Alomgir Hossain 191-29-235 - Academia.edu (original) (raw)
Papers by Alomgir Hossain 191-29-235
Nutrients
Background: Nearly 22% of the Canadian population are first-generation immigrants. We investigate... more Background: Nearly 22% of the Canadian population are first-generation immigrants. We investigated immigrants’ health status and health deterioration over time in terms of the prevalence of chronic diseases (CDs) and their relationship to vitD status. Methods: We used cycles three (2012–2013) and four (2014–2015) of the Canadian Health Measures Survey. These data contained unique health information and direct physical/blood measures, including serum 25-hydroxyvitamin D (S-25(OH)D). Indicators of health status and deterioration were the prevalence of CDs diagnosed by healthcare professionals, self-reported general and mental health, and CD-related biomarkers. Results: The data (n = 11,579) included immigrants from more than 153 countries. Immigrants were healthier than non-immigrants for most health status measures. The prevalence of CDs was higher among those who migrated to Canada aged ≥ 18 years. A longer time in Canada after immigration was associated with a higher risk for CDs. ...
The Journal of Nuclear Medicine, May 1, 2021
JACC: Cardiovascular Imaging, 2021
OBJECTIVES This study sought to assess training volumes and its relationship to learning and iden... more OBJECTIVES This study sought to assess training volumes and its relationship to learning and identify potential new thresholds for determining expertise. BACKGROUND Competency-based medical education (CBME) is being rapidly adopted and therefore training programs will need to adapt and identify new and novel methods of defining, measuring, and assessing clinical skills. METHODS Consecutive cardiac computed tomography (CT) studies were interpreted independently by trainees and expert readers, and their interpretations (Agatston score, coronary artery disease severity, and Coronary Artery Disease Reporting and Data System) were collected. Kappa agreements were measured between trainees and experts for every 50 consecutive cases. Agreements between trainees and experts were tracked and compared with the agreement between expert readers. RESULTS A total of 36 trainees interpreted 14,432 cardiac CT studies. Agreement between trainees and experts increased with CT case volumes, but trainees learned at different rates. Using a threshold for expertise, skill of measuring coronary calcification was achieved within 50 cases, but expertise for coronary CT angiography appeared to require a mean case volume of 750, comprising 400 abnormal cases. CONCLUSIONS Current volume-based training guidelines may be insufficient and higher case volumes may be required. We demonstrate that tracking cardiac CT learners is feasible and that CBME could be incorporated into CT training programs.
Search strategy. (DOCX 34 kb)
A. PubMed search strategy for updating the American College of Rheumatology (ACR) lupus treatment... more A. PubMed search strategy for updating the American College of Rheumatology (ACR) lupus treatment guideline and the Cochrane library searches. B. Second Search strategy to identify any lupus trial for side effects of medications in PubMed and Scopus databases (data abstracted, but not used due to scant data and the possibility of heterogeneity in patient population, i.e., lupus nephritis vs. lupus with all other manifestations). (DOC 25Â kb)
Data extraction form. (XLSX 20 kb)
Search strategies. (DOCX 24 kb)
Circulation: Cardiovascular Imaging, 2022
Background: Abnormalities in computed tomography myocardial perfusion has been associated with co... more Background: Abnormalities in computed tomography myocardial perfusion has been associated with coronary artery disease and major adverse cardiovascular events (MACE). We sought to investigate if subendocardial attenuation using coronary computed tomography angiography predicts MACE 30 days postelective noncardiac surgery. Methods: Using a 17-segment model, coronary computed tomography angiography images were analyzed for subendocardial and transmural attenuation and the corresponding blood pool. The segment with the lowest subendocardial attenuation and transmural attenuation were normalized to the segment with the highest subendocardial and transmural attenuation, respectively (SUB normalized , and TRANS normalized , respectively). We evaluated the independent and incremental value of myocardial attenuation to predict the composite of cardiovascular death or nonfatal myocardial infarction. Results: Of a total of 995 coronary CTA VISION (Coronary Computed Tomographic Angiography and...
