Amol Taywade - Academia.edu (original) (raw)
Uploads
Papers by Amol Taywade
A new dimension to Hunig's base i.e. diisopropylethylamine (DIPEA) utilization in the organic rea... more A new dimension to Hunig's base i.e. diisopropylethylamine (DIPEA) utilization in the organic reaction has been introduced. Present study projects DIPEA as a green alternative for C-N bond formation reactions. In terms of optimization of yield of C-N coupling reactions, DIPEA exclusively serves as base, catalyst and solvent in mild conditions to fulfill criteria for green reaction methodology.
Synthetic Communications, May 23, 2018
Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) ... more Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.
All starting materials were of the highest commercially available grade and used without further ... more All starting materials were of the highest commercially available grade and used without further purification. All solvents used in the reactions good quality. Reactions were monitored by thin layer chromatography using silica gel plates. Compound purified by column chromatography used 100-200 silica gel. 1 H and 13 C (400 and 200 MHz, respectively) spectra were recorded in CDCl3 and DMSO. 1 H-NMR chemical shifts are reported in ppm (δ) relative to tetramethylsilane (TMS) with the solvent resonance employed as the internal standard (CDCl3 and DMSO, δ 7.26 and 2.6 ppm). Data are reported as follows: chemical shift, multiplicity (s= singlet, d= doublet, dd= double doublet, t = triplet, m = multiplet). 13 C-NMR chemical shifts are reported in ppm from tetramethylsilane (TMS) with the solvent resonance as the internal standard (CDCl3, δ 77.0 ppm). LCMS spectra were recorded on .Chemical yields refer to pure isolated substances.
Synthetic Communications, 2018
Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) ... more Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.
A new dimension to Hunig's base i.e. diisopropylethylamine (DIPEA) utilization in the organic rea... more A new dimension to Hunig's base i.e. diisopropylethylamine (DIPEA) utilization in the organic reaction has been introduced. Present study projects DIPEA as a green alternative for C-N bond formation reactions. In terms of optimization of yield of C-N coupling reactions, DIPEA exclusively serves as base, catalyst and solvent in mild conditions to fulfill criteria for green reaction methodology.
Synthetic Communications, May 23, 2018
Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) ... more Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.
All starting materials were of the highest commercially available grade and used without further ... more All starting materials were of the highest commercially available grade and used without further purification. All solvents used in the reactions good quality. Reactions were monitored by thin layer chromatography using silica gel plates. Compound purified by column chromatography used 100-200 silica gel. 1 H and 13 C (400 and 200 MHz, respectively) spectra were recorded in CDCl3 and DMSO. 1 H-NMR chemical shifts are reported in ppm (δ) relative to tetramethylsilane (TMS) with the solvent resonance employed as the internal standard (CDCl3 and DMSO, δ 7.26 and 2.6 ppm). Data are reported as follows: chemical shift, multiplicity (s= singlet, d= doublet, dd= double doublet, t = triplet, m = multiplet). 13 C-NMR chemical shifts are reported in ppm from tetramethylsilane (TMS) with the solvent resonance as the internal standard (CDCl3, δ 77.0 ppm). LCMS spectra were recorded on .Chemical yields refer to pure isolated substances.
Synthetic Communications, 2018
Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) ... more Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.