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Papers by Amrita Srivastava

Research paper thumbnail of Neutrophil-lymphocyte ratio as a prognostic tool for the evaluation of laryngeal carcinoma

International Journal of Otorhinolaryngology and Head and Neck Surgery, 2021

Background: The objective of the study was to review the neutrophil lymphocyte ratio (NLR) as a p... more Background: The objective of the study was to review the neutrophil lymphocyte ratio (NLR) as a prognostic tool in carcinoma larynx.Methods: Patients who were fulfilling inclusion criteria after screening were selected for study. On the basis of cutoff pretreatment NLR (<3 or >3) divided into two groups high pretreatment NLR and low pretreatment NLR. Patient undergo chemo or radiotherapy and at the end of follow up these two group NLR were compared with tumor negative prognostic score, survival at the end of follow up, resolving of symptoms, staging change, tumor regression and overall prognosis at the end of follow up were assessed.Results: Mean value of tumor negative prognostic score of early carcinoma with low NLR, early carcinoma with high NLR, late carcinoma with low NLR and late carcinoma with High NLR were 13.833±2.80, 24.04±4.5538, 37.833±8.68 and 55.33±6.429 respectively. 10 (17.5%) patients with high NLR show more than 50% tumor regression while 17 (29.82%) with hig...

Research paper thumbnail of High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers—Preliminary results

Brachytherapy, 2007

Purpose: High-dose-rate (HDR) interstitial brachytherapy has an established role in head and neck... more Purpose: High-dose-rate (HDR) interstitial brachytherapy has an established role in head and neck malignancies and offers good survival rates; however, there is scant data on improved local control (LC) and treatment-related complications in recurrent cases. We present our results in patients with recurrent head and neck cancers treated with HDR interstitial brachytherapy. Material and methods: Twenty-five patients with recurrent head and neck cancers were treated with HDR interstitial brachytherapy using Iridium 192 between 2009 and 2016. Of these, 75% received radical brachytherapy, and 25% received external beam radiation therapy (EBRT) followed by brachytherapy boost. Treatment sites included oral cavity (15/25) and oropharynx (10/25). Median dose of 4.5 Gy was administered twice per day, with median total brachytherapy dose of 40.5 Gy in radical and 27 Gy for EBRT cases. Results: With median follow-up of 25 months, 4 local recurrences were observed within first year of follow-up. Two-year local control and overall survival outcomes for the entire group were 75% and 68%, respectively. Local control rate with radical BRT vs. BRT as a boost following EBRT was found to be significant (2-year LCR 62% vs. 85%; p < 0.02). Dosimetric assessment revealed D 90-4.08 Gy, V 100-94.1%, V 150-24.7%, and V 200-10.1%. Xerostomia, altered taste, and dysphagia were the major complications commonly grade 1 and 2. Grade 3 toxicity was only 2%. Pre-treatment volume > 85 cc had a negative impact on overall survival (26 months vs. 12 months; p = 0.02), and interval time between primary and recurrence more than 15 months had an impact on the local control rate (p < 0.01). Conclusions: Results of HDR interstitial brachytherapy have shown acceptable local control and overall survival rates along with tolerable toxicities and morbidity in recurrent head and neck cancers.

Research paper thumbnail of Intermittent Food Absence Motivates Reallocation of Locomotion and Feeding in Spotted Munia (Lonchura punctulata)

Journal of Circadian Rhythms, 2015

Background: Daily feeding and locomotion are interrelated behaviours. The time spent in feeding a... more Background: Daily feeding and locomotion are interrelated behaviours. The time spent in feeding and rate of food intake depends on food availability. In low food condition, the birds would show intense movement (locomotion) for a longer time throughout the day however during abundant food supply they may chose higher activity and food intake in the morning and evening only. In the present study we hypothesized that in Spotted Munia (Lonchura punctulata), intermittent food availability during day would reallocate their interrelated behaviors, the feeding (food intake) and locomotor activity patterns. Methods: Two groups of birds (N = 6 each) were kept individually in activity cages under 12L:12D. Group 1 (Control; C) had ad libitum food but group 2 (Treatment; T) had food for 6 hours only (2 h presence followed by 2 h absence; 2P:2A) during 12 hour light period. In the first week, group 2 received food with 'lights on' (TI; ZT 0-2, 4-6 and 8-10; where ZT 0= zeitgeber time 0, time of lights ON). In the following week, the food was given 2 hours after 'lights on' (TII; ZT 2-4, 6-8, 10-12). The food intake and locomotor activity under each condition were observed. Results: The results showed that locomotor activity was induced during food deprivation and suppressed during food availability. Also the food deprivation led to increased food intake. Conclusion: Our results suggest that intermittent food availability/ deprivation reallocates the locomotor activity and food intake in Spotted Munia.

