Amirhossein Parsaei - Academia.edu (original) (raw)

Papers by Amirhossein Parsaei

BMC Medical Genomics

Background This study aimed to investigate the pooled diagnostic ability of circular RNA (circRNA... more Background This study aimed to investigate the pooled diagnostic ability of circular RNA (circRNA) molecules for diabetes mellitus. Methods We searched PubMed, Scopus, and Web of Science for relevant studies. A total of 2070 participants, including 775 diabetic patients and 1295 healthy individuals, from five studies were included in this meta-analysis. True positive, true negative, false positive, and false negative data were extracted to calculate pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the receiver operating characteristics curve. The Deeks’ funnel plot was applied for publication bias assessment, Cochran’s Q test and I2 index were applied for inter-study heterogeneity assessment. Besides, a subgroup analysis was performed for determining the source of heterogeneity between studies. P value < 0.05 was considered significance. All analysis were done by STATA version 14. Results CircRNA presented a sensitivi...

Clinical Case Reports

Central venous catheters are the prevalent path for dialysis. Our case was a 54‐years‐old male wi... more Central venous catheters are the prevalent path for dialysis. Our case was a 54‐years‐old male with a new case of end‐stage renal disease with a complaint of right jugular hemodialysis catheter dysfunction. In our case, the early dysfunctional catheter should be evaluated with contrast studies to achieve accurate information.

$Research paper thumbnail of Diagnostic accuracy of an abbreviated MRI protocol for detecting radiographically occult hip and pelvis fractures in the elderly$

Skeletal radiology, Jan 18, 2018

To determine the diagnostic accuracy of an abbreviated, two-sequence MRI protocol using limited p... more To determine the diagnostic accuracy of an abbreviated, two-sequence MRI protocol using limited pulse sequences for the detection of radiographically occult hip and pelvis fractures in the elderly compared to the complete MRI examination. One hundred and eleven consecutive emergency department patients age 65 or older who had undergone MRI to evaluate for clinically suspected hip fracture after negative radiographs were included in the study. The large field-of-view coronal T1 and STIR sequences were isolated from the complete six-sequence MRI protocol and reviewed independently in a blinded fashion by two musculoskeletal fellowship-trained radiologists who recorded presence or absence of fractures of the proximal femora or pelvis, fracture type, and presence or absence of soft tissue injury. Test accuracy was calculated with 95% confidence intervals and accuracy of fracture classification for the abbreviated protocol was compared to that made on the basis of the full exam. For prox...

Frontiers in Public Health

IntroductionMetabolic risk factors (MRFs) predispose populations to a variety of chronic diseases... more IntroductionMetabolic risk factors (MRFs) predispose populations to a variety of chronic diseases with a huge burden globally. With the increasing burden of these risk factors in Iran, in this study, we aimed to report the estimated burden attributed to MRFs at national and subnational scales in Iran, from 1990 to 2019.MethodsBased on the comparative risk assessment method of the Global Burden of Disease (GBD) Study 2019, data of deaths and disability-adjusted life years (DALYs) attributable to four top MRFs in Iran including high systolic blood pressure (SBP), high fasting plasma glucose (FPG), high body mass index (BMI), and high low-density lipoprotein (LDL) for the 1990–2019 period, were extracted. The socio-demographic index (SDI) was used to report the data based on the corresponding socio-economic stratifications. The results were reported in national and subnational 31 provinces of Iran to discover disparities regarding the attributable burden to MRFs. Furthermore, we report...

Modern Rheumatology Case Reports

Although the safety and efficacy of vaccinations have been evaluated through clinical trials, med... more Although the safety and efficacy of vaccinations have been evaluated through clinical trials, medical experts and authorities are very interested in the reporting and investigation of adverse events following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunisation in the general public. This article reports about a 41-year-old man without a history of underlying diseases, complaining of continuous morning stiffness and acute discomfort in his left elbow joint, 20 days after taking the first dosage of Sputnik V. The case was extensively studied, and a possible diagnosis of reactive arthritis was made.

Journal of Renal Endocrinology

Introduction: Fibromyalgia (FM) syndrome is a chronic musculoskeletal disorder with extensive sym... more Introduction: Fibromyalgia (FM) syndrome is a chronic musculoskeletal disorder with extensive symptoms. Its most characteristic manifestation is the presence of persistent and diffuse chronic pain. The prevalence of this disease is 1% to 6% in different studies. Its exact nature and manifestations are not fully known; hence the empirical diagnosis of doctors and the proposed diagnostic criteria may differ in diagnosis. Objectives: This study aims to investigate the prevalence of FM symptoms among rheumatology patients, identify components of symptom and laboratory markers, and determine the interrater agreement between clinician judgment and diagnostic criteria. Patients and Methods: During one year, all patients referred to the rheumatology clinic were selected by simple sampling and underwent medical history collecting and physical examination by a single experienced rheumatologist, and the clinician’s judgment on the diagnosis of FM in the patients was recorded. Also, the America...

