Amir Farabi - Academia.edu (original) (raw)

Papers by Amir Farabi

Inverted Follicular Keratosis (IFK) a benign tumor of skin appendages which is mostly presented a... more Inverted Follicular Keratosis (IFK) a benign tumor of skin appendages which is mostly presented as a solitary nodule with keratotic or scaling surface on the face of a middle aged or old patients but it can develop in other parts of the body. Different studies have lead to development of different theories about the role of human papillomavirus (HPV) in this kind of skin tumor. The purpose of this study is to determine the probable role of HPV in this lesion. In a cross-sectional study, we selected all the samples with the diagnosis of IFK referred to pathology department of Farabi Eye Hospital, from April 1995 to April 2006. All these samples were evaluated for histopathologic changes specific for HPV. Immunohistochemistry (IHC) staining was performed using antibody against HPV common antigen. The age range of the patients was 37 to 78 years (Mean=53). 18 patients (58%) were males and 13 patients (42%) were females. The lesion can develop in deferent areas of eyelid. Histopathologic changes regarding viral infection such as focal parakeratosis (80.6%), acanthosis (80.6%), papillomatosis (64.5%), hypergranulosis (67.7%), large keratohyaline granules (32.2%) and koilocytosis (16.1%) were evident within the lesions but HPV detection by IHC revealed positive result in any of the samples. The results about age, sex, anatomic site of the lesion and IHC staining were consistent with previous studies which consider no role for HPV in development of IFK lesions. Performing a more sensitive test such as PCR in order to strongly reject the role of HPV is recommended.

Ophthalmic Epidemiology, 2006

Purpose: The current study was undertaken to determine the frequency of specific primary conjunct... more Purpose: The current study was undertaken to determine the frequency of specific primary conjunctival neoplastic lesions in a patient population treated at an ocular service over a 15-year period. Materials and Methods: We analyzed the data of all primary cases of conjunctival neoplasia diagnosed from 1990 to 2004 in the pathology department of Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Results: Of 3,242 conjunctival specimens, 447 were identified as primary conjunctival neoplasms. The patient group comprised 270 (60.4%) males and 177 (39.6%) females, with an age range of 1 to 90 years. The mean age was 38 years and the median was 32 years. The most common primary conjunctival neoplastic lesion was nevus (38.7%), followed by squamous cell carcinoma, (25.1%), papilloma (7.8%), dysplasia (5.6%), and hemangioma (5.1%), respectively. Of 447 lesions, 261 (58.4%) were benign, 134 (30%) were malignant, and 52 (11.6%) were precancerous. Conclusion: As in previously published studies, benign lesions were the most frequent, but the percent of malignant lesions was much higher than that described in other reports. The high percentage of squamous cell carcinoma that we observed can likely be attributed to elevated sun exposure and ultraviolet light in Iran. The characterization of precancerous lesions in this study emphasizes their potential to transform into malignant lesions and the need for sufficient early management and follow up.

Background: Hospitals generate relatively large quantities of wastewater that may contain various... more Background: Hospitals generate relatively large quantities of wastewater that may contain various potentially hazardous materials; therefore the proper management of hospital wastewater is essential. Methods: In this cross-sectional study, the quality and quantity of wastewater in the hospitals of Tehran University of Medical Sciences (TUMS), Tehran, Iran, were studied and the suitable method for wastewater management in the hospitals was determined. Results: Monitoring of pH, TSS, BOD 5 , COD and total coliforms indicated that the quality of wastewater in the hospitals was similar to domestic wastewater. The wastewater production in the hospitals was determined to be in the range of 398 to 1090 L/d/(occupied bed). The study on wastewater treatment and disposal methods demonstrated that discharge to municipal wastewater collection system is the best alternative for wastewater management in the hospitals, but this approach is not applicable for all of the hospitals. Baharloo, Cancer Institute, Children, Farabi, Imam Khomeini, Razi, Roozbeh, Shariati and Valiasr hospitals can be connected to municipal wastewater collection system at present. Conclusion: It is recommended that these hospitals' wastewater be discharged to municipal wastewater collection system. Amir Alam, Bahrami, Mirza Koochak Khan and Sina hospitals will be able to discharge their wastewater into sewerage network at second phase of Tehran sewerage project (in 2010) and Arash Hospital will be able to discharge its wastewater into sewerage network at third phase of Tehran sewerage project (in 2015). These hospitals have to select onsite separate wastewater treatment alternative.

