Amel Ali - Academia.edu (original) (raw)

Papers by Amel Ali

Research paper thumbnail of Pediatric Dental Fluorosis and Its Correlation with Dental Caries and Oral-Health-Related Quality of Life: A Descriptive Cross-Sectional Study among Preschool Children Living in Belagavi

Children

Aim: This study aims to assess the prevalence of dental fluorosis and its association with dental... more Aim: This study aims to assess the prevalence of dental fluorosis and its association with dental caries, oral health behaviors, oral-health-related quality of life and parents’ perceptions among preschool children in the 3–5-year-old preschool children living in the Belagavi district of Karnataka, a non-endemic fluorosis region. Methods: A descriptive cross-sectional questionnaire-based study was conducted among 1200 individuals of the preschool population from 48 government-sponsored child-care development centers in Belagavi, Karnataka, over a three-month period. They were examined following the Dean’s fluorosis index (1942) and dmft (decayed, missed, and filled) scores of the participants were also recorded. Parents’ perception of oral health was assessed using the self-administered Early Childhood Oral Health Impact Scale (ECOHIS). SPSS software (version 20) was used for statistical analysis. Chi-square test computed categorical data. One-way ANOVA test was used for multiple gr...

Research paper thumbnail of Assessment of Parental Knowledge towards Space Maintainer as an Essential Intervention after Premature Extraction of Primary Teeth

Healthcare

This study assessed parents’ knowledge about space maintainers as an interceptive strategy after ... more This study assessed parents’ knowledge about space maintainers as an interceptive strategy after premature loss of primary teeth. Methods and Material: A cross-sectional questionnaire-based descriptive study was conducted on a sample of 600 parents; 456 (76%) were females, and 144 (24%) were males, recruited from an outpatient dental clinic at Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. The questionnaire consisted of two sections; the first section collected sociodemographic data of participants, and the second section gathered parental knowledge of space maintainers. The research ethics committee granted ethical approval, and informed consent was obtained before participation. Results: 600 parents participated in this study. The total mean knowledge score regarding space maintainers was 7.97 ± 3.38. The mean knowledge score was 7.06 ± 2.99 for male parents and 8.26 ± 3.45 for female parents. The difference in the mean knowledge score between female and male p...

Research paper thumbnail of Comprehensive Computational Analysis Revealed Seven Novel Mutations in Human Insulin gene

Background: Insulin gene mapped on chromosome 11p15.5 consists of 3 exons, which translated to 51... more Background: Insulin gene mapped on chromosome 11p15.5 consists of 3 exons, which translated to 51 residues of small globular protein secreted from the secretory granules in β-cells of the pancreatic gland. In this study, we used various computational approaches to identify nsSNPs, which probably be deleterious to the structure and/or function of insulin protein that might be associated with different disease pathophysiology. Methods: The data on human insulin gene retrieved from dbSNP/NCBI. Three functional analysis tools SIFT, Polyphen-2, Provean used to predict whether the effect of retrieved SNPs on the biological function of Insulin based on sequence homology, position-specific independent count scores and the impact of amino acid substitution on protein 3D structure. Then the shortlisted SNPs tested by three disease-associated SNPs predicting tools; Predictor of human Deleterious Single Nucleotide Polymorphisms, Pathogenic mutation prediction and SNPS&GO. Then the disease-causi...

Research paper thumbnail of Isolation and identification of bacteria associated with diabetic foot infections

Research paper thumbnail of Bioinformatics Analysis and the Revelation of Thirteen Novel Mutations in Human LH-B Gene Related to PCOS

Luteinizing hormone beta subunit (LH-B) (protein ID P01229) is gonadotropin hormone secreted from... more Luteinizing hormone beta subunit (LH-B) (protein ID P01229) is gonadotropin hormone secreted from the anterior pituitary belongs to the glycoprotein family, mapped on chr19p13.3 and consists of three exons, three transcript variants with two phenotypes encoded for one protein known as Lutropin subunit beta (P01229) It has a central role in promoting spermatogenesis and ovulation by stimulating the testes and ovaries for steroidogenesis. PCOS is a common endocrinopathy affecting of women within the reproductive age, abnormal ovulation associated with a high level of LH as a result of gene polymorphisms lead to infertility problems. In this study, we used various computational approaches to identify nsSNPs which probably be deleterious to the structure and/or function of LH-B protein that might be associated with polycystic ovary syndrome. The data on human LH-B gene was retrieved from dbSNP/NCBI. Eleven different bioinformatics prediction algorithms; SIFT, Polyphen, PROVEAN, SNAP2, P...

Research paper thumbnail of Antimicrobial Studies of novel metal complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one

Journal of Biotechnology Research Center, 2009

Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-... more Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one have been synthesized and characterized by elemental analysis, FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. Cadmium complex is expected to have tetrahedral structure while the other complexes are expected to have octahedral structure. The free ligands and their metal complexes have been tested in vitro against a number of microorganisms (Staphylococcus aurous, E.coli, Proteus vulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties.

