Amit Jain - Independent Researcher (original) (raw)

Papers by Amit Jain

Solar Energy Materials and Solar Cells, 2006

Exact closed-form solution based on Lambert W-function are presented to express the transcendenta... more Exact closed-form solution based on Lambert W-function are presented to express the transcendental current-voltage characteristic containing parasitic power consuming parameters like series and shunt resistances for solar cell array. Maple software was used to solve the transcendental equation of solar cell array.

Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy

Nanomedicine: Nanotechnology, Biology and Medicine, 2014

The present work focuses on the anticancer potential of quercetin (QT) loaded self-nanoemulsifyin... more The present work focuses on the anticancer potential of quercetin (QT) loaded self-nanoemulsifying drug delivery system (QT-SNEDDS) composed of Capmul MCM, Tween 20 and ethanol. In vitro cell culture studies revealed potential cell cytotoxicity of developed formulation mediated by its ability to induce DNA damage and apoptosis in MCF-7 cells. QT-SNEDDS at a dose of 50mg/kg demonstrated the antioxidant activity measured as function of prophylactic antitumor efficacy against DMBA induced breast tumors which revealed higher latency to the tumor growth as compared to free QT. This appreciation was further supported by normalized levels of tumor angiogenesis markers (MMP-2, MMP-9, TNF-α and IL-6). At higher doses (100mg/kg) the pro-oxidant activity was noted and exhibited significantly higher therapeutic anticancer efficacy (~65% tumor suppression) in the same model as compared to that of free QT (~20%). Finally, safety profile of developed formulation was established assessing various hepatotoxicity markers. This basic science study focuses on the anticancer potential of a specific quercetin loaded self-nanoemulsifying drug delivery system. At higher doses significantly higher therapeutic anticancer efficacy (~65% tumor suppression) was noted in the same model as compared to that of free quercetin (~20%).

Highly Stereoselective Ene Reaction of Aldimines with 2-(Alkylthio)allyl Silyl Ethers

The Journal of Organic Chemistry, 1994

A stereoselective ene reaction of aldimines with 2-(alkylthio)allyl silyl ethers was developed. U... more A stereoselective ene reaction of aldimines with 2-(alkylthio)allyl silyl ethers was developed. Under the influence of Lewis acids, N-acylimine or geminal biscarbamates reacted with a (Z)-2-(methylthio)allyl silyl ether to afford syn adducts in >94% selectivity

The Journal of Organic Chemistry, 2010

We have synthesized nine β-hydroxy-R-sulfenyl-γ-butyrolactones having different substituents. The... more We have synthesized nine β-hydroxy-R-sulfenyl-γ-butyrolactones having different substituents. The syn-anti or syn-syn lactones (or any mixture of both) invariably isomerized into syn-anti/syn-syn lactones in a ratio of ∼6/4. The other two possible isomeric lactones (anti-syn or anti-anti) were never observed. The crystal structures of syn-syn lactones have been determined. We found sulfur-oxygen distances to be less than the sum of the van der Waals radii (3.3 Å), with the angle formed among the hydroxylic oxygen, sulfur, and quaternary aromatic carbon being close to 180°. In addition, carbonylic oxygen-sulfur is directed <40°from the perpendicular to the C-S-C. Theoretical calculations were performed which emphasize the directionality of the sulfur-oxygen interaction. The X-ray and theoretical studies demonstrate that two concomitant, attractive 1,4 intramolecular interactions of divalent sulfur with both carbonyl and hydroxyl oxygens are the driving force for the aforementioned stereochemical preference. Then nonbonded sulfur-oxygen interactions would control the stereoselectivity of the reaction. The same features are observed in the X-ray structure of a β-hydroxy-R-sulfinyl-γ-butyrolactone.

European Journal of Pharmaceutical Sciences, 2007

Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. He... more Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate buffered saline (PBS):ethanol (EtOH) solvent. Effect of 44 different compositions of NLS:S20 on skin constituents was probed by Fourier transform-infrared (FT-IR) spectroscopy while behavior of surfactant molecules in the solvent system was probed by FT-IR and NMR spectroscopy. No aggregation of NLS or S20 alone was observed in 1:1 PBS:EtOH at all concentrations studied (0-2%, w/v). However, mixtures of NLS and S20 resulted in micellelike aggregates at certain specific compositions. Interestingly, compositions with increased aggregation showed resemblance to those that exhibited highest skin permeabilization.

