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Papers by Anderson Camargo

Behavioural Brain Research, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Esta pesquisa tem como objetivo principal apresentar um comparativo entre tres tecnicas de cobert... more Esta pesquisa tem como objetivo principal apresentar um comparativo entre tres tecnicas de coberturas com diferentes telhas muito utilizadas no Brasil, sao elas com telhas metalicas termoisolantes, policarbonato e fibrocimento. A metodologia utilizada nesta pesquisa e o metodo indutivo, que se classifica como pesquisa experimental. Utilizando o metodo de testes em ambiente reduzido nao normatizados, a pesquisa de custo para as diferentes tecnicas. A populacao alvo a ser abordado nessa pesquisa sao todas as telhas que sao utilizadas para cobertura em telhados. Em relacao a analise e interpretacao de dados classifica-se essa pesquisa como sendo quantitativa. No quesito resultados da pesquisa foram executadas todas as tecnicas abordadas nessa pesquisa que seriam para coberturas com telhas metalicas termoisolantes, com telhas de policarbonato e telhas de fibrocimento verificando a produtividade, custo e eficiencia termica. Para tanto foram desenvolvidos testes para comprovar a eficienci...

World Journal of Psychiatry, 2021

Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well as a co... more Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have all been shown to play crucial roles in the pathophysiology of MDD. Although conventional antidepressants are widely used in the clinic, they can take weeks to months to produce therapeutic effects. The discovery that ketamine promotes fast and sustaining antidepressant responses is one of the most important breakthroughs in the pharmacotherapy of MDD. However, the adverse psychomimetic/dissociative and neurotoxic effects of ketamine discourage its chronic use. Therefore, agmatine, an endogenous glutamatergic modulator, has been postulated to elicit fast behavioral and synaptogenic effects by stimulating the mechanistic target of rapamycin complex 1 signaling pathway, similar to ketamine. However, recent evidence has demonstrated that the modulation of the NLR family pyrin domain containing 3 inflammasome and gut microbiota, which have been shown to play a crucial role in the pathophysiology of MDD, may also participate in the antidepressant-like effects of both ketamine and agmatine. This review seeks to provide evidence about the mechanisms that may underlie the fast antidepressant-like responses of agmatine in preclinical studies. Considering the anti-inflammatory properties of agmatine, it may also be further investigated as a useful compound for the management of MDD associated with a pro-inflammatory state. Moreover, the fast antidepressant-like response of agmatine noted in animal models should be investigated in clinical studies.

Natural Product Research, 2021

Considering the drawbacks elicited by the conventional antidepressants, the interest in natural p... more Considering the drawbacks elicited by the conventional antidepressants, the interest in natural products for the management of major depressive disorder (MDD) has increased in the last years. Therefore, this study investigated the phenolic profile of Maclura tinctoria leaf aqueous extract (MtAE) and its possible antidepressant-like effect in mice. The LC-MS/MS analysis demonstrated MtAE has epicatechin as the major phenolic, followed by catechin, gallic acid, quercetin, syringaldehyde, ferulic acid, and syringic acid. Moreover, the acute treatment of MtAE elicited an antidepressant-like response in mice. Importantly, this antidepressant-like effect produced by MtAE was reinforced in the chronic corticosterone (20 mg/kg p.o.) administration model. MtAE treatment was also effective to protect hippocampal

Metabolic Brain Disease, 2020

Amyloid beta (Aβ), one of the main hallmarks of Alzheimer’s Disease (AD), may stimulate pattern r... more Amyloid beta (Aβ), one of the main hallmarks of Alzheimer’s Disease (AD), may stimulate pattern recognition receptors (PRR) such as the NLRP3 inflammasome, inducing a pro-inflammatory state in the brain that contributes to disease development. Physical exercise can have multiple beneficial effects on brain function, including anti-inflammatory and neuroprotective roles. The objective of this study was to investigate the prophylactic effect of moderate treadmill exercise for 4 weeks on inflammatory events related to NLRP3 signaling in the hippocampus of mice after intracerebroventricular Aβ 1−40 administration. Our results show that Aβ 1−40 administration (400 pmol/mouse, i.c.v.) significantly increased the immunocontent Iba-1 (a microglial reactivity marker), NLRP3, TXNIP, and caspase-1 in the hippocampus of mice. However, physical exercise prevented the hippocampal increase in Iba-1, TXNIP, and activation of the NLRP3 inflammasome pathway caused by Aβ 1−40 . Moreover, physical exercise per se reduced the TXNIP and caspase-1 immunocontent in the hippocampus. No alterations were observed on the immunocontent of GFAP, ASC, and IL-1β in the hippocampus after Aβ 1−40 and/or physical exercise. These results reinforce the role of NLRP3 inflammasome pathway in AD and point to physical exercise as a possible non-pharmacological strategy to prevent inflammatory events triggered by Aβ 1−40 in mice.

Revista Ecuatoriana de Neurologia, 2021

El trastorno depresivo mayor (TDM) es un trastorno neuropsiquiátrico debilitante que afecta más d... more El trastorno depresivo mayor (TDM) es un trastorno neuropsiquiátrico debilitante que afecta más de 300 millones de personas, causando una enorme carga socioeconómica. Pocos datos con conocidos sobre la prevalencia del TDM en el Ecuador. Así, el objetivo de ese estudio fue describir la prevalencia del TDM en la población de un cantón altamente poblado de la costa ecuatoriana. Este estudio de base poblacional se realizó en Portoviejo, Manabí. Aquí se analizaron 114.239 registros sobre TDM mediante la entrevista Clínica Estructurada para el Diagnóstico de Trastornos del DSM-IV en personas jóvenes, adultos y adultos mayores. Nosotros observamos que en la población estudiada 8.6% tenían el TDM. Fueran adecuados los puntajes del TDM leve y de ubicación de residencia (zona urbana o rural). Ambos modelos tenían un buen estándar de ajuste (R2 = 0,91 y 0,95) y un valor p medio de 0,04 para ambas ubicaciones. También se demostró una correlación positiva significativa entre el estado civil y la...

Psychopharmacology, 2021

RATIONALE Guanosine has been shown to potentiate ketamine's antidepressant-like actions, alth... more RATIONALE Guanosine has been shown to potentiate ketamine's antidepressant-like actions, although its ability to augment the anxiolytic effect of ketamine remains to be determined. OBJECTIVE This study investigated the anxiolytic-like effects of a single administration with low doses of ketamine and/or guanosine in mice subjected to chronic administration of corticosterone and the role of NLRP3-driven signaling. METHODS Corticosterone (20 mg/kg, p.o.) was administered for 21 days, followed by a single administration of ketamine (0.1 mg/kg, i.p.), guanosine (0.01 mg/kg, p.o.), or ketamine (0.1 mg/kg, i.p.) plus guanosine (0.01 mg/kg, p.o.). Anxiety-like behavior and NLRP3-related targets were analyzed 24 h following treatments. RESULTS Corticosterone reduced the time spent in the open arms and the central zone in the elevated plus-maze test and open-field test, respectively. Corticosterone raised the number of unsupported rearings and the number and time of grooming, and decreased the latency to start grooming in the open-field test. Disturbances in regional distribution (increased rostral grooming) and grooming transitions (increased aborted and total incorrect transitions) were detected in corticosterone-treated mice. These behavioral alterations were accompanied by increased immunocontent of Iba-1, ASC, NLRP3, caspase-1, TXNIP, and IL-1β in the hippocampus, but not in the prefrontal cortex. The treatments with ketamine, guanosine, and ketamine plus guanosine were effective to counteract corticosterone-induced anxiety-like phenotype, but not disturbances in the hippocampal NLRP3 pathway. CONCLUSIONS Our study provides novel evidence that low doses of ketamine and/or guanosine reverse corticosterone-induced anxiety-like behavior and shows that the NLRP3 inflammasome pathway is likely unrelated to this response.

Experimental Neurology, 2020

Ketamine has been reported to exert a prophylactic effect against stress-induced depressive-like ... more Ketamine has been reported to exert a prophylactic effect against stress-induced depressive-like behavior by modulating the guanosine-based purinergic system. However, the molecular pathways underlying its prophylactic effect and whether guanosine also elicits a similar effect remain to be determined. Here, we investigated the prophylactic effect of ketamine and guanosine against corticosterone (CORT-20 mg/kg, p.o.)-induced depressive-like behavior in mice. Furthermore, we characterized if the prophylactic response may be associated with mTORC1-driven signaling in the hippocampus and prefrontal cortex. A single administration of ketamine (5 mg/kg, i.p.), but not guanosine (1 or 5 mg/kg, p.o.), given 1 week before the pharmacological stress prevented CORT-induced depressive-like behavior in the tail suspension test (TST) and splash test (SPT). Fluoxetine treatment for 3 weeks did not prevent CORT-induced behavioral effects. A single administration of subthreshold doses of ketamine (1 mg/kg, i.p.) plus guanosine (5 mg/kg, p.o.) partially prevented the CORT-induced depressive-like behavior in the SPT. Additionally, CORT reduced Akt (Ser 473) and GSK-3β (Ser 9) phosphorylation and PSD-95, GluA1, and synapsin immunocontent in the hippocampus, but not in the prefrontal cortex. No alterations on mTORC1/p70S6K immunocontent were found in both regions in any experimental group. CORTinduced reductions on PSD-95, GluA1, and synapsin immunocontent were prevented only by ketamine treatment. Collectively, these findings suggest that ketamine, but not guanosine, exerts a prophylactic effect against depressive-like behavior, an effect associated with the stimulation of long-lasting pro-synaptogenic signaling in the hippocampus.

Metabolic Brain Disease, 2021

Emerging evidence has shown that ursolic acid exerts antidepressant-like effects, however, its ab... more Emerging evidence has shown that ursolic acid exerts antidepressant-like effects, however, its ability to elicit an antidepressant-like response in rodents subjected to stress model that mimics behavioral and neurochemical alterations found in depression remains to be determined. Thus, this study investigated the possible antidepressant-like effect of ursolic acid in mice subjected to chronic unpredictable stress (CUS) for 14 days, and whether this effect could be associated with the modulation of serum corticosterone levels and hippocampal Bcl-2/Bax mRNA expression. Our results indicated that CUS induced a depressive-like behavior, as demonstrated by an increase in the immobility time and latency to first grooming in the tail suspension test and splash test, respectively. Conversely, the repeated administration of ursolic acid (0.1 mg/kg, p.o.) or fluoxetine (10 mg/kg, p.o.) in the last 7 days of CUS completely prevented CUS-induced behavioral alterations, suggesting an antidepressant-like effect. Additionally, CUS significantly increased the mRNA expression of Bax (pro-apoptosis marker), but not Bcl-2 (anti-apoptosis marker) in the hippocampus. Moreover, reduced hippocampal mRNA expression of Bcl-2/Bax ratio was detected in CUS-exposed mice. Ursolic acid, but not fluoxetine, prevented CUS-induced increase in the expression of Bax, but both ursolic acid and fluoxetine prevented CUS-induced reduction on Bcl-2/Bax ratio. Furthermore, neither CUS nor treatments with ursolic acid or fluoxetine altered serum corticosterone levels. Our study unveils the ability of ursolic acid to prevent the depressive-like behavior induced by stress and the modulation of Bcl-2/Bax expression could be associated with this response.

Pharmacology Biochemistry and Behavior, 2020

Several attempts have been made to understand the role of cholecalciferol (vitamin D 3) in the mo... more Several attempts have been made to understand the role of cholecalciferol (vitamin D 3) in the modulation of neuropsychiatric disorders. Notably, the deficiency of vitamin D 3 is considered a pandemic and has been postulated to enhance the risk of major depressive disorder (MDD). Therefore, this study aims to investigate the antidepressant-like effect of cholecalciferol in a mouse model of depression induced by corticosterone, and the possible role of glucocorticoid receptors (GR), NLRP3 and autophagic pathways in this effect. Corticosterone administration (20 mg/kg, p.o., for 21 days) significantly increased the immobility time and grooming latency, as well as reduced the total time spent grooming in mice subjected to the tail suspension test (TST) and splash test (ST), respectively. Importantly, these behavioral alterations were associated with reduced GR immunocontent in the hippocampus of mice. Conversely, the repeated administration of cholecalciferol (2.5 μg/kg, p.o.) in the last 7 days of corticosterone administration was effective to prevent the increased immobility time in the TST and the reduced time spent grooming in the ST, and partially abolished the increase in the grooming latency induced by corticosterone, suggesting its antidepressant-like effect. These behavioral effects were similar to those exerted by fluoxetine (10 mg/kg, p.o.). Moreover, the corticosterone-induced reduction on hippocampal GR immunocontent was not observed in mice treated with cholecalciferol. Additionally, cholecalciferol treatment per se reduced the immunocontent of NLRP3 inflammasome-related proteins ASC, caspase-1, and TXNIP in the hippocampus of mice. No alterations on hippocampal immunocontent of the autophagic-related proteins phospho-mTORC1, beclin-1, and LC3A/B were observed following cholecalciferol treatment and/or corticosterone administration. Collectively, our results provide insights into the effects of cholecalciferol in depressionrelated behaviors that seem to be related, at least in part, to GR modulation.

Neurochemistry International, 2020

Journal of Affective Disorders, 2020

Background Augmentation therapies may be effective strategies to potentiate the ketamine's action... more Background Augmentation therapies may be effective strategies to potentiate the ketamine's actions with lower potential for knock-on effects. Thus, this study investigated the ability of combined administration of guanosine plus ketamine to elicit an antidepressant-like effect associated with mTOR pathway modulation. The ability of this combined administration to exert an antidepressant-like effect in a model of depression was also evaluated. Methods Mice were administered with subthreshold doses of ketamine (0.1 mg/kg, i.p.) and guanosine (0.01 mg/kg, p.o.) and submitted to the tail suspension test, and immunoblotting analyses (p-mTOR, p-p70S6K, PSD-95, GluA1, and synapsin) in the hippocampus and prefrontal cortex. The antidepressant-like effect of ketamine plus guanosine in mice subjected to administration of corticosterone (20 mg/kg, p.o., 21 days) was also evaluated. Results Ketamine plus guanosine treatment elicited an antidepressant-like effect, which was associated with increased mTOR (Ser 2448) and p70S6K (Thr 389) phosphorylation in the hippocampus, but not in the prefrontal cortex. Furthermore, increased PSD-95 and GluA1 immunocontent were observed in the prefrontal cortex, but not in the hippocampus of ketamine plus guanosine-treated mice. Reinforcing the notion that guanosine may potentiate the ketamine's behavioral response, a single administration of subthreshold doses of ketamine plus guanosine counteracted the corticosterone-induced depressive-like behavior. Conclusions Our results indicate that guanosine potentiates the antidepressant-like effect of subthreshold doses of ketamine, an effect likely associated with the stimulation of synaptogenic pathway in the hippocampus and prefrontal cortex, although with a different profile. The augmentation effect of ketamine by guanosine could have therapeutic relevance for patients with treatment-resistant depression.

Anais da Academia Brasileira de Ciências, 2020

Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) extract has been demonstrated hypol... more Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) extract has been demonstrated hypolipidemic and antioxidant capacity. Herein, we investigated the effect of red cabbage aqueous extract (RC) or fenofi brate (FF) in oxidative stress induced by Triton WR-1339 in rats. The antioxidant capacity was evaluated through the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities and, thiobarbituric reactive species (TBARS) and protein carbonyl (PC) levels in erythrocytes, liver, kidneys, cerebral cortex and hippocampus of male rats. The alterations promoted by Triton WR-1339 in enzymatic antioxidant defense in the liver, kidneys and hippocampus were reversed by RC or FF treatments. The TBARS and PC levels increased in the liver, cerebral cortex and hippocampus of hyperlipidemic rats were decreased by the treatments with RC or FF. These fi ndings demonstrated that RC is a potential therapy to treat diseases not only involving dyslipidemic condition but also oxidative stress.

Brazilian Journal of Health Review, 2020

RESUMO Nosso grupo de pesquisa tem investigado os efeitos anti-inflamatório e tipo-antidepressivo... more RESUMO Nosso grupo de pesquisa tem investigado os efeitos anti-inflamatório e tipo-antidepressivo do plumierídeo (PLU-0,5, 1 e 2 µg/Kg). Contudo, não há evidências na literatura científica quanto a atividade antioxidante do PLU quando usado em doses extremamente baixas, que podem ser relacionados aos seus efeitos farmacológicos. Neste estudo, foi administrado PLU (0,5, 1 e 2 µg/Kg) à camundongos durante 7 dias. Posteriormente, nós avaliados a capacidade do PLU em modular a lipoperoxidação, nitritos, carbonilação de proteínas e tióis não-proteicos no cérebro, plasma, fígado e rins dos camundongos. Nossos resultados fundamentam, pelo menos em parte, o potencial farmacológico que tem sido atribuído ao iridoide.

Journal of Neural Transmission, 2020

Physical exercise has been shown to exert antidepressant effects, but the mechanisms underlying t... more Physical exercise has been shown to exert antidepressant effects, but the mechanisms underlying this effect are not completely elucidated. Therefore, we aimed at investigating the antidepressant, pro-neurogenic, and neuroprotective effects of physical exercise and the possible role of FNDC5/irisin for this effect. Treadmill running was used as a protocol of physical exercise (45 min/day/5 days/week for 4 weeks) in female Swiss mice. Immobility time was registered in the tail suspension test (TST) and forced swim test (FST). Immunohistochemical analyses to evaluate hippocampal cell proliferation, neuronal survival, and neuronal commitment and maturation, as well as expression of FNDC5 C-terminal fragment were performed in the entire, dorsal, and ventral dentate gyrus (DG) of the hippocampus. Fluoro-Jade B staining was performed to evaluate degenerating neurons in DG. FNDC5 C-terminal and FNDC5/irisin immunocontents were analyzed by western blot. Exposure to physical exercise reduced the immobility time both in the TST and the FST. This antidepressant-like effect was accompanied by an increase in hippocampal cell proliferation, hippocampal neuronal differentiation, and neuronal survival in the dorsal and ventral DG. Fluoro-Jade B staining was reduced in entire and dorsal DG in exercised mice. Finally, physical exercise also resulted in increased number of FNDC5-positive cells in the hippocampal DG as well as elevated FNDC5 C-terminal and FNDC5/irisin immunocontent in the entire hippocampus. The results suggest that the FNDC5 C-terminal fragment/irisin pathway may be implicated in the antidepressant-like, pro-neurogenic, and neuroprotective effects of treadmill running.

Chemico-Biological Interactions, 2019

Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with g... more Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investigate the antidepressant-like and neuroprotective effects of Morus nigra (MN) and its major phenolic, syringic acid (SA), against glutamate-induced damage, as well as, the role of the PI3K/Akt/GSK-3β signaling pathway in these effects. Treatment with MN (3 mg/kg) and SA (1 mg/kg) for 7 days, similar to fluoxetine (10 mg/kg), triggered an antidepressant-like effect. Moreover, the treatments evoked neuroprotection against glutamatergic excitotoxicity in hippocampal slices, and MN treatment also afforded protection in cerebrocortical slices. Notably, ex vivo neuroprotective effect of MN and SA was mediated, at least in part, by PI3K/Akt/GSK-3β signaling pathway. Furthermore, the ability of MN and SA to counteract the glutamate-induced damage were evaluated in three different in vitro experiments. The hippocampal slices pretreated with MN (0.05 and 0.1 μg/mL) or SA (0.01-0.1 μg/mL) as well as the concomitant treatment with MN (0.01 and 0.05 μg/mL) or SA (0.05 and 0.1 μg/ mL) exhibited protection against glutamate toxicity. Interestingly, post-treatment with MN in all doses (0.01-0.1 μg/mL) and SA at dose of 0.1 μg/mL were capable of preventing glutamate-induced cell death. In vitro neuroprotective effect of SA, but not MN, involves the activation of Akt, since the pretreatment with LY294002 completely abolished the protective effect. Overall, MN and SA presented antidepressant-like and neuroprotective effects against glutamatergic excitotoxicity via PI3K/Akt/GSK-3β.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019

Industrial Crops and Products, 2018

Morus nigra L. has demonstrated a wide range of biological properties potentially related to its ... more Morus nigra L. has demonstrated a wide range of biological properties potentially related to its antioxidant capacity. However, there are a few investigations on climate seasonal variation impacting on the phytocompounds yield. The monitoring of seasonal influences is a promising research area to optimize the specific production of metabolites. This study evaluated the seasonal phytochemical profile and antioxidant activity of the M. nigra leaves (MN), thereby correlating with climatic data during the period of two years. Furthermore, the cytotoxicity and the antioxidant effect of MN extract and its major compound, syringic acid (SA), against H 2 O 2 were determined. The MN recorded diverse seasonal tendencies in their phytocompounds production, since the higher concentration of total phenolics was observed in the Summer/2016, flavonoids and carotenoids in the Spring/2014 and 2015, respectively, whilst the ascorbic acid was more abundant in the Autumn/2014. However, the Pearson's correlation revealed weak to moderate influence of the climate parameters on the phytoconstituents measured. Indeed, both DPPH-scavenging and β-carotene/linoleic acid co-oxidation assays demonstrated a high antioxidant activity of MN correlated to the polyphenolic index. The MN and SA did not present cytotoxicity, since L929 cells treated with different concentrations maintain the cell viability. Moreover, the doses of the MN (3-30 μg/mL) and SA (60-250 μg/mL) were able to reduce the mortality induced by H 2 O 2 demonstrated in both, MTT and LDH assays. The leaves of MN could be an antioxidant source of potential use in food and supplements for either human or animal production due to its attractive biomass yield, palatability and nutritional value.

Journal of Psychiatric Research, 2019

The ketamine's potential for the treatment of refractory depression and anxiety has been consider... more The ketamine's potential for the treatment of refractory depression and anxiety has been considered one the most important discoveries in the last years, however, repeated use of ketamine is limited due to its side/adverse effects. Therefore, the search for effective augmentation strategies that may reduce ketamine doses is welcome. Therefore, this study sought to augment the effect of ketamine by guanosine in the novelty-suppressed feeding (NSF) test, a behavioral paradigm able to detect depression/anxiety-related behavior. Acute administration of guanosine (0.05 mg/kg, p.o.), similar to ketamine (1 mg/kg, i.p.), produced a rapid behavioral response in mice submitted to NSF test. Moreover, the coadministration of sub-effective doses of guanosine (0.01 mg/kg, p.o.) and ketamine (0.1 mg/kg, i.p.) was effective in mice submitted to NSF test. Subsequently, the intracellular mechanism underpinning the augmentation effect of ketamine by guanosine was investigated. Our results suggest that augmentation response of ketamine by guanosine in the NSF test probably involves the activation of mTOR signaling, since the treatment with rapamycin (0.2 nmol/site, i.c.v., a selective mTOR inhibitor) completely abolished this effect. This augmentation strategy also increased mTOR phosphorylation (Ser 2448) in the hippocampus, reinforcing the role of mTOR in this augmentation response. However, no changes in the p70S6K, PSD-95, GluA1, and synapsin immunocontents were found in the hippocampus of ketamine plus guanosine-treated mice. Overall, results provide evidence that guanosine is able to augment the effect of ketamine in the NSF test via mTOR activation, a finding that might have therapeutic implications for the management of depression/anxiety.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019

Alzheimer's disease (AD) is characterized by progressive cognitive impairments as well as non-cog... more Alzheimer's disease (AD) is characterized by progressive cognitive impairments as well as non-cognitive symptoms such as depressed mood. Physical exercise has been proposed as a preventive strategy against AD and depression, an effect that may be related, at least partially, to its ability to prevent impairments on cell proliferation and neuronal survival in the hippocampus, a structure implicated in both cognition and affective behavior. Here, we investigated the ability of treadmill exercise (4 weeks) to counteract amyloid β 1-40 peptideinduced depressive-like and anxiety-like behavior in mice. Moreover, we addressed the role of the BDNF/mTOR intracellular signaling pathway as well as hippocampal cell proliferation and survival in the effects of physical exercise and/or Aβ 1-40. Aβ 1-40 administration (400 pmol/mouse, i.c.v.) increased immobility time and reduced the latency to immobility in the forced swim test, a finding indicative of depressive-like behavior. In addition, Aβ 1-40 administration also decreased time spent in the center of the open field and

Behavioural Brain Research, 2021

World Journal of Psychiatry, 2021

Natural Product Research, 2021

Metabolic Brain Disease, 2020

Revista Ecuatoriana de Neurologia, 2021

Psychopharmacology, 2021

Experimental Neurology, 2020

Metabolic Brain Disease, 2021

Pharmacology Biochemistry and Behavior, 2020

Neurochemistry International, 2020

Journal of Affective Disorders, 2020

Anais da Academia Brasileira de Ciências, 2020

Brazilian Journal of Health Review, 2020

Journal of Neural Transmission, 2020

Chemico-Biological Interactions, 2019

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019

Industrial Crops and Products, 2018

Journal of Psychiatric Research, 2019

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019