Amin Kabir - Academia.edu (original) (raw)

Papers by Amin Kabir

Blood, Jan 28, 2016

Venous thromboembolism (VTE) is a common complication in patients with cancer but only limited da... more Venous thromboembolism (VTE) is a common complication in patients with cancer but only limited data are available in AML. In a prospective study in a cohort of 272 adult patients (aged 18-65) and an independent validation cohort of 132 elderly adults (aged > 60) with newly diagnosed AML we assessed markers of disseminated intravascular coagulation (DIC) (fibrinogen, D-dimer, alpha-2-antiplasmin, antitrombin, Prothrombin time and platelet count), the DIC score according the International Society of Thrombosis and Haemostasis and their associations with the occurrence of venous and arterial thrombosis during follow up. The prevalence of thrombosis was 8.7% (4.7% venous, 4.0% arterial) in the younger adults over a median follow up of 478 days and 10.4% (4.4% venous, 5.9% arterial) in elderly patients. Most thrombotic events (66%) occurred before start of the second course of chemotherapy. The calculated DIC score significantly predicted venous and arterial thrombosis with a Hazard R...

Journal of Dhaka Medical College, 2020

Background: Multiple Myeloma (MM) accounts for 1% of malignant tumors and 10%–15% of hematopoieti... more Background: Multiple Myeloma (MM) accounts for 1% of malignant tumors and 10%–15% of hematopoietic neoplasms. Bortezomib, a first in class proteasome inhibitor, induces apoptosis and growth arrest and reverse chemoresistence in Myeloma cell and has demonstrated no irreversible adverse effect on haemopoietic stem cell. Dexamethasone increases the response rate. Thus, Bortezomib plus dexamethasone represent highly effective regimen for previously untreated Multiple Myeloma cases and significantly higher response rates approximately 70%– 90% have been observed.This combination thus may serve the basis of future strands of care in Multiple Myeloma patients. Objective: The aim of the study was to assess the efficacy , safety and tolerability of Bortezomib in newly diagnosed cases of Multiple Myeloma patients in Bangladesh. Materials & Methods: This prospective observational study was carried out in the Haematology department of BSMMU from June 2017 to December 2018. Patients received inj...

Bangladesh Medical Journal, 2019

Acute myeloid leukaemia (AML) is treatable and potentially curable disease. Significant morbidity... more Acute myeloid leukaemia (AML) is treatable and potentially curable disease. Significant morbidity is related to the prolonged, severe neutropenia resulting from the disease as well as the intensive chemotherapy. The administration of granulocyte - colony stimulating factor (G-CSF) is recommended to reduce the neutropenic period. But the current information and guidelines are insufficient about the most appropriate time to start G-CSF and the optimum duration of treatment after chemotherapy in consolidation phase. This study explores better timing to start G-CSF after completion of chemotherapy in consolidation phase of AML patient. This prospective study was conducted in the department of Haematology, Bangabandhu Sheikh Mujib Medical University among AML patients, who received consolidation chemotherapy (high dose cytarabine). Samples were grouped into two arms. Arm-A (Absolute Neutrophil Count >1000/cmm) received prophylactic G-CSF and Arm-B (Absolute Neutrophil Count <100...

Bangabandhu Sheikh Mujib Medical University Journal, 2010

The inherited diseases of haemoglobin are the most common single gene disorders. With global impr... more The inherited diseases of haemoglobin are the most common single gene disorders. With global improvement in childhood diseases thalassaemia will become a major health issue in millennium. The beta-thalassaemia is the most common type of thalassaemia because they are so common, occur widely in a broad belt ranging from Mediterranean and parts of North and West Africa through the Middle East,

Haematology Journal of Bangladesh, 2019

Among the haemoglobinopathies non-transfusion dependent thalassaemia (NTDT) are more common than ... more Among the haemoglobinopathies non-transfusion dependent thalassaemia (NTDT) are more common than the major patients. Bangladesh is located within the thalassaemia belt, moreover, Hb-E is prevalent here. So, the burden of non-transfusion dependent haemoglobinopathies is pretty massive. Due to less severe presentation and unawareness of general people, most patients with NTDT present with complications. On the other hand, cardiac complications are the major causes of death in these patients, and, negligence in early treatment increases the death. This review discusses haemoglobinopathies in general, followed by pathogenesis, clinical features and management of cardiac complications.