European Heart Journal - Cardiovascular Imaging, 2020
Aims This large prospective cohort study sought to confirm the incremental prognostic value of c... more Aims This large prospective cohort study sought to confirm the incremental prognostic value of coronary computed tomographic angiography (CCTA) measured over a prolonged follow-up duration. CCTA has diagnostic and prognostic value but data supporting its long-term prognostic value in a large prospectively recruited cohort with suspected coronary artery disease (CAD) has been limited. Methods and results Consecutive patients (without history of myocardial infarction, revascularization, cardiac transplantation, and congenital heart disease) were prospectively enrolled. CCTA was evaluated for CAD severity, total plaque score (TPS), and left ventricular ejection fraction. Patients were followed for major adverse events (MAE) and major adverse cardiac events (MACE). Over a total of 99 months, 8667 consecutive CCTA patients (mean age = 57.1 ± 11.1 years, 52.9% men) were prospectively enrolled and followed for a mean duration of 7.0 ± 2.6 years. At follow-up, there were a total of 723 MA...
Journal of Addictive Diseases, 2020
Online activities such as online gaming and social media use have become very popular and for mos... more Online activities such as online gaming and social media use have become very popular and for most individuals, engagement in such activities is highly enjoyable. However, for a small minority of individuals, such behaviors can lead to problematic internet use. There are many screening instruments that assess problematic internet use including the nine-item Internet Disorder Scale-Short-Form (IDS9-SF). The present study translated the IDS9-SF into Bangla and investigated its psychometric properties. The sample comprised 534 adolescents aged 13 to 18 years (61.0% male; mean age 15.7 years (SD=1.5) from selected schools (secondary and higher secondary) in Dhaka City. The study included confirmatory factor analysis, Cronbach's alpha, and item-total correlation. Results demonstrated that the Bangla IDS9-SF had very good internal validity (Cronbach's alpha = .82), and that IDS score was positively and significantly correlated with scores on depression and anxiety scales. A confirmatory factor analysis showed the model had an excellent fit to the data. Therefore, the Bangla IDS9-SF appears to be a valid and reliable instrument that may be employed in further research on problematic internet use in Bangladesh.
F1000Research, 2021
Background: The prevalence of coronary artery disease (CAD) with reduced left ventricular ejecti... more Background: The prevalence of coronary artery disease (CAD) with reduced left ventricular ejection fraction (LVEF) is rising, but the optimal treatment remains unclear. The present study aims to investigate the impact of revascularization (coronary artery bypass grafting (CABG), or percutaneous coronary intervention (PCI)) and medical therapy (MT) on LVEF recovery in patients with CAD and LVEF ≤ 40%. Methods: All clinical studies which reported LVEF in patients with CAD and LVEF ≤ 40% undergoing either revascularization or MT were included. A systematic literature search up to May 11, 2017 was performed on MEDLINE, EMBASE and the Cochrane Library in Ovid. Studies were assessed for eligibility and data were extracted by independent reviewers in duplicate with disagreements resolved by a third reviewer. Bias assessment was performed using the Newcastle-Ottawa Scale. Random effect meta-analysis was performed on included studies. The primary outcome was change in LVEF after interventi...
Characteristics of included studies. (DOCX 41Â kb)
Detailed definitions of efficacy outcomes and medication doses. (DOCX 22Â kb)
Nutrients, 2021
One in five Canadians are first-generation immigrants. Evidence suggests the baseline risk for vi... more One in five Canadians are first-generation immigrants. Evidence suggests the baseline risk for vitamin D (vitD) deficiency is increased among immigrants who move from equatorial to northern countries. We investigated the prevalence and determinants of vitD deficiency/insufficiency among first-generation immigrants compared with native-born Canadians and identified explanatory covariables. We used a cross-sectional design with data from the national Canadian Health Measures Survey (Cycles 3 and 4) (11,579 participants aged 3–79 years). We assessed serum 25-hydroxyvitamin D (S-25(OH)D) levels, sociodemographic and environmental factors, immigration status, length of time in Canada, vitD-rich food intake, ethnicity, and place of birth. Immigrants had lower mean S-25(OH)D than non-immigrants (51.23 vs. 62.72 nmol/L, p < 0.001). Those with younger age at the time of immigration (<18 years) had a high risk for low vitD, and S-25(OH)D levels increased with the length of time they had...
Frontiers in Psychiatry, 2021
Background: Smartphone and social media use are an integral part of our daily life. Currently, th... more Background: Smartphone and social media use are an integral part of our daily life. Currently, the impact of excessive smartphone and social media use during the COVID-19 pandemic is poorly understood. The present study aimed to investigate problematic smartphone use (PSPU) and problematic social media use (PSMU) among Bangladeshi college and university students during the COVID-19 pandemic.Methods: A cross-sectional study was carried out involving 5,511 Bangladeshi college and university students (male: 58.9%; mean age: 21.2 years [SD = 1.7]; age range: 18–25) during the social-distancing in the COVID-19 pandemic (July 2020). A self-reported survey containing questions regarding socio-demographic, lifestyle, and home quarantine activities along with four psychometric scales was completed by participants.Results: The mean scores of PSPU and PSMU were 20.8 ± 6.8 (out of 36) and 14.7 ± 4.8 (out of 30). Based on a hierarchical regression analysis, PSPU and PSMU were positively associat...
