Oana Almasan - Academia.edu (original) (raw)
Papers by Oana Almasan
Medicine and Pharmacy Reports, 2020
Background and aims The objective of this study was to evaluate the accuracy of the CADIAX Compac... more Background and aims The objective of this study was to evaluate the accuracy of the CADIAX Compact 2 axiograph in confirming the presumptive clinical diagnosis of temporomandibular dysfunction, established according to the muscular-articular clinical examination. Methods A retrospective analytical study was carried out on 50 patients, aged between 21 and 62 years, 31 women and 19 men. A clinical diagnosis was established after masticatory muscles, temporomandibular joints and mandibular border limit movements were assessed. During the same day a computerized axiography (Cadiax Compact 2, Gamma, Vienna, Austria) was performed in order to confirm the diagnosis. Results The study had a sensitivity of 100%, which means that the CADIAX device detected all clinically positive patients. On the other hand, the specificity of the study was 74%, representing the percentage of patients negatively diagnosed by CADIAX device out of the total number of patients clinically diagnosed as negative. T...
Medicine and Pharmacy Reports
Background and aims. Identifying the optimal method for occlusion analysis by comparing examinati... more Background and aims. Identifying the optimal method for occlusion analysis by comparing examination sensitivity of the static and dynamic occlusion using three systems: clinical occlusion analysis, semi-adjustable articulator and virtual articulator (3Shape, Denmark) occlusion analysis. Methods. The occlusion analysis of sixteen patients was performed using the three systems. In order to analyze the number of concordant and discordant points and trajectories, the clinical method was compared to the semi-adjustable articulator and to the computerized method. Results. The greatest correspondence was obtained by comparing the clinical and the articulator methods, having a success rate of 85.25%, versus the clinical and the computerized method with a success rate of 73.25%. The propulsion registered the highest discrepancies: 35% in case of the semi-adjustable articulator comparison and 62% in case of the virtual articulator comparison. Conclusions. The semi-adjustable articulator was ...
Scientific Reports
An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Balneo Research Journal
Introduction: Temporomandibular disorders are complex pathologies with multifactorial aetiology. ... more Introduction: Temporomandibular disorders are complex pathologies with multifactorial aetiology. Due to this matter, different therapeutic approaches have been developed, one of them being physical therapy (also known as physiotherapy). Low-level laser therapy is often used in treating musculoskeletal diseases, TMJ pain and, although the exact mechanism of LLLT has not yet been completely elucidated, it seems that this kind of therapy induces analgesic, anti-inflammatory and bio-stimulating effects. The aim of this study was to create an update of scientific literature regarding the clinical use of LLLT in patients with temporomandibular disorders, and to identify the impact of this therapy on reducing pain in the masticatory muscles. Methods: A research of literature was performed - articles published over the last 10 years (January 2009 until December 2019) were searched for by introducing a combination of different keywords on the PubMed and ScienceDirect databases. Results: A to...
Scientific Reports
Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the... more Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the uncertainties of the risks of the low-dose radiation exposures. The aim of this work was to investigate the clinical performance of different CBCT acquisition protocols towards the optimization of paediatric exposures. Custom-made anthropomorphic phantoms were scanned using a CBCT unit in six protocols. CT slices were blinded, randomized and presented to three observers, who scored the image quality using a 4-point scale along with their level of confidence. Sharpness level was also measured using a test object containing an air/PMMA e,dge. The effective dose was calculated by means of a customized Monte Carlo (MC) framework using previously validated paediatric voxels models. The results have shown that the protocols set with smaller voxel size (180 µm), even when decreasing exposure parameters (kVp and mAs), showed high image quality scores and increased sharpness. The MC analysis showed a gradual decrease in effective dose when exposures parameters were reduced, with an emphasis on an average reduction of 45% for the protocol that combined 70 kVp, 16 mAs and 180 µm voxel size. In contrast, both "ultra-low dose" protocols that combined a larger voxel size (400 µm) with lower mAs (7.4 mAs) demonstrated the lowest scores with high levels of confidence unsuitable for an anatomical approach. In conclusion, a significant decrease in the effective dose can be achieved while maintaining the image quality required for paediatric CBCT. The use of cone beam CT (CBCT) for dentomaxillofacial diagnosis has been growing substantially