6 cm(3), range 0.3-27.3 cm(3)), the mean margin dose was 12.9 Gy (range 10-...
Journal of neurosurgery, 2014
The goal of this study was to assess the clinical and pathological features of benign brain tumor... more The goal of this study was to assess the clinical and pathological features of benign brain tumors that had been treated with Gamma Knife surgery (GKS) followed by resection. In this retrospective chart review, the authors identified 61 patients with intracranial benign tumors who had undergone neurosurgical intervention after GKS. Of these 61 patients, 27 were male and 34 were female; mean age was 49.1 years (range 19-73 years). There were 24 meningiomas, 18 schwannomas, 14 pituitary adenomas, 3 hemangioblastomas, and 2 craniopharyngiomas. The interval between GKS and craniotomy was 2-168 months, with a median of 24 months; for 7 patients, the interval was 10 years or longer. For 21 patients, a craniotomy was performed before and after GKS; in 9 patients, pathological specimens were obtained before and after GKS. A total of 29 patients underwent GKS at the Beijing Tiantan Hospital. All specimens obtained by surgical intervention underwent histopathological examination. Most patient...
Surgical Neurology, 2000
The treatment of brainstem gliomas remains controversial. This article focuses on surgical result... more The treatment of brainstem gliomas remains controversial. This article focuses on surgical results. The authors retrospectively analyzed 35 patients with primary midbrain gliomas who were treated at Beijing Neurosurgical Institute from 1986 to 1997. The diagnosis was verified by histological examination. The incidence of midbrain glioma was 10.3% (35/340) in our patients with brain stem tumors. The 35 gliomas were classified into three therapeutic groups by their locations: 7 were located in the tectal region, 8 in the aqueductal region, and 20 in the tegmental region. All of the patients underwent microsurgical treatment based on a minimally invasive approach. The operation took the form of total resection in 19 cases, subtotal resection in 12, and partial resection in 4. The operative mortality was 0. With a mean follow-up of 28 months (range, 6-48 months), 65.7% (23/35) of patients could live independently. The volume and location of midbrain tumors were highly correlated with outcome. The resection of as much tumor as possible was optimal for the treatment of midbrain gliomas and radiotherapy after operation was beneficial to patients.
Frontiers in Aging Neuroscience
Background: More and more elderly patients are being diagnosed with arteriovenous malformation (A... more Background: More and more elderly patients are being diagnosed with arteriovenous malformation (AVM) in this global aging society, while the treatment strategy remains controversial among these aging population. This study aimed to clarify the long-term outcomes of elderly AVMs after different management modalities.Methods: The authors retrospectively reviewed 71 elderly AVMs (>60 years) in two tertiary neurosurgery centers between 2011 and 2019. Patients were divided into four groups: conservation, microsurgery, embolization, and stereotactic radiosurgery (SRS). The perioperative complications, short-term and long-term neurological outcomes, obliteration rates, annualized rupture risk, and mortality rates were compared among different management modalities in the ruptured and unruptured subgroups. Kaplan-Meier survival analysis was employed to compare the death-free survival rates among different management modalities. Logistic regression analyses were conducted to calculate the...
Chinese Neurosurgical Journal
Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in ... more Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological impairment. The registry of Multimodality treatment for brain ArTeriovenous malformation in mainland CHina (MATCH) is a national prospective registry to identify the natural history of AVMs in Asian population; to investigate traditional and emerging hemorrhagic predictors; and to explore the superiority of the multidisciplinary assessment in improving the long-term outcomes. Methods Consecutive AVM patients will be enrolled from 52 participating hospitals in mainland China. Baseline demographic, clinical and imaging data will be collected prospectively. Conservation, microsurgery, embolization, stereotactic radiosurgery (SRS), and multimodal strategies are all included in this study. Patients will be divided into experimental and control group according to whether the treatment protocols are formulated by multidisciplinary team. Neuro...
Frontiers in Oncology
Background and PurposeThe purpose of this study was to identify morphologic and dosimetric featur... more Background and PurposeThe purpose of this study was to identify morphologic and dosimetric features associated with volume reduction velocity for arteriovenous malformation (AVM) after dose-stage stereotactic radiosurgery (DS-SRS).MethodsThirty patients with intracranial AVM were treated with DS fractionated SRS at Beijing Tiantan Hospital from 2011 to 2019. The AVM nidus was automatically segmented from DICOMRT files using the 3D Slicer software. The change in lesion volume was obtained from the decrease in the planning target volume (PTV) between the two treatment sessions. The volume reduction velocity was measured by the change in volume divided by the time interval between treatments. Fourteen morphologic features of AVM prior to treatment were extracted from the PTV using ‘Pyradiomics’ implemented in Python. Along with other dosimetric features, univariate and multivariate analyses were performed to explore predictors of the volume reduction velocity.ResultsAmong the 15 male (...
