Fareeha Ambreen - Academia.edu (original) (raw)

Papers by Fareeha Ambreen

Age-related macular degeneration (AMD) has been a significant cause of blindness in elderly popul... more Age-related macular degeneration (AMD) has been a significant cause of blindness in elderly population and an issue for public health concern due to its high prevalence in aged people. 1 The causative factors of AMD include multiple genetic and environmental factors. Two types of AMD are recognized, "dry" and "wet". Early symptoms in both types of AMD include deposition of debris known as drusen on bruch's membrane (BM) and the appearance of extracellular matrix separating the choriocapillaries from the retinal pigment epithelium (RPE). Later stages of dry AMD involve the degeneration of photoreceptor and RPE cells resulting in geographic atrophy. In wet AMD, new blood vessels grow from the choriocapillaries through the BM known as choroidal neovascularization (CNV) that leads to visual loss. CNV occurs in 10-15% of AMD cases, yet it accounts for over 80% of debilitating visual loss in AMD patients. 2 Normally, photoreceptors are maintained by the RPE, which ...

Objective: To evaluate the effect of single Intravitreal Bevacizumab (Avastin) injection on visua... more Objective: To evaluate the effect of single Intravitreal Bevacizumab (Avastin) injection on visual acuity (VA) and central retinal thickness (CRT) in patients with macular edema secondary to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).

Pakistan Armed Forces Medical Journal, 2016

Objective: To evaluate the anatomical and visual outcome of surgical management of retinal detach... more Objective: To evaluate the anatomical and visual outcome of surgical management of retinal detachment associated with chorio-retinal coloboma. Study Design: Prospective interventional case series Place and Duration of Study: This study was conducted at Al-Shifa Trust Eye Hospital Rawalpindi from Jan 2012 to Dec 2013. Material and Methods: Twenty one eyes (21 patients) that underwent surgery for retinal detachment associated with chorio-retinal colobomas were selected. Evaluation was done on the basis of type of intervention, final visual acuity and anatomical outcome and complications. Out of 21, 19(90.47%) eyes underwent pars plana vitrectomy with silicone oil (SO) and 2(9.52%) underwent primary scleral buckling surgery. SO was removed in 9 (47.36%) eyes at final follow up. Encircling band was placed in 12 (63.15%) eyes based on peroperative judgment of surgeon. Intra-operative lensectomy was performed in 6 (28.57%) eyes. The main outcome measures were retinal re-attachment and vis...

Rawal Medical Journal, 2006

Objective: To determine in-hospital outcomes post AMI hyperglycemia. Methods: 109 patients of acu... more Objective: To determine in-hospital outcomes post AMI hyperglycemia. Methods: 109 patients of acute myocardial infarction were included in this study. Physical examination, ECG tracings, random plasma glucose, serum cholesterol, triglycerides and cardiac enzymes (CPK, LDH and AST) were measured. Hyperglycemic patients (plasma glucose ≥ 126mg/dl) were sub-divided into those with a previous history of diabetes and those without any such history. Results: Post AMI plasma glucose levels were exceptionally higher in female patients aged 61-70 years while they were moderately higher in males of age groups 31-40 and 51-60, and females of age group 41-50 years. In-hospital mortality rate was greater in hyperglycemic patients. Most importantly also, significantly greater complications of the heart were encountered in hyperglycemics. Conclusion: Post AMI patients are at a greater risk of developing diabetes and concurrent AMI attack. (Rawal Med J 2006;31:55-57)

OBJECTIVE To determine serum lipids in patients with age related macular degeneration from Pakist... more OBJECTIVE To determine serum lipids in patients with age related macular degeneration from Pakistani population. METHODS The study was a cross sectional, randomized and case-control. Selected subjects ages were > or = 50 years and were normotensive, non-diabetic with no family history of any such disease and no complication of posterior ocular chamber other than age related macular degeneration (AMD). Controls were age matched healthy individuals with no symptoms of AMD. Diagnosis of AMD was done through conventional diagnostic techniques by professional ophthalmologists. Serum samples were analyzed for total cholesterol, triglycerides, LDL and HDL using commercially available kits. Data were compared with Student's t-test. Pearson correlation was calculated for relationship between different parameters. P < 0.05 was considered significant. RESULTS Compared to controls, AMD patients had significantly greater total cholesterol concentration (p < 0.041), and power HDL/LDL...