Cochrane Database of Systematic Reviews, 2021
Behavioural interventions delivered through interactive social media for health behaviour change,... more Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population (Review)
Chronic Diseases and Injuries in Canada, 2013
Introduction Knowledge about chronic bronchitis (CB) among Aboriginal people in Canada is limited... more Introduction Knowledge about chronic bronchitis (CB) among Aboriginal people in Canada is limited. The aim of this study was to determine the prevalence of CB and its associated factors among Aboriginal people aged 15 years plus. Methods Logistic regression analysis was used on data from the cross-sectional 2006 Aboriginal Peoples Survey to determine risk factors associated with CB. Results CB prevalence was 6.6% among First Nations, 6.2% among Métis and 2.4% among Inuit. Prevalence was higher among females than males (7.2% versus 5.0%). Individuals with CB were more likely to be older, living at a lower income, with a lower educational attainment and residing in rural areas. Smoking status and body mass index were also significantly associated with CB, but their effect differed by sex. Obesity was particularly significantly associated with CB among females compared with males, and current smoking and non-smoking status was significantly associated with CB among females but not male...
Journal of Cardiovascular Computed Tomography, 2020
Background: Coronary CT angiography (CCTA) is increasing seen as a first line investigation in pa... more Background: Coronary CT angiography (CCTA) is increasing seen as a first line investigation in patients with suspected coronary artery disease. Heart-rate control improves the image quality and diagnostic accuracy of CCTA. Typically, beta-blockers are administered to induce sinus bradycardia. Sinus bradycardia may also be induced by ivabradine. We hypothesized that in a real-world population ivabradine would be an effective alternative to metoprolol at heart rate lowering for CCTA. Methods: This was a retrospective analysis of consecutive patients who were exposed to an ivabradine-based (IB) versus a metoprolol-only (MO) protocol to achieve a target heart rate </ = 65bpm. Hemodynamic responses to both strategies were compared along with differences in cost and the time expired from medication administration to CCTA. Results: 5955 consecutive patients were included in the analysis: 3211 were imaged during an era of a metoprolol only strategy (MO) and 2744 CCTA following an ivabradine based (IB) strategy. 2676 patients had heart rates >65 and received heart-rate lowering medication: 1958 patients had MO, and 718 received IB protocol. Target heart rate of </ = 65bpm was achieved in 77% of MO and 89% of IB patients (p < 0.01). The time from initial medication administration to CCTA was longer in the IB versus MO patients (77 versus 48 min, p < 0.01). Conclusions: Introduction of a novel single dose ivabradine-based protocol to control heart rate for CCTA was more successful in achieving target heart rate than a metoprolol-only strategy. The use of ivabradine however incurred a 1.6-fold increase in the time delay from medication administration and imaging compared to a metoprolol only protocol.
JACC: Cardiovascular Imaging, 2020
OBJECTIVES This study sought to develop a clinical model that identifies a lower-risk population ... more OBJECTIVES This study sought to develop a clinical model that identifies a lower-risk population for coronary artery disease that could benefit from stress-first myocardial perfusion imaging (MPI) protocols and that can be used at point of care to risk stratify patients. BACKGROUND There is an increasing interest in stress-first and stress-only imaging to reduce patient radiation exposure and improve patient workflow and experience. METHODS A secondary analysis was conducted on a single-center cohort of patients undergoing single-photon emission computed tomography (SPECT) and positron emission tomography (PET) studies. Normal MPI was defined by the absence of perfusion abnormalities and other ischemic markers and the presence of normal left ventricular wall motion and left ventricular ejection fraction. A model was derived using a cohort of 18,389 consecutive patients who underwent SPECT and was validated in a separate cohort of patients who underwent SPECT (n ¼ 5,819), 1 internal cohort of patients who underwent PET (n¼4,631), and 1 external PET cohort (n ¼ 7,028). RESULTS Final models were made for men and women and consisted of 9 variables including age, smoking, hypertension, diabetes, dyslipidemia, typical angina, prior percutaneous coronary intervention, prior coronary artery bypass graft, and prior myocardial infarction. Patients with a score #1 were stratified as low risk. The model was robust with areas under the curve of 0.684 (95% confidence interval [
Nutrients
Background: Nearly 22% of the Canadian population are first-generation immigrants. We investigate... more Background: Nearly 22% of the Canadian population are first-generation immigrants. We investigated immigrants’ health status and health deterioration over time in terms of the prevalence of chronic diseases (CDs) and their relationship to vitD status. Methods: We used cycles three (2012–2013) and four (2014–2015) of the Canadian Health Measures Survey. These data contained unique health information and direct physical/blood measures, including serum 25-hydroxyvitamin D (S-25(OH)D). Indicators of health status and deterioration were the prevalence of CDs diagnosed by healthcare professionals, self-reported general and mental health, and CD-related biomarkers. Results: The data (n = 11,579) included immigrants from more than 153 countries. Immigrants were healthier than non-immigrants for most health status measures. The prevalence of CDs was higher among those who migrated to Canada aged ≥ 18 years. A longer time in Canada after immigration was associated with a higher risk for CDs. ...