Magnetic Resonance Imaging
Frontiers in Neurology, 2021
Background and purpose: To evaluate whether a radiosurgery-based arteriovenous malformation (AVM)... more Background and purpose: To evaluate whether a radiosurgery-based arteriovenous malformation (AVM) scale (RBAS) could be used to predict obliteration of brain arteriovenous malformations (bAVMs) supposed for combined endovascular embolization (EMB) and gamma knife surgery (GKS) treatment.Methods: bAVM patients who underwent GKS with or without previous EMB from January 2011 to December 2016 at our institution were retrospectively reviewed. The patients were categorized into a combined treatment group and a GKS group. A 1:1 propensity score matching (PSM) was used to match the two groups. Pre-EMB and pre-GKS RBAS were assessed for every patient. Multivariate analysis was performed to find factors associated with complete obliteration in the combined treatment group. Survival analysis based on sub-groups according to RBAS was performed to compare obliteration rate and find cutoffs for appropriate treatment modalities.Results: A total of 96 patients were involved, and each group compris...
Additional file 1. Contemporary web-based nationwide questionnaire survey on brain arteriovenous ... more Additional file 1. Contemporary web-based nationwide questionnaire survey on brain arteriovenous malformations management in mainland China
Additional file 2: Table S2. Genomic regions explained more than 1% of genetic variance for sperm... more Additional file 2: Table S2. Genomic regions explained more than 1% of genetic variance for sperm motility.
Additional file 1: Table S1. Genomic regions explained more than 1% of genetic variance for the n... more Additional file 1: Table S1. Genomic regions explained more than 1% of genetic variance for the number of sperm cells.
Additional file 4: Table S4. Genomic regions explained more than 1% of genetic variance for total... more Additional file 4: Table S4. Genomic regions explained more than 1% of genetic variance for total morphological abnormalities.
Additional file 3: Table S3. Genomic regions explained more than 1% of genetic variance for progr... more Additional file 3: Table S3. Genomic regions explained more than 1% of genetic variance for progressive motility.
Frontiers in Neurology, 2021
Objective: Whether partial embolization could facilitate the post-stereotactic radiosurgery (SRS)... more Objective: Whether partial embolization could facilitate the post-stereotactic radiosurgery (SRS) obliteration for brain arteriovenous malformations (bAVMs) remains controversial. We performed this study to compare the outcomes of SRS with and without prior embolization for bAVMs.Methods: We retrospectively reviewed the Beijing Tiantan AVMs prospective registration research database from September 2011 to October 2014. Patients were categorized into two groups, combined upfront embolization and SRS (Em+SRS group) and SRS alone (SRS group), and we performed a propensity score matching analysis based on pre-embolization baseline characteristics; the matched groups each comprised 76 patients.Results: The obliteration rate was similar between SRS and Em+SRS (44.7 vs. 31.6%; OR, 1.754; 95% CI, 0.905–3.401; p = 0.096). However, the SRS group was superior to the Em+SRS group in terms of cumulative obliteration rate at a follow-up of 5 years (HR,1.778; 95% CI, 1.017–3.110; p = 0.033). The s...
Stroke and Vascular Neurology, 2020
ObjectiveThe aims of this study are to clarify the long-term outcomes of brainstem arteriovenous ... more ObjectiveThe aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations (AVMs) after different management modalities.MethodsThe authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and 2017. The rupture risk was represented by annualised haemorrhagic rate. Patients were divided into five groups: conservation, microsurgery, embolisation, stereotactic radiosurgery (SRS) and embolisation+SRS. Neurofunctional outcomes were evaluated by the modified Rankin Scale (mRS). Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured cohorts.ResultsAll of 61 brainstem AVMs (12 unruptured and 49 ruptured) were followed up for an average of 4.5 years. The natural annualised rupture risk was 7.3%, and the natural annualised reruptured risk in the ruptured cohort was 8.9%. 13 cases were conservative managed and 48 cases underwent intervention (including 6 mi...
BMC Genomics, 2019
BackgroundIn the pig production industry, artificial insemination (AI) plays an important role in... more BackgroundIn the pig production industry, artificial insemination (AI) plays an important role in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and detecting genetic markers associated with semen traits can help in improving genetic selection for such traits and accelerate genetic progress. In this study, we utilized a weighted single-step genome-wide association study (wssGWAS) procedure to detect genetic regions and further candidate genes associated with semen traits in a Duroc boar population. Overall, the full pedigree consists of 5284 pigs (12 generations), of which 2693 boars have semen data (143,113 ejaculations) and 1733 pigs were genotyped with 50 K single nucleotide polymorphism (SNP) array.ResultsResults show that the most significant genetic regions (0.4 Mb windows) explained approximately 2%~ 6% of the total genetic variances for the studied traits. Totally, the identified significant windows (windows explaining more than 1% of ...
World Neurosurgery, 2019
The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery... more The aim of this study was to evaluate the long-term clinical outcomes of Gamma Knife radiosurgery (GKRS) for residual and recurrent nonfunctioning pituitary adenomas (NFPAs) after surgery and the role of GKRS in the management of NFPAs.-METHODS: Between January 2000 and December 2010, 204 patients with residual or recurrent NFPAs undergoing GKRS were enrolled in this study according to the inclusion criteria. The median age of the patients was 48 years (mean, 48 years; range, 14e79 years). The median tumor volume was 3.3 mL (mean, 5.2 mL; range, 0.3e26.4 mL). The median margin dose was 14 Gy (mean, 14 Gy; range, 9e18 Gy). The median maximum dose was 31 Gy (mean, 30 Gy; 20e40 Gy). The median duration of follow-up was 86 months (mean, 88 months; range, 12e213 months).-RESULTS: Of these 204 patients, the latest follow-up magnetic resonance imaging studies showed tumor regression in 102 patients (50%), tumor stability in 81 patients (40%), and tumor enlargement in 21 patients (10%). The tumor control rate of this cohort was 90%. The cumulative progression-free survival at 3, 5, 8, 10, and 15 years was 97%, 95%, 92%, 92%, and 81%, respectively. Thirty-seven patients (18%) developed new-onset hypopituitarism, with 1 patient experiencing panhypopituitarism. Five patients (2.5%) presented with new or worsening visual dysfunction without tumor growth. No new cranial nerve dysfunction was shown and no second brain tumor was identified.-CONCLUSIONS: GKRS provided high tumor control and a low complication rate in our long-term follow-up. We recommend that early GKRS should be considered the routine adjuvant treatment for residual NFPAs approximately 6 months after subtotal surgical resection.
Zhonghua yi xue za zhi
To explore the core controlling genes and their functions and pathways of gamma knife in the trea... more To explore the core controlling genes and their functions and pathways of gamma knife in the treatment of epilepsy in rats. The temporal epilepsy rats induced by stereotactic technique were irradiated with gamma knife. Total RNA samples were isolated at 3 weeks post-irradiation. After hybridization, washing and staining, the probe arrays were scanned to acquire the gene chip data. The functional categories and affected pathways of differentially regulated genes were analyzed. And the gene co-expression network was constructed to determine the core controlling genes. The differentiated genes of normal, epileptic and epileptic rats treated with gamma knife were screened by 1.5-fold method. There were a total of 766 union genes. The differentiated up-regulated and down-regulated genes were obtained. These genes were involved in functional categories such as ion transport (P = 6.85 × 10(-24)), cell adhesion (P = 1.55 × 10(-8)) , response to mechanical stimulus (P = 7.86 × 10(-7)) , potassium ion transport (P = 2.63 × 10(-6)) and such pathways as MAPK signaling (P = 5.55 × 10(-6)), calcium signaling (P = 4.29 × 10(-5)) and TGF-beta signaling (P < 0.01), etc. And the core controlling genes from the gene co-expression network included Arf3, Akap5, Omd and Rtn4r, etc. Gamma knife achieves its antiepileptic effect through modulating target genes involved in different functions and pathways.
Journal of neurosurgery, 2006
The authors sought to assess the clinical effect of Gamma Knife surgery (GKS) for trigeminal schw... more The authors sought to assess the clinical effect of Gamma Knife surgery (GKS) for trigeminal schwannomas. Between December 1994 and December 2003, 69 patients with trigeminal schwannomas underwent GKS, and 58 patients were followed up and reviewed at the Beijing Neurosurgical Institute. The mean target volume was 4.6 cm3. The mean peripheral dose was 13.1 Gy, and the mean central dose was 28.3 Gy. The mean radiological follow-up period was 42.5 months. Radiological follow-up demonstrated near-complete disappearance of the tumors in four patients (6.9%), in 34 patients (58.6%) a reduction was seen, in 16 patients (27.6%) no change was observed, and in four patients (6.9%) an enlargement was revealed. The overall tumor control rate was 93.1%. Improvement of presenting neurological symptoms was observed in 28 patients (48.3%), stabilization of presenting neurological symptoms was observed in 23 patients (39.6%), continued progression of presenting neurological symptoms was observed in ...
