Anat Grinfeld - Academia.edu (original) (raw)

Papers by Anat Grinfeld

Research paper thumbnail of <p>Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature</p&gt

Journal of Pain Research, 2019

Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) a... more Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search failed to detect even one published manuscript, clearly documenting LESI induced arachnoiditis. This article presents two patients who received a transforaminal L5-S1 and two L3-L4 interlaminar LESIs. Although the presented patients developed clear radiological (MRI) findings of arachnoiditis, they were not accompanied by any improvement or deterioration in their clinical condition. The article also reviews the literature on the prevalence, pathogenesis, diagnosis, and clinical features of adhesive arachnoiditis. Literature suggests that adhesive arachnoiditis following LESIs is a rare entity, which-as seen in our patients-has clear radiological characteristics but uncertain pathogenesis. It has a large spectrum of clinical presentation, ranging from an incidental finding to a serious neurological sequela. In at least some patients with adhesive arachnoiditis following LESI, the radiological and clinical findings may fail to correlate with each other. In light of the fact that LESI is one of the most commonly performed procedures for managing LBP, clinicians should be aware of this rare yet existing entity.

Research paper thumbnail of Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Journal of Ultrasound in Medicine, May 28, 2022

Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes... more Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (&gt;65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted.

Research paper thumbnail of Withdrawal seizures vs on-medication seizures: an intracranial EEG recording case report

Acta Epileptologica

Background It has long been an interesting question of whether withdrawal seizures in epileptic p... more Background It has long been an interesting question of whether withdrawal seizures in epileptic patients differ from habitual seizures in terms of semiology and electrophysiology. Case presentation Here, we addressed this issue in a 40 year-old woman with drug-resistant focal epilepsy monitored by presurgical intracranial EEG. As a part of this routine pre-operative investigation, anti-seizure medications (ASMs) were halted; as a result, multiple withdrawal seizures were recorded before ASM readministration. During 4 days of invasive monitoring, we noticed three different phases in seizure organization: Acute withdrawal seizure (AWS): The first recorded seizure 10h after the implantation; the stabilized withdrawal seizures (SWS): seven habitual seizures recorded from 24h post implantation to readministration of ASMs; and the Non-withdrawal seizures (NWS): ten seizures recorded 24h after readministration of ASMs. AWS and SWS had the same semiology and same epileptic network, but the ...

Research paper thumbnail of List of Abstracts (1) Epileptic Seizures Prediction Based on ECG Signals Using Machine Learning Methods

The students aim to provide solutions that meet research and development needs in the Biomedical ... more The students aim to provide solutions that meet research and development needs in the Biomedical industries and research departments. Through working on their projects, students gained invaluable, hands-on experience. They had to work through technical challenges and adhere to strict standards comparable to those in a real-world setting. We believe that this hands-on experience engages graduates with the Biomedical industry and/or the wide variety of Biomedical research in a very strong way encouraging multidisciplinary work that is vital to the students’ futures.

Research paper thumbnail of Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature

Journal of Pain Research, 2019

Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) a... more Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search failed to detect even one published manuscript, clearly documenting LESI induced arachnoiditis. This article presents two patients who received a transforaminal L5-S1 and two L3-L4 interlaminar LESIs. Although the presented patients developed clear radiological (MRI) findings of arachnoiditis, they were not accompanied by any improvement or deterioration in their clinical condition. The article also reviews the literature on the prevalence, pathogenesis, diagnosis, and clinical features of adhesive arachnoiditis. Literature suggests that adhesive arachnoiditis following LESIs is a rare entity, which -as seen in our patients -has clear radiological characteristics but uncertain pathogenesis. It has a large spectrum of clinical presentation, ranging from an incidental finding to a serious neurological sequela. In at least some patients with adhesive arachnoiditis following LESI, the radiological and clinical findings may fail to correlate with each other. In light of the fact that LESI is one of the most commonly performed procedures for managing LBP, clinicians should be aware of this rare yet existing entity.

Research paper thumbnail of Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Journal of Ultrasound in Medicine

Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes... more Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (>65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted.

