Angélica Soto - Academia.edu (original) (raw)

Papers by Angélica Soto

Research paper thumbnail of Huentelauquén coastal groups in the Andean highlands? An assessment of human occupations of the Early Holocene in Salar de Pedernales, Chile (26°S, 3356 masl)

Research paper thumbnail of Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress

Current Medicinal Chemistry, 2022

: Aging is defined as the functional loss of tissues and organs over time. This is a biological, ... more : Aging is defined as the functional loss of tissues and organs over time. This is a biological, irreversible, progressive, and universal process that results from genetic and environmental factors, such as diet, physical activity, smoking, harmful alcohol consumption, and exposure to toxins, among others. Aging is a consequence of molecular and cellular damage built up over time. This damage begins with a gradual decrease in physical and mental capacity, thus increasing the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Neuronal, functional, and structural damage can be explained by an imbalance among free radicals, reactive oxygen species, reactive nitrogen species, and antioxidants, which finally lead to oxidative stress. Due to the key role of free radicals, reactive oxygen species, and reactive nitrogen species, antioxidant therapy may reduce the oxidative damage associated with neurodegeneration. Exogenous antioxidants are molecules that may help maintain the balance between the formation and elimination of free radicals, thus protecting the cell from their toxicity. Among them, polyphenols are a broad group of secondary plant metabolites with potent antioxidant properties. Here, we review several studies that show the potential role of polyphenol consumption to prevent, or slow down, harmful oxidative processes linked to neurodegenerative disorders.

Research paper thumbnail of Análisis de cuentos escritos por trabajadores chilenos

Este seminario es un trabajo de investigacion enfocado al analisis de cuentos escritos por trabaj... more Este seminario es un trabajo de investigacion enfocado al analisis de cuentos escritos por trabajadores chilenos para el concurso “Mi Vida y mi Trabajo” realizado por la Direccion del Trabajo durante los anos 2002 y 2003. El objetivo principal de este trabajo es conocer el mundo laboral chileno desde otra perspectiva, en este caso, el estudio de la literatura escrita por trabajadores chilenos que nos narran sus experiencias y situaciones permitiendonos tomar conocimiento de lo que ocurre en las organizaciones del pais. Para ello, elegimos una muestra posible de analizar dentro de la totalidad de cuentos de ambos anos, remitiendonos solo a los relatos provenientes de la ciudad de Santiago, clasificados segun genero y representativa de todos los estratos socioeconomicos, con lo que posterior al analisis, logramos obtener nuestras conclusiones. Estas dicen relacion al aprendizaje de lo que sucede en las organizaciones chilenas, a los diversos tipos de trabajos que se presentan junto a ...

Research paper thumbnail of On the Construction of a Phylogenetic Tree

Zeitschrift für Naturforschung C, 1979

An algorithm for phylogenetic trees’ construction is analyzed.

Research paper thumbnail of Red de investigación sobre trabajo en equipo y pedagogía de proyectos: un modelo alternativo para la formación docente

Revista Iberoamericana de Educación, 2012

Los docentes son el centro de los sistemas educativos de calidad. Todo sistema educativo que pr... more Los docentes son el centro de los sistemas educativos de calidad. Todo sistema educativo que pretenda alcanzar importantes indicadores de calidad, debe procurar procesos de formación de sus docentes. La formación continua de los docentes, es un aspecto fundamental para la cualificación del magisterio, pues es a través de ella que se garantiza el desarrollo de habilidades profesionales que con urgencia reclama la escuela hoy. La formación de los docentes encuentra una importante alternativa en la configuración de comunidades pedagógicas, concepto que se ha articulado a la Red de Investigación sobre Trabajo en Equipo y Pedagogía de Proyectos, impulsada por la Fundación Convivencia – Centro de Investigación Educativa. Es la Red de docentes una importante expresión de lo que es una comunidad pedagógica, cuya preocupación es la formación docente y, por supuesto, contribuir a la calidad de la educación en el escenario nacional.

Research paper thumbnail of Perfil social y económico de los pacientes diagnosticados con esquizofrenia en Cali

Revista de Sociología, 2018

El objetivo de este artículo consiste en la construcción de un perfil social, económico y demográ... more El objetivo de este artículo consiste en la construcción de un perfil social, económico y demográfico de la población registrada con el Sistema de Selección de Beneficiarios para Programas Sociales (SISBEN) del Hospital Departamental Psiquiátrico Universitario del Valle (HDPUV) entre el 2009 y el 2017, cuyo diagnóstico se encuentra dentro del clúster de esquizofrenia, trastorno esquizotípico o trastorno de ideas delirantes. Se optó por un trabajo en el que se complementó la información entre las bases de datos del SISBEN de Cali y la del HDPUV para profundizar en datos sobre pobreza y vulnerabilidad de las personas que son potenciales beneficiarios de programas sociales estatales. Finalmente, el documento sugiere que hay una necesidad por estudiar la relación entre la pobreza, vulnerabilidad y salud mental, que no es casual, pero sí implica una prolongación o recrudecimiento de un ciclo de pobreza y de dificultades para la atención de los trastornos mentales agudos.

Research paper thumbnail of A novel approach to molecular evolution study

Origins of Life and Evolution of the Biosphere, 1996

Research paper thumbnail of Automorphic structures and molecular evolution

Origins of Life and Evolution of the Biosphere, 1996

Research paper thumbnail of Biocryptography

Research paper thumbnail of On the Determination of Internal Nodes of an Evolutionary Dendrogram

Origins of Life and Evolution of Biospheres, 1998

In this communication the determination of intermediary nodes in evolutionary dendrograms of prot... more In this communication the determination of intermediary nodes in evolutionary dendrograms of proteins is analyzed, based on the molecular mechanisms involved in these transitions and the probability of acceptance of the amino acid substitutions.

Research paper thumbnail of On the codon evolution

Origins of Life and Evolution of the Biosphere, 1986

Research paper thumbnail of Phylogenetic tree of tRNAs using a simple algorithm

Origins of Life and Evolution of the Biosphere, 1990

A simple method for phylogenetic tree construction is described. In this method each node is calc... more A simple method for phylogenetic tree construction is described. In this method each node is calculated considering the distance between the elements and the difference between these elements and an average element, allowing the selection of the most probable node. Two examples of tRNA phylogenies (E coti set and Phe family) are analyzed, giving both reliable trees. Data from these dendrograms give support to the idea of an early cloverleaf arising.

Research paper thumbnail of Dissimilar rates in molecular evolution

Origins of Life, 1984

In this work we present an evolutionary tree based on the differences in the physico-chemical pro... more In this work we present an evolutionary tree based on the differences in the physico-chemical properties involved in ami,o acid substitutions, instead of considering, for its construction, only the number of changes between species. Phylogenetic trees were constructed from the differences in bulkiness, refractivity index, hydrophobicity, polarity and optical rotation of 9 vertebrate calcitonins. A correlation of the form y = a x b was found between the number of changes (x) and the differences in any given physico-chemical property (y). This correlation implies that the evolutionary time can not be evaluated directly from the number of changes between species.

Research paper thumbnail of Experimental bases for a primordial genetic code

Origins of Life and Evolution of the Biosphere, 1986

Research paper thumbnail of A quantitative method for pattern recognition. An application to E. coli tRNA configuration

Origins of Life and Evolution of the Biosphere, 1989

Without Abstract

Research paper thumbnail of Phylogenetic tree of E. coli T rans using a simple algorithm

Origins of Life and Evolution of the Biosphere, 1989

Without Abstract

Research paper thumbnail of Conservation of the secondary structure of protein during evolution and the role of the genetic code

Origins of Life and Evolution of the Biosphere, 1985

In this communication we demonstrate, in a group of modern proteins, following an algorithm descr... more In this communication we demonstrate, in a group of modern proteins, following an algorithm described by Argyle (1980), that the ordination of the amino acids in terms of the most frequent substitutions agrees with the conservation of the alpha-helix, beta-sheet, and beta-turn formation tendencies during evolution. The same correspondence has been demonstrated for the conservation of the physico-chemical properties in the amino acid substitutions. Both parameters are similar in showing higher correlation with the most frequent amino acid substitutions than with the feasibility of changes at the level of the respective codons. Some kind of restrictions for the expression of the genomic changes, due to the conservation of the secondary structure of proteins and/or the physicochemical properties of the substituted amino acids, could account for the differences found between the distribution of the amino acid substitutions and the most probable codon changes.

Research paper thumbnail of Secondary Structure of Proteins and Three-dimensional Pattern Recognition

Journal of Theoretical Biology, 1999

We describe a new, parameter-free, method to predict the secondary structure of a protein. It is ... more We describe a new, parameter-free, method to predict the secondary structure of a protein. It is based on the recognition of well-de"ned pentapeptides, which allows the discrimination of helices, sheets and random coils in proteins. Presently, a success rate of about 65% is achieved for a three-state model.

Research paper thumbnail of Removal of faecal coliform in high pH ponds using rapid growth alga biomass

International Journal of Environmental Health Research, 1991

A simple device for an efficient waste water treatment is described. The procedure uses a massive... more A simple device for an efficient waste water treatment is described. The procedure uses a massive microalga culture as a source of OH-, which increases the pH of the medium killing the bacterial population. In the device the alga culture remains separated from the waste water by a mesh of synthetic material or a ceramic permeable to OH- .

Research paper thumbnail of Huentelauquén coastal groups in the Andean highlands? An assessment of human occupations of the Early Holocene in Salar de Pedernales, Chile (26°S, 3356 masl)

Research paper thumbnail of Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress

Current Medicinal Chemistry, 2022

: Aging is defined as the functional loss of tissues and organs over time. This is a biological, ... more : Aging is defined as the functional loss of tissues and organs over time. This is a biological, irreversible, progressive, and universal process that results from genetic and environmental factors, such as diet, physical activity, smoking, harmful alcohol consumption, and exposure to toxins, among others. Aging is a consequence of molecular and cellular damage built up over time. This damage begins with a gradual decrease in physical and mental capacity, thus increasing the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Neuronal, functional, and structural damage can be explained by an imbalance among free radicals, reactive oxygen species, reactive nitrogen species, and antioxidants, which finally lead to oxidative stress. Due to the key role of free radicals, reactive oxygen species, and reactive nitrogen species, antioxidant therapy may reduce the oxidative damage associated with neurodegeneration. Exogenous antioxidants are molecules that may help maintain the balance between the formation and elimination of free radicals, thus protecting the cell from their toxicity. Among them, polyphenols are a broad group of secondary plant metabolites with potent antioxidant properties. Here, we review several studies that show the potential role of polyphenol consumption to prevent, or slow down, harmful oxidative processes linked to neurodegenerative disorders.

Research paper thumbnail of Análisis de cuentos escritos por trabajadores chilenos

Este seminario es un trabajo de investigacion enfocado al analisis de cuentos escritos por trabaj... more Este seminario es un trabajo de investigacion enfocado al analisis de cuentos escritos por trabajadores chilenos para el concurso “Mi Vida y mi Trabajo” realizado por la Direccion del Trabajo durante los anos 2002 y 2003. El objetivo principal de este trabajo es conocer el mundo laboral chileno desde otra perspectiva, en este caso, el estudio de la literatura escrita por trabajadores chilenos que nos narran sus experiencias y situaciones permitiendonos tomar conocimiento de lo que ocurre en las organizaciones del pais. Para ello, elegimos una muestra posible de analizar dentro de la totalidad de cuentos de ambos anos, remitiendonos solo a los relatos provenientes de la ciudad de Santiago, clasificados segun genero y representativa de todos los estratos socioeconomicos, con lo que posterior al analisis, logramos obtener nuestras conclusiones. Estas dicen relacion al aprendizaje de lo que sucede en las organizaciones chilenas, a los diversos tipos de trabajos que se presentan junto a ...

Research paper thumbnail of On the Construction of a Phylogenetic Tree

Zeitschrift für Naturforschung C, 1979

An algorithm for phylogenetic trees’ construction is analyzed.

Research paper thumbnail of Red de investigación sobre trabajo en equipo y pedagogía de proyectos: un modelo alternativo para la formación docente

Revista Iberoamericana de Educación, 2012

Los docentes son el centro de los sistemas educativos de calidad. Todo sistema educativo que pr... more Los docentes son el centro de los sistemas educativos de calidad. Todo sistema educativo que pretenda alcanzar importantes indicadores de calidad, debe procurar procesos de formación de sus docentes. La formación continua de los docentes, es un aspecto fundamental para la cualificación del magisterio, pues es a través de ella que se garantiza el desarrollo de habilidades profesionales que con urgencia reclama la escuela hoy. La formación de los docentes encuentra una importante alternativa en la configuración de comunidades pedagógicas, concepto que se ha articulado a la Red de Investigación sobre Trabajo en Equipo y Pedagogía de Proyectos, impulsada por la Fundación Convivencia – Centro de Investigación Educativa. Es la Red de docentes una importante expresión de lo que es una comunidad pedagógica, cuya preocupación es la formación docente y, por supuesto, contribuir a la calidad de la educación en el escenario nacional.

Research paper thumbnail of Perfil social y económico de los pacientes diagnosticados con esquizofrenia en Cali

Revista de Sociología, 2018

El objetivo de este artículo consiste en la construcción de un perfil social, económico y demográ... more El objetivo de este artículo consiste en la construcción de un perfil social, económico y demográfico de la población registrada con el Sistema de Selección de Beneficiarios para Programas Sociales (SISBEN) del Hospital Departamental Psiquiátrico Universitario del Valle (HDPUV) entre el 2009 y el 2017, cuyo diagnóstico se encuentra dentro del clúster de esquizofrenia, trastorno esquizotípico o trastorno de ideas delirantes. Se optó por un trabajo en el que se complementó la información entre las bases de datos del SISBEN de Cali y la del HDPUV para profundizar en datos sobre pobreza y vulnerabilidad de las personas que son potenciales beneficiarios de programas sociales estatales. Finalmente, el documento sugiere que hay una necesidad por estudiar la relación entre la pobreza, vulnerabilidad y salud mental, que no es casual, pero sí implica una prolongación o recrudecimiento de un ciclo de pobreza y de dificultades para la atención de los trastornos mentales agudos.

Research paper thumbnail of A novel approach to molecular evolution study

Origins of Life and Evolution of the Biosphere, 1996

Research paper thumbnail of Automorphic structures and molecular evolution

Origins of Life and Evolution of the Biosphere, 1996

Research paper thumbnail of Biocryptography

Research paper thumbnail of On the Determination of Internal Nodes of an Evolutionary Dendrogram

Origins of Life and Evolution of Biospheres, 1998

In this communication the determination of intermediary nodes in evolutionary dendrograms of prot... more In this communication the determination of intermediary nodes in evolutionary dendrograms of proteins is analyzed, based on the molecular mechanisms involved in these transitions and the probability of acceptance of the amino acid substitutions.

Research paper thumbnail of On the codon evolution

Origins of Life and Evolution of the Biosphere, 1986

Research paper thumbnail of Phylogenetic tree of tRNAs using a simple algorithm

Origins of Life and Evolution of the Biosphere, 1990

A simple method for phylogenetic tree construction is described. In this method each node is calc... more A simple method for phylogenetic tree construction is described. In this method each node is calculated considering the distance between the elements and the difference between these elements and an average element, allowing the selection of the most probable node. Two examples of tRNA phylogenies (E coti set and Phe family) are analyzed, giving both reliable trees. Data from these dendrograms give support to the idea of an early cloverleaf arising.

Research paper thumbnail of Dissimilar rates in molecular evolution

Origins of Life, 1984

In this work we present an evolutionary tree based on the differences in the physico-chemical pro... more In this work we present an evolutionary tree based on the differences in the physico-chemical properties involved in ami,o acid substitutions, instead of considering, for its construction, only the number of changes between species. Phylogenetic trees were constructed from the differences in bulkiness, refractivity index, hydrophobicity, polarity and optical rotation of 9 vertebrate calcitonins. A correlation of the form y = a x b was found between the number of changes (x) and the differences in any given physico-chemical property (y). This correlation implies that the evolutionary time can not be evaluated directly from the number of changes between species.

Research paper thumbnail of Experimental bases for a primordial genetic code

Origins of Life and Evolution of the Biosphere, 1986

Research paper thumbnail of A quantitative method for pattern recognition. An application to E. coli tRNA configuration

Origins of Life and Evolution of the Biosphere, 1989

Without Abstract

Research paper thumbnail of Phylogenetic tree of E. coli T rans using a simple algorithm

Origins of Life and Evolution of the Biosphere, 1989

Without Abstract

Research paper thumbnail of Conservation of the secondary structure of protein during evolution and the role of the genetic code

Origins of Life and Evolution of the Biosphere, 1985

In this communication we demonstrate, in a group of modern proteins, following an algorithm descr... more In this communication we demonstrate, in a group of modern proteins, following an algorithm described by Argyle (1980), that the ordination of the amino acids in terms of the most frequent substitutions agrees with the conservation of the alpha-helix, beta-sheet, and beta-turn formation tendencies during evolution. The same correspondence has been demonstrated for the conservation of the physico-chemical properties in the amino acid substitutions. Both parameters are similar in showing higher correlation with the most frequent amino acid substitutions than with the feasibility of changes at the level of the respective codons. Some kind of restrictions for the expression of the genomic changes, due to the conservation of the secondary structure of proteins and/or the physicochemical properties of the substituted amino acids, could account for the differences found between the distribution of the amino acid substitutions and the most probable codon changes.

Research paper thumbnail of Secondary Structure of Proteins and Three-dimensional Pattern Recognition

Journal of Theoretical Biology, 1999

We describe a new, parameter-free, method to predict the secondary structure of a protein. It is ... more We describe a new, parameter-free, method to predict the secondary structure of a protein. It is based on the recognition of well-de"ned pentapeptides, which allows the discrimination of helices, sheets and random coils in proteins. Presently, a success rate of about 65% is achieved for a three-state model.

Research paper thumbnail of Removal of faecal coliform in high pH ponds using rapid growth alga biomass

International Journal of Environmental Health Research, 1991

A simple device for an efficient waste water treatment is described. The procedure uses a massive... more A simple device for an efficient waste water treatment is described. The procedure uses a massive microalga culture as a source of OH-, which increases the pH of the medium killing the bacterial population. In the device the alga culture remains separated from the waste water by a mesh of synthetic material or a ceramic permeable to OH- .