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Papers by Andy Smith

Research paper thumbnail of Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure

TETRAHEDRON, 2011

The conjugate addition of an enantiopure lithium amide to a z-hydroxy-a,b-unsaturated ester follo... more The conjugate addition of an enantiopure lithium amide to a z-hydroxy-a,b-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)coniine and (R)-d-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides AeC).

Research paper thumbnail of Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure

TETRAHEDRON, 2011

The conjugate addition of an enantiopure lithium amide to a z-hydroxy-a,b-unsaturated ester follo... more The conjugate addition of an enantiopure lithium amide to a z-hydroxy-a,b-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)coniine and (R)-d-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides AeC).

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