in conjunction with the concern regarding undetermined risks of the low-dose radiation exposures, especially for children and adolescents 1. Despite the well-known higher radiosensitivity of paediatric patients, several indications have been described on how CBCT can positively impact the diagnosis and treatment outcomes 2. In this way, the DIMITRA project (Dentomaxillofacial paediatric IMaging: an Investigation Towards low dose RAdiation induced risks-www.dimitra.be) aims to define the appropriate balance between dose and image quality in an ageand indication-oriented way, according to the recently introduced ALADAIP principle (As Low as Diagnostically Acceptable being Indication-oriented and Patient-specific) 2. The concept of image quality involves a number of variables, especially for three-dimensional modalities such as CBCT. In general, a better quality is achieved when the technical parameters of the unit are adjusted towards a high-resolution mode, which is often correlated with higher dose values. However, there is a noticeable difference between a high-quality or high-definition image and a diagnostically acceptable one for a given indication. On the other hand, if an exam is rejected for being of insufficient image quality, the principle of optimization is disregarded, since the patient will be re-exposed without any additional benefits 3. To approach the optimized
European journal of radiology, 2018
Children are more sensitive to ionizing radiation effects due to their high radiosensitivity. To ... more Children are more sensitive to ionizing radiation effects due to their high radiosensitivity. To estimate doses and risks for dental radiological examinations in children. A pediatric population consisting of 7150 children and young adults which underwent 12252 dental radiological examinations (4220 intraoral, 1324 cephalometric, 5284 panoramic radiographs and 1424 CBCTs) within two years were included. Two groups were studied: CBCT group (exposed to CBCT ± conventional radiographs) and 2D group (exposed only to 2D radiological examinations). The effective doses were corrected according to age at exposure and settings parameters (mA;FOV) by using logarithmic fit equations for dose interpolation. The individual cumulative dose, per-caput collective dose and radiation risk were calculated for each group. The median effective and cumulative doses for conventional radiographs were lower than 20 μSv and did not vary with age. Children exposed to CBCT had a higher median effective dose (1...
Turkish Journal of Veterinary and Animal Sciences
Histological changes in bone structure were induced at 12 weeks by experimental administration of... more Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone defect, the 2nd experimental group received 1 mL of bisphosphonate as a 10-day fractionated dose, and the control group comprised rats who did not receive any bisphosphonate. At 12 weeks after the injection, new bone tissue was collected and a histological examination was performed. At 12 weeks after the bisphosphonate administratio...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2011
Osteonecrosis of the jaws is increasing worldwide in patients treated with bisphosphonates. A ret... more Osteonecrosis of the jaws is increasing worldwide in patients treated with bisphosphonates. A retrospective review of 52 patients who were treated during 2007-2010 for bisphosphonate related maxillofacial symptoms of the jaws was conducted. Patient characteristics and other factors that influenced the disease process were studied. Thirteen patients received bisphosphonates for the prevention or treatment of osteoporosis; 39 for preventing bone metastases from malignant tumors. Thirty-six patients were females (age range 32-87 years, median 64 years); 16 were males (age range 30-81 years, median 73.5 years). Bisphosphonate used was ibandronic acid in four cases, alendronate sodium in 14 cases, and zoledronic acid in 34 cases. Mean bisphosphonate treatment period was 22.44 months (95%CI 19.33-25.55). Thirty patients received intravenous, 22 received oral bisphosphonate. The average period until occurrence of maxillofacial symptoms was 6 months (range 0.5-24 months) in subjects with in...
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
Anchorage represents a great issue that challenged orthodontists all over the years. Nowadays, wi... more Anchorage represents a great issue that challenged orthodontists all over the years. Nowadays, with the use of microimplants, it has become possible even to induce complex teeth movements. To present a clinical case in which mesialisation of upper second molars was performed by the means of using miniimplants. The present case shows how a bilateral mesialization of upper second molars using skeletal anchorage was performed by orthodontic treatment using fixed appliances and miniimplants. The placing site of the miniimplants plays a huge role in the moments of force produced and delivered to the teeth, thus influencing tooth movement. Miniimplants increase tooth movement control, by the use of skeletal anchorage. The success of their usage depends upon its good primary stabilization and a judicious loading.
Journal of Oral and Maxillofacial Surgery, 2011
Dentomaxillofacial Radiology, 2012
ABSTRACT Objectives The aim of the study was to establish the changes in posteroanterior cephalom... more ABSTRACT Objectives The aim of the study was to establish the changes in posteroanterior cephalometric variables in subjects with temporomandibular joint disorders (TMDs). Methods Posteroanterior cephalograms of 61 subjects (age range 16-36.6 years, standard deviation 4.88 years) were used to determine cephalometric differences. Subjects were classified according to the Research Diagnostic Criteria for Temporomandibular Joint Disorders into three groups: unilateral TMD, bilateral TMD and no TMD. 14 linear and angular measurements were assessed on the posteroanterior cephalogram. For assessing facial asymmetry, the asymmetry index for bilateral measurements was calculated between the right and the left side. In cases with unilateral TMD, the asymmetry index was calculated using the difference between the unaffected and affected side. The differences among multiple groups were analysed using the one-way analysis of variance test and Scheffé post hoc test. Results 47 subjects were females (77%) and 14 were males (23%). 19 subjects had unilateral TMDs and 16 subjects had bilateral TMDs. The asymmetry index of the distance from the horizontal plane to the antegonion was higher in subjects with unilateral TMD than in patients with bilateral or no TMD (p < 0.05). Also, the asymmetry index of the distances from the vertical plane to the condyle (p = 0.05), gonion (Go) (p = 0.0004), antegonion (p = 0.002) and chin (Ch) (p = 0.02) was higher in subjects with unilateral TMDs. The asymmetry index of the O point-Go-Go' and O point-Ch-Ch' angles differed significantly in subjects with unilateral TMDs (p < 0.05). Conclusions Unilateral TMDs are associated with changes in posteroanterior cephalometric measurements. The assessment of posteroanterior cephalometric variables could be used as a key factor for evaluating the presence of TMDs.
Rom J Morphol …, 2011
Bisphosphonates, stable analogues of pyrophosphate, have the ability to bind to bone molecules, p... more Bisphosphonates, stable analogues of pyrophosphate, have the ability to bind to bone molecules, possessing anti-resorbtion properties influenced by the radicals linked to the carbon group of their structure. Bisphosphonates link to the hydroxyapatite of the mineral surfaces and are selectively internalized by osteoclasts, whose activity they inhibit, jeopardizing the osteoblastic activity. The purpose of this study is to determine the influence of intramedular administration (at the hip bone) of bisphosphonates on the serum values of alkaline phosphatase, total Ca, Ca 2+ , proteins and serum osteocalcin in a lot of experience Wistar rats. Fifteen Wistar rats of experience, five in the control group and 10 in the experimental group. All rats underwent surgery to create a bone defect with a 1.5 mm diameter bone-bur at the right femur transcortical through the medullar canal. Rats from experimental group were divided into two groups: group A, who received Zometa 1 mL single dose intramedular, intraoperative and group B, who received Zometa 1 mL in divided doses daily, 0.1 mL for 10 days. 3 mL of blood from the frontal sinus were collected from each subject at 24 hours, 14 days and 21 days postoperatively. From the blood samples were determined: alkaline phosphatase [U/L], seric proteins [g/dL], total Ca [mmol/L, mg/dL], osteocalcin [mmol/L]. The data were statistically analyzed using the ANOVA test. We found an increase in alkaline phosphatase [U/L] in all groups studied. In group B there was a significant decrease in total Ca levels [mg/dL] throughout the experiment compared with controls (11.82→10.36→9.25 mg/dL; 2.95→2.59→2.31 mmol/L; p=0.001). Ca 2+ has changed significantly both in group A (1.18→1.25→1.25 mmol/L; p=0.01) and group B (1.21→1.24→1.13 mmol/L; p=0.02). Serum proteins were significantly reduced both in the control group (9.4→8.5→8.1 g/dL; p=0.03) and the experimental groups A (9.3→8.5→8.3 g/dL; p=0.01) and B (9.9→7.6→7.3 g/dL; p=0.0008). At each stage of bone development, multiple factors act in a coordinated manner that leads to increased local metabolic processes, acting both on the process of bone resorption and bone repair. Healing processes are initiated within 24 hours in both studied groups and the control group; at 14 and 21 days the bone healing processes are compromised directly proportional to the administration manner and dose of bisphosphonates.
Archives of Medical Science, 2013
I In nt tr ro od du uc ct ti io on n: : To establish the skeletal pattern in subjects with malocc... more I In nt tr ro od du uc ct ti io on n: : To establish the skeletal pattern in subjects with malocclusions and temporomandibular disorders (TMD); to assess the relationship between craniofacial skeletal structures and TMD in subjects with malocclusions. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Sixty-four subjects with malocclusions, over 18 years of age, were included in the study. Temporomandibular disorders were clinically assessed according to the Helkimo Anamnestic Index. Subjects underwent a lateral cephalogram. Subjects were grouped according to the sagittal skeletal pattern (ANB angle) into class I, II and III. Parametric Student tests with equal or unequal variations were used (variations were previously tested with Levene test). R Re es su ul lt ts s: : Twenty-four patients with TMD (experimental sample); 40 patients without TMD (control group); interincisal angle was higher in class I and II (p < 0.05) experimental subjects; overjet was larger in experimental subjects; midline shift and Wits appraisal were broader in the experimental group in all three classes. In class III subjects, the SNB angle was higher in the experimental group (p = 0.01). Joint noises followed by reduced mandible mobility, muscular pain and temporomandibular joint (TMJ) pain were the most frequent symptoms in subjects with TMD and malocclusions. C Co on nc cl lu us si io on ns s: : Temporomandibular joint status is an important factor to consider when planning orthodontic treatment in patients with severe malocclusions; midline shift, large overjet and deep overbite have been associated with signs and symptoms of TMD.
Journal of Cranio-Maxillofacial Surgery, 2007
Studies prior to 1990 showed an incidence of 5% for oral and maxillofacial cancer in Romania. In ... more Studies prior to 1990 showed an incidence of 5% for oral and maxillofacial cancer in Romania. In this paper (Part 1) an evaluation of malignant tumour cases, covering a 10-year period is made regarding histological forms, the relationships of malignant tumours to patients&amp;#39; geographic origin, environment, age, gender of patients and lymph node involvement. From 1485 patients with malignant oral and maxillofacial tumours, 1072 cases fulfilled the criteria for inclusion in this study. The following data were examined: patients&amp;#39; charts and medical records as well as pathology reports. From 16,315 patients admitted to this hospital between 1993 and 2002, 9% presented with primary (&amp;#39;de novo&amp;#39;) malignant tumours; 2/3 were male patients; average age at presentation was 61 years for males and 59 years for females; 47% presented with stage IV tumours; out of the &amp;#39;de novo&amp;#39; tumours, 93% were carcinomas and 4% sarcomas; 56% of patients had positive lymph nodes at presentation. The number of head and neck cancer cases increased in the last 15 years; almost half of the patients presented with tumours in stage IV.
Clinical Oral Investigations, 2013
This study aims to assess the disk morphology and the condyle position in subjects with temporoma... more This study aims to assess the disk morphology and the condyle position in subjects with temporomandibular (TMJ) disk displacements on sagittal and coronal magnetic resonance imaging (MRI). Seventy-four TMJs (from 37 patients) with positive clinical TMD symptoms according to the RDC/TMD axis I protocol were evaluated by 1.5 T MRI. Disk position, disk morphology, sagittal and coronal condyle position, joint effusion, joint space, and coronal condyle angulation were evaluated. Multivariate logistic regression was used to explore the relationship between disk displacement and MRI variables. Disk displacement with reduction (DDR) was found in 36.48 % and without reduction (DDwR), in 21.62 % of the joints. Disk displacement was anterior in 35.1 %, anterior-medial in 13.5 %, and anterior-lateral in 9.45 % of cases. The thickened posterior band (94.48 OR, p = 0.001) and the posterior condyle position (4.57 OR, p = 0.03) were more likely found on sagittal MRI in disk displacements. On coronal slices, the disk displacement was significantly associated with the distance from the most medial condyle point to the midplane (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Disk displacement is associated with changes of disk shape, disk dimension, and condyle position on sagittal MRI. A significant variation of the distance from the most medial condyle point to the midplane in disk displacement was found on coronal MRI. Our study highlights the existence of changes on coronal MRI in TMD patients which should be assessed for better understanding of the clinical evolution of temporomandibular disorders.