Haematology Journal of Bangladesh, 2021

Background: Hb-E/Beta thalassaemia is a congenital haemoglobin disorder which is a compound heter... more Background: Hb-E/Beta thalassaemia is a congenital haemoglobin disorder which is a compound heterozygous state consists of qualitative disorder like Hb E variant & quantitative Hb disorder caused by genetic mutation of Beta chain. Objective: The aim of the study was to identify the beta gene mutation in Hb E/Beta thalassaemia. Method: A total of 32 diagnosed Hb E/Beta thalassaemia patients were included in this cross-sectional study from May 2019 to July 2020. Genetic analysis was done by sanger sequencing. Results: In this observational study, we found 13 different types of Beta gene mutations. Heterozygous for IVS 1-5(G>C) mutation was most frequent (53.1%). Conclusion: Genetic mutation is the confirmatory diagnosis for thalassaemia as well as one of the main factors for clinical expression. Mutation pattern also varies according to the geographical distribution. So, this study shows the frequently found mutation in Bangladesh and should carry out routinely to point out phenoty...

KYAMC Journal, 2020

Background: Multiple Myeloma (MM) represents approximately 15% of all hematological malignancies.... more Background: Multiple Myeloma (MM) represents approximately 15% of all hematological malignancies. Despite the use of high-dose chemotherapy followed by stem cell rescue MM remains incurable at present. The goal is to control the disease as much as possible, providing the best quality of life to patients for the longest duration. Currently, CTDa (attenuated Cyclophosphamide, Thalidomide, Dexamethasone) is the best option of treatment as it is cost-effective, with no need for hospitalization with a good response. Objective: To find out the symptomatic responses and toxicities of CTDa in Multiple Myeloma patients. Materials and Methods: 25 patients of newly diagnosed MM patients were treated in the Haematology Department, Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2016 to July 2017. The mean age of the patients was 54 years, Male female ratio was 1.5:1 and most of the patients were farmers. After induction of 4 to 6 cycles of CTDa all patients were followed up at 6th...

Haematology Journal of Bangladesh

Background: In lymphoma, bone marrow infiltration of lymphocytes is a vital information of stagin... more Background: In lymphoma, bone marrow infiltration of lymphocytes is a vital information of staging can be done primarily by observer dependent bone marrow study or trephine biopsy. Objective: Aim of this study is to observe the frequency of bone marrow involvement in Non-Hodgkin lymphoma at the time of diagnosis by trephine biopsy and to determine importance of bone marrow trephine biopsy over bone marrow aspiration for staging of Non-Hodgkin lymphoma. Methodology: This was a prospective observational study conducted between January 2014 to July 2014 in department of Haematology, Bangabandhu Shaikh Mujib Medical University (BSMMU) including 30 newly diagnosed patients of Non-Hodgkin’s Lymphoma (NHL) between 15 to 75 years of both sex in non-probability purposive sampling manner confirmed by histopathology of biopsy of lymph node or extra nodal mass. Any secondary disease associated NHL and if there were history of prior chemotherapy was excluded from this study. Detailed clinical hi...

Bangladesh Medical Journal

Here we describe a case of a 20-year-old, otherwise healthy man, who consulted a physician due to... more Here we describe a case of a 20-year-old, otherwise healthy man, who consulted a physician due to acute low back pain presenting for a couple of days. Pain appeared suddenly, without any preceding trauma. Physical examination was unremarkable. Initial laboratory tests showed elevated inflammatory marker and thrombocytopenia. Patient was treated conservatively but due to increasing pain MRI of spine with contrast was advised which showed feature suggestive of infiltrative disease. Eventually patient was diagnosed as a case of acute lymphoblastic leukaemia on further peripheral blood film and bone marrow study.Bangladesh Med J. 2017 Jan; 46 (1): 41-43

Bangabandhu Sheikh Mujib Medical University Journal, 2016

Anwer Khan Modern Medical College Journal, 2017

commonest inherited gene disorder is prevalent worldwide 1,2. Bangladesh is situated in the thala... more commonest inherited gene disorder is prevalent worldwide 1,2. Bangladesh is situated in the thalassaemia belt and Beta-thalassaemia is common here 2,3. There are a significant number of patients who have concurrent iron deficiency and beta

Background: The global burden from cancer is rising, especially as low-income countries like Bang... more Background: The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.