The Journal of Nuclear Medicine, May 1, 2021
JACC: Cardiovascular Imaging, 2021
OBJECTIVES This study sought to assess training volumes and its relationship to learning and iden... more OBJECTIVES This study sought to assess training volumes and its relationship to learning and identify potential new thresholds for determining expertise. BACKGROUND Competency-based medical education (CBME) is being rapidly adopted and therefore training programs will need to adapt and identify new and novel methods of defining, measuring, and assessing clinical skills. METHODS Consecutive cardiac computed tomography (CT) studies were interpreted independently by trainees and expert readers, and their interpretations (Agatston score, coronary artery disease severity, and Coronary Artery Disease Reporting and Data System) were collected. Kappa agreements were measured between trainees and experts for every 50 consecutive cases. Agreements between trainees and experts were tracked and compared with the agreement between expert readers. RESULTS A total of 36 trainees interpreted 14,432 cardiac CT studies. Agreement between trainees and experts increased with CT case volumes, but trainees learned at different rates. Using a threshold for expertise, skill of measuring coronary calcification was achieved within 50 cases, but expertise for coronary CT angiography appeared to require a mean case volume of 750, comprising 400 abnormal cases. CONCLUSIONS Current volume-based training guidelines may be insufficient and higher case volumes may be required. We demonstrate that tracking cardiac CT learners is feasible and that CBME could be incorporated into CT training programs.
Search strategy. (DOCX 34 kb)
A. PubMed search strategy for updating the American College of Rheumatology (ACR) lupus treatment... more A. PubMed search strategy for updating the American College of Rheumatology (ACR) lupus treatment guideline and the Cochrane library searches. B. Second Search strategy to identify any lupus trial for side effects of medications in PubMed and Scopus databases (data abstracted, but not used due to scant data and the possibility of heterogeneity in patient population, i.e., lupus nephritis vs. lupus with all other manifestations). (DOC 25Â kb)
Data extraction form. (XLSX 20 kb)
Search strategies. (DOCX 24 kb)
Circulation: Cardiovascular Imaging, 2022
Background: Abnormalities in computed tomography myocardial perfusion has been associated with co... more Background: Abnormalities in computed tomography myocardial perfusion has been associated with coronary artery disease and major adverse cardiovascular events (MACE). We sought to investigate if subendocardial attenuation using coronary computed tomography angiography predicts MACE 30 days postelective noncardiac surgery. Methods: Using a 17-segment model, coronary computed tomography angiography images were analyzed for subendocardial and transmural attenuation and the corresponding blood pool. The segment with the lowest subendocardial attenuation and transmural attenuation were normalized to the segment with the highest subendocardial and transmural attenuation, respectively (SUB normalized , and TRANS normalized , respectively). We evaluated the independent and incremental value of myocardial attenuation to predict the composite of cardiovascular death or nonfatal myocardial infarction. Results: Of a total of 995 coronary CTA VISION (Coronary Computed Tomographic Angiography and...
European Heart Journal - Cardiovascular Imaging, 2020
Aims This large prospective cohort study sought to confirm the incremental prognostic value of c... more Aims This large prospective cohort study sought to confirm the incremental prognostic value of coronary computed tomographic angiography (CCTA) measured over a prolonged follow-up duration. CCTA has diagnostic and prognostic value but data supporting its long-term prognostic value in a large prospectively recruited cohort with suspected coronary artery disease (CAD) has been limited. Methods and results Consecutive patients (without history of myocardial infarction, revascularization, cardiac transplantation, and congenital heart disease) were prospectively enrolled. CCTA was evaluated for CAD severity, total plaque score (TPS), and left ventricular ejection fraction. Patients were followed for major adverse events (MAE) and major adverse cardiac events (MACE). Over a total of 99 months, 8667 consecutive CCTA patients (mean age = 57.1 ± 11.1 years, 52.9% men) were prospectively enrolled and followed for a mean duration of 7.0 ± 2.6 years. At follow-up, there were a total of 723 MA...