Solar Energy Materials and Solar Cells, 2006

Exact closed-form solution based on Lambert W-function are presented to express the transcendenta... more Exact closed-form solution based on Lambert W-function are presented to express the transcendental current-voltage characteristic containing parasitic power consuming parameters like series and shunt resistances for solar cell array. Maple software was used to solve the transcendental equation of solar cell array.

Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy

Nanomedicine: Nanotechnology, Biology and Medicine, 2014

The present work focuses on the anticancer potential of quercetin (QT) loaded self-nanoemulsifyin... more The present work focuses on the anticancer potential of quercetin (QT) loaded self-nanoemulsifying drug delivery system (QT-SNEDDS) composed of Capmul MCM, Tween 20 and ethanol. In vitro cell culture studies revealed potential cell cytotoxicity of developed formulation mediated by its ability to induce DNA damage and apoptosis in MCF-7 cells. QT-SNEDDS at a dose of 50mg/kg demonstrated the antioxidant activity measured as function of prophylactic antitumor efficacy against DMBA induced breast tumors which revealed higher latency to the tumor growth as compared to free QT. This appreciation was further supported by normalized levels of tumor angiogenesis markers (MMP-2, MMP-9, TNF-α and IL-6). At higher doses (100mg/kg) the pro-oxidant activity was noted and exhibited significantly higher therapeutic anticancer efficacy (~65% tumor suppression) in the same model as compared to that of free QT (~20%). Finally, safety profile of developed formulation was established assessing various hepatotoxicity markers. This basic science study focuses on the anticancer potential of a specific quercetin loaded self-nanoemulsifying drug delivery system. At higher doses significantly higher therapeutic anticancer efficacy (~65% tumor suppression) was noted in the same model as compared to that of free quercetin (~20%).

Highly Stereoselective Ene Reaction of Aldimines with 2-(Alkylthio)allyl Silyl Ethers

The Journal of Organic Chemistry, 1994

A stereoselective ene reaction of aldimines with 2-(alkylthio)allyl silyl ethers was developed. U... more A stereoselective ene reaction of aldimines with 2-(alkylthio)allyl silyl ethers was developed. Under the influence of Lewis acids, N-acylimine or geminal biscarbamates reacted with a (Z)-2-(methylthio)allyl silyl ether to afford syn adducts in >94% selectivity

The Journal of Organic Chemistry, 2010

We have synthesized nine β-hydroxy-R-sulfenyl-γ-butyrolactones having different substituents. The... more We have synthesized nine β-hydroxy-R-sulfenyl-γ-butyrolactones having different substituents. The syn-anti or syn-syn lactones (or any mixture of both) invariably isomerized into syn-anti/syn-syn lactones in a ratio of ∼6/4. The other two possible isomeric lactones (anti-syn or anti-anti) were never observed. The crystal structures of syn-syn lactones have been determined. We found sulfur-oxygen distances to be less than the sum of the van der Waals radii (3.3 Å), with the angle formed among the hydroxylic oxygen, sulfur, and quaternary aromatic carbon being close to 180°. In addition, carbonylic oxygen-sulfur is directed <40°from the perpendicular to the C-S-C. Theoretical calculations were performed which emphasize the directionality of the sulfur-oxygen interaction. The X-ray and theoretical studies demonstrate that two concomitant, attractive 1,4 intramolecular interactions of divalent sulfur with both carbonyl and hydroxyl oxygens are the driving force for the aforementioned stereochemical preference. Then nonbonded sulfur-oxygen interactions would control the stereoselectivity of the reaction. The same features are observed in the X-ray structure of a β-hydroxy-R-sulfinyl-γ-butyrolactone.

European Journal of Pharmaceutical Sciences, 2007

Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. He... more Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate buffered saline (PBS):ethanol (EtOH) solvent. Effect of 44 different compositions of NLS:S20 on skin constituents was probed by Fourier transform-infrared (FT-IR) spectroscopy while behavior of surfactant molecules in the solvent system was probed by FT-IR and NMR spectroscopy. No aggregation of NLS or S20 alone was observed in 1:1 PBS:EtOH at all concentrations studied (0-2%, w/v). However, mixtures of NLS and S20 resulted in micellelike aggregates at certain specific compositions. Interestingly, compositions with increased aggregation showed resemblance to those that exhibited highest skin permeabilization.