Ananda Kumar C N - Academia.edu (original) (raw)

Ananda Kumar C N

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Sackler School of Medicine/American Program of Tel Aviv University School of Medicine

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Papers by Ananda Kumar C N

Research paper thumbnail of Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

Bioorganic & medicinal …, Jan 1, 2008

The semi-IPN hydrogels consisting of poly(methacrylic acid) and guar gum (GG) are prepared at roo... more The semi-IPN hydrogels consisting of poly(methacrylic acid) and guar gum (GG) are prepared at room temperature using water as solvent. 5-aminosalicylic acid (5-ASA) is entrapped in the hydrogel in the synthesis of hydrogel and all entrapment efficiencies are found above 85%. The hydrogel shows excellent pH-sensitivity. It exhibited minimum swelling in an acidic pH medium through the formation of a complex hydrogen-bonded structure and maximal swelling due to the electrostatic repulsion due to the ionization of the carboxylic groups in pH 7.4 medium. The degradation in vitro shows that the degree of degradation (R%) depended on the concentration of cross-linking agent and content of GG. The hydrogel shows a minimum release of 5-ASA due to the complex hydrogen bonded structure of the hydrogels in the medium of pH 2.2. The enzymatic degradation of hydrogels by cecal bacteria can accelerate the release of 5-ASA entrapped in the hydrogel in pH 7.4 medium.

Research paper thumbnail of Advances in microbial control of insect pests

... of Crop Pests 265 SS Hussaini Genetic Improvement of Entomopathogenic Nematodes for Insect Bi... more ... of Crop Pests 265 SS Hussaini Genetic Improvement of Entomopathogenic Nematodes for Insect Biocontrol 297 Christopher W. Brey, and Sarwar Hashmi Mathematical Models of Insect Pest Control 313 RA Norman, AC Fenton, JP Fairbairn, and PJ Hudson Index 323 XI ...

Research paper thumbnail of Medical management of cervical pregnancy-a report of two cases

Singapore medical journal, Jan 1, 2001

Cervical ectopic pregnancy is a rare life-threatening condition that can be managed conservativel... more Cervical ectopic pregnancy is a rare life-threatening condition that can be managed conservatively. In this report, the authors describe the use of systemic methotrexate and prostaglandin (sulprostone) in the management of two cases of viable cervical pregnancy. Both cases were successfully treated without the need for surgical intervention.

Research paper thumbnail of Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

Bioorganic & medicinal …, Jan 1, 2008

The semi-IPN hydrogels consisting of poly(methacrylic acid) and guar gum (GG) are prepared at roo... more The semi-IPN hydrogels consisting of poly(methacrylic acid) and guar gum (GG) are prepared at room temperature using water as solvent. 5-aminosalicylic acid (5-ASA) is entrapped in the hydrogel in the synthesis of hydrogel and all entrapment efficiencies are found above 85%. The hydrogel shows excellent pH-sensitivity. It exhibited minimum swelling in an acidic pH medium through the formation of a complex hydrogen-bonded structure and maximal swelling due to the electrostatic repulsion due to the ionization of the carboxylic groups in pH 7.4 medium. The degradation in vitro shows that the degree of degradation (R%) depended on the concentration of cross-linking agent and content of GG. The hydrogel shows a minimum release of 5-ASA due to the complex hydrogen bonded structure of the hydrogels in the medium of pH 2.2. The enzymatic degradation of hydrogels by cecal bacteria can accelerate the release of 5-ASA entrapped in the hydrogel in pH 7.4 medium.

Research paper thumbnail of Advances in microbial control of insect pests

... of Crop Pests 265 SS Hussaini Genetic Improvement of Entomopathogenic Nematodes for Insect Bi... more ... of Crop Pests 265 SS Hussaini Genetic Improvement of Entomopathogenic Nematodes for Insect Biocontrol 297 Christopher W. Brey, and Sarwar Hashmi Mathematical Models of Insect Pest Control 313 RA Norman, AC Fenton, JP Fairbairn, and PJ Hudson Index 323 XI ...

Research paper thumbnail of Medical management of cervical pregnancy-a report of two cases

Singapore medical journal, Jan 1, 2001

Cervical ectopic pregnancy is a rare life-threatening condition that can be managed conservativel... more Cervical ectopic pregnancy is a rare life-threatening condition that can be managed conservatively. In this report, the authors describe the use of systemic methotrexate and prostaglandin (sulprostone) in the management of two cases of viable cervical pregnancy. Both cases were successfully treated without the need for surgical intervention.

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