Altan Yalciner - Academia.edu (original) (raw)

Papers by Altan Yalciner

Archives of Pediatric Infectious Diseases, 2014

Neuropsychiatric Disease and Treatment, 2014

It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels ... more It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders -especially in obsessive-compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale-Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale-Brown compulsion and Yale-Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels.

Transfusion and Apheresis Science, 2011

In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbio... more In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbiology and Clinical Microbiology Basic Sciences Branch and Duzen laboratories, 123 cases, where HCV RNA and anti-HCV positivity are identified with molecular (real-time PCR) and serologic (ELISA) methods as a positive control group, and 48 cases where HCV RNA and anti-HCV negativity are identified as a negative control group are established. The values of sensitivity, specificity, positive and negative approximation of recently developed HCV Core Ag (Abbott Diagnostics, Germany) kit are determined successively as 94.3%, 97.9%, 99.1%, 87%, 95.3% and 88%. Although the new HCV Ag assay is clearly not sensitive enough to replace HCV NAT it may serve as a valuable tool in the HCV diagnostic algorithm as it is able to pick up a great majority of anti-HCV and HCV RNA positive samples, thus allowing a timely and less expensive serological diagnosis of an active HCV infection. This may be an advantage for labs that do not have access to PCR easily.

Journal of Clinical Virology, 2009

In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbio... more In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbiology and Clinical Microbiology Basic Sciences Branch and Duzen laboratories, 123 cases, where HCV RNA and anti-HCV positivity are identified with molecular (real-time PCR) and serologic (ELISA) methods as a positive control group, and 48 cases where HCV RNA and anti-HCV negativity are identified as a negative control group are established. The values of sensitivity, specificity, positive and negative approximation of recently developed HCV Core Ag (Abbott Diagnostics, Germany) kit are determined successively as 94.3%, 97.9%, 99.1%, 87%, 95.3% and 88%. Although the new HCV Ag assay is clearly not sensitive enough to replace HCV NAT it may serve as a valuable tool in the HCV diagnostic algorithm as it is able to pick up a great majority of anti-HCV and HCV RNA positive samples, thus allowing a timely and less expensive serological diagnosis of an active HCV infection. This may be an advantage for labs that do not have access to PCR easily.

Clinical and Applied Thrombosis/Hemostasis, 2007

Acta Orthopaedica Et Traumatologica Turcica, 2001

Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shoc... more Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shock wave therapy (ESWT) (500 shock waves at 14 kV) on the healing potential of tendon injuries that may accompany fractures. Methods: The study included 48 rats for histopathologic (n=28) and biochemical (n=20) studies. The right Achilles tendons of all rats were cut and then sutured using the modified Kessler method. For histopathologic examination, ESWT was administered to the injured tendons under the guidance of fluoroscopy in 14 rats, while the remaining 14 rats remained as controls following sham operation. On the other hand, for biochemical studies 20 rats were divided into four equal groups where two groups received ESWT. On the postoperative third and ninth days, rats (one study with one control group, respectively) were sacrificed to measure the hydroxyproline levels. Results: Histopathologic examination in the second week showed highly cellular granulation tissue with more vascularization and massive inflammatory infiltration in ESWT-administered rats. There were many multinuclear giant cells. On the third week, the healing in the ESWT group was considerably better than that of the controls. In addition, the irregularity of the fibrils, intensity of lymphocyte and histiocyte infiltration were less and there was a reduction in the number of giant cells. Hydroxyproline levels were found to be high in the study groups. Conclusion: Histopathological findings and increased hydroxyproline levels suggest that ESWT may facilitate tendon healing.

Journal of Orthopaedic Science, Oct 31, 2001

The use of low-energy extracorporeal shock wave therapy (ESWT) has recently been introduced in ps... more The use of low-energy extracorporeal shock wave therapy (ESWT) has recently been introduced in pseudoarthrosis, fracture, and wound healing for both clinical and experimental purposes. In this study, we created an experimental rat model to investigate the histopathological and biochemical effects of ESWT in the healing of tendon injury that may accompany fractures. Twenty-eight rats were used for the histopathological investigation. The right achilles tendon of the rat was cut and then sutured, using Modified Kessler stitches method. Five hundred shock waves, set at 14 kV, were applied to the achilles tendon under fluoroscopic guidance. Fourteen rats that underwent a sham operation served as the control group. Biochemical studies were done on 20 rats, divided into four groups of 5 rats in each. The first and second groups received 500 shock waves, at 14 kV, after the cutting and repairing of the Achilles tendon. To measure hydroxyproline levels, the rats in the first and second groups were killed on postoperative days 3 and 9, respectively. The third and fourth groups served as controls. Hydroxyproline levels were found to be high in the study groups. The histopathological findings and the increased hydroxyproline levels revealed that ESWT may facilitate tendon healing after trauma.