Journal of Addictive Diseases, 2020
Online activities such as online gaming and social media use have become very popular and for mos... more Online activities such as online gaming and social media use have become very popular and for most individuals, engagement in such activities is highly enjoyable. However, for a small minority of individuals, such behaviors can lead to problematic internet use. There are many screening instruments that assess problematic internet use including the nine-item Internet Disorder Scale-Short-Form (IDS9-SF). The present study translated the IDS9-SF into Bangla and investigated its psychometric properties. The sample comprised 534 adolescents aged 13 to 18 years (61.0% male; mean age 15.7 years (SD=1.5) from selected schools (secondary and higher secondary) in Dhaka City. The study included confirmatory factor analysis, Cronbach's alpha, and item-total correlation. Results demonstrated that the Bangla IDS9-SF had very good internal validity (Cronbach's alpha = .82), and that IDS score was positively and significantly correlated with scores on depression and anxiety scales. A confirmatory factor analysis showed the model had an excellent fit to the data. Therefore, the Bangla IDS9-SF appears to be a valid and reliable instrument that may be employed in further research on problematic internet use in Bangladesh.
F1000Research, 2021
Background: The prevalence of coronary artery disease (CAD) with reduced left ventricular ejecti... more Background: The prevalence of coronary artery disease (CAD) with reduced left ventricular ejection fraction (LVEF) is rising, but the optimal treatment remains unclear. The present study aims to investigate the impact of revascularization (coronary artery bypass grafting (CABG), or percutaneous coronary intervention (PCI)) and medical therapy (MT) on LVEF recovery in patients with CAD and LVEF ≤ 40%. Methods: All clinical studies which reported LVEF in patients with CAD and LVEF ≤ 40% undergoing either revascularization or MT were included. A systematic literature search up to May 11, 2017 was performed on MEDLINE, EMBASE and the Cochrane Library in Ovid. Studies were assessed for eligibility and data were extracted by independent reviewers in duplicate with disagreements resolved by a third reviewer. Bias assessment was performed using the Newcastle-Ottawa Scale. Random effect meta-analysis was performed on included studies. The primary outcome was change in LVEF after interventi...
Characteristics of included studies. (DOCX 41Â kb)
Detailed definitions of efficacy outcomes and medication doses. (DOCX 22Â kb)
Nutrients, 2021
One in five Canadians are first-generation immigrants. Evidence suggests the baseline risk for vi... more One in five Canadians are first-generation immigrants. Evidence suggests the baseline risk for vitamin D (vitD) deficiency is increased among immigrants who move from equatorial to northern countries. We investigated the prevalence and determinants of vitD deficiency/insufficiency among first-generation immigrants compared with native-born Canadians and identified explanatory covariables. We used a cross-sectional design with data from the national Canadian Health Measures Survey (Cycles 3 and 4) (11,579 participants aged 3–79 years). We assessed serum 25-hydroxyvitamin D (S-25(OH)D) levels, sociodemographic and environmental factors, immigration status, length of time in Canada, vitD-rich food intake, ethnicity, and place of birth. Immigrants had lower mean S-25(OH)D than non-immigrants (51.23 vs. 62.72 nmol/L, p < 0.001). Those with younger age at the time of immigration (<18 years) had a high risk for low vitD, and S-25(OH)D levels increased with the length of time they had...
Frontiers in Psychiatry, 2021
Background: Smartphone and social media use are an integral part of our daily life. Currently, th... more Background: Smartphone and social media use are an integral part of our daily life. Currently, the impact of excessive smartphone and social media use during the COVID-19 pandemic is poorly understood. The present study aimed to investigate problematic smartphone use (PSPU) and problematic social media use (PSMU) among Bangladeshi college and university students during the COVID-19 pandemic.Methods: A cross-sectional study was carried out involving 5,511 Bangladeshi college and university students (male: 58.9%; mean age: 21.2 years [SD = 1.7]; age range: 18–25) during the social-distancing in the COVID-19 pandemic (July 2020). A self-reported survey containing questions regarding socio-demographic, lifestyle, and home quarantine activities along with four psychometric scales was completed by participants.Results: The mean scores of PSPU and PSMU were 20.8 ± 6.8 (out of 36) and 14.7 ± 4.8 (out of 30). Based on a hierarchical regression analysis, PSPU and PSMU were positively associat...