Medicine and Pharmacy Reports, 2020
Background and aims The objective of this study was to evaluate the accuracy of the CADIAX Compac... more Background and aims The objective of this study was to evaluate the accuracy of the CADIAX Compact 2 axiograph in confirming the presumptive clinical diagnosis of temporomandibular dysfunction, established according to the muscular-articular clinical examination. Methods A retrospective analytical study was carried out on 50 patients, aged between 21 and 62 years, 31 women and 19 men. A clinical diagnosis was established after masticatory muscles, temporomandibular joints and mandibular border limit movements were assessed. During the same day a computerized axiography (Cadiax Compact 2, Gamma, Vienna, Austria) was performed in order to confirm the diagnosis. Results The study had a sensitivity of 100%, which means that the CADIAX device detected all clinically positive patients. On the other hand, the specificity of the study was 74%, representing the percentage of patients negatively diagnosed by CADIAX device out of the total number of patients clinically diagnosed as negative. T...
Medicine and Pharmacy Reports
Background and aims. Identifying the optimal method for occlusion analysis by comparing examinati... more Background and aims. Identifying the optimal method for occlusion analysis by comparing examination sensitivity of the static and dynamic occlusion using three systems: clinical occlusion analysis, semi-adjustable articulator and virtual articulator (3Shape, Denmark) occlusion analysis. Methods. The occlusion analysis of sixteen patients was performed using the three systems. In order to analyze the number of concordant and discordant points and trajectories, the clinical method was compared to the semi-adjustable articulator and to the computerized method. Results. The greatest correspondence was obtained by comparing the clinical and the articulator methods, having a success rate of 85.25%, versus the clinical and the computerized method with a success rate of 73.25%. The propulsion registered the highest discrepancies: 35% in case of the semi-adjustable articulator comparison and 62% in case of the virtual articulator comparison. Conclusions. The semi-adjustable articulator was ...
Scientific Reports
An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Balneo Research Journal
Introduction: Temporomandibular disorders are complex pathologies with multifactorial aetiology. ... more Introduction: Temporomandibular disorders are complex pathologies with multifactorial aetiology. Due to this matter, different therapeutic approaches have been developed, one of them being physical therapy (also known as physiotherapy). Low-level laser therapy is often used in treating musculoskeletal diseases, TMJ pain and, although the exact mechanism of LLLT has not yet been completely elucidated, it seems that this kind of therapy induces analgesic, anti-inflammatory and bio-stimulating effects. The aim of this study was to create an update of scientific literature regarding the clinical use of LLLT in patients with temporomandibular disorders, and to identify the impact of this therapy on reducing pain in the masticatory muscles. Methods: A research of literature was performed - articles published over the last 10 years (January 2009 until December 2019) were searched for by introducing a combination of different keywords on the PubMed and ScienceDirect databases. Results: A to...
Scientific Reports
Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the... more Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the uncertainties of the risks of the low-dose radiation exposures. The aim of this work was to investigate the clinical performance of different CBCT acquisition protocols towards the optimization of paediatric exposures. Custom-made anthropomorphic phantoms were scanned using a CBCT unit in six protocols. CT slices were blinded, randomized and presented to three observers, who scored the image quality using a 4-point scale along with their level of confidence. Sharpness level was also measured using a test object containing an air/PMMA e,dge. The effective dose was calculated by means of a customized Monte Carlo (MC) framework using previously validated paediatric voxels models. The results have shown that the protocols set with smaller voxel size (180 µm), even when decreasing exposure parameters (kVp and mAs), showed high image quality scores and increased sharpness. The MC analysis showed a gradual decrease in effective dose when exposures parameters were reduced, with an emphasis on an average reduction of 45% for the protocol that combined 70 kVp, 16 mAs and 180 µm voxel size. In contrast, both "ultra-low dose" protocols that combined a larger voxel size (400 µm) with lower mAs (7.4 mAs) demonstrated the lowest scores with high levels of confidence unsuitable for an anatomical approach. In conclusion, a significant decrease in the effective dose can be achieved while maintaining the image quality required for paediatric CBCT. The use of cone beam CT (CBCT) for dentomaxillofacial diagnosis has been growing substantially in conjunction with the concern