British Journal of Ophthalmology, 2005

Inverted Follicular Keratosis (IFK) a benign tumor of skin appendages which is mostly presented a... more Inverted Follicular Keratosis (IFK) a benign tumor of skin appendages which is mostly presented as a solitary nodule with keratotic or scaling surface on the face of a middle aged or old patients but it can develop in other parts of the body. Different studies have lead to development of different theories about the role of human papillomavirus (HPV) in this kind of skin tumor. The purpose of this study is to determine the probable role of HPV in this lesion. In a cross-sectional study, we selected all the samples with the diagnosis of IFK referred to pathology department of Farabi Eye Hospital, from April 1995 to April 2006. All these samples were evaluated for histopathologic changes specific for HPV. Immunohistochemistry (IHC) staining was performed using antibody against HPV common antigen. The age range of the patients was 37 to 78 years (Mean=53). 18 patients (58%) were males and 13 patients (42%) were females. The lesion can develop in deferent areas of eyelid. Histopathologic changes regarding viral infection such as focal parakeratosis (80.6%), acanthosis (80.6%), papillomatosis (64.5%), hypergranulosis (67.7%), large keratohyaline granules (32.2%) and koilocytosis (16.1%) were evident within the lesions but HPV detection by IHC revealed positive result in any of the samples. The results about age, sex, anatomic site of the lesion and IHC staining were consistent with previous studies which consider no role for HPV in development of IFK lesions. Performing a more sensitive test such as PCR in order to strongly reject the role of HPV is recommended.

Ophthalmic Epidemiology, 2006

Purpose: The current study was undertaken to determine the frequency of specific primary conjunct... more Purpose: The current study was undertaken to determine the frequency of specific primary conjunctival neoplastic lesions in a patient population treated at an ocular service over a 15-year period. Materials and Methods: We analyzed the data of all primary cases of conjunctival neoplasia diagnosed from 1990 to 2004 in the pathology department of Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Results: Of 3,242 conjunctival specimens, 447 were identified as primary conjunctival neoplasms. The patient group comprised 270 (60.4%) males and 177 (39.6%) females, with an age range of 1 to 90 years. The mean age was 38 years and the median was 32 years. The most common primary conjunctival neoplastic lesion was nevus (38.7%), followed by squamous cell carcinoma, (25.1%), papilloma (7.8%), dysplasia (5.6%), and hemangioma (5.1%), respectively. Of 447 lesions, 261 (58.4%) were benign, 134 (30%) were malignant, and 52 (11.6%) were precancerous. Conclusion: As in previously published studies, benign lesions were the most frequent, but the percent of malignant lesions was much higher than that described in other reports. The high percentage of squamous cell carcinoma that we observed can likely be attributed to elevated sun exposure and ultraviolet light in Iran. The characterization of precancerous lesions in this study emphasizes their potential to transform into malignant lesions and the need for sufficient early management and follow up.

Background: Hospitals generate relatively large quantities of wastewater that may contain various... more Background: Hospitals generate relatively large quantities of wastewater that may contain various potentially hazardous materials; therefore the proper management of hospital wastewater is essential. Methods: In this cross-sectional study, the quality and quantity of wastewater in the hospitals of Tehran University of Medical Sciences (TUMS), Tehran, Iran, were studied and the suitable method for wastewater management in the hospitals was determined. Results: Monitoring of pH, TSS, BOD 5 , COD and total coliforms indicated that the quality of wastewater in the hospitals was similar to domestic wastewater. The wastewater production in the hospitals was determined to be in the range of 398 to 1090 L/d/(occupied bed). The study on wastewater treatment and disposal methods demonstrated that discharge to municipal wastewater collection system is the best alternative for wastewater management in the hospitals, but this approach is not applicable for all of the hospitals. Baharloo, Cancer Institute, Children, Farabi, Imam Khomeini, Razi, Roozbeh, Shariati and Valiasr hospitals can be connected to municipal wastewater collection system at present. Conclusion: It is recommended that these hospitals' wastewater be discharged to municipal wastewater collection system. Amir Alam, Bahrami, Mirza Koochak Khan and Sina hospitals will be able to discharge their wastewater into sewerage network at second phase of Tehran sewerage project (in 2010) and Arash Hospital will be able to discharge its wastewater into sewerage network at third phase of Tehran sewerage project (in 2015). These hospitals have to select onsite separate wastewater treatment alternative.

British Journal of Ophthalmology, 2005