Amy Douglas - Academia.edu (original) (raw)
Papers by Amy Douglas
Reciprocal crosses, both intraspecific and interspecific, were made among five Chilean species of... more Reciprocal crosses, both intraspecific and interspecific, were made among five Chilean species of Nolana (Solanaceae), a genus native to western South America. With the exception of N. paradoxa, plants of all species used were grown from mericarps collected from wild populations. Self-pollinations were generally not successful, suggesting obligate allogamy. A total of 333 hybridizations were performed, of which 109 were intraspecific and 224 interspecific. Successful intraspecific hybridizations, as measured by formation of fruits, were produced for N. acuminata (83%), N. elegans (94%), N. paradoxa (82%), and N. rupicola (100%), however viable hybrids were only obtained for N. paradoxa. Interspecific combinations resulted in over 80% fruit set, however, viable hybrid success ranged from only 1% to 5%. Crosses included N. elegans × N. paradoxa with 20 viable hybrids, N. paradoxa × N. elegans with two hybrids, N. paradoxa × N. rupicola with seven hybrids, and N. rupicola × N. paradoxa with five hybrids. Exceptions included crosses involving N. aplocaryoides, with up to 20% fruit set. Also, the combination N. paradoxa × N. aplocaryoides with five hybrids, had a 26% success. All interspecific hybrids obtained had N. paradoxa as one of the parents, which could be related to artificial selection for high germination frequency.
Differentiation, 1992
Abstract. Between days 36–38 of pregnancy equine trophoblastic cells of the chorionic girdle migr... more Abstract. Between days 36–38 of pregnancy equine trophoblastic cells of the chorionic girdle migrate and form endometrial cups. Just prior to invasion, the chorionic girdle cells express high levels of polymorphic, paternally inherited, major histocompatibility complex (MHC) class I antigens. Their descendents, the mature, invasive trophoblast cells of the endometrial cups, however, express low or undetectable levels of MHC class I antigens by day 44 of pregnancy. Experiments with MHC compatible pregnancies, the study of residual chorionic girdle cells that had failed to invade the endometrium and remained on the surface of a conceptus, and the study of chorionic girdle cells recovered on days 34–36 of pregnancy and then maintained in vitro for up to 24 days strongly suggest that the reduction of MHC class I antigen expression by mature invasive trophoblast cells of the endometrial cups is developmentally regulated. This phenomenon does not appear to be induced by a maternal antibody response or by other uterine factors acting after the chorionic girdle trophoblast cells invade the endometrium.
Disasters, 1995
Despite efforts made in the last few decades to improve disaster relief programs, there is still ... more Despite efforts made in the last few decades to improve disaster relief programs, there is still no uniform international reporting scheme for the documentation of morbidity and mortality incurred during disasters caused by flood. The Midwest flooding of the Mississippi and Missouri Rivers during the summer of 1993 served to remind us of further improvements required in flood and disaster aid programs. For appropriate provision of aid, it is necessary to have accurate information regarding injuries and illnesses sustained during and after the disaster. Such information guides planning efforts for tailored assistance programs following a specific type of disaster. Unfortunately, such data for specific types of disasters have been largely incomplete.
Journal of The American Pharmacists Association, 2008
J o u r n a l o f t h e A m e r i c a n P h a r m a c i s t s A s s o c i a t i o n w w w.japh a ... more J o u r n a l o f t h e A m e r i c a n P h a r m a c i s t s A s s o c i a t i o n w w w.japh a .org No v / De c 20 0 8 • 4 8 : 6 • JAPhA • 731
Brenham High School (Brenham, TX): Ellen Flenniken, Megan Flenniken Brentwood School (Los Anglele... more Brenham High School (Brenham, TX): Ellen Flenniken, Megan Flenniken Brentwood School (Los Angleles, CA): Emily Elson, Teddy Newmyer The Bromfield School (Harvard, MA): Charlie Broadbent, Margaret Cardenas, Hannah Nestler The Browning School (New York, NY): Stephan Wollenburg Brunswick High School (Brunswick, ME): Phillips Exeter Academy (Exeter, NH): Allison Lassiter, Lydia Peelle The Pingry School (Martinsville, NJ): Zarine Alam Pomfret School (Pomfret, CT):
Annals of Thoracic Surgery, 1995
Platelet transfusion and aprotinin administration improve platelet function and clinical hemostas... more Platelet transfusion and aprotinin administration improve platelet function and clinical hemostasis after extracorporeal circulation. To compare two methods of improving postoperative hemostasis, we preoperatively randomized 40 patients undergoing various open heart procedures into two groups. Group A included 20 patients who, immediately after bypass, received single-donor plateletpheresis concentrates collected from ABO-compatible donors (Baxter Autopheresis-C System). They were compared with 20 patients who received high-dose aprotinin (6 × 106 KIU) before and during cardiopulmonary bypass (group B). Group A patients showed significantly higher platelet count after single-donor plateletpheresis concentrate transfusion (157 ± 36 × 109/L compared with 118 ± 42 × 109/L (p < 0.05). However, platelet aggregation on extracellular matrix was better in group B (3.4 ± 0.7 versus 2.8 ± 0.9; p < 0.05). Total 24-hour blood loss and exposure to homologous blood products were significantly less in group B (396 ± 125 mL and 1.1 ± 1.6 units compared with 617 ± 233 mL and 5.4 ± 3.4 units; p < 0.01). Despite higher platelet count in patients after single-donor plateletpheresis concentrates transfusion, hemostasis in patients receiving aprotinin is better due to improved platelet function.
Reciprocal crosses, both intraspecific and interspecific, were made among five Chilean species of... more Reciprocal crosses, both intraspecific and interspecific, were made among five Chilean species of Nolana (Solanaceae), a genus native to western South America. With the exception of N. paradoxa, plants of all species used were grown from mericarps collected from wild populations. Self-pollinations were generally not successful, suggesting obligate allogamy. A total of 333 hybridizations were performed, of which 109 were intraspecific and 224 interspecific. Successful intraspecific hybridizations, as measured by formation of fruits, were produced for N. acuminata (83%), N. elegans (94%), N. paradoxa (82%), and N. rupicola (100%), however viable hybrids were only obtained for N. paradoxa. Interspecific combinations resulted in over 80% fruit set, however, viable hybrid success ranged from only 1% to 5%. Crosses included N. elegans × N. paradoxa with 20 viable hybrids, N. paradoxa × N. elegans with two hybrids, N. paradoxa × N. rupicola with seven hybrids, and N. rupicola × N. paradoxa with five hybrids. Exceptions included crosses involving N. aplocaryoides, with up to 20% fruit set. Also, the combination N. paradoxa × N. aplocaryoides with five hybrids, had a 26% success. All interspecific hybrids obtained had N. paradoxa as one of the parents, which could be related to artificial selection for high germination frequency.
Differentiation, 1992
Abstract. Between days 36–38 of pregnancy equine trophoblastic cells of the chorionic girdle migr... more Abstract. Between days 36–38 of pregnancy equine trophoblastic cells of the chorionic girdle migrate and form endometrial cups. Just prior to invasion, the chorionic girdle cells express high levels of polymorphic, paternally inherited, major histocompatibility complex (MHC) class I antigens. Their descendents, the mature, invasive trophoblast cells of the endometrial cups, however, express low or undetectable levels of MHC class I antigens by day 44 of pregnancy. Experiments with MHC compatible pregnancies, the study of residual chorionic girdle cells that had failed to invade the endometrium and remained on the surface of a conceptus, and the study of chorionic girdle cells recovered on days 34–36 of pregnancy and then maintained in vitro for up to 24 days strongly suggest that the reduction of MHC class I antigen expression by mature invasive trophoblast cells of the endometrial cups is developmentally regulated. This phenomenon does not appear to be induced by a maternal antibody response or by other uterine factors acting after the chorionic girdle trophoblast cells invade the endometrium.
Disasters, 1995
Despite efforts made in the last few decades to improve disaster relief programs, there is still ... more Despite efforts made in the last few decades to improve disaster relief programs, there is still no uniform international reporting scheme for the documentation of morbidity and mortality incurred during disasters caused by flood. The Midwest flooding of the Mississippi and Missouri Rivers during the summer of 1993 served to remind us of further improvements required in flood and disaster aid programs. For appropriate provision of aid, it is necessary to have accurate information regarding injuries and illnesses sustained during and after the disaster. Such information guides planning efforts for tailored assistance programs following a specific type of disaster. Unfortunately, such data for specific types of disasters have been largely incomplete.
Journal of The American Pharmacists Association, 2008
J o u r n a l o f t h e A m e r i c a n P h a r m a c i s t s A s s o c i a t i o n w w w.japh a ... more J o u r n a l o f t h e A m e r i c a n P h a r m a c i s t s A s s o c i a t i o n w w w.japh a .org No v / De c 20 0 8 • 4 8 : 6 • JAPhA • 731
Brenham High School (Brenham, TX): Ellen Flenniken, Megan Flenniken Brentwood School (Los Anglele... more Brenham High School (Brenham, TX): Ellen Flenniken, Megan Flenniken Brentwood School (Los Angleles, CA): Emily Elson, Teddy Newmyer The Bromfield School (Harvard, MA): Charlie Broadbent, Margaret Cardenas, Hannah Nestler The Browning School (New York, NY): Stephan Wollenburg Brunswick High School (Brunswick, ME): Phillips Exeter Academy (Exeter, NH): Allison Lassiter, Lydia Peelle The Pingry School (Martinsville, NJ): Zarine Alam Pomfret School (Pomfret, CT):
Annals of Thoracic Surgery, 1995
Platelet transfusion and aprotinin administration improve platelet function and clinical hemostas... more Platelet transfusion and aprotinin administration improve platelet function and clinical hemostasis after extracorporeal circulation. To compare two methods of improving postoperative hemostasis, we preoperatively randomized 40 patients undergoing various open heart procedures into two groups. Group A included 20 patients who, immediately after bypass, received single-donor plateletpheresis concentrates collected from ABO-compatible donors (Baxter Autopheresis-C System). They were compared with 20 patients who received high-dose aprotinin (6 × 106 KIU) before and during cardiopulmonary bypass (group B). Group A patients showed significantly higher platelet count after single-donor plateletpheresis concentrate transfusion (157 ± 36 × 109/L compared with 118 ± 42 × 109/L (p < 0.05). However, platelet aggregation on extracellular matrix was better in group B (3.4 ± 0.7 versus 2.8 ± 0.9; p < 0.05). Total 24-hour blood loss and exposure to homologous blood products were significantly less in group B (396 ± 125 mL and 1.1 ± 1.6 units compared with 617 ± 233 mL and 5.4 ± 3.4 units; p < 0.01). Despite higher platelet count in patients after single-donor plateletpheresis concentrates transfusion, hemostasis in patients receiving aprotinin is better due to improved platelet function.