Background The objective of this study is to quantitatively compare the diagnostic value of conve... more Background The objective of this study is to quantitatively compare the diagnostic value of conventional diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) in differentiating the histopathological features and subtypes of breast cancer. Materials and Methods There were 98 patients with breast cancer studied by multiple b value DWIs and DKIs grouped according to their molecular prognostic factors. Entropy and histogram derived parameters of volumetric ADC values, true diffusivity (Dt), pseudo-diffusion coefficient (Dp), perfusion fraction (f), mean kurtosis (MK), and mean diffusivity (MD) maps were calculated using voxel based analysis for the whole lesion volume. The diagnostic efficacy of various diffusion parameters for predicting both molecular prognostic factors (Hormone-Receptor (HR, ER or PR positive), HER2 and ki67) and breast cancer subtypes were compared. Diagnostic performance was evaluated using the univariate and m...

Osteoarthritis and Cartilage, 2020

to 2.5 years later, we evaluated outcomes (KR, WOMAC pain) at time-points after 2.5 years up to 7... more to 2.5 years later, we evaluated outcomes (KR, WOMAC pain) at time-points after 2.5 years up to 7 years. Results: Overall, 1755 subjects (2554 knees) met inclusion criteria (mean age 62, 64% female, 86.5% White, mean WOMAC pain 2.7). 113 knees underwent KR overall (4.4%), whereas of those knees that were JSN¼2 at baseline, 19.8% (41/258) underwent KR and of those knees with WOMAC 8-18 at baseline, 10.2% (25/244) underwent KR. Overall, both severity and extent of baseline cartilage lesions as well as change in cartilage lesions over 2.5 years were significantly associated with risk of KR (Table). In contrast, while cartilage lesions were significantly associated with WOMAC pain severity, the relationship was weak (Table). Conclusions: These findings support the clinical relevance of cartilage lesions to the clinically important endpoint of KR. Further, relatively short-term changes in cartilage lesions over 2.5 years may be potentially useful as a prognostic marker for later clinical endpoints such as KR. However, the magnitude of these effects estimates may not be sufficient for validation as an imaging biomarker. In contrast, cartilage lesions were not strongly associated with WOMAC pain. This may partly reflect the uncertainty in the utility of WOMAC pain as an instrument to detect long-term change in pain over years since WOMAC has primarily been used and validated in RCTs to date that are of 3-6 months rather than years-long studies.

Rheumatology and Therapy

Introduction: SARS-CoV-2 causes more severe symptoms in most chronic diseases, and rheumatic dise... more Introduction: SARS-CoV-2 causes more severe symptoms in most chronic diseases, and rheumatic disease is no exception. This study aims to investigate whether there is an association between the use of immunomodulatory medications, including conventional disease-modifying agents (csDMARDs), glucocorticoids, and biologic DMARDs, and outcomes such as hospitalization and lung involvement in patients with rheumatic disease with COVID-19. Methods: We performed a cross-sectional study on 177 COVID-19 cases with rheumatologic diseases using immunomodulatory drugs as their regular treatment. All patients were evaluated regarding their initial chest computed tomography (CT) scan, COVID-19 symptoms, and comorbidities. We ran predictive models to find variables associated with chest CT-scan involvement and hospitalization status. Results: CT findings showed lung involvement in 87 patients with chest CT-scan severity score (C-ss) of less than 8 in 59 (33%) and more than 8 in 28 (16%) of our patients. Of all patients, 76 (43%) were hospitalized. Hospitalized patients were significantly older and had more comorbidities (P = 0.02). On multivariate analysis, older age [odds ratio (OR) 1.90, 95% confidence interval (CI) 1.31-3.08] and comorbidity (OR 2.75, 95% CI 1.06-3.66) were significantly associated with higher odds of hospitalization (P = 0.03). On multivariate analysis, older age (OR 1.15, 95% CI 0.94-2.01), pulmonary diseases (OR 2.05, 95% CI 1.18-3.32), and treatment with csDMARDs (OR 1.88, 95% CI 0.37-1.93) were associated with higher C-ss (P = 0.039). Conclusions: This study found that advanced age and comorbidities, similar to the general population, are risk factors for hospitalization in patients with COVID-19 with rheumatic disorders. Administration of csDMARDs, older age, and pulmonary disorders were linked to increased risk of COVID-19 pneumonia in these individuals.