BMC Cancer, 2014

Background: The global burden from cancer is rising, especially as low-income countries like Bang... more Background: The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.

Journal of Paediatric Surgeons of Bangladesh, 2016

Journal of Bangladesh College of Physicians and Surgeons, 2015

ABSTRACT

Bangladesh Journal of Medicine, 2015

Abstract Title: Treatment Outcome of Acute Lymphoblastic Leukemia: Five Years Experience in Two S... more Abstract Title: Treatment Outcome of Acute Lymphoblastic Leukemia: Five Years Experience in Two Specialized Hospitals in a Developing Country. Authors: Kabir AL, Yunus ABM, Begum M, Islam MK, Rahman M, Ahmed M, Aziz A Department: Haematology, Bangbandhu Sheikh Mujib Medical University Organization: BSMMU City: Dhaka Country: Bangladesh Introduction/Background: In a developing country the treatment outcome of malignant diseases significantly depends on the economic status as completion of treatment protocols are dependent upon the affordability of the patient. We have reviewed the treatment outcome of patients who had received chemotherapy for ALL as per the BFM 1995, UKALL XII and MCP 841 in two specialized hospitals in Bangladesh for the last five years. Methods: 54 patients (38 males & 16 females) with ALL who had received BFM 1995 (23 patients) UKALL XII (16 patients) and MCP 841 (15 patients) protocols in BSMMU & Delta Medical College and Hospital during the period of January 20...

Journal of Dhaka Medical College, 2010

Bangabandhu Sheikh Mujib Medical University Journal, 2010

Blood, Jan 28, 2016

Venous thromboembolism (VTE) is a common complication in patients with cancer but only limited da... more Venous thromboembolism (VTE) is a common complication in patients with cancer but only limited data are available in AML. In a prospective study in a cohort of 272 adult patients (aged 18-65) and an independent validation cohort of 132 elderly adults (aged > 60) with newly diagnosed AML we assessed markers of disseminated intravascular coagulation (DIC) (fibrinogen, D-dimer, alpha-2-antiplasmin, antitrombin, Prothrombin time and platelet count), the DIC score according the International Society of Thrombosis and Haemostasis and their associations with the occurrence of venous and arterial thrombosis during follow up. The prevalence of thrombosis was 8.7% (4.7% venous, 4.0% arterial) in the younger adults over a median follow up of 478 days and 10.4% (4.4% venous, 5.9% arterial) in elderly patients. Most thrombotic events (66%) occurred before start of the second course of chemotherapy. The calculated DIC score significantly predicted venous and arterial thrombosis with a Hazard R...

Journal of Dhaka Medical College, 2020

Background: Multiple Myeloma (MM) accounts for 1% of malignant tumors and 10%–15% of hematopoieti... more Background: Multiple Myeloma (MM) accounts for 1% of malignant tumors and 10%–15% of hematopoietic neoplasms. Bortezomib, a first in class proteasome inhibitor, induces apoptosis and growth arrest and reverse chemoresistence in Myeloma cell and has demonstrated no irreversible adverse effect on haemopoietic stem cell. Dexamethasone increases the response rate. Thus, Bortezomib plus dexamethasone represent highly effective regimen for previously untreated Multiple Myeloma cases and significantly higher response rates approximately 70%– 90% have been observed.This combination thus may serve the basis of future strands of care in Multiple Myeloma patients. Objective: The aim of the study was to assess the efficacy , safety and tolerability of Bortezomib in newly diagnosed cases of Multiple Myeloma patients in Bangladesh. Materials & Methods: This prospective observational study was carried out in the Haematology department of BSMMU from June 2017 to December 2018. Patients received inj...