Archives of Pediatric Infectious Diseases, 2014

Neuropsychiatric Disease and Treatment, 2014

It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels ... more It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders -especially in obsessive-compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale-Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale-Brown compulsion and Yale-Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels.

Transfusion and Apheresis Science, 2011

In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbio... more In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbiology and Clinical Microbiology Basic Sciences Branch and Duzen laboratories, 123 cases, where HCV RNA and anti-HCV positivity are identified with molecular (real-time PCR) and serologic (ELISA) methods as a positive control group, and 48 cases where HCV RNA and anti-HCV negativity are identified as a negative control group are established. The values of sensitivity, specificity, positive and negative approximation of recently developed HCV Core Ag (Abbott Diagnostics, Germany) kit are determined successively as 94.3%, 97.9%, 99.1%, 87%, 95.3% and 88%. Although the new HCV Ag assay is clearly not sensitive enough to replace HCV NAT it may serve as a valuable tool in the HCV diagnostic algorithm as it is able to pick up a great majority of anti-HCV and HCV RNA positive samples, thus allowing a timely and less expensive serological diagnosis of an active HCV infection. This may be an advantage for labs that do not have access to PCR easily.

Journal of Clinical Virology, 2009

In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbio... more In between the dates of February 2008-March 2009, by applying to Istanbul University CTF Microbiology and Clinical Microbiology Basic Sciences Branch and Duzen laboratories, 123 cases, where HCV RNA and anti-HCV positivity are identified with molecular (real-time PCR) and serologic (ELISA) methods as a positive control group, and 48 cases where HCV RNA and anti-HCV negativity are identified as a negative control group are established. The values of sensitivity, specificity, positive and negative approximation of recently developed HCV Core Ag (Abbott Diagnostics, Germany) kit are determined successively as 94.3%, 97.9%, 99.1%, 87%, 95.3% and 88%. Although the new HCV Ag assay is clearly not sensitive enough to replace HCV NAT it may serve as a valuable tool in the HCV diagnostic algorithm as it is able to pick up a great majority of anti-HCV and HCV RNA positive samples, thus allowing a timely and less expensive serological diagnosis of an active HCV infection. This may be an advantage for labs that do not have access to PCR easily.

Clinical and Applied Thrombosis/Hemostasis, 2007

Acta Orthopaedica Et Traumatologica Turcica, 2001

Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shoc... more Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shock wave therapy (ESWT) (500 shock waves at 14 kV) on the healing potential of tendon injuries that may accompany fractures. Methods: The study included 48 rats for histopathologic (n=28) and biochemical (n=20) studies. The right Achilles tendons of all rats were cut and then sutured using the modified Kessler method. For histopathologic examination, ESWT was administered to the injured tendons under the guidance of fluoroscopy in 14 rats, while the remaining 14 rats remained as controls following sham operation. On the other hand, for biochemical studies 20 rats were divided into four equal groups where two groups received ESWT. On the postoperative third and ninth days, rats (one study with one control group, respectively) were sacrificed to measure the hydroxyproline levels. Results: Histopathologic examination in the second week showed highly cellular granulation tissue with more vascularization and massive inflammatory infiltration in ESWT-administered rats. There were many multinuclear giant cells. On the third week, the healing in the ESWT group was considerably better than that of the controls. In addition, the irregularity of the fibrils, intensity of lymphocyte and histiocyte infiltration were less and there was a reduction in the number of giant cells. Hydroxyproline levels were found to be high in the study groups. Conclusion: Histopathological findings and increased hydroxyproline levels suggest that ESWT may facilitate tendon healing.

Journal of Orthopaedic Science, Oct 31, 2001

The use of low-energy extracorporeal shock wave therapy (ESWT) has recently been introduced in ps... more The use of low-energy extracorporeal shock wave therapy (ESWT) has recently been introduced in pseudoarthrosis, fracture, and wound healing for both clinical and experimental purposes. In this study, we created an experimental rat model to investigate the histopathological and biochemical effects of ESWT in the healing of tendon injury that may accompany fractures. Twenty-eight rats were used for the histopathological investigation. The right achilles tendon of the rat was cut and then sutured, using Modified Kessler stitches method. Five hundred shock waves, set at 14 kV, were applied to the achilles tendon under fluoroscopic guidance. Fourteen rats that underwent a sham operation served as the control group. Biochemical studies were done on 20 rats, divided into four groups of 5 rats in each. The first and second groups received 500 shock waves, at 14 kV, after the cutting and repairing of the Achilles tendon. To measure hydroxyproline levels, the rats in the first and second groups were killed on postoperative days 3 and 9, respectively. The third and fourth groups served as controls. Hydroxyproline levels were found to be high in the study groups. The histopathological findings and the increased hydroxyproline levels revealed that ESWT may facilitate tendon healing after trauma.