regarding undetermined risks of the low-dose radiation exposures, especially for children and adolescents 1. Despite the well-known higher radiosensitivity of paediatric patients, several indications have been described on how CBCT can positively impact the diagnosis and treatment outcomes 2. In this way, the DIMITRA project (Dentomaxillofacial paediatric IMaging: an Investigation Towards low dose RAdiation induced risks-www.dimitra.be) aims to define the appropriate balance between dose and image quality in an ageand indication-oriented way, according to the recently introduced ALADAIP principle (As Low as Diagnostically Acceptable being Indication-oriented and Patient-specific) 2. The concept of image quality involves a number of variables, especially for three-dimensional modalities such as CBCT. In general, a better quality is achieved when the technical parameters of the unit are adjusted towards a high-resolution mode, which is often correlated with higher dose values. However, there is a noticeable difference between a high-quality or high-definition image and a diagnostically acceptable one for a given indication. On the other hand, if an exam is rejected for being of insufficient image quality, the principle of optimization is disregarded, since the patient will be re-exposed without any additional benefits 3. To approach the optimized
European journal of radiology, 2018
Children are more sensitive to ionizing radiation effects due to their high radiosensitivity. To ... more Children are more sensitive to ionizing radiation effects due to their high radiosensitivity. To estimate doses and risks for dental radiological examinations in children. A pediatric population consisting of 7150 children and young adults which underwent 12252 dental radiological examinations (4220 intraoral, 1324 cephalometric, 5284 panoramic radiographs and 1424 CBCTs) within two years were included. Two groups were studied: CBCT group (exposed to CBCT ± conventional radiographs) and 2D group (exposed only to 2D radiological examinations). The effective doses were corrected according to age at exposure and settings parameters (mA;FOV) by using logarithmic fit equations for dose interpolation. The individual cumulative dose, per-caput collective dose and radiation risk were calculated for each group. The median effective and cumulative doses for conventional radiographs were lower than 20 μSv and did not vary with age. Children exposed to CBCT had a higher median effective dose (1...
Turkish Journal of Veterinary and Animal Sciences
Histological changes in bone structure were induced at 12 weeks by experimental administration of... more Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone defect, the 2nd experimental group received 1 mL of bisphosphonate as a 10-day fractionated dose, and the control group comprised rats who did not receive any bisphosphonate. At 12 weeks after the injection, new bone tissue was collected and a histological examination was performed. At 12 weeks after the bisphosphonate administratio...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2011
Osteonecrosis of the jaws is increasing worldwide in patients treated with bisphosphonates. A ret... more Osteonecrosis of the jaws is increasing worldwide in patients treated with bisphosphonates. A retrospective review of 52 patients who were treated during 2007-2010 for bisphosphonate related maxillofacial symptoms of the jaws was conducted. Patient characteristics and other factors that influenced the disease process were studied. Thirteen patients received bisphosphonates for the prevention or treatment of osteoporosis; 39 for preventing bone metastases from malignant tumors. Thirty-six patients were females (age range 32-87 years, median 64 years); 16 were males (age range 30-81 years, median 73.5 years). Bisphosphonate used was ibandronic acid in four cases, alendronate sodium in 14 cases, and zoledronic acid in 34 cases. Mean bisphosphonate treatment period was 22.44 months (95%CI 19.33-25.55). Thirty patients received intravenous, 22 received oral bisphosphonate. The average period until occurrence of maxillofacial symptoms was 6 months (range 0.5-24 months) in subjects with in...
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
Anchorage represents a great issue that challenged orthodontists all over the years. Nowadays, wi... more Anchorage represents a great issue that challenged orthodontists all over the years. Nowadays, with the use of microimplants, it has become possible even to induce complex teeth movements. To present a clinical case in which mesialisation of upper second molars was performed by the means of using miniimplants. The present case shows how a bilateral mesialization of upper second molars using skeletal anchorage was performed by orthodontic treatment using fixed appliances and miniimplants. The placing site of the miniimplants plays a huge role in the moments of force produced and delivered to the teeth, thus influencing tooth movement. Miniimplants increase tooth movement control, by the use of skeletal anchorage. The success of their usage depends upon its good primary stabilization and a judicious loading.
Journal of Oral and Maxillofacial Surgery, 2011
Dentomaxillofacial Radiology, 2012
ABSTRACT Objectives The aim of the study was to establish the changes in posteroanterior cephalom... more ABSTRACT Objectives The aim of the study was to establish the changes in posteroanterior cephalometric variables in subjects with temporomandibular joint disorders (TMDs). Methods Posteroanterior cephalograms of 61 subjects (age range 16-36.6 years, standard deviation 4.88 years) were used to determine cephalometric differences. Subjects were classified according to the Research Diagnostic Criteria for Temporomandibular Joint Disorders into three groups: unilateral TMD, bilateral TMD and no TMD. 14 linear and angular measurements were assessed on the posteroanterior cephalogram. For assessing facial asymmetry, the asymmetry index for bilateral measurements was calculated between the right and the left side. In cases with unilateral TMD, the asymmetry index was calculated using the difference between the unaffected and affected side. The differences among multiple groups were analysed using the one-way analysis of variance test and Scheffé post hoc test. Results 47 subjects were females (77%) and 14 were males (23%). 19 subjects had unilateral TMDs and 16 subjects had bilateral TMDs. The asymmetry index of the distance from the horizontal plane to the antegonion was higher in subjects with unilateral TMD than in patients with bilateral or no TMD (p < 0.05). Also, the asymmetry index of the distances from the vertical plane to the condyle (p = 0.05), gonion (Go) (p = 0.0004), antegonion (p = 0.002) and chin (Ch) (p = 0.02) was higher in subjects with unilateral TMDs. The asymmetry index of the O point-Go-Go' and O point-Ch-Ch' angles differed significantly in subjects with unilateral TMDs (p < 0.05). Conclusions Unilateral TMDs are associated with changes in posteroanterior cephalometric measurements. The assessment of posteroanterior cephalometric variables could be used as a key factor for evaluating the presence of TMDs.
Rom J Morphol …, 2011
Bisphosphonates, stable analogues of pyrophosphate, have the ability to bind to bone molecules, p... more Bisphosphonates, stable analogues of pyrophosphate, have the ability to bind to bone molecules, possessing anti-resorbtion properties influenced by the radicals linked to the carbon group of their structure. Bisphosphonates link to the hydroxyapatite of the mineral surfaces and are selectively internalized by osteoclasts, whose activity they inhibit, jeopardizing the osteoblastic activity. The purpose of this study is to determine the influence of intramedular administration (at the hip bone) of bisphosphonates on the serum values of alkaline phosphatase, total Ca, Ca 2+ , proteins and serum osteocalcin in a lot of experience Wistar rats. Fifteen Wistar rats of experience, five in the control group and 10 in the experimental group. All rats underwent surgery to create a bone defect with a 1.5 mm diameter bone-bur at the right femur transcortical through the medullar canal. Rats from experimental group were divided into two groups: group A, who received Zometa 1 mL single dose intramedular, intraoperative and group B, who received Zometa 1 mL in divided doses daily, 0.1 mL for 10 days. 3 mL of blood from the frontal sinus were collected from each subject at 24 hours, 14 days and 21 days postoperatively. From the blood samples were determined: alkaline phosphatase [U/L], seric proteins [g/dL], total Ca [mmol/L, mg/dL], osteocalcin [mmol/L]. The data were statistically analyzed using the ANOVA test. We found an increase in alkaline phosphatase [U/L] in all groups studied. In group B there was a significant decrease in total Ca levels [mg/dL] throughout the experiment compared with controls (11.82→10.36→9.25 mg/dL; 2.95→2.59→2.31 mmol/L; p=0.001). Ca 2+ has changed significantly both in group A (1.18→1.25→1.25 mmol/L; p=0.01) and group B (1.21→1.24→1.13 mmol/L; p=0.02). Serum proteins were significantly reduced both in the control group (9.4→8.5→8.1 g/dL; p=0.03) and the experimental groups A (9.3→8.5→8.3 g/dL; p=0.01) and B (9.9→7.6→7.3 g/dL; p=0.0008). At each stage of bone development, multiple factors act in a coordinated manner that leads to increased local metabolic processes, acting both on the process of bone resorption and bone repair. Healing processes are initiated within 24 hours in both studied groups and the control group; at 14 and 21 days the bone healing processes are compromised directly proportional to the administration manner and dose of bisphosphonates.