Bangladesh Medical Journal, 2019

Acute myeloid leukaemia (AML) is treatable and potentially curable disease. Significant morbidity... more Acute myeloid leukaemia (AML) is treatable and potentially curable disease. Significant morbidity is related to the prolonged, severe neutropenia resulting from the disease as well as the intensive chemotherapy. The administration of granulocyte - colony stimulating factor (G-CSF) is recommended to reduce the neutropenic period. But the current information and guidelines are insufficient about the most appropriate time to start G-CSF and the optimum duration of treatment after chemotherapy in consolidation phase. This study explores better timing to start G-CSF after completion of chemotherapy in consolidation phase of AML patient. This prospective study was conducted in the department of Haematology, Bangabandhu Sheikh Mujib Medical University among AML patients, who received consolidation chemotherapy (high dose cytarabine). Samples were grouped into two arms. Arm-A (Absolute Neutrophil Count >1000/cmm) received prophylactic G-CSF and Arm-B (Absolute Neutrophil Count <100...

Bangabandhu Sheikh Mujib Medical University Journal, 2010

The inherited diseases of haemoglobin are the most common single gene disorders. With global impr... more The inherited diseases of haemoglobin are the most common single gene disorders. With global improvement in childhood diseases thalassaemia will become a major health issue in millennium. The beta-thalassaemia is the most common type of thalassaemia because they are so common, occur widely in a broad belt ranging from Mediterranean and parts of North and West Africa through the Middle East,

Haematology Journal of Bangladesh, 2019

Among the haemoglobinopathies non-transfusion dependent thalassaemia (NTDT) are more common than ... more Among the haemoglobinopathies non-transfusion dependent thalassaemia (NTDT) are more common than the major patients. Bangladesh is located within the thalassaemia belt, moreover, Hb-E is prevalent here. So, the burden of non-transfusion dependent haemoglobinopathies is pretty massive. Due to less severe presentation and unawareness of general people, most patients with NTDT present with complications. On the other hand, cardiac complications are the major causes of death in these patients, and, negligence in early treatment increases the death. This review discusses haemoglobinopathies in general, followed by pathogenesis, clinical features and management of cardiac complications.

Haematology Journal of Bangladesh, 2021

Background: Hb-E/Beta thalassaemia is a congenital haemoglobin disorder which is a compound heter... more Background: Hb-E/Beta thalassaemia is a congenital haemoglobin disorder which is a compound heterozygous state consists of qualitative disorder like Hb E variant & quantitative Hb disorder caused by genetic mutation of Beta chain. Objective: The aim of the study was to identify the beta gene mutation in Hb E/Beta thalassaemia. Method: A total of 32 diagnosed Hb E/Beta thalassaemia patients were included in this cross-sectional study from May 2019 to July 2020. Genetic analysis was done by sanger sequencing. Results: In this observational study, we found 13 different types of Beta gene mutations. Heterozygous for IVS 1-5(G>C) mutation was most frequent (53.1%). Conclusion: Genetic mutation is the confirmatory diagnosis for thalassaemia as well as one of the main factors for clinical expression. Mutation pattern also varies according to the geographical distribution. So, this study shows the frequently found mutation in Bangladesh and should carry out routinely to point out phenoty...

KYAMC Journal, 2020

Background: Multiple Myeloma (MM) represents approximately 15% of all hematological malignancies.... more Background: Multiple Myeloma (MM) represents approximately 15% of all hematological malignancies. Despite the use of high-dose chemotherapy followed by stem cell rescue MM remains incurable at present. The goal is to control the disease as much as possible, providing the best quality of life to patients for the longest duration. Currently, CTDa (attenuated Cyclophosphamide, Thalidomide, Dexamethasone) is the best option of treatment as it is cost-effective, with no need for hospitalization with a good response. Objective: To find out the symptomatic responses and toxicities of CTDa in Multiple Myeloma patients. Materials and Methods: 25 patients of newly diagnosed MM patients were treated in the Haematology Department, Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2016 to July 2017. The mean age of the patients was 54 years, Male female ratio was 1.5:1 and most of the patients were farmers. After induction of 4 to 6 cycles of CTDa all patients were followed up at 6th...