Cochrane Database of Systematic Reviews, 2021
Behavioural interventions delivered through interactive social media for health behaviour change,... more Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population (Review)
Chronic Diseases and Injuries in Canada, 2013
Introduction Knowledge about chronic bronchitis (CB) among Aboriginal people in Canada is limited... more Introduction Knowledge about chronic bronchitis (CB) among Aboriginal people in Canada is limited. The aim of this study was to determine the prevalence of CB and its associated factors among Aboriginal people aged 15 years plus. Methods Logistic regression analysis was used on data from the cross-sectional 2006 Aboriginal Peoples Survey to determine risk factors associated with CB. Results CB prevalence was 6.6% among First Nations, 6.2% among Métis and 2.4% among Inuit. Prevalence was higher among females than males (7.2% versus 5.0%). Individuals with CB were more likely to be older, living at a lower income, with a lower educational attainment and residing in rural areas. Smoking status and body mass index were also significantly associated with CB, but their effect differed by sex. Obesity was particularly significantly associated with CB among females compared with males, and current smoking and non-smoking status was significantly associated with CB among females but not male...
Journal of Cardiovascular Computed Tomography, 2020
Background: Coronary CT angiography (CCTA) is increasing seen as a first line investigation in pa... more Background: Coronary CT angiography (CCTA) is increasing seen as a first line investigation in patients with suspected coronary artery disease. Heart-rate control improves the image quality and diagnostic accuracy of CCTA. Typically, beta-blockers are administered to induce sinus bradycardia. Sinus bradycardia may also be induced by ivabradine. We hypothesized that in a real-world population ivabradine would be an effective alternative to metoprolol at heart rate lowering for CCTA. Methods: This was a retrospective analysis of consecutive patients who were exposed to an ivabradine-based (IB) versus a metoprolol-only (MO) protocol to achieve a target heart rate </ = 65bpm. Hemodynamic responses to both strategies were compared along with differences in cost and the time expired from medication administration to CCTA. Results: 5955 consecutive patients were included in the analysis: 3211 were imaged during an era of a metoprolol only strategy (MO) and 2744 CCTA following an ivabradine based (IB) strategy. 2676 patients had heart rates >65 and received heart-rate lowering medication: 1958 patients had MO, and 718 received IB protocol. Target heart rate of </ = 65bpm was achieved in 77% of MO and 89% of IB patients (p < 0.01). The time from initial medication administration to CCTA was longer in the IB versus MO patients (77 versus 48 min, p < 0.01). Conclusions: Introduction of a novel single dose ivabradine-based protocol to control heart rate for CCTA was more successful in achieving target heart rate than a metoprolol-only strategy. The use of ivabradine however incurred a 1.6-fold increase in the time delay from medication administration and imaging compared to a metoprolol only protocol.
JACC: Cardiovascular Imaging, 2020
OBJECTIVES This study sought to develop a clinical model that identifies a lower-risk population ... more OBJECTIVES This study sought to develop a clinical model that identifies a lower-risk population for coronary artery disease that could benefit from stress-first myocardial perfusion imaging (MPI) protocols and that can be used at point of care to risk stratify patients. BACKGROUND There is an increasing interest in stress-first and stress-only imaging to reduce patient radiation exposure and improve patient workflow and experience. METHODS A secondary analysis was conducted on a single-center cohort of patients undergoing single-photon emission computed tomography (SPECT) and positron emission tomography (PET) studies. Normal MPI was defined by the absence of perfusion abnormalities and other ischemic markers and the presence of normal left ventricular wall motion and left ventricular ejection fraction. A model was derived using a cohort of 18,389 consecutive patients who underwent SPECT and was validated in a separate cohort of patients who underwent SPECT (n ¼ 5,819), 1 internal cohort of patients who underwent PET (n¼4,631), and 1 external PET cohort (n ¼ 7,028). RESULTS Final models were made for men and women and consisted of 9 variables including age, smoking, hypertension, diabetes, dyslipidemia, typical angina, prior percutaneous coronary intervention, prior coronary artery bypass graft, and prior myocardial infarction. Patients with a score #1 were stratified as low risk. The model was robust with areas under the curve of 0.684 (95% confidence interval [