Anchal Singhal - Academia.edu (original) (raw)
Papers by Anchal Singhal
RSC Advances, Dec 31, 2023
Rapid industrialization and agricultural development have resulted in the accumulation of a varie... more Rapid industrialization and agricultural development have resulted in the accumulation of a variety of harmful contaminants in water resources. Thus, various approaches such as adsorption, photocatalytic degradation and methods for sensing water contaminants have been developed to solve the problem of water pollution. Metal-organic frameworks (MOFs) are a class of coordination networks comprising organic-inorganic hybrid porous materials having organic ligands attached to inorganic metal ions/ clusters via coordination bonds. MOFs represent an emerging class of materials for application in water remediation owing to their versatile structural and chemical characteristics, such as well-ordered porous structures, large specific surface area, structural diversity, and tunable sites. The present review is focused on recent advances in various MOFs for application in water remediation via the adsorption and photocatalytic degradation of water contaminants. The sensing of water pollutants using MOFs via different approaches, such as luminescence, electrochemical, colorimetric, and surface-enhanced Raman spectroscopic techniques, is also discussed. The high porosity and chemical tunability of MOFs are the main driving forces for their widespread applications, which have huge potential for their commercial use.
Applications of Advanced Green Materials, 2021
Abstract Catalysis comprises the critical feature of green chemistry that brings out economic ben... more Abstract Catalysis comprises the critical feature of green chemistry that brings out economic benefit and environmental protection. The design and application of new greener and milder catalysts over traditional and hazardous ones offer numerous benefits, including atom economy, low energy requirement, simple purification procedures, increased selectivity, and pollution prevention. Different polymers, biopolymers, and clay materials are the most widely used green materials in catalysis applications. In the present chapter, an overview of the implementation of these green materials in various catalytic transformations has been demonstrated. These green materials promise excellent recovery and reusability in different catalytic processes as heterogeneous catalysts.
Smart Nanocontainers, 2020
Abstract A large number of chemicals intruded into the environment in the form of dyes, pesticide... more Abstract A large number of chemicals intruded into the environment in the form of dyes, pesticides, and heavy metals have become a prime cause of water pollution. The removal of organic and inorganic matter from water through adsorption is the major and widely used step in conventional water treatment processes. Recently, various magnetic nanoparticle-based nanocontainers have been developed for effective removal of a wide range of water pollutants. Magnetite nanoparticles represent the most promising materials with good adsorption efficiency for water remediation applications, which on further modification with carbon-based materials such as carbon nanotubes, graphene, calixarenes, β-cyclodextrin, polymer, and bio-based materials exhibit enhanced malleable competence. In this chapter the recent development in magnetite nanoparticle-based nanocontainers has been discussed in brief, and their application in water remediation has been demonstrated.
![Research paper thumbnail of Efficient Synthesis of Calix[4]phyrins Catalyzed by Amberlyst™-15 and Its Noncovalent Interactions with Neutral Molecules](https://attachments.academia-assets.com/95365578/thumbnails/1.jpg)
](Current Organic Chemistry, 2018
Letters in Organic Chemistry
Background: The calix[4]pyrrole is reported as a novel organocatalyst for regioselective ring ope... more Background: The calix[4]pyrrole is reported as a novel organocatalyst for regioselective ring opening of epoxides under mild reaction conditions. Methods: The reaction involves elemental halogen as a nucleophile to afford vicinal halohydrins in good to excellent yield (75-95%). Results : The reactivity of the halide anion in the reaction is governed by different factors, including solvent polarity, temperature and non-covalent interactions of the functional group present on calix[4]pyrrole moiety with halide ions. Conclusion: An efficient methodology has been developed for the regioselective synthesis of halohydrins in good to excellent yields.