Haematology Journal of Bangladesh

Background: In lymphoma, bone marrow infiltration of lymphocytes is a vital information of stagin... more Background: In lymphoma, bone marrow infiltration of lymphocytes is a vital information of staging can be done primarily by observer dependent bone marrow study or trephine biopsy. Objective: Aim of this study is to observe the frequency of bone marrow involvement in Non-Hodgkin lymphoma at the time of diagnosis by trephine biopsy and to determine importance of bone marrow trephine biopsy over bone marrow aspiration for staging of Non-Hodgkin lymphoma. Methodology: This was a prospective observational study conducted between January 2014 to July 2014 in department of Haematology, Bangabandhu Shaikh Mujib Medical University (BSMMU) including 30 newly diagnosed patients of Non-Hodgkin’s Lymphoma (NHL) between 15 to 75 years of both sex in non-probability purposive sampling manner confirmed by histopathology of biopsy of lymph node or extra nodal mass. Any secondary disease associated NHL and if there were history of prior chemotherapy was excluded from this study. Detailed clinical hi...

Bangladesh Medical Journal

Here we describe a case of a 20-year-old, otherwise healthy man, who consulted a physician due to... more Here we describe a case of a 20-year-old, otherwise healthy man, who consulted a physician due to acute low back pain presenting for a couple of days. Pain appeared suddenly, without any preceding trauma. Physical examination was unremarkable. Initial laboratory tests showed elevated inflammatory marker and thrombocytopenia. Patient was treated conservatively but due to increasing pain MRI of spine with contrast was advised which showed feature suggestive of infiltrative disease. Eventually patient was diagnosed as a case of acute lymphoblastic leukaemia on further peripheral blood film and bone marrow study.Bangladesh Med J. 2017 Jan; 46 (1): 41-43

Bangabandhu Sheikh Mujib Medical University Journal, 2016

Anwer Khan Modern Medical College Journal, 2017

commonest inherited gene disorder is prevalent worldwide 1,2. Bangladesh is situated in the thala... more commonest inherited gene disorder is prevalent worldwide 1,2. Bangladesh is situated in the thalassaemia belt and Beta-thalassaemia is common here 2,3. There are a significant number of patients who have concurrent iron deficiency and beta

Background: The global burden from cancer is rising, especially as low-income countries like Bang... more Background: The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.

BMC Cancer, 2014

Background: The global burden from cancer is rising, especially as low-income countries like Bang... more Background: The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.

Journal of Paediatric Surgeons of Bangladesh, 2016

Journal of Bangladesh College of Physicians and Surgeons, 2015

ABSTRACT

Bangladesh Journal of Medicine, 2015

Abstract Title: Treatment Outcome of Acute Lymphoblastic Leukemia: Five Years Experience in Two S... more Abstract Title: Treatment Outcome of Acute Lymphoblastic Leukemia: Five Years Experience in Two Specialized Hospitals in a Developing Country. Authors: Kabir AL, Yunus ABM, Begum M, Islam MK, Rahman M, Ahmed M, Aziz A Department: Haematology, Bangbandhu Sheikh Mujib Medical University Organization: BSMMU City: Dhaka Country: Bangladesh Introduction/Background: In a developing country the treatment outcome of malignant diseases significantly depends on the economic status as completion of treatment protocols are dependent upon the affordability of the patient. We have reviewed the treatment outcome of patients who had received chemotherapy for ALL as per the BFM 1995, UKALL XII and MCP 841 in two specialized hospitals in Bangladesh for the last five years. Methods: 54 patients (38 males & 16 females) with ALL who had received BFM 1995 (23 patients) UKALL XII (16 patients) and MCP 841 (15 patients) protocols in BSMMU & Delta Medical College and Hospital during the period of January 20...

Journal of Dhaka Medical College, 2010

Bangabandhu Sheikh Mujib Medical University Journal, 2010