Stereotactic and Functional Neurosurgery, 2009
Aims: The aim of this study was to assess the clinical effects of Gamma Knife radiosurgery (GKS) ... more Aims: The aim of this study was to assess the clinical effects of Gamma Knife radiosurgery (GKS) for recurrent and residual meningeal hemangiopericytomas (M-HPC). Methods: Between December 1994 and December 2006, 22 patients with recurrent and residual M-HPC with 58 foci underwent GKS at the Gamma Knife Center of Beijing Neurosurgical Institute. Of these 22 patients, 13 patients (59.1%) were males and 9 patients (40.9%) were females. The mean age was 40.9 years (range 16–64 years). The mean volume of these tumors was 5.4 cm3 (range 0.1–37.2 cm3). The mean tumor margin dose was 13.5 Gy (range 10.0–20.0 Gy). The mean tumor central dose was 28.2 Gy (range 21.8–35.0 Gy). The mean prescription isodose line was 48.4% (range 30.0–70.0%). Results: The mean period of follow-up was 26.0 months (range 5–90 months). Of these 22 patients, intracranial metastases developed in 7 patients (31.8%), extracranial metastases developed in 3 patients (13.6%). Four patients died. The mean life expectancy ...
Journal of neurosurgery, 2014
The aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS)... more The aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS) for patients with neurofibromatosis Type 2 (NF2) and the role of GKS in the management of NF2. From December 1994 through December 2008, a total of 46 patients (21 male, 25 female) with NF2 underwent GKS and follow-up evaluation for at least 5 years at the Gamma Knife Center of the Beijing Neurosurgical Institute. GKS was performed using the Leksell Gamma Knife Models B and C. The mean age of the patients was 30 years (range 13-59 years). A family history of NF2 was found for 9 (20%) patients. The NF2 phenotype was thought to be Wishart for 20 (44%) and Feiling-Gardner for 26 (56%) patients. Among these 46 patients, GKS was performed to treat 195 tumors (73 vestibular schwannomas and 122 other tumors including other schwannomas and meningiomas). For vestibular schwannomas, the mean volume was 5.1 cm(3) (median 3.6 cm(3), range 0.3-27.3 cm(3)), the mean margin dose was 12.9 Gy (range 10-...
Journal of neurosurgery, 2014
The goal of this study was to assess the clinical and pathological features of benign brain tumor... more The goal of this study was to assess the clinical and pathological features of benign brain tumors that had been treated with Gamma Knife surgery (GKS) followed by resection. In this retrospective chart review, the authors identified 61 patients with intracranial benign tumors who had undergone neurosurgical intervention after GKS. Of these 61 patients, 27 were male and 34 were female; mean age was 49.1 years (range 19-73 years). There were 24 meningiomas, 18 schwannomas, 14 pituitary adenomas, 3 hemangioblastomas, and 2 craniopharyngiomas. The interval between GKS and craniotomy was 2-168 months, with a median of 24 months; for 7 patients, the interval was 10 years or longer. For 21 patients, a craniotomy was performed before and after GKS; in 9 patients, pathological specimens were obtained before and after GKS. A total of 29 patients underwent GKS at the Beijing Tiantan Hospital. All specimens obtained by surgical intervention underwent histopathological examination. Most patient...
Surgical Neurology, 2000
The treatment of brainstem gliomas remains controversial. This article focuses on surgical result... more The treatment of brainstem gliomas remains controversial. This article focuses on surgical results. The authors retrospectively analyzed 35 patients with primary midbrain gliomas who were treated at Beijing Neurosurgical Institute from 1986 to 1997. The diagnosis was verified by histological examination. The incidence of midbrain glioma was 10.3% (35/340) in our patients with brain stem tumors. The 35 gliomas were classified into three therapeutic groups by their locations: 7 were located in the tectal region, 8 in the aqueductal region, and 20 in the tegmental region. All of the patients underwent microsurgical treatment based on a minimally invasive approach. The operation took the form of total resection in 19 cases, subtotal resection in 12, and partial resection in 4. The operative mortality was 0. With a mean follow-up of 28 months (range, 6-48 months), 65.7% (23/35) of patients could live independently. The volume and location of midbrain tumors were highly correlated with outcome. The resection of as much tumor as possible was optimal for the treatment of midbrain gliomas and radiotherapy after operation was beneficial to patients.