Organic Preparations and Procedures International
Environmental Science and Pollution Research
Journal of Water Process Engineering
Anti-Cancer Agents in Medicinal Chemistry
: Hydrogels are water insoluble, hydrophilic, cross-linked, three dimensional networks of polymer... more : Hydrogels are water insoluble, hydrophilic, cross-linked, three dimensional networks of polymer chains having the ability to swell and absorb water but does not dissolve in it, that comprise the major difference between gels and hydrogels. The mechanical strength, physical integrity and solubility are offered by the crosslinks. The different applications of hydrogels can be derived based on the methods of their synthesis, response to different stimuli, and their different kinds. Hydrogels are highly biocompatible and have properties similar to human tissues that makes it suitable to be used in various biomedical applications including drug delivery and tissue engineering. The role of hydrogels in cancer therapy is highly emerging in recent years. In the present review, we highlighted different methods of synthesis of hydrogels and their classification based on different parameters. Distinctive applications of hydrogels in the treatment of cancer are also discussed.
Topics in Current Chemistry
Current Organic Synthesis
Background: Quinolines represent an important class of bioactive molecules which are present in v... more Background: Quinolines represent an important class of bioactive molecules which are present in various synthetic drugs, biologically active natural compounds and pharmaceuticals. Quinolines find their potential applications in various chemical and biomedical fields. Thereby, the demand for more efficient and simple methodologies for the synthesis of quinolines is growing rapidly. Objective: The green one-pot Friedlander Synthesis of Functionalized Quinolines has been demonstrated by using graphene oxide as a carbocatalyst. Method: The graphene oxide catalyzed condensation reaction of 2–aminoaryl carbonyl compounds with different cyclic/ acyclic/ aromatic carbonyl compounds in methanol at 70°C affords different quinoline derivatives. Results: The reaction has been examined in different protic and aprotic solvents and the best yield of quinoline is observed in methanol at 70°C. Conclusion: The present method of quinoline synthesis offers various advantages over other reported methods...
Current Medicinal Chemistry
Zika Virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes.... more Zika Virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes. The number of Zika virus caused cases of acute infections, neurological disorders and congenital microcephaly are rapidly growing and therefore, in 2016, the World Health Organization declared a global “Public Health Emergency of International Concern”. Anti-ZIKV therapeutic and vaccine development strategies are growing worldwide in recent years, however, no specific and safe treatment is available till date to save the human life. Currently, development of peptide therapeutics against ZIKV has attracted rising attention on account of their high safety concern and low development cost, in comparison to small therapeutic molecules and antibody-based anti-viral drugs. In present review, an overview of ZIKV inhibition by peptide-based inhibitors including E-protein derived peptides, antimicrobial peptides, frog skin peptides and probiotic peptides has been discussed. Peptides inhibitors h...
Current Medicinal Chemistry
Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge ... more Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring revolutionary advancement in cancer eradication process. Oncology is achieving new heights under nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy, bio imaging and gene therapy. Various nanovectors have been developed for targeted therapy which acts as "Nano-bullets" for tumour cells selectively. Recently combinational therapies are catching more attention due to their enhanced effect leading towards the use of combined organic-inorganic nano platforms. The current review covers organic, inorganic and their hybrid nanomaterials for various therapeutic action. The technological aspect of this review emphasizes on the use of inorganic-organic hybrids and combinational therapies for better results and also explores the future opportunities in this field.
Journal of Polymer Research
Inorganic chemistry, Jan 17, 2018
The synthesis of selenium and tellurium core-modified carbaporphyrinogens was carried out by the ... more The synthesis of selenium and tellurium core-modified carbaporphyrinogens was carried out by the reaction of functional selenophene/tellurophene diols with azulene or a benzitripyrrane in the presence of acid. The products were obtained in moderate yields and were characterized by using H and C NMR, UV-vis, FT-IR, CV, and HRMS spectroscopic techniques. Further, oxidation of the obtained core-modified carbaporphyrinogens in the presence of DDQ in CHCl afforded the corresponding carbaporphyrins in good yields. Benziporphyrins showed no indication of a ring current or macrocyclic aromaticity as confirmed by using proton NMR spectroscopy, but the addition of TFA gave rise to the formation of weakly diatropic dications.
Applied Organometallic Chemistry
Current topics in medicinal chemistry, Jan 30, 2017
The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their hor... more The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus is more dangerous for pregnant women as it is suspected to cause brain damage in babies by targeting their neuron cells. A less common but highly dangerous type of Dengue is the one which causes hemorrhagic fever (DHF) and shock syndrome (DSS) which are lethal. Chikungunya is not as lethal as Zika and Dengue are, but it triggers joints pain which could last for months and even for years. There...
RSC Advances, Dec 31, 2023
Rapid industrialization and agricultural development have resulted in the accumulation of a varie... more Rapid industrialization and agricultural development have resulted in the accumulation of a variety of harmful contaminants in water resources. Thus, various approaches such as adsorption, photocatalytic degradation and methods for sensing water contaminants have been developed to solve the problem of water pollution. Metal-organic frameworks (MOFs) are a class of coordination networks comprising organic-inorganic hybrid porous materials having organic ligands attached to inorganic metal ions/ clusters via coordination bonds. MOFs represent an emerging class of materials for application in water remediation owing to their versatile structural and chemical characteristics, such as well-ordered porous structures, large specific surface area, structural diversity, and tunable sites. The present review is focused on recent advances in various MOFs for application in water remediation via the adsorption and photocatalytic degradation of water contaminants. The sensing of water pollutants using MOFs via different approaches, such as luminescence, electrochemical, colorimetric, and surface-enhanced Raman spectroscopic techniques, is also discussed. The high porosity and chemical tunability of MOFs are the main driving forces for their widespread applications, which have huge potential for their commercial use.
Applications of Advanced Green Materials, 2021
Abstract Catalysis comprises the critical feature of green chemistry that brings out economic ben... more Abstract Catalysis comprises the critical feature of green chemistry that brings out economic benefit and environmental protection. The design and application of new greener and milder catalysts over traditional and hazardous ones offer numerous benefits, including atom economy, low energy requirement, simple purification procedures, increased selectivity, and pollution prevention. Different polymers, biopolymers, and clay materials are the most widely used green materials in catalysis applications. In the present chapter, an overview of the implementation of these green materials in various catalytic transformations has been demonstrated. These green materials promise excellent recovery and reusability in different catalytic processes as heterogeneous catalysts.
Smart Nanocontainers, 2020
Abstract A large number of chemicals intruded into the environment in the form of dyes, pesticide... more Abstract A large number of chemicals intruded into the environment in the form of dyes, pesticides, and heavy metals have become a prime cause of water pollution. The removal of organic and inorganic matter from water through adsorption is the major and widely used step in conventional water treatment processes. Recently, various magnetic nanoparticle-based nanocontainers have been developed for effective removal of a wide range of water pollutants. Magnetite nanoparticles represent the most promising materials with good adsorption efficiency for water remediation applications, which on further modification with carbon-based materials such as carbon nanotubes, graphene, calixarenes, β-cyclodextrin, polymer, and bio-based materials exhibit enhanced malleable competence. In this chapter the recent development in magnetite nanoparticle-based nanocontainers has been discussed in brief, and their application in water remediation has been demonstrated.
Current Organic Chemistry, 2018
Letters in Organic Chemistry
Background: The calix[4]pyrrole is reported as a novel organocatalyst for regioselective ring ope... more Background: The calix[4]pyrrole is reported as a novel organocatalyst for regioselective ring opening of epoxides under mild reaction conditions. Methods: The reaction involves elemental halogen as a nucleophile to afford vicinal halohydrins in good to excellent yield (75-95%). Results : The reactivity of the halide anion in the reaction is governed by different factors, including solvent polarity, temperature and non-covalent interactions of the functional group present on calix[4]pyrrole moiety with halide ions. Conclusion: An efficient methodology has been developed for the regioselective synthesis of halohydrins in good to excellent yields.
Organic Preparations and Procedures International
Environmental Science and Pollution Research
Journal of Water Process Engineering
Anti-Cancer Agents in Medicinal Chemistry
: Hydrogels are water insoluble, hydrophilic, cross-linked, three dimensional networks of polymer... more : Hydrogels are water insoluble, hydrophilic, cross-linked, three dimensional networks of polymer chains having the ability to swell and absorb water but does not dissolve in it, that comprise the major difference between gels and hydrogels. The mechanical strength, physical integrity and solubility are offered by the crosslinks. The different applications of hydrogels can be derived based on the methods of their synthesis, response to different stimuli, and their different kinds. Hydrogels are highly biocompatible and have properties similar to human tissues that makes it suitable to be used in various biomedical applications including drug delivery and tissue engineering. The role of hydrogels in cancer therapy is highly emerging in recent years. In the present review, we highlighted different methods of synthesis of hydrogels and their classification based on different parameters. Distinctive applications of hydrogels in the treatment of cancer are also discussed.
Topics in Current Chemistry
Current Organic Synthesis
Background: Quinolines represent an important class of bioactive molecules which are present in v... more Background: Quinolines represent an important class of bioactive molecules which are present in various synthetic drugs, biologically active natural compounds and pharmaceuticals. Quinolines find their potential applications in various chemical and biomedical fields. Thereby, the demand for more efficient and simple methodologies for the synthesis of quinolines is growing rapidly. Objective: The green one-pot Friedlander Synthesis of Functionalized Quinolines has been demonstrated by using graphene oxide as a carbocatalyst. Method: The graphene oxide catalyzed condensation reaction of 2–aminoaryl carbonyl compounds with different cyclic/ acyclic/ aromatic carbonyl compounds in methanol at 70°C affords different quinoline derivatives. Results: The reaction has been examined in different protic and aprotic solvents and the best yield of quinoline is observed in methanol at 70°C. Conclusion: The present method of quinoline synthesis offers various advantages over other reported methods...
Current Medicinal Chemistry
Zika Virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes.... more Zika Virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes. The number of Zika virus caused cases of acute infections, neurological disorders and congenital microcephaly are rapidly growing and therefore, in 2016, the World Health Organization declared a global “Public Health Emergency of International Concern”. Anti-ZIKV therapeutic and vaccine development strategies are growing worldwide in recent years, however, no specific and safe treatment is available till date to save the human life. Currently, development of peptide therapeutics against ZIKV has attracted rising attention on account of their high safety concern and low development cost, in comparison to small therapeutic molecules and antibody-based anti-viral drugs. In present review, an overview of ZIKV inhibition by peptide-based inhibitors including E-protein derived peptides, antimicrobial peptides, frog skin peptides and probiotic peptides has been discussed. Peptides inhibitors h...
Current Medicinal Chemistry
Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge ... more Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring revolutionary advancement in cancer eradication process. Oncology is achieving new heights under nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy, bio imaging and gene therapy. Various nanovectors have been developed for targeted therapy which acts as "Nano-bullets" for tumour cells selectively. Recently combinational therapies are catching more attention due to their enhanced effect leading towards the use of combined organic-inorganic nano platforms. The current review covers organic, inorganic and their hybrid nanomaterials for various therapeutic action. The technological aspect of this review emphasizes on the use of inorganic-organic hybrids and combinational therapies for better results and also explores the future opportunities in this field.
Journal of Polymer Research
Inorganic chemistry, Jan 17, 2018
The synthesis of selenium and tellurium core-modified carbaporphyrinogens was carried out by the ... more The synthesis of selenium and tellurium core-modified carbaporphyrinogens was carried out by the reaction of functional selenophene/tellurophene diols with azulene or a benzitripyrrane in the presence of acid. The products were obtained in moderate yields and were characterized by using H and C NMR, UV-vis, FT-IR, CV, and HRMS spectroscopic techniques. Further, oxidation of the obtained core-modified carbaporphyrinogens in the presence of DDQ in CHCl afforded the corresponding carbaporphyrins in good yields. Benziporphyrins showed no indication of a ring current or macrocyclic aromaticity as confirmed by using proton NMR spectroscopy, but the addition of TFA gave rise to the formation of weakly diatropic dications.
Applied Organometallic Chemistry
Current topics in medicinal chemistry, Jan 30, 2017
The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their hor... more The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus is more dangerous for pregnant women as it is suspected to cause brain damage in babies by targeting their neuron cells. A less common but highly dangerous type of Dengue is the one which causes hemorrhagic fever (DHF) and shock syndrome (DSS) which are lethal. Chikungunya is not as lethal as Zika and Dengue are, but it triggers joints pain which could last for months and even for years. There...