Research paper thumbnail of Pediatric Dental Fluorosis and Its Correlation with Dental Caries and Oral-Health-Related Quality of Life: A Descriptive Cross-Sectional Study among Preschool Children Living in Belagavi

Children

Aim: This study aims to assess the prevalence of dental fluorosis and its association with dental... more Aim: This study aims to assess the prevalence of dental fluorosis and its association with dental caries, oral health behaviors, oral-health-related quality of life and parents’ perceptions among preschool children in the 3–5-year-old preschool children living in the Belagavi district of Karnataka, a non-endemic fluorosis region. Methods: A descriptive cross-sectional questionnaire-based study was conducted among 1200 individuals of the preschool population from 48 government-sponsored child-care development centers in Belagavi, Karnataka, over a three-month period. They were examined following the Dean’s fluorosis index (1942) and dmft (decayed, missed, and filled) scores of the participants were also recorded. Parents’ perception of oral health was assessed using the self-administered Early Childhood Oral Health Impact Scale (ECOHIS). SPSS software (version 20) was used for statistical analysis. Chi-square test computed categorical data. One-way ANOVA test was used for multiple gr...

Research paper thumbnail of Assessment of Parental Knowledge towards Space Maintainer as an Essential Intervention after Premature Extraction of Primary Teeth

Healthcare

This study assessed parents’ knowledge about space maintainers as an interceptive strategy after ... more This study assessed parents’ knowledge about space maintainers as an interceptive strategy after premature loss of primary teeth. Methods and Material: A cross-sectional questionnaire-based descriptive study was conducted on a sample of 600 parents; 456 (76%) were females, and 144 (24%) were males, recruited from an outpatient dental clinic at Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. The questionnaire consisted of two sections; the first section collected sociodemographic data of participants, and the second section gathered parental knowledge of space maintainers. The research ethics committee granted ethical approval, and informed consent was obtained before participation. Results: 600 parents participated in this study. The total mean knowledge score regarding space maintainers was 7.97 ± 3.38. The mean knowledge score was 7.06 ± 2.99 for male parents and 8.26 ± 3.45 for female parents. The difference in the mean knowledge score between female and male p...

Research paper thumbnail of Comprehensive Computational Analysis Revealed Seven Novel Mutations in Human Insulin gene

Background: Insulin gene mapped on chromosome 11p15.5 consists of 3 exons, which translated to 51... more Background: Insulin gene mapped on chromosome 11p15.5 consists of 3 exons, which translated to 51 residues of small globular protein secreted from the secretory granules in β-cells of the pancreatic gland. In this study, we used various computational approaches to identify nsSNPs, which probably be deleterious to the structure and/or function of insulin protein that might be associated with different disease pathophysiology. Methods: The data on human insulin gene retrieved from dbSNP/NCBI. Three functional analysis tools SIFT, Polyphen-2, Provean used to predict whether the effect of retrieved SNPs on the biological function of Insulin based on sequence homology, position-specific independent count scores and the impact of amino acid substitution on protein 3D structure. Then the shortlisted SNPs tested by three disease-associated SNPs predicting tools; Predictor of human Deleterious Single Nucleotide Polymorphisms, Pathogenic mutation prediction and SNPS&GO. Then the disease-causi...

Research paper thumbnail of Isolation and identification of bacteria associated with diabetic foot infections

Research paper thumbnail of Bioinformatics Analysis and the Revelation of Thirteen Novel Mutations in Human LH-B Gene Related to PCOS

Luteinizing hormone beta subunit (LH-B) (protein ID P01229) is gonadotropin hormone secreted from... more Luteinizing hormone beta subunit (LH-B) (protein ID P01229) is gonadotropin hormone secreted from the anterior pituitary belongs to the glycoprotein family, mapped on chr19p13.3 and consists of three exons, three transcript variants with two phenotypes encoded for one protein known as Lutropin subunit beta (P01229) It has a central role in promoting spermatogenesis and ovulation by stimulating the testes and ovaries for steroidogenesis. PCOS is a common endocrinopathy affecting of women within the reproductive age, abnormal ovulation associated with a high level of LH as a result of gene polymorphisms lead to infertility problems. In this study, we used various computational approaches to identify nsSNPs which probably be deleterious to the structure and/or function of LH-B protein that might be associated with polycystic ovary syndrome. The data on human LH-B gene was retrieved from dbSNP/NCBI. Eleven different bioinformatics prediction algorithms; SIFT, Polyphen, PROVEAN, SNAP2, P...

Research paper thumbnail of Antimicrobial Studies of novel metal complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one

Journal of Biotechnology Research Center, 2009

Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-... more Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one have been synthesized and characterized by elemental analysis, FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. Cadmium complex is expected to have tetrahedral structure while the other complexes are expected to have octahedral structure. The free ligands and their metal complexes have been tested in vitro against a number of microorganisms (Staphylococcus aurous, E.coli, Proteus vulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties.