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Papers by Andrea Mendonca Gusmao Cunha

Research paper thumbnail of Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Multiple Myeloma

Acta Haematologica, Feb 1, 2001

... Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Mult... more ... Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Multiple Myeloma A. Cunha a , SC ... Fernando F. Costa Hemocentro – UNICAMP Cidade Universitária Zeferino Vaz Caixa Postal 6198, CEP Campinas, SP, 13083-970 (Brazil) Tel. ...

Research paper thumbnail of Active Cytomegalovirus (CMV) Infection in Liver Recipients in a High CMV Seroprevalence Region - Outcomes and the Use of Antigenemia

VIRUS Reviews & Research, 2013

Cytomegalovirus (CMV) is the most frequent viral infection in liver recipients, acting as immunom... more Cytomegalovirus (CMV) is the most frequent viral infection in liver recipients, acting as immunomodulatory factor for other opportunistic infections and rejection. We assessed the outcomes of CMV infection in liver recipients in a high CMV seroprevalence region and the use of antigenemia for the diagnosis of CMV syndrome. Between March 2007 and April 2009, 44 liver recipients collected 344 samples for CMV antigenemia. Defi nition of active CMV infections used literature criteria. Recipients' outcomes [CMV syndrome, Hepatitis C Virus (HCV) recurrence, rejection and mortality] were analyzed. Performance of antigenemia for the diagnosis of CMV syndrome was assessed by the area under the Receiver Operating Curve (AUROC) of 52 positive samples, representing 24 recipients. CMV serology was positive (R+) in 90.9% of liver recipients. CMV syndrome occurred in 18 (40.9%) recipients. CMV negative serology (R-) recipients had lower disease-free time, as well as lower one-year and four-year survival rates (p = 0.022 and p = 0.004, respectively). HCV+ recipients presented CMV-associated indirect eff ects and had a tendency to lower fouryear survival rate (p=0.089). Th e AUROC for CMV syndrome was 0.745 (95% CI 0.606 to 0.856, p = 0.006), with a cutoff of more than 8 positive cells/200,000 leukocytes, (sensitivity of 88.9% and specifi city of 74.4%). CMV infection is associated to morbidity and lower survival rates in liver recipients in a high CMV seroprevalence region. Using antigenemia, the cutoff for diagnosing CMV syndrome was higher than 8 positive cells/200,000 leukocytes, with an appropriated performance through its accuracy.

Research paper thumbnail of Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene

Research paper thumbnail of Seroprevalence of human herpesvirus-8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Journal of medical …, 2004

Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in bot... more Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV-infected and uninfected patients. HHV-8 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV-8 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV-8 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92/2,470; 95% CI 2.9-4.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and Có rdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (P > 0.05) between men and women or age related, except in Brazil where positive cases were 30-49-year-old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low-prevalence regions. South America is a large sub-continent with a wide spectrum of population and geographical characteristics, thus, more HHV-8 prevalence studies should be necessary to establish possible regional differences.

Research paper thumbnail of Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Multiple Myeloma

Acta Haematologica, Feb 1, 2001

... Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Mult... more ... Low Incidence of Human Herpesvirus 8 in Bone Marrow Samples from Brazilian Patients with Multiple Myeloma A. Cunha a , SC ... Fernando F. Costa Hemocentro – UNICAMP Cidade Universitária Zeferino Vaz Caixa Postal 6198, CEP Campinas, SP, 13083-970 (Brazil) Tel. ...

Research paper thumbnail of Active Cytomegalovirus (CMV) Infection in Liver Recipients in a High CMV Seroprevalence Region - Outcomes and the Use of Antigenemia

VIRUS Reviews & Research, 2013

Cytomegalovirus (CMV) is the most frequent viral infection in liver recipients, acting as immunom... more Cytomegalovirus (CMV) is the most frequent viral infection in liver recipients, acting as immunomodulatory factor for other opportunistic infections and rejection. We assessed the outcomes of CMV infection in liver recipients in a high CMV seroprevalence region and the use of antigenemia for the diagnosis of CMV syndrome. Between March 2007 and April 2009, 44 liver recipients collected 344 samples for CMV antigenemia. Defi nition of active CMV infections used literature criteria. Recipients' outcomes [CMV syndrome, Hepatitis C Virus (HCV) recurrence, rejection and mortality] were analyzed. Performance of antigenemia for the diagnosis of CMV syndrome was assessed by the area under the Receiver Operating Curve (AUROC) of 52 positive samples, representing 24 recipients. CMV serology was positive (R+) in 90.9% of liver recipients. CMV syndrome occurred in 18 (40.9%) recipients. CMV negative serology (R-) recipients had lower disease-free time, as well as lower one-year and four-year survival rates (p = 0.022 and p = 0.004, respectively). HCV+ recipients presented CMV-associated indirect eff ects and had a tendency to lower fouryear survival rate (p=0.089). Th e AUROC for CMV syndrome was 0.745 (95% CI 0.606 to 0.856, p = 0.006), with a cutoff of more than 8 positive cells/200,000 leukocytes, (sensitivity of 88.9% and specifi city of 74.4%). CMV infection is associated to morbidity and lower survival rates in liver recipients in a high CMV seroprevalence region. Using antigenemia, the cutoff for diagnosing CMV syndrome was higher than 8 positive cells/200,000 leukocytes, with an appropriated performance through its accuracy.

Research paper thumbnail of Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene

Research paper thumbnail of Seroprevalence of human herpesvirus-8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

Journal of medical …, 2004

Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in bot... more Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV-infected and uninfected patients. HHV-8 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV-8 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV-8 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92/2,470; 95% CI 2.9-4.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and Có rdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (P > 0.05) between men and women or age related, except in Brazil where positive cases were 30-49-year-old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low-prevalence regions. South America is a large sub-continent with a wide spectrum of population and geographical characteristics, thus, more HHV-8 prevalence studies should be necessary to establish possible regional differences.