Journal of Scleroderma and Related Disorders

Introduction: The Sinopharm BBIBP-CorV vaccine produces a variety of cutaneous adverse effects. S... more Introduction: The Sinopharm BBIBP-CorV vaccine produces a variety of cutaneous adverse effects. Scleromyxedema is a mucinous connective tissue disorder that causes skin thickness and sclerodermoid changes. According to our findings, this is the first case of scleromyxedema induced by the Sinopharm immunization. Case description: We discuss the case of a 75-year-old woman who acquired progressive thickening of the skin in her limbs and trunk after getting the Sinopharm vaccination. Examination, laboratory testing, and a biopsy were used to verify scleromyxedema diagnosis. Intravenous immunoglobulins, mycophenolate mofetil, and prednisolone were used in the treatment of the patient. The outcomes from the 4-month follow-up were reassuring. Conclusion: This study emphasizes the need of considering scleromyxedema as a connective tissue pathology in patients who have recently received Sinopharm vaccine and have similar cutaneous signs.

Journal of Iranian Medical Council

Background: Burnout is relatively frequent among medical students and has a major impact on menta... more Background: Burnout is relatively frequent among medical students and has a major impact on mental health. We aimed to determine the prevalence of burnout among medical students of Tehran University of Medical Sciences (TUMS). Methods: It was a cross-sectional study conducted at TUMS. All medical students at the university entrance (first semester), beginning of the clerkship, beginning of the internship, and end of the internship (graduation time) were enrolled. Maslach`s Burnout Inventory for Students (MBI-SS) was used to assess the prevalence of burnout. Chi-square test and Kendal tau_c test were utilized to compare subscales and curricular phases. Results: 668 students participated in the study. The prevalence of burnout was 24.1% which was significantly higher at the end of their internship. 65% of the students had high emotional exhaustion, 75.4% had high cynicism, and 37% had low academic efficacy. There was no association between gender and burnout. Conclusion: The prevalenc...

BackgroundCompared to the healthy population, the psychological impact of rheumatoid arthritis(RA... more BackgroundCompared to the healthy population, the psychological impact of rheumatoid arthritis(RA) on patients' lives could dramatically lower their oral health-related quality of life (OHRQoL). Our goal is to analyze OHRQoL in RA patients and look into the role of disease activity, dental health index, and Temporomandibular disorders score in maintaining their oral health.MethodsIn a cross-sectional comparative study, we compared a random sample of 40 RA patients with 40 age- and gender-matched healthy controls in terms of oral health and OHRQoL. Temporomandibular disorders (TMD), number of decayed, filled, or missing teeth (DMFT), and Oral Health Impact Profile (OHIP) were among the oral health factors studied (OHIP-14). This study also looked at the link between the RA disease activity score (DAS28) and oral health factors.ResultsRA patients had a significantly higher mean than healthy controls in total oral function, total psychosocial impact, OHIP-14 sum score, OHIP-14 exte...

Background: Delirium is a neurobehavioral syndrome, which is characterized by fluctuation of ment... more Background: Delirium is a neurobehavioral syndrome, which is characterized by fluctuation of mental status, disorientation, confusion and inappropriate behavior and it is prevalent among hospitalized patients. Recognizing modifiable risk factors of delirium is the key point for improving our preventive strategies and restraining its devastating consequences. The present study investigated a wide range of possible predisposing factors of delirium, mainly focused on underlying diseases and mediations, of hospitalized patients in the different wards of a general hospital.Method: In a prospective, observational trial, we investigated 220 patients who had been admitted to the internal, emergency, surgery and hematology-oncology departments. We employed the Confusion Assessment Method (CAM) questionnaire, The Richmond Agitation Sedation Scale (RASS), the General Practitioner Assessment of Cognition (GPCOG), demographic questionnaire, patient interviews and medical records. Multivariate lo...

Obstetrics & gynecology science, 1997

Journal of Nephropathology

Acute kidney injury (AKI) is the second prevalent organ damage among COVID-19 infected individual... more Acute kidney injury (AKI) is the second prevalent organ damage among COVID-19 infected individuals, which mainly affects those with critical diseases or underlying kidney disorders. Emerging data have suggested that AKI is associated with adverse outcomes, severe COVID-19 disease, and high mortality. However, the true nature and pathophysiology of COVID-19-associated kidney injury, and its effect on patients with underlying kidney diseases and transplant recipients, still remains controversial. Accordingly, this review study aimed primarily to describe the history of AKI in COVID-19 infected patients and to achieve a robust understanding of the latest findings on the mechanism of the injury. Secondly, this systematic and precise review of the literature concerning the aspects of AKI in infected patients with chronic kidney disease and transplant recipients provided a comprehensive report of mortality in these individuals. Finally, the present research suggested the possible protecti...

Iranian Journal of Public Health, 2022

The article's abstract is not available.

Infectious Diseases in Clinical Practice

Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin... more Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity.Methods: Participants (n=514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (A...

Background Behcet's disease (BD) as a chronic in ammatory condition that affects the eyes, skin, ... more Background Behcet's disease (BD) as a chronic in ammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity. Methods Participants (n = 514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and speci city and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP. Result Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p < 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR = 1.