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Placenta, 2021

INTRODUCTION Antenatal corticosteroids (ACS) are frequently used to reduce neonatal morbidity in ... more INTRODUCTION Antenatal corticosteroids (ACS) are frequently used to reduce neonatal morbidity in preterm births (PTBs). A 'rescue' dose of ACS can be administer, if the risk of PTB remains. Some reports indicated that repeated doses of ACS might impact placental histology and possibly its function. We aimed to study whether repeated doses of ACS effect placental histopathology and pregnancy outcome. METHODS The medical files and placental reports of all PTB, at 24-336/7 weeks, between Nov 2008-Dec 2019, were reviewed. The study population was divided into three groups; no-ACS (PTBs without ACS treatment), one-ACS (PTBs after a full or partial ACS course), and rescue-ACS (PTBs after a 'rescue' course of ACS). Placental lesions were classified according to "Amsterdam" criteria into maternal and fetal vascular malperfusion lesions, maternal and fetal inflammatory responses and chronic villitis. Placental lesions and pregnancy outcome were compared between the ...

The Journal of …, 2005

Randomized, double-blinded, controlled trial; 49 hospitalized infants with viral bronchiolitis, a... more Randomized, double-blinded, controlled trial; 49 hospitalized infants with viral bronchiolitis, age 2.75 ± 2.2 months (mean ± SD), were grouped to either the hood (n = 25) or the mask (n = 24). Each subject received inhalation treatments with the use of both devices. Half of the ...

The Israel Medical Association journal : IMAJ, 2006

We recently published preliminary evidence on the effectiveness of hypertonic saline in infants w... more We recently published preliminary evidence on the effectiveness of hypertonic saline in infants with viral bronchiolitis. To further establish the efficacy of nebulized hypertonic saline in these infants. In a continuing, second-year randomized, doubleblind controlled trial, an additional 41 infants (age 2.6 +/- 1 months) hospitalized with viral bronchiolitis were recruited during the winter of 2001-2002. The infants received inhalation of 1.5 mg epinephrine dissolved either in 4 ml normal (0.9%) saline (Group I, n=20) or 4 ml hypertonic (3%) saline (Group II, n=22). The therapy was repeated three times daily until discharge. Pooling our 2 years of experience (2000-2002), a total of 93 hospitalized infants with viral bronchiolitis were recruited; 45 were assigned to Group I and 48 to Group II. The clinical scores at baseline were 7.6 +/- 0.7 for Group I vs. 7.4 +/- 1.3 for Group II (P = NS). However, the clinical scores at days 1 and 2 after inhalation differed significantly between...

The Journal of Infectious Diseases, 2004

The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy in... more The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV.

The Journal of Pediatrics, 2005

Objectives To compare the utility of the hood versus the face mask for delivery of inhaled medica... more Objectives To compare the utility of the hood versus the face mask for delivery of inhaled medications to infants hospitalized with viral bronchiolitis.