1 Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan 2 De... more 1 Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan 2 Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan 3 Department of Biotechnology and Bioinformatics, International Islamic University, Islamabad, Pakistan. 4 Department of Chemistry, Hazara University, Mansehra, Pakistan 5 Ripah Institute of Pharmaceutical Sciences, Islamabad. 6 Department of Pharmacy, Government College University, Faisalabad, Pakistan * Department of Quality Operations Laboratory, University of Veterinary and Animal Sciences, Lahore, Pakistan.

OBJECTIVE To determine the association between serum levels of apolipoprotein E, leptin, complime... more OBJECTIVE To determine the association between serum levels of apolipoprotein E, leptin, complimentary factor H and high temperature requirement A-1 in patients with age-related macular degeneration. METHODS This case-control study was conducted at the Quaid-i-Azam University, Islamabad, Pakistan, from May to October 2013, and comprised patients with age-related macular degeneration and matching controls. The confirmation of age-related macular degeneration was carried out through slit lamp examination, fundoscopy and ocular coherence tomography. The selected subjects were not suffering with any other systemic or ophthalmic complication(s). Serum apolipoprotein E, leptin, complimentary factor H and high temperature requirement A-1 were estimated in serum samples of all subjects. SPSS 18 was used for data analysis. RESULTS Of the 190 participants, 90(47.4%) were patients with age-related macular degeneration and 100(52.6%) were controls. Significantly elevated serum apolipoprotein E ...

Purpose To study the association of serum levels of inflammatory mediators and angiogenic factors... more Purpose To study the association of serum levels of inflammatory mediators and angiogenic factors with genetic polymorphism in Pakistani age-related macular degeneration (AMD) patients. Methods This was a cross-sectional and case-control study that included 90 AMD patients diagnosed through slit-lamp examination, fundoscopy, and ocular coherence tomography. For reference and comparison purposes, 100 healthy age-matched subjects (controls) were also recruited. IL-6, IL-8, VEGF, and CRP levels were estimated in the serum samples of patients and control subjects. Using restriction fragment length polymorphism, single nucleotide polymorphisms were studied in IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227543), VEGF (rs3025039, rs699947), and CRP genes (rs1205, rs1130864). Since the data were obtained from a sample population, the Box–Cox transformation algorithm was applied to reduce heterogeneity of error. Multivariate analyses of variance (M-ANOVA) were applied...

JPMA. The Journal of the Pakistan Medical Association, 2017

To determine the association between serum levels of apolipoprotein E, leptin, complimentary fact... more To determine the association between serum levels of apolipoprotein E, leptin, complimentary factor H and high temperature requirement A-1 in patients with age-related macular degeneration. This case-control study was conducted at the Quaid-i-Azam University, Islamabad, Pakistan, from May to October 2013, and comprised patients with age-related macular degeneration and matching controls. The confirmation of age-related macular degeneration was carried out through slit lamp examination, fundoscopy and ocular coherence tomography. The selected subjects were not suffering with any other systemic or ophthalmic complication(s). Serum apolipoprotein E, leptin, complimentary factor H and high temperature requirement A-1 were estimated in serum samples of all subjects. SPSS 18 was used for data analysis. Of the 190 participants, 90(47.4%) were patients with age-related macular degeneration and 100(52.6%) were controls. Significantly elevated serum apolipoprotein E (p<0.0024) and high tem...