Research paper thumbnail of Synthesis and X-ray crystallographic investigation of N-(α-d-arabinopyranosyl)alkanamides as N-glycoprotein linkage region analogs

Carbohydrate Research, 2013

Research paper thumbnail of Neutrophil-lymphocyte ratio as a prognostic tool for the evaluation of laryngeal carcinoma

International Journal of Otorhinolaryngology and Head and Neck Surgery, 2021

Background: The objective of the study was to review the neutrophil lymphocyte ratio (NLR) as a p... more Background: The objective of the study was to review the neutrophil lymphocyte ratio (NLR) as a prognostic tool in carcinoma larynx.Methods: Patients who were fulfilling inclusion criteria after screening were selected for study. On the basis of cutoff pretreatment NLR (<3 or >3) divided into two groups high pretreatment NLR and low pretreatment NLR. Patient undergo chemo or radiotherapy and at the end of follow up these two group NLR were compared with tumor negative prognostic score, survival at the end of follow up, resolving of symptoms, staging change, tumor regression and overall prognosis at the end of follow up were assessed.Results: Mean value of tumor negative prognostic score of early carcinoma with low NLR, early carcinoma with high NLR, late carcinoma with low NLR and late carcinoma with High NLR were 13.833±2.80, 24.04±4.5538, 37.833±8.68 and 55.33±6.429 respectively. 10 (17.5%) patients with high NLR show more than 50% tumor regression while 17 (29.82%) with hig...

Research paper thumbnail of High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers—Preliminary results

Brachytherapy, 2007

Purpose: High-dose-rate (HDR) interstitial brachytherapy has an established role in head and neck... more Purpose: High-dose-rate (HDR) interstitial brachytherapy has an established role in head and neck malignancies and offers good survival rates; however, there is scant data on improved local control (LC) and treatment-related complications in recurrent cases. We present our results in patients with recurrent head and neck cancers treated with HDR interstitial brachytherapy. Material and methods: Twenty-five patients with recurrent head and neck cancers were treated with HDR interstitial brachytherapy using Iridium 192 between 2009 and 2016. Of these, 75% received radical brachytherapy, and 25% received external beam radiation therapy (EBRT) followed by brachytherapy boost. Treatment sites included oral cavity (15/25) and oropharynx (10/25). Median dose of 4.5 Gy was administered twice per day, with median total brachytherapy dose of 40.5 Gy in radical and 27 Gy for EBRT cases. Results: With median follow-up of 25 months, 4 local recurrences were observed within first year of follow-up. Two-year local control and overall survival outcomes for the entire group were 75% and 68%, respectively. Local control rate with radical BRT vs. BRT as a boost following EBRT was found to be significant (2-year LCR 62% vs. 85%; p < 0.02). Dosimetric assessment revealed D 90-4.08 Gy, V 100-94.1%, V 150-24.7%, and V 200-10.1%. Xerostomia, altered taste, and dysphagia were the major complications commonly grade 1 and 2. Grade 3 toxicity was only 2%. Pre-treatment volume > 85 cc had a negative impact on overall survival (26 months vs. 12 months; p = 0.02), and interval time between primary and recurrence more than 15 months had an impact on the local control rate (p < 0.01). Conclusions: Results of HDR interstitial brachytherapy have shown acceptable local control and overall survival rates along with tolerable toxicities and morbidity in recurrent head and neck cancers.

Research paper thumbnail of Intermittent Food Absence Motivates Reallocation of Locomotion and Feeding in Spotted Munia (Lonchura punctulata)

Journal of Circadian Rhythms, 2015

Background: Daily feeding and locomotion are interrelated behaviours. The time spent in feeding a... more Background: Daily feeding and locomotion are interrelated behaviours. The time spent in feeding and rate of food intake depends on food availability. In low food condition, the birds would show intense movement (locomotion) for a longer time throughout the day however during abundant food supply they may chose higher activity and food intake in the morning and evening only. In the present study we hypothesized that in Spotted Munia (Lonchura punctulata), intermittent food availability during day would reallocate their interrelated behaviors, the feeding (food intake) and locomotor activity patterns. Methods: Two groups of birds (N = 6 each) were kept individually in activity cages under 12L:12D. Group 1 (Control; C) had ad libitum food but group 2 (Treatment; T) had food for 6 hours only (2 h presence followed by 2 h absence; 2P:2A) during 12 hour light period. In the first week, group 2 received food with 'lights on' (TI; ZT 0-2, 4-6 and 8-10; where ZT 0= zeitgeber time 0, time of lights ON). In the following week, the food was given 2 hours after 'lights on' (TII; ZT 2-4, 6-8, 10-12). The food intake and locomotor activity under each condition were observed. Results: The results showed that locomotor activity was induced during food deprivation and suppressed during food availability. Also the food deprivation led to increased food intake. Conclusion: Our results suggest that intermittent food availability/ deprivation reallocates the locomotor activity and food intake in Spotted Munia.

Research paper thumbnail of Synthesis and X-ray crystallographic investigation of N-(α-d-arabinopyranosyl)alkanamides as N-glycoprotein linkage region analogs

Carbohydrate Research, 2013