Research paper thumbnail of <p>Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature</p&gt

Journal of Pain Research, 2019

Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) a... more Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search failed to detect even one published manuscript, clearly documenting LESI induced arachnoiditis. This article presents two patients who received a transforaminal L5-S1 and two L3-L4 interlaminar LESIs. Although the presented patients developed clear radiological (MRI) findings of arachnoiditis, they were not accompanied by any improvement or deterioration in their clinical condition. The article also reviews the literature on the prevalence, pathogenesis, diagnosis, and clinical features of adhesive arachnoiditis. Literature suggests that adhesive arachnoiditis following LESIs is a rare entity, which-as seen in our patients-has clear radiological characteristics but uncertain pathogenesis. It has a large spectrum of clinical presentation, ranging from an incidental finding to a serious neurological sequela. In at least some patients with adhesive arachnoiditis following LESI, the radiological and clinical findings may fail to correlate with each other. In light of the fact that LESI is one of the most commonly performed procedures for managing LBP, clinicians should be aware of this rare yet existing entity.

Research paper thumbnail of Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Journal of Ultrasound in Medicine, May 28, 2022

Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes... more Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (&gt;65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted.

Research paper thumbnail of Withdrawal seizures vs on-medication seizures: an intracranial EEG recording case report

Acta Epileptologica

Background It has long been an interesting question of whether withdrawal seizures in epileptic p... more Background It has long been an interesting question of whether withdrawal seizures in epileptic patients differ from habitual seizures in terms of semiology and electrophysiology. Case presentation Here, we addressed this issue in a 40 year-old woman with drug-resistant focal epilepsy monitored by presurgical intracranial EEG. As a part of this routine pre-operative investigation, anti-seizure medications (ASMs) were halted; as a result, multiple withdrawal seizures were recorded before ASM readministration. During 4 days of invasive monitoring, we noticed three different phases in seizure organization: Acute withdrawal seizure (AWS): The first recorded seizure 10h after the implantation; the stabilized withdrawal seizures (SWS): seven habitual seizures recorded from 24h post implantation to readministration of ASMs; and the Non-withdrawal seizures (NWS): ten seizures recorded 24h after readministration of ASMs. AWS and SWS had the same semiology and same epileptic network, but the ...

Research paper thumbnail of List of Abstracts (1) Epileptic Seizures Prediction Based on ECG Signals Using Machine Learning Methods

The students aim to provide solutions that meet research and development needs in the Biomedical ... more The students aim to provide solutions that meet research and development needs in the Biomedical industries and research departments. Through working on their projects, students gained invaluable, hands-on experience. They had to work through technical challenges and adhere to strict standards comparable to those in a real-world setting. We believe that this hands-on experience engages graduates with the Biomedical industry and/or the wide variety of Biomedical research in a very strong way encouraging multidisciplinary work that is vital to the students’ futures.

Research paper thumbnail of Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature

Journal of Pain Research, 2019

Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) a... more Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search failed to detect even one published manuscript, clearly documenting LESI induced arachnoiditis. This article presents two patients who received a transforaminal L5-S1 and two L3-L4 interlaminar LESIs. Although the presented patients developed clear radiological (MRI) findings of arachnoiditis, they were not accompanied by any improvement or deterioration in their clinical condition. The article also reviews the literature on the prevalence, pathogenesis, diagnosis, and clinical features of adhesive arachnoiditis. Literature suggests that adhesive arachnoiditis following LESIs is a rare entity, which -as seen in our patients -has clear radiological characteristics but uncertain pathogenesis. It has a large spectrum of clinical presentation, ranging from an incidental finding to a serious neurological sequela. In at least some patients with adhesive arachnoiditis following LESI, the radiological and clinical findings may fail to correlate with each other. In light of the fact that LESI is one of the most commonly performed procedures for managing LBP, clinicians should be aware of this rare yet existing entity.

Research paper thumbnail of Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Feasibility of Magnetic Resonance‐Guided High‐Intensity‐Focused Ultrasound (MRgHIFU) Ablation of Stump Neuromas for the Relief of Chronic Postamputation Neuropathic Pain

Journal of Ultrasound in Medicine

Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes... more Up to 70% of limb amputees develop chronic postamputation neuropathic pain (CPANP) which includes phantom pain and residual limb neuropathic pain due to neuroma formation. CPANP often requires invasive procedures aimed at neuroma ablation. Five amputees received 6 noninvasive magnetic resonance‐guided high‐intensity‐focused ultrasound MRgHIFU treatments ExAblate®, Insightec, Tirat‐Carmel, Israel). Although ablative temperature (>65°C) at the neuroma was reached in only 1 patient, pain intensity dropped from 5.7 at baseline to 4.3 and back to 5.6 at 3 and 6 month follow‐up. Post‐treatment bone necrosis was demonstrated in 1 patient. Although no firm conclusion about the effectiveness of MRgHIFU for CPANP could be drawn, further studies are warranted.