Saudi medical journal, 2007

To investigate the effects of angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor... more To investigate the effects of angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) and other anti-hypertensive agents on recombinant human erythropoietin (rHuEPO) in chronic renal failure (CRF) patients. The present study was conducted at the Nephrology Department, Khan Research Laboratories Hospital and Quaid-i-Azam University, Islamabad, Pakistan during March 2004 to February 2005. One hundred patients, 55 males and 45 females (age range 13-78 years) were divided into 2 groups. Group-I patients received rHuEPO and ACE inhibitors/ARBs while Group-II patients received rHuEPO with other antihypertensives such as calcium channel blockers or beta-adrenergic receptor blockers. Monthly increment in hematocrit (HCT%) was monitored in both groups for 4 continuous months. One-way ANOVA on Dunn's, univariate and multivariate analyses were carried out to determine any significant improvement in erythropoiesis between the 2 treatment groups. Monthly increase ...

Molecular vision, 2015

To study the association of serum levels of inflammatory mediators and angiogenic factors with ge... more To study the association of serum levels of inflammatory mediators and angiogenic factors with genetic polymorphism in Pakistani age-related macular degeneration (AMD) patients. This was a cross-sectional and case-control study that included 90 AMD patients diagnosed through slit-lamp examination, fundoscopy, and ocular coherence tomography. For reference and comparison purposes, 100 healthy age-matched subjects (controls) were also recruited. IL-6, IL-8, VEGF, and CRP levels were estimated in the serum samples of patients and control subjects. Using restriction fragment length polymorphism, single nucleotide polymorphisms were studied in IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227543), VEGF (rs3025039, rs699947), and CRP genes (rs1205, rs1130864). Since the data were obtained from a sample population, the Box-Cox transformation algorithm was applied to reduce heterogeneity of error. Multivariate analyses of variance (M-ANOVA) were applied on the transfor...

JPMA. The Journal of the Pakistan Medical Association, 2014

To determine serum lipids in patients with age related macular degeneration from Pakistani popula... more To determine serum lipids in patients with age related macular degeneration from Pakistani population. The study was a cross sectional, randomized and case-control. Selected subjects ages were > or = 50 years and were normotensive, non-diabetic with no family history of any such disease and no complication of posterior ocular chamber other than age related macular degeneration (AMD). Controls were age matched healthy individuals with no symptoms of AMD. Diagnosis of AMD was done through conventional diagnostic techniques by professional ophthalmologists. Serum samples were analyzed for total cholesterol, triglycerides, LDL and HDL using commercially available kits. Data were compared with Student's t-test. Pearson correlation was calculated for relationship between different parameters. P < 0.05 was considered significant. Compared to controls, AMD patients had significantly greater total cholesterol concentration (p < 0.041), and power HDL/LDL ratio (p < 0.038), whi...

Dreaming is a coniplex neuropliysiolog,icaI cognitive ability of tlie brain and rcllccts )~syclio... more Dreaming is a coniplex neuropliysiolog,icaI cognitive ability of tlie brain and rcllccts )~sycliopliysiological feat~lres of dreamer's personality. The aiinof the present study was to gather first hand data on dream contents of Pakistani srlbjects and compare these \vitIi drcam norms established fromwestem populations. A total of 150 dreams from40 subjects \rere collected over a period of tlirec months. Tl~ese were

Saudi medical journal, 2007

... Accepted 25th September 2006. Address correspondence and reprint request to: Dr. Irfan Z. Qur... more ... Accepted 25th September 2006. Address correspondence and reprint request to: Dr. Irfan Z. Qureshi, Department of Animal Sciences, Laboratory of Animal Physiology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan. Tel. +92 (51) 9219809. ...

Pakistan Armed Forces Medical Journal, 2016

Rawal Medical Journal, 2006

JPMA. The Journal of the Pakistan Medical Association, 2017

Saudi medical journal, 2007

Molecular vision, 2015

JPMA. The Journal of the Pakistan Medical Association, 2014

Saudi medical journal, 2007