Archives of Medical Science, 2013
I In nt tr ro od du uc ct ti io on n: : To establish the skeletal pattern in subjects with malocc... more I In nt tr ro od du uc ct ti io on n: : To establish the skeletal pattern in subjects with malocclusions and temporomandibular disorders (TMD); to assess the relationship between craniofacial skeletal structures and TMD in subjects with malocclusions. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Sixty-four subjects with malocclusions, over 18 years of age, were included in the study. Temporomandibular disorders were clinically assessed according to the Helkimo Anamnestic Index. Subjects underwent a lateral cephalogram. Subjects were grouped according to the sagittal skeletal pattern (ANB angle) into class I, II and III. Parametric Student tests with equal or unequal variations were used (variations were previously tested with Levene test). R Re es su ul lt ts s: : Twenty-four patients with TMD (experimental sample); 40 patients without TMD (control group); interincisal angle was higher in class I and II (p < 0.05) experimental subjects; overjet was larger in experimental subjects; midline shift and Wits appraisal were broader in the experimental group in all three classes. In class III subjects, the SNB angle was higher in the experimental group (p = 0.01). Joint noises followed by reduced mandible mobility, muscular pain and temporomandibular joint (TMJ) pain were the most frequent symptoms in subjects with TMD and malocclusions. C Co on nc cl lu us si io on ns s: : Temporomandibular joint status is an important factor to consider when planning orthodontic treatment in patients with severe malocclusions; midline shift, large overjet and deep overbite have been associated with signs and symptoms of TMD.
Journal of Cranio-Maxillofacial Surgery, 2007
Studies prior to 1990 showed an incidence of 5% for oral and maxillofacial cancer in Romania. In ... more Studies prior to 1990 showed an incidence of 5% for oral and maxillofacial cancer in Romania. In this paper (Part 1) an evaluation of malignant tumour cases, covering a 10-year period is made regarding histological forms, the relationships of malignant tumours to patients&amp;#39; geographic origin, environment, age, gender of patients and lymph node involvement. From 1485 patients with malignant oral and maxillofacial tumours, 1072 cases fulfilled the criteria for inclusion in this study. The following data were examined: patients&amp;#39; charts and medical records as well as pathology reports. From 16,315 patients admitted to this hospital between 1993 and 2002, 9% presented with primary (&amp;#39;de novo&amp;#39;) malignant tumours; 2/3 were male patients; average age at presentation was 61 years for males and 59 years for females; 47% presented with stage IV tumours; out of the &amp;#39;de novo&amp;#39; tumours, 93% were carcinomas and 4% sarcomas; 56% of patients had positive lymph nodes at presentation. The number of head and neck cancer cases increased in the last 15 years; almost half of the patients presented with tumours in stage IV.
Clinical Oral Investigations, 2013
This study aims to assess the disk morphology and the condyle position in subjects with temporoma... more This study aims to assess the disk morphology and the condyle position in subjects with temporomandibular (TMJ) disk displacements on sagittal and coronal magnetic resonance imaging (MRI). Seventy-four TMJs (from 37 patients) with positive clinical TMD symptoms according to the RDC/TMD axis I protocol were evaluated by 1.5 T MRI. Disk position, disk morphology, sagittal and coronal condyle position, joint effusion, joint space, and coronal condyle angulation were evaluated. Multivariate logistic regression was used to explore the relationship between disk displacement and MRI variables. Disk displacement with reduction (DDR) was found in 36.48 % and without reduction (DDwR), in 21.62 % of the joints. Disk displacement was anterior in 35.1 %, anterior-medial in 13.5 %, and anterior-lateral in 9.45 % of cases. The thickened posterior band (94.48 OR, p = 0.001) and the posterior condyle position (4.57 OR, p = 0.03) were more likely found on sagittal MRI in disk displacements. On coronal slices, the disk displacement was significantly associated with the distance from the most medial condyle point to the midplane (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Disk displacement is associated with changes of disk shape, disk dimension, and condyle position on sagittal MRI. A significant variation of the distance from the most medial condyle point to the midplane in disk displacement was found on coronal MRI. Our study highlights the existence of changes on coronal MRI in TMD patients which should be assessed for better understanding of the clinical evolution of temporomandibular disorders.