Aliye Gediz Ertürk - Academia.edu (original) (raw)
Papers by Aliye Gediz Ertürk
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Journal of Physical Organic Chemistry, 2014
ABSTRACT The mechanism of acidâcatalyzed hydrolysis of a series of pâsubstituted N,Nâ²âdiarylsulf... more ABSTRACT The mechanism of acidâcatalyzed hydrolysis of a series of pâsubstituted N,Nâ²âdiarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations. Copyright © 2013 John Wiley & Sons, Ltd. The mechanism of N,Nâ²âdiarylsulfamides was investigated in high aqueous mineral acid solutions at elevated temperatures. Various criteria, such as the excess acidity method, the values of the reaction activation entropies, and the kinetic solvent isotope effect were applied to the kinetic data obtained by using the UVâ“Visible method. The data consistently suggest an A2 mechanism in low acid concentrations (up to 13â‰M) and an A1 mechanism in high acid concentrations (above 13â‰M).
Journal of Molecular Structure, Jun 1, 2023
Journal of Molecular Structure, Feb 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Social Science Research Network, 2023
Social Science Research Network, 2022
Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji
Organosulfur compound's functionality constitutes an essential class of therapeutic agents in... more Organosulfur compound's functionality constitutes an essential class of therapeutic agents in current medicinal chemistry. Especially sulfonamides called sulfa drugs were performed as both chemotherapeutic agents and useful antibacterial derivatives developed for medicine. The sulfamides in the same family with the sulfonamides have similar biological activities. In our research, it was studied with some 3-imino-4-substituted-1, 2, 5-thiadiazolidine 1,1-dioxides (ISTDs- 4a-d, four samples) that are five-membered cyclosulfamides. These compounds were previously synthesized and structurally characterized. The goals of this study are to investigate minimum inhibition concentration (MIC) values and antibacterial effects of these ISTDs compounds on Bacillus subtilis NRRL B-209T, Escherichia coli ATCC®25922T, Micrococcus luteusNRRL B-1018T, Nocardia abscessus DSM 44432T, Nocardia cyriacigeorgica DSMZ 44484T, Pseudomonas aeruginosa NRRL B-2679T Staphylococcus aureus ATCC®6538T, Strepto...
Applied Organometallic Chemistry, 2018
In the present work some substituted pyrazole derivatives were synthesized and used as ligands (4... more In the present work some substituted pyrazole derivatives were synthesized and used as ligands (4-[2-vinylthiophene]-3-methyl pyrozolin-5(4H)one (L 1), 4-[4-chloro benzylidine]-3-methyl pyrozolin-5(4H)one (L 2) and 4-[4-dimethylnitro benzylidine]-3-methylpyrozolin-5(4H)one (L 3)) to prepare the zirconium (IV) complexes. The synthesized ligands and their complexes were obtained as colored powdered materials and were characterized using magnetic measurements, melting point, molar conductance, infrared, electronic, 1 HNMR, mass spectra and thermogravimetric analyses. All of the tested compounds showed good microbial activity against pathogenic microorganisms. The tested compounds exhibited considerable antitumor activity and cytotoxic specificity towards human colon carcinoma cell line (HCT-116).
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-excha... more Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating.
Celal Bayar Üniversitesi Fen Bilimleri Dergisi, 2018
Antioxidant and antimicrobial activities of ethanol extracts of leaves, seeds and roots of 48 fru... more Antioxidant and antimicrobial activities of ethanol extracts of leaves, seeds and roots of 48 fruits and vegetables belonging to different families were investigated. Also, the phytochemical constituents were established in samples. Antimicrobial activity tests were carried out using agar disc diffusion methods with ten microbial species and only two fungi strains. The extracts showed high antibacterial activity against all the strains tested. It was observed that the plant extracts were more active against Gram-negative bacteria than against Gram-positive bacteria. The antioxidant properties of extracts were appraised by means of different antioxidant tests, including total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and metal chelating activities. Phytochemical analysis revealed the presence of carbohydrates, saponins, flavonoids, glycosides, tannins, phenols and alkaloids in the extracts. When the protein content in samples was analyzed, the lar...
Journal of Physical Organic Chemistry, 2015
ABSTRACT The acid-catalyzed hydrolysis of a series of 5-substituted-1H,3H-2,1,3-benzothiadiazole ... more ABSTRACT The acid-catalyzed hydrolysis of a series of 5-substituted-1H,3H-2,1,3-benzothiadiazole 2,2-dioxides has been investigated in aqueous solutions of sulfuric, perchloric, and hydrochloric acid at 85.0 ± 0.05 °C. Analysis of the kinetic data by the excess acidity method, Arrhenius parameters, the order of the catalytic effects of strong acids, the kinetic deuterium isotope effect, and the substituent effect have indicated that the hydrolysis of 5-substituted benzosulfamides 1a, 1b, 1c, 1d occur with a mechanistic switchover from A2 to A1 in the studied range: an A2 mechanism in low acidity regions and an A1 mechanism in high acid concentrations.
Microscopy Research and Technique, 2013
To examine different types of restorative materials used in children as well as primary and perma... more To examine different types of restorative materials used in children as well as primary and permanent teeth enamel when affected by erosive foods. Buttermilk, fruit yoghurt, Coca-cola, fruit juice, Filtek Z-250, Dyract Extra, Fuji II LC, and Fuji IX and tooth enamel were used. Measurements were performed on 1-day, 1-week, 1-month, 3-month, 6-month time periods by using ATR-FTIR technique and surface of the specimens were examined with SEM. Permanent tooth showed the least change among human tooth samples when compared to restorative materials. Among filler materials, the most change was observed in Fuji IX. In terms of beverages the most changes on absorption peaks obtained from spectra were seen on the samples held in Coca-Cola and orange-juice. The exposure of human enamel and restorative materials to acidic drinks may accelerate the degradation process and so reduce the life time of filler materials at equivalent integral exposure times longer than three months. Clinical Relevance Erosive foods and drinks having acidic potential destroy not only tooth enamel but also restorative materials.
Journal of Physical Organic Chemistry, 2013
The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was... more The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by am... more ABSTRACT Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating.[Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]
Molecules, 2021
Since December 2019, humanity has faced an important global threat. Many studies have been publis... more Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We ...
R factor = 0.038; wR factor = 0.109; data-to-parameter ratio = 15.8. The title compound, C10H14N4... more R factor = 0.038; wR factor = 0.109; data-to-parameter ratio = 15.8. The title compound, C10H14N4O2S, exists in the amine tautomeric form. The dihedral angle between the benzene and thiadiazolidine rings is 66.54 (19). In the crystal, molecules are linked by N—H O and N—H N hydrogen bonds into a layer parallel to the ac plane. The layers are further linked by C—H O hydrogen bonds. Related literature For background to and applications of sulfamides, see:
Bioorganic Chemistry, 2021
Sulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibact... more Sulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibacterial, anti-inflammatory, and anticonvulsant properties. They also activate serine protease enzymes that catalyze the hydrolysis of peptide bonds. Five 3-imino sulfahydantoin compounds were synthesized by using Strecker synthesis reaction with minor modifications. We used reflux of various aldehydes with excess sulfamide in 85% methanol in the presence of sodium cyanide. The spectroscopic properties of these compounds were studied in detail. Antibacterial activities of all synthesized new compounds against four Gram-positive (Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Streptococcus mutans) and four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella Enteritidis) bacteria were investigated by disc diffusion and microdilution method. pBR322 plasmid DNA binding abilities of compounds were investigated in vitro by agarose gel electrophoresis. In addition, the cytotoxic activities of the compounds against the human malignant pleural mesothelioma (SPC212) cell line were determined by the MTT method. The remarkable result in this study is that the synthesized compounds, especially 4b, 4d, and 4e, have significant biological activities. It has been demonstrated that these compounds, which cause DNA damage, also have an important antibacterial effect on both Gram-negative and Gram-positive bacteria when results compared with the control group antibiotics. Compound 4e exhibited the highest antibacterial potency against Streptococcus mutans (24.33 ± 0.57) from Gram-positive bacteria and Pseudomonas aeruginosa (24.66 ± 1.15) from Gram-negative bacteria. At the same time, MTT results determined that compounds 4b, 4d, and 4e showed cytotoxic activity against the SPC212 cells. In particular, compound 4b had a high cytotoxic effect, and the IC50 value was determined as 6.25 µM.
Chemical Physics Letters, 2016
Abstract Sulfonamide derivatives have been widely incorporated in different types of studies, par... more Abstract Sulfonamide derivatives have been widely incorporated in different types of studies, particularly in bioorganics and medicinal chemistry. Molecular conformation or tautomeric forms of molecules are directly related to their pharmaceutical and biological activities. In the scope of this work two possible tautomeric forms of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide (C 10 H 14 N 4 O 2 S) molecule were tried to be identified by employing infrared and nuclear magnetic resonance spectroscopic methods. Obtained spectroscopic results suggest that 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide in its powder form shows the traces of both conformers (amino and imino) while in its liquid state in deuterated dimethyl sulfoxide it is mainly in imino form.
Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, 2019
![Research paper thumbnail of 3-Amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide](https://attachments.academia-assets.com/85030434/thumbnails/1.jpg)
](Acta Crystallographica Section E Structure Reports Online, 2011
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Journal of Physical Organic Chemistry, 2014
ABSTRACT The mechanism of acidâcatalyzed hydrolysis of a series of pâsubstituted N,Nâ²âdiarylsulf... more ABSTRACT The mechanism of acidâcatalyzed hydrolysis of a series of pâsubstituted N,Nâ²âdiarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations. Copyright © 2013 John Wiley & Sons, Ltd. The mechanism of N,Nâ²âdiarylsulfamides was investigated in high aqueous mineral acid solutions at elevated temperatures. Various criteria, such as the excess acidity method, the values of the reaction activation entropies, and the kinetic solvent isotope effect were applied to the kinetic data obtained by using the UVâ“Visible method. The data consistently suggest an A2 mechanism in low acid concentrations (up to 13â‰M) and an A1 mechanism in high acid concentrations (above 13â‰M).
Journal of Molecular Structure, Jun 1, 2023
Journal of Molecular Structure, Feb 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Social Science Research Network, 2023
Social Science Research Network, 2022
Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji
Organosulfur compound's functionality constitutes an essential class of therapeutic agents in... more Organosulfur compound's functionality constitutes an essential class of therapeutic agents in current medicinal chemistry. Especially sulfonamides called sulfa drugs were performed as both chemotherapeutic agents and useful antibacterial derivatives developed for medicine. The sulfamides in the same family with the sulfonamides have similar biological activities. In our research, it was studied with some 3-imino-4-substituted-1, 2, 5-thiadiazolidine 1,1-dioxides (ISTDs- 4a-d, four samples) that are five-membered cyclosulfamides. These compounds were previously synthesized and structurally characterized. The goals of this study are to investigate minimum inhibition concentration (MIC) values and antibacterial effects of these ISTDs compounds on Bacillus subtilis NRRL B-209T, Escherichia coli ATCC®25922T, Micrococcus luteusNRRL B-1018T, Nocardia abscessus DSM 44432T, Nocardia cyriacigeorgica DSMZ 44484T, Pseudomonas aeruginosa NRRL B-2679T Staphylococcus aureus ATCC®6538T, Strepto...
Applied Organometallic Chemistry, 2018
In the present work some substituted pyrazole derivatives were synthesized and used as ligands (4... more In the present work some substituted pyrazole derivatives were synthesized and used as ligands (4-[2-vinylthiophene]-3-methyl pyrozolin-5(4H)one (L 1), 4-[4-chloro benzylidine]-3-methyl pyrozolin-5(4H)one (L 2) and 4-[4-dimethylnitro benzylidine]-3-methylpyrozolin-5(4H)one (L 3)) to prepare the zirconium (IV) complexes. The synthesized ligands and their complexes were obtained as colored powdered materials and were characterized using magnetic measurements, melting point, molar conductance, infrared, electronic, 1 HNMR, mass spectra and thermogravimetric analyses. All of the tested compounds showed good microbial activity against pathogenic microorganisms. The tested compounds exhibited considerable antitumor activity and cytotoxic specificity towards human colon carcinoma cell line (HCT-116).
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-excha... more Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating.
Celal Bayar Üniversitesi Fen Bilimleri Dergisi, 2018
Antioxidant and antimicrobial activities of ethanol extracts of leaves, seeds and roots of 48 fru... more Antioxidant and antimicrobial activities of ethanol extracts of leaves, seeds and roots of 48 fruits and vegetables belonging to different families were investigated. Also, the phytochemical constituents were established in samples. Antimicrobial activity tests were carried out using agar disc diffusion methods with ten microbial species and only two fungi strains. The extracts showed high antibacterial activity against all the strains tested. It was observed that the plant extracts were more active against Gram-negative bacteria than against Gram-positive bacteria. The antioxidant properties of extracts were appraised by means of different antioxidant tests, including total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and metal chelating activities. Phytochemical analysis revealed the presence of carbohydrates, saponins, flavonoids, glycosides, tannins, phenols and alkaloids in the extracts. When the protein content in samples was analyzed, the lar...
Journal of Physical Organic Chemistry, 2015
ABSTRACT The acid-catalyzed hydrolysis of a series of 5-substituted-1H,3H-2,1,3-benzothiadiazole ... more ABSTRACT The acid-catalyzed hydrolysis of a series of 5-substituted-1H,3H-2,1,3-benzothiadiazole 2,2-dioxides has been investigated in aqueous solutions of sulfuric, perchloric, and hydrochloric acid at 85.0 ± 0.05 °C. Analysis of the kinetic data by the excess acidity method, Arrhenius parameters, the order of the catalytic effects of strong acids, the kinetic deuterium isotope effect, and the substituent effect have indicated that the hydrolysis of 5-substituted benzosulfamides 1a, 1b, 1c, 1d occur with a mechanistic switchover from A2 to A1 in the studied range: an A2 mechanism in low acidity regions and an A1 mechanism in high acid concentrations.
Microscopy Research and Technique, 2013
To examine different types of restorative materials used in children as well as primary and perma... more To examine different types of restorative materials used in children as well as primary and permanent teeth enamel when affected by erosive foods. Buttermilk, fruit yoghurt, Coca-cola, fruit juice, Filtek Z-250, Dyract Extra, Fuji II LC, and Fuji IX and tooth enamel were used. Measurements were performed on 1-day, 1-week, 1-month, 3-month, 6-month time periods by using ATR-FTIR technique and surface of the specimens were examined with SEM. Permanent tooth showed the least change among human tooth samples when compared to restorative materials. Among filler materials, the most change was observed in Fuji IX. In terms of beverages the most changes on absorption peaks obtained from spectra were seen on the samples held in Coca-Cola and orange-juice. The exposure of human enamel and restorative materials to acidic drinks may accelerate the degradation process and so reduce the life time of filler materials at equivalent integral exposure times longer than three months. Clinical Relevance Erosive foods and drinks having acidic potential destroy not only tooth enamel but also restorative materials.
Journal of Physical Organic Chemistry, 2013
The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was... more The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by am... more ABSTRACT Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating.[Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]
Molecules, 2021
Since December 2019, humanity has faced an important global threat. Many studies have been publis... more Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We ...
R factor = 0.038; wR factor = 0.109; data-to-parameter ratio = 15.8. The title compound, C10H14N4... more R factor = 0.038; wR factor = 0.109; data-to-parameter ratio = 15.8. The title compound, C10H14N4O2S, exists in the amine tautomeric form. The dihedral angle between the benzene and thiadiazolidine rings is 66.54 (19). In the crystal, molecules are linked by N—H O and N—H N hydrogen bonds into a layer parallel to the ac plane. The layers are further linked by C—H O hydrogen bonds. Related literature For background to and applications of sulfamides, see:
Bioorganic Chemistry, 2021
Sulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibact... more Sulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibacterial, anti-inflammatory, and anticonvulsant properties. They also activate serine protease enzymes that catalyze the hydrolysis of peptide bonds. Five 3-imino sulfahydantoin compounds were synthesized by using Strecker synthesis reaction with minor modifications. We used reflux of various aldehydes with excess sulfamide in 85% methanol in the presence of sodium cyanide. The spectroscopic properties of these compounds were studied in detail. Antibacterial activities of all synthesized new compounds against four Gram-positive (Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Streptococcus mutans) and four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella Enteritidis) bacteria were investigated by disc diffusion and microdilution method. pBR322 plasmid DNA binding abilities of compounds were investigated in vitro by agarose gel electrophoresis. In addition, the cytotoxic activities of the compounds against the human malignant pleural mesothelioma (SPC212) cell line were determined by the MTT method. The remarkable result in this study is that the synthesized compounds, especially 4b, 4d, and 4e, have significant biological activities. It has been demonstrated that these compounds, which cause DNA damage, also have an important antibacterial effect on both Gram-negative and Gram-positive bacteria when results compared with the control group antibiotics. Compound 4e exhibited the highest antibacterial potency against Streptococcus mutans (24.33 ± 0.57) from Gram-positive bacteria and Pseudomonas aeruginosa (24.66 ± 1.15) from Gram-negative bacteria. At the same time, MTT results determined that compounds 4b, 4d, and 4e showed cytotoxic activity against the SPC212 cells. In particular, compound 4b had a high cytotoxic effect, and the IC50 value was determined as 6.25 µM.
Chemical Physics Letters, 2016
Abstract Sulfonamide derivatives have been widely incorporated in different types of studies, par... more Abstract Sulfonamide derivatives have been widely incorporated in different types of studies, particularly in bioorganics and medicinal chemistry. Molecular conformation or tautomeric forms of molecules are directly related to their pharmaceutical and biological activities. In the scope of this work two possible tautomeric forms of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide (C 10 H 14 N 4 O 2 S) molecule were tried to be identified by employing infrared and nuclear magnetic resonance spectroscopic methods. Obtained spectroscopic results suggest that 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide in its powder form shows the traces of both conformers (amino and imino) while in its liquid state in deuterated dimethyl sulfoxide it is mainly in imino form.
Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, 2019
Acta Crystallographica Section E